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Nature Reviews Genetics, ISSN 1471-0056, 05/2016, Volume 17, Issue 5, pp. 300 - 312
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 02/2016, Volume 428, Issue 5, pp. 963 - 989
Genome engineering with programmable nucleases depends on cellular responses to a targeted double-strand break (DSB). The first truly targetable reagents were... 
zinc finger nucleases (ZFNs) | genome editing | gene therapy | transcription activator-like effector nucleases (TALENs) | CRISPR-Cas9 | Zinc finger nucleases (ZFNs) | Genome editing | Gene therapy | Transcription activator-like effector nucleases (TALENs) | RESTRICTION-MODIFICATION SYSTEM | CONTROLLING GENE-EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | ZINC-FINGER NUCLEASES | DNA-BINDING SPECIFICITY | OFF-TARGET CLEAVAGE | HOMOLOGY-DIRECTED REPAIR | EFFECTOR NUCLEASES | TRANSCRIPTION FACTOR-IIIA | HEMATOPOIETIC STEM | Genetic Engineering - methods | Recombinant Proteins - metabolism | Gene Targeting - methods | Ribonucleases - genetics | Humans | Recombinant Proteins - genetics | Plants | Mammals | Deoxyribonucleases - metabolism | Ribonucleases - metabolism | Molecular Medicine - methods | Deoxyribonucleases - genetics | Animals | Cell Engineering - methods | Recombination, Genetic | Enzymes | Nucleases | Usage | RNA | Analysis | Genomics | Genetic research | DNA binding proteins | Nucleotide sequencing | Zinc finger proteins | Cells | DNA sequencing | Genomes | Genetic transcription | Medical ethics | Anopheles | Designer nucleases | Homology-directed repair (HDR) | Gene targeting (GT) | Double-strand break (DSB) | Homologous recombination (HR) | Chimeric nucleases | Non-homologous end joining (NHEJ)
Journal Article
Plant and Cell Physiology, ISSN 0032-0781, 2015, Volume 56, Issue 3, pp. 389 - 400
Journal Article
Plant Physiology, ISSN 0032-0889, 4/2016, Volume 170, Issue 4, pp. 1917 - 1928
Journal Article
NATURE BIOTECHNOLOGY, ISSN 1087-0156, 06/2014, Volume 32, Issue 6, pp. 569 - 569
Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we... 
ACTIVATION | ENDONUCLEASE | TALENS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CAS9
Journal Article
The FEBS Journal, ISSN 1742-464X, 09/2016, Volume 283, Issue 17, pp. 3239 - 3248
Recent advances in gene editing with engineered nucleases have transformed our ability to manipulate the genome from diverse organisms for applications ranging... 
homology‐directed repair | meganuclease | CRISPR/Cas9 | off‐target effect | transcription activator‐like effector nuclease | zinc finger nuclease | engineered nuclease | gene editing | nonhomologous end‐joining | Engineered nuclease | Transcription activator-like effector nuclease | Gene editing | Off-target effect | Nonhomologous end-joining | Zinc finger nuclease | Homology-directed repair | Meganuclease | transcription activator-like effector nuclease | off-target effect | nonhomologous end-joining | homology-directed repair | STRAND BREAK REPAIR | SPECIFICITY | TALENS | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESTRICTION ENZYMES | DNA-CLEAVAGE | ZINC-FINGER NUCLEASES | GENOME | CRISPR-CAS NUCLEASES | HOMING ENDONUCLEASE | Zinc Fingers | Protein Engineering - methods | Humans | Transcription Activator-Like Effector Nucleases - chemistry | Transcription Activator-Like Effector Nucleases - metabolism | Substrate Specificity | Binding Sites - genetics | Transcription Activator-Like Effector Nucleases - genetics | DNA Breaks, Double-Stranded | Deoxyribonucleases - metabolism | Deoxyribonucleases - genetics | Animals | DNA Repair | Gene Editing - methods | Deoxyribonucleases - chemistry | Animal genetics | Nucleases | DNA binding proteins | Analysis | Genomics | Enzymes | Genetic engineering | Genomes | Biomedical research | DNA repair
Journal Article
Plant Biotechnology Journal, ISSN 1467-7644, 02/2016, Volume 14, Issue 2, pp. 448 - 462
Summary Targeted genome‐editing technology using designed nucleases has been evolving rapidly, and its applications are widely expanding in research, medicine... 
homology‐directed repair | double‐strand break | transcription activator‐like effector nuclease | CRISPR‐Cas9 | zinc‐finger nuclease | nonhomologous end‐joining | Zinc-finger nuclease | Transcription activator-like effector nuclease | Nonhomologous end-joining | Double-strand break | CRISPR-Cas9 | Homology-directed repair | CRISPR-CAS SYSTEMS | PLANT-CELLS | DOUBLE-STRAND BREAKS | ZINC-FINGER NUCLEASES | DNA-BINDING SPECIFICITY | PROGRAMMABLE NUCLEASES | PLANT SCIENCES | PLURIPOTENT STEM-CELLS | transcription activator-like effector nuclease | zinc-finger nuclease | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | nonhomologous end-joining | GENE-EXPRESSION | double-strand break | RNA-GUIDED ENDONUCLEASES | homology-directed repair | Genetic Engineering | Base Sequence | DNA Repair - genetics | Endonucleases - metabolism | Genome, Plant | DNA Breaks, Double-Stranded | Gene Editing | Genetic research | Nucleases | DNA binding proteins | Genomics | Plant genetics | Editing | DNA repair | Genomes | CRISPR | Biotechnology | Transcription | Homology | Research | Ribonucleic acid--RNA | Gene expression | Zinc | Gene sequencing | Efficiency | Technology | Cell cycle | Stem cells | Non-homologous end joining | Genetic engineering | Mutation | Repair | Chromosomes | Deoxyribonucleic acid--DNA | Methods | Technology utilization | Breaking | Bacteria | Nuclease
Journal Article