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1. Full Text Inflammasomes: current understanding and open questions
by Bauernfeind, Franz and Bauernfeind, Franz and Ablasser, Andrea and Ablasser, Andrea and Bartok, Eva and Bartok, Eva and Kim, Sarah and Kim, Sarah and Schmid-Burgk, Jonathan and Schmid-Burgk, Jonathan and Cavlar, Taner and Cavlar, Taner and Hornung, Veit and Hornung, Veit
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 3/2011, Volume 68, Issue 5, pp. 765 - 783
Life Sciences | Biochemistry, general | AIM2 | Life Sciences, general | NLR | NLRP3 | IL-1β | Biomedicine general | Cell Biology | Caspase-1 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Adaptor Proteins, Signal Transducing - chemistry | Calcium-Binding Proteins - chemistry | Carrier Proteins - physiology | Interleukin-1beta - physiology | CARD Signaling Adaptor Proteins - physiology | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein | Apoptosis Regulatory Proteins - chemistry | Humans | Caspase 1 - metabolism | Immunity, Innate | Nuclear Proteins - chemistry | Inflammasomes - physiology | Adaptor Proteins, Signal Transducing - physiology | Models, Immunological | Interleukin-1beta - metabolism | Calcium-Binding Proteins - physiology | CARD Signaling Adaptor Proteins - chemistry | Apoptosis Regulatory Proteins - physiology | Carrier Proteins - chemistry | Nuclear Proteins - physiology | DNA-Binding Proteins | Proteins | Signal transduction | Cellular biology | Rodents | Molecular biology | Gene expression | Immune system | Index Medicus
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2. Full Text The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex
by Reed, John C and Fombonne, Joanna and Thibert, Chantal and Hayashi, Hideki and Guix, Catherine and Corset, Véronique and Mehlen, Patrick and Mille, Frédéric and Rama, Nicolas
Nature cell biology, ISSN 1465-7392, 06/2009, Volume 11, Issue 6, pp. 739 - 746
Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Caspase 9 - metabolism | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Hedgehog Proteins - genetics | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Patched Receptors | Neoplasm Proteins - genetics | Cell Line | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Chick Embryo | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Adaptor Proteins, Signal Transducing - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Causes of | Physiological aspects | Cell receptors | Research | Proteases | Apoptosis | Index Medicus | Caspase 9 | Signal Transduction | Multiprotein Complexes | Receptors, Cell Surface | Cellular Biology | Hedgehog Proteins | Life Sciences | Muscle Proteins | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Homeodomain Proteins | Neoplasm Proteins | CARD Signaling Adaptor Proteins | RNA, Small Interfering | Transcription Factors | Development Biology | physiology | genetics | metabolism
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3. Full Text Signaling pathways downstream of pattern-recognition receptors and their cross talk
by Lee, Myeong Sup and Kim, Young-Joon
Annual Review of Biochemistry, ISSN 0066-4154, 2007, Volume 76, Issue 1, pp. 447 - 480
Nod-like receptor | Innate immunity | Dectin-1 | Inflammasome | Card helicase | Toll-like receptor | Immune System - physiology | Membrane Proteins - genetics | Lectins, C-Type | Neuronal Apoptosis-Inhibitory Protein - genetics | Nerve Tissue Proteins - genetics | Neuronal Apoptosis-Inhibitory Protein - metabolism | CARD Signaling Adaptor Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Receptors, Pattern Recognition - metabolism | CARD Signaling Adaptor Proteins - metabolism | Animals | Carrier Proteins - metabolism | Nod Signaling Adaptor Proteins - genetics | Toll-Like Receptors - genetics | Nod Signaling Adaptor Proteins - metabolism | Interleukin-10 - metabolism | Receptors, Pattern Recognition - genetics | Signal Transduction - physiology | Membrane Proteins - metabolism | Toll-Like Receptors - metabolism | Transforming Growth Factor beta - metabolism | Pathogens | Pathology | Biochemistry | Inflammatory diseases | Medical immunity | Index Medicus
Conference Proceeding
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4. Full Text Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
by Finger, Katrin and Peschel, Christian and Schäfer, Martin and Gross, Olaf and Ruland, Jürgen and Gewies, Andreas and Sparwasser, Tim and Förster, Irmgard
Nature (London), ISSN 0028-0836, 08/2006, Volume 442, Issue 7103, pp. 651 - 656
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Signal transduction | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Protein-Tyrosine Kinases - metabolism | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | Fungi - immunology | Toll-Like Receptors | Lymphocyte Activation - immunology | Caspases - metabolism | Adaptor Proteins, Signal Transducing - immunology | Membrane Proteins - metabolism | Syk Kinase | Cytokines - immunology | Signal Transduction | Lectins, C-Type | Antigens, Fungal - immunology | Candida albicans - immunology | Zymosan - immunology | Nerve Tissue Proteins - metabolism | Immunity, Innate - immunology | Animals | Adaptor Proteins, Signal Transducing - deficiency | B-Cell CLL-Lymphoma 10 Protein | CARD Signaling Adaptor Proteins | Adaptor Proteins, Signal Transducing - genetics | Mice | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Cytokines - biosynthesis | Proteins | Fungal infections | Cytokines | Immune system | Index Medicus
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5. Full Text Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
by Akira, Shizuo and Hornung, Veit and Rebsamen, Manuele and Kato, Hiroki and Gross, Olaf and Roth, Susanne and Schlee, Martin and Bscheider, Michael and Poeck, Hendrik and Barchet, Winfried and Endres, Stefan and Inoue, Satoshi and Peschel, Christian and Ruland, Jürgen and Rothenfusser, Simon and Finger, Katrin and Hannesschläger, Nicole and Hartmann, Gunther
Nature immunology, ISSN 1529-2908, 01/2010, Volume 11, Issue 1, pp. 63 - 69
Life Sciences & Biomedicine | Immunology | Science & Technology | Humans | bcl-X Protein - genetics | RNA Viruses - physiology | Caspase 1 - metabolism | Immunoblotting | Interferon-Induced Helicase, IFIH1 | Interleukin-1beta - metabolism | RNA Viruses - immunology | DEAD-box RNA Helicases - metabolism | RNA Virus Infections - immunology | Encephalomyocarditis virus - physiology | Vesicular stomatitis Indiana virus - physiology | Cell Line | DEAD Box Protein 58 | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Cells, Cultured | Inflammation - virology | Inflammation - immunology | RNA Virus Infections - virology | Encephalomyocarditis virus - immunology | Mice, Knockout | Host-Pathogen Interactions | DEAD-box RNA Helicases - genetics | Animals | RNA Virus Infections - physiopathology | Models, Biological | CARD Signaling Adaptor Proteins | Adaptor Proteins, Signal Transducing - genetics | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | bcl-X Protein - metabolism | Vesicular stomatitis Indiana virus - immunology | Inflammation - physiopathology | Index Medicus
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6. Full Text Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation
by Cao, Zhifang and Conway, Kara L and Heath, Robert J and Rush, Jason S and Leshchiner, Elizaveta S and Ramirez-Ortiz, Zaida G and Nedelsky, Natalia B and Huang, Hailiang and Ng, Aylwin and Gardet, Agnès and Cheng, Shih-Chin and Shamji, Alykhan F and Rioux, John D and Wijmenga, Cisca and Netea, Mihai G and Means, Terry K and Daly, Mark J and Xavier, Ramnik J
Immunity (Cambridge, Mass.), ISSN 1074-7613, 10/2015, Volume 43, Issue 4, pp. 715 - 726
Life Sciences & Biomedicine | Immunology | Science & Technology | Adjuvants, Immunologic - pharmacology | Colitis - genetics | Dendritic Cells - immunology | Humans | CARD Signaling Adaptor Proteins - deficiency | Receptors, Endothelin - physiology | Candidiasis, Invasive - genetics | Mice, 129 Strain | Ubiquitin-Protein Ligases - physiology | Recombinant Fusion Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Tripartite Motif Proteins | Ubiquitination | Genes, Dominant | Protein Isoforms - chemistry | Colitis - chemically induced | HEK293 Cells | Inflammatory Bowel Diseases - genetics | Receptors, Angiotensin - chemistry | Receptors, Angiotensin - deficiency | Dendritic Cells - metabolism | Receptors, Endothelin - deficiency | Protein Structure, Tertiary | Genetic Predisposition to Disease | Specific Pathogen-Free Organisms | CARD Signaling Adaptor Proteins - physiology | Signal Transduction | Ubiquitin-Protein Ligases - chemistry | Receptors, Angiotensin - physiology | Protein Isoforms - physiology | Mice, Knockout | Protein Interaction Mapping | Receptors, Endothelin - chemistry | Animals | Candidiasis, Invasive - immunology | CARD Signaling Adaptor Proteins - chemistry | Mice | Protein Processing, Post-Translational | HeLa Cells | Colitis - prevention & control | Cytokines - biosynthesis | Protein Isoforms - genetics | Ubiquitin | Lectins | Mycoses | Inflammation | Ligases | Antifungal agents | Inflammatory bowel disease | Proteins | Phosphorylation | Hospitals | Cytokines | Regulation | Fungal infections | Grants | Kinases | Experiments | Manuscripts | Index Medicus
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7. Full Text The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
by You, Yun and Li, Hongxiu and Qin, Xiao-Feng and Hsu, Yen-Michael S and Zhang, Yongliang and Lin, Xin and Wang, Donghai and Dong, Chen and Duramad, Omar
Nature immunology, ISSN 1529-2908, 02/2007, Volume 8, Issue 2, pp. 198 - 205
Life Sciences & Biomedicine | Immunology | Science & Technology | NF-kappa B - metabolism | Listeria monocytogenes - immunology | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Adaptor Proteins, Signal Transducing - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Listeria monocytogenes - physiology | Gene Expression | Cytokines - metabolism | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Immunity, Innate - immunology | Macrophages - metabolism | Animals | Intracellular Space - microbiology | Nod2 Signaling Adaptor Protein - metabolism | Adaptor Proteins, Signal Transducing - deficiency | CARD Signaling Adaptor Proteins | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Ligands | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Infection | Evaluation | Immune response | Development and progression | Cellular signal transduction | Research | Properties | Health aspects | Index Medicus
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8. Full Text ASC/caspase‐1/IL‐1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury
by Kamo, Naoko and Ke, Bibo and Ghaffari, Amir A and Shen, Xiu‐da and Busuttil, Ronald W and Cheng, Genhong and Kupiec‐Weglinski, Jerzy W
Hepatology (Baltimore, Md.), ISSN 0270-9139, 07/2013, Volume 58, Issue 1, pp. 351 - 362
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Interleukin-1beta - physiology | Male | Cytoskeletal Proteins - deficiency | Mice, Knockout | HMGB1 Protein - biosynthesis | Liver - injuries | Toll-Like Receptor 4 - physiology | Animals | Apoptosis Regulatory Proteins | Reperfusion Injury - prevention & control | CARD Signaling Adaptor Proteins | Reperfusion Injury - immunology | Signal Transduction - physiology | Mice | Caspase 1 - physiology | Cytoskeletal Proteins - physiology | Apoptosis | Index Medicus | Inflammation | injury | TLR4 | Liver
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