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Journal Article
Lancet, The, ISSN 0140-6736, 2011, Volume 378, Issue 9792, pp. 676 - 683
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 04/2016, Volume 94, Issue 10, pp. 1033 - 1039
Journal Article
Journal Article
ORGANIC PROCESS RESEARCH & DEVELOPMENT, ISSN 1083-6160, 08/2019, Volume 23, Issue 8, pp. 1558 - 1567
The development of a factory process to manufacture the novel cardiac myosin activator omecamtiv mecarbil (1) is described. Omecamtiv mecarbil is prepared via... 
MORTALITY | PRACTICAL SYNTHESIS | omecamtiv mecarbil | nitro reduction | CHEMISTRY, ORGANIC | masked isocyanate | UNSYMMETRICAL UREAS | cardiac myosin activator | NITROARENES | REDUCTION | urea formation | benzylic bromination | CHEMISTRY, APPLIED | SELECTIVE CATALYTIC-HYDROGENATION
Journal Article
Journal Article
Circulation: Heart Failure, ISSN 1941-3289, 05/2015, Volume 8, Issue 4, pp. 766 - 775
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2016, Volume 94, Issue 10, pp. 1033 - 1039
Heart failure became a leading cause of mortality in the past few decades with a progressively increasing prevalence. Its current therapy is restricted largely... 
contractilité cardiaque | inotropic agents | cardiac myosin activator | heart failure | sensibilisateur de calcium | agents inotropes | omecamtiv mecarbil | CK-1827452 | insuffisance cardiaque | activateur de la myosine cardiaque | cardiac contractility | calcium sensitizer
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 03/2016, Volume 67, Issue 12, pp. 1456 - 1458
  The dyspnea endpoint was intricate: dyspnea was measured at multiple time points and required an improvement at 6 h as a contingency to assess subsequent... 
volume | dyspnea | omecamtiv mecarbil | left ventricular ejection fraction | CARDIAC & CARDIOVASCULAR SYSTEMS | SERELAXIN | Stroke Volume | Heart Failure | Cardiac Myosins | Ventricular Function, Left | Humans | Heart rate | Heart failure | Heart attacks | Ischemia | Mortality | Clinical trials | Physiology
Journal Article
Journal Article