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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 7, pp. 1499 - 1504
The CARMA1-BCL10-MALT1 (CBM) signalosome is a central mediator of T cell receptor and B cell receptor-induced NF-kappa B signaling that regulates multiple... 
Innate immunity | CARMA1–BCL10–MALT1 | Cryo-EM | TRAF6 | Assembly | COMPLEX | PHOSPHORYLATION | CRYSTAL-STRUCTURE | CARMA1 | MULTIDISCIPLINARY SCIENCES | KINASE C-THETA | MALT1 | innate immunity | T-CELL-ACTIVATION | assembly | CARD11 MUTATIONS | cryo-EM | NF-KAPPA-B | CRYO-EM STRUCTURE | CARMA1-BCL10-MALT1 | Biological Sciences
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2008, Volume 9, Issue 3, pp. 263 - 271
The paracaspase MALT1 mediates T cell antigen receptor-induced signaling to the transcription factor NF-kappa B and is indispensable for T cell activation and... 
ACTIVATION | CYTOKINE PRODUCTION | SIGNALING PATHWAY | UBIQUITIN LIGASE | CARMA1 | LIPID RAFTS | LYMPHOMA | BCL10 | IMMUNOLOGY | DEPENDENT GENE-EXPRESSION | CHROMOSOMAL TRANSLOCATION
Journal Article
Nature, ISSN 0028-0836, 06/2019, Volume 570, Issue 7759, pp. 112 - 112
Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as well as by regulatory T (T ) cells that restrict the... 
EFFECTOR | RESPONSES | ACTIVATION | PD-1 BLOCKADE | CARMA1 | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | SIGNALS | MALT1 PROTEASE | INHIBITORS | REQUIREMENT
Journal Article
IMMUNITY, ISSN 1074-7613, 12/2012, Volume 37, Issue 6, pp. 998 - 1008
Forkhead box P3 positive (Foxp3(+)) regulatory T (Treg) cells suppress immune responses and regulate peripheral tolerance. Here we show that the atypical... 
ACTIVATION | DISRUPTION | GENE | CARMA1 | INFLAMMATION | THYMIC DEVELOPMENT | RECEPTOR | C-REL | SELF | IMMUNOLOGY | EXPRESSION
Journal Article
Nature, ISSN 0028-0836, 03/2009, Volume 458, Issue 7234, pp. 92 - 96
The transcription factor NF-kappa B is required for lymphocyte activation and proliferation as well as the survival of certain lymphoma types(1,2). Antigen... 
UBIQUITINATION | REGULATOR | PHOSPHORYLATION | CARMA1 | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | T-CELL | WNT | ADDICTION | REQUIREMENT | BETA
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 11/2015, Volume 136, Issue 5, pp. 1139 - 1149
Three members of the caspase recruitment domain (CARD) family of adaptors (CARD9, CARD10, and CARD11) are known to form heterotrimers with B-cell lymphoma 10... 
BCL10 | CARMA1 | MALT1 | CARD9 | Primary immunodeficiency | combined immunodeficiency
Journal Article
Oncotarget, ISSN 1949-2553, 10/2017, Volume 8, Issue 49, pp. 84626 - 84627
Journal Article
Nature Immunology, ISSN 1529-2908, 2009, Volume 10, Issue 2, pp. 158 - 166
In addition to ligation of the T cell antigen receptor (TCR), activation of the CD28 coreceptor by the costimulatory molecule B7 is required for induction of... 
SURVIVAL | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | PHOSPHORYLATION | CD28-DEFICIENT MICE | CARMA1 | COSTIMULATION | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | EXPRESSION | BETA | LYMPHOCYTES
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 35, pp. 14596 - 14601
The protease activity of the paracaspase Malt1 contributes to antigen receptor-mediated lymphocyte activation and lymphomagenesis. Malt1 activity is required... 
T lymphocytes | Solvents | Phosphorylation | rev genes | Lymphocytes | DNA | Genes | Cell lines | Antibodies | Gene expression regulation | PARACASPASE | MECHANISM | signal transduction | PHOSPHORYLATION | CARMA1 | MULTIDISCIPLINARY SCIENCES | MULTIORGAN INFLAMMATION | TRANSCRIPTION | CANCER | MALT1 | T-cell receptor | IMMUNE-SYSTEM | MODULATION | Biological Sciences
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2014, Volume 5, Issue MAY, p. 249
T cell stimulation requires the input and integration of external signals. Signaling through the T cell receptor (TCR) is known to induce formation of the... 
NF-κb | Signal transduction | T cell subject category: immunology | NOTCH1 | Non-canonical | Cytosolic | PKCΘ | CARMA1
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2019, Volume 10, p. 1871
We report here two new familial cases of associated del15q11 and del7p22, with the latter underlining the clinical variability of this deletion. Two siblings... 
7p22 | vasculitis | LYMPHOCYTE | CARMA1 | CGH array | 11 CARD11 | hypogammaglobulinemia | dysimmunity | IMMUNOLOGY
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2018, Volume 215, Issue 9, pp. 2445 - 2461
Activating mutations in the adapter protein CARD11 associated with diffuse large B cell lymphomas (DLB CLs) are predicted to arise during germinal center (GC)... 
SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNOGLOBULIN SECRETION | CELL LYMPHOMA | CARMA1 | KINASE | HUMORAL IMMUNITY | CENTER LIGHT | PROLIFERATION | MUTATIONS | IMMUNOLOGY | NF-KAPPA-B | 314
Journal Article
Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 692 - 705
Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T cell activation is poorly understood. We have... 
MAMMALIAN TARGET | RAPAMYCIN | EFFECTOR | METABOLISM | PATHWAY | C-MYC | DIFFERENTIATION | IMMUNOLOGY | GLUCOSE-UPTAKE | NF-KAPPA-B | TRANSLATIONAL CONTROL | TOR Serine-Threonine Kinases - metabolism | Minor Histocompatibility Antigens | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Glutamine - metabolism | Adoptive Transfer | Neoplasm Proteins - metabolism | Th1 Cells - immunology | Enzyme Activation - immunology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Signal Transduction - immunology | CARD Signaling Adaptor Proteins - metabolism | Lymphocyte Activation - immunology | Caspases - metabolism | Biological Transport | Receptors, Antigen, T-Cell - immunology | Amino Acid Transport System ASC - genetics | Leucine - metabolism | Encephalomyelitis, Autoimmune, Experimental - pathology | Amino Acid Transport System ASC - immunology | Jurkat Cells | Mice, Inbred C57BL | Amino Acid Transport System ASC - metabolism | CD28 Antigens - immunology | Inflammation - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Cell CLL-Lymphoma 10 Protein | Mice | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-2 - biosynthesis | Autoimmunity | T cells | Analysis | Glutamine | Cytokines | Sucrose | Colleges & universities | Homeostasis | Amino acids | T cell receptors | Glucose | Kinases | Proteins | Cell growth | Lymphocytes | Immune system | Cancer | ASCT2 | CARMA1 | TCR signaling | EAE | T-cell differentiation | mTORC1 | Glutamine uptake
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2007, Volume 8, Issue 9, pp. 984 - 991
NF-kappa B (Rel) transcription factors control physiological and pathological immune cell function. The scaffold proteins Bcl-10 and MALT1 couple... 
APOPTOSIS | IMMUNITY | CARMA1 | TRANSCRIPTION | COMPLEXES | PROLIFERATION | T-CELL | IMMUNOLOGY | PROTEINS | LYMPHOCYTE-ACTIVATION | BCL-2 EXPRESSION
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2004, Volume 200, Issue 9, pp. 1167 - 1177
Carma1 (also known as caspase recruitment domain [CARD]11, Bimp3) is a CARD-containing membrane-associated guanylate kinase family protein that plays an... 
MAGUK | Immune synapse | T cell | Carma1 | IKK | Bimp3 | CARD11 | MEDICINE, RESEARCH & EXPERIMENTAL | TCR | PROTEIN | Carma1/CARD11/Bimp3 | IMMUNOLOGY | immune synapse | ANTIGEN-INDUCED TRANSLOCATION | T-CELL-ACTIVATION | LIPID RAFTS | C-THETA | IMMUNOLOGICAL SYNAPSE | LYMPHOCYTE-ACTIVATION | PKC-THETA | RECEPTOR-INDUCED ACTIVATION
Journal Article
Science, ISSN 0036-8075, 3/2008, Volume 319, Issue 5870, pp. 1676 - 1679
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2007, Volume 26, Issue 22, pp. 4634 - 4645
Triggering of antigen receptors on lymphocytes is critical for initiating adaptive immune response against pathogens. T‐cell receptor (TCR) engagement induces... 
NF‐κB | regulatory ubiquitination | Malt1 | T‐cell signaling | NF-κB | Regulatory ubiquitination | T-cell signaling | PHOSPHORYLATION | CARMA1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | BCL10 | CELL BIOLOGY | REGULATOR | kappa B | PATHWAY | IMMUNE-RESPONSES | ANTIGEN-RECEPTOR | malt1 | NF | LYMPHOCYTE-ACTIVATION | PKC-THETA
Journal Article