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Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 2, pp. 236 - 250
Caspase-8 activation can be triggered by death receptor-mediated formation of the death-inducing signaling complex (DISC... 
caspase-8 | DED | MC159 | cFLIP | DISC | Fas | death domain | FADD | vFLIP | filament | APOPTOSIS | ACTIVATION | IMMUNE-SYSTEM | INHIBITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | UNIFIED MODEL | EFFECTOR DOMAIN | CELL-DEATH | CELL BIOLOGY | Death Domain Receptor Signaling Adaptor Proteins - chemistry | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Humans | Caspase 8 - metabolism | Caspase 8 - chemistry | CASP8 and FADD-Like Apoptosis Regulating Protein - chemistry | Death Domain Receptor Signaling Adaptor Proteins - genetics | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Caspase 8 - genetics | Transfection | Cytoskeletal Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Death Effector Domain | Fas-Associated Death Domain Protein - genetics | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Jurkat Cells | Viral Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Viral Proteins - genetics | fas Receptor - pharmacology | Cytoskeletal Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | Fas-Associated Death Domain Protein - chemistry | Cryoelectron Microscopy | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation, beta-Strand | CARD Signaling Adaptor Proteins | Plasmids - chemistry | Protein Binding | Recombinant Fusion Proteins - genetics | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Autoimmunity | Medical colleges | Skin diseases | Molecular biology | Analysis | Index Medicus
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2010, Volume 207, Issue 4, pp. 777 - 792
...), which mobilize downstream signaling cascades. We investigated the role of the cytosolic adaptor caspase recruitment domain family, member 9 (CARD9) in tuberculosis... 
MYCOBACTERIUM-TUBERCULOSIS | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | MURINE TUBERCULOSIS | INTERFERON-GAMMA | DENDRITIC CELLS | TOLL-LIKE RECEPTORS | IMMUNOLOGY | ACUTE-INFLAMMATION | 2-DEFICIENT MICE | MACROPHAGE ACTIVATION | INNATE IMMUNITY | Lung - microbiology | Chemokines - blood | Pneumonia - therapy | Gene Expression - genetics | Protein-Tyrosine Kinases - metabolism | Immunity, Innate - genetics | Radiation Chimera - microbiology | Apoptosis - genetics | Male | Intracellular Signaling Peptides and Proteins - metabolism | Hypersensitivity, Delayed - immunology | Granulocyte Colony-Stimulating Factor - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - immunology | Neutrophils - metabolism | Syk Kinase | Tuberculosis - pathology | Hypersensitivity, Delayed - genetics | Radiation Chimera - immunology | Antigen-Presenting Cells - metabolism | Macrophage Activation - immunology | Antigen-Presenting Cells - drug effects | Lectins, C-Type | Neutrophils - drug effects | Mice, Knockout | Membrane Proteins - antagonists & inhibitors | Lung - drug effects | Survival Analysis | Chemokines - metabolism | Mice | Protein-Tyrosine Kinases - antagonists & inhibitors | T-Lymphocyte Subsets - immunology | Macrophage Activation - genetics | Pneumonia - pathology | Tuberculosis - microbiology | Antigen-Presenting Cells - microbiology | Leukocyte Reduction Procedures | Tuberculosis - drug therapy | Interleukin-10 - metabolism | Female | Lung - metabolism | Membrane Proteins - metabolism | Antitubercular Agents - therapeutic use | Cytokines - blood | Neutrophils - pathology | Polysaccharides, Bacterial - pharmacology | Nerve Tissue Proteins - antagonists & inhibitors | Genetic Predisposition to Disease - genetics | Lung - pathology | Cytokines - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Neutrophils - immunology | Antigen-Presenting Cells - immunology | Nerve Tissue Proteins - metabolism | Tuberculosis - immunology | Immunity, Innate - immunology | Animals | T-Lymphocyte Subsets - metabolism | CARD Signaling Adaptor Proteins | Adaptor Proteins, Signal Transducing - genetics | Macrophage Activation - drug effects | Lung - immunology
Journal Article
Nature immunology, ISSN 1529-2916, 2014, Volume 15, Issue 8, pp. 727 - 737
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2019, Volume 129, Issue 7, pp. 2717 - 2729
.... Here, we report that the downstream of kinase 3 (Dok3) adaptor negatively regulates antifungal immunity in neutrophils... 
Adaptor proteins | Infectious disease | Innate immunity | Immunology | MEDICINE, RESEARCH & EXPERIMENTAL | REGULATOR | ADAPTER PROTEIN CARD9 | CANDIDA-ALBICANS | C-TYPE LECTIN | RECOGNITION | PATHWAY | DOK-3 | NEGATIVE REGULATION | CELL-DIFFERENTIATION | RECEPTORS | Candidiasis - genetics | CARD Signaling Adaptor Proteins - immunology | Neutrophils - immunology | Signal Transduction - genetics | Candida albicans - immunology | Protein Phosphatase 1 - immunology | CARD Signaling Adaptor Proteins - genetics | Mice, Knockout | Signal Transduction - immunology | Animals | Adaptor Proteins, Signal Transducing - genetics | Protein Phosphatase 1 - genetics | Adaptor Proteins, Signal Transducing - immunology | Mice | Candidiasis - immunology | Candidiasis - pathology | Neutrophils - pathology | Infection | Canada | Phosphatases | Singapore | Cytokines | Mortality | Antifungal agents | Mycoses | B cells | Health aspects | Phosphorylation | Phosphoprotein phosphatase | Disseminated infection | Fungal infections | Kinases | Drug resistance | Phosphatase | Autophagy | Immunosuppressive agents | Lethal dose | Proteins | Fungi | Drug dosages | NF-κB protein | Cell survival | Immune response | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Gene expression | Morbidity | Defense | Medical prognosis | Lymphomas | Protein phosphatase | Mutation | Candidemia | Phagocytosis | Viral infections
Journal Article
Nature communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 10791
.... Through basic and translational approaches involving murine models and human genetic epidemiology, we show here the importance of the different inflammasomes in regulating inflammatory responses... 
AIRWAY EPITHELIAL-CELLS | ASPERGILLUS-FUMIGATUS | III SECRETION APPARATUS | CHRONIC GRANULOMATOUS-DISEASE | ENVIRONMENT INTERACTIONS | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | HOST-DEFENSE | NLRP3 INFLAMMASOME | LUNG INFECTION | IMMUNE RECOGNITION | Immunohistochemistry | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Child, Preschool | Male | Cystic Fibrosis - immunology | Young Adult | Calcium-Binding Proteins - immunology | Autophagy - genetics | Interleukin 1 Receptor Antagonist Protein - pharmacology | Child | Cytokines - genetics | Carrier Proteins - immunology | Disease Models, Animal | Apoptosis Regulatory Proteins - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Respiratory Mucosa - cytology | Cystic Fibrosis - microbiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Cystic Fibrosis - genetics | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | Aspergillus fumigatus | Calcium-Binding Proteins - genetics | Infant | Interleukin 1 Receptor Antagonist Protein - genetics | CARD Signaling Adaptor Proteins - genetics | Autophagy - immunology | Apoptosis Regulatory Proteins - genetics | Adult | Female | Pseudomonas aeruginosa | Lung - metabolism | Macrophages - immunology | Cytokines - immunology | In Situ Nick-End Labeling | CARD Signaling Adaptor Proteins - immunology | Cell Line | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Inflammation | Inflammasomes - genetics | Pseudomonas Infections - immunology | Carrier Proteins - genetics | Animals | Epithelial Cells - immunology | Inflammasomes - immunology | Fluorescent Antibody Technique | Polymorphism, Single Nucleotide | Aspergillosis - immunology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here... 
Cytoskeletal Proteins | Flagellin | Immunoblotting | Legionella pneumophila | Macrophages | Adaptor Proteins, Vesicular Transport | Necrosis | Receptor, Interferon alpha-beta | Caspase 1 | Carrier Proteins | Calcium-Binding Proteins | Cytokines | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 | Mice, Knockout | Host-Pathogen Interactions | Animals | Apoptosis Regulatory Proteins | Bone Marrow Cells | Mice | Caspases | Enzyme Activation | Mutation | Apoptosis | Cell death | Innate immunity | Inflammasome | PATTERN-RECOGNITION | innate immunity | cell death | inflammasome | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | INFECTION | RECEPTORS | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Calcium-Binding Proteins - genetics | Genetic aspects | Research | Properties | Immunological research | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 12/2015, Volume 112, Issue 52, pp. E7230 - E7238
Journal Article
Nature immunology, ISSN 1529-2916, 2009, Volume 11, Issue 1, pp. 63 - 69
Journal Article