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Cell Reports, ISSN 2211-1247, 12/2015, Volume 13, Issue 11, pp. 2425 - 2439
To identify therapeutic targets for glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 knockout (KO) screens in patient-derived GBM stem-like cells... 
WEE1 | CRISPR-Cas9 | Glioblastoma | cancer therapeutics | functional genomics | PKMYT1 | gene editing | Myt1 | Cancer therapeutics | Gene editing | Functional genomics | ACTIVATION | PROTEIN | GENE-EXPRESSION | GOLGI | PHOSPHORYLATES CDC2 | HUMAN MYT1 | INHIBITORY KINASE | BRAIN | RNAI SCREEN | REQUIREMENT | CELL BIOLOGY | Neoplastic Stem Cells - cytology | Phosphorylation | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | Microscopy, Video | Time-Lapse Imaging | Tumor Suppressor Protein p53 - genetics | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Neoplastic Stem Cells - metabolism | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Glioblastoma - metabolism | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | ErbB Receptors - metabolism | Gene Library | CDC2 Protein Kinase - antagonists & inhibitors | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Pyrimidinones | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | CRISPR-Cas Systems - genetics | Membrane Proteins - antagonists & inhibitors | Glioblastoma - pathology | Nuclear Proteins - antagonists & inhibitors | Cyclin B - metabolism | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Cell Stress & Chaperones, ISSN 1355-8145, 5/2018, Volume 23, Issue 3, pp. 347 - 355
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. 2868 - 2873
A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane,... 
Protein delivery | Genome editing | CRISPR/Cas9 | Cre recombinase | Lipid nanoparticle | THERAPEUTICS | genome editing | COMBINATORIAL LIBRARY | VIVO | RNA | CELLS IN-VITRO | CAS9 PROTEIN | TRANSFECTION | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | lipid nanoparticle | protein delivery | INTRACELLULAR DELIVERY | Endonucleases - genetics | Thalamus - metabolism | Nanoparticles - chemistry | Humans | Green Fluorescent Proteins - genetics | Structure-Activity Relationship | Recombinant Proteins - biosynthesis | Endosomes - metabolism | Drug Carriers | Luminescent Proteins - biosynthesis | RNA - genetics | Cholesterol - chemistry | Endocytosis | Lipids - chemistry | Integrases - administration & dosage | Endonucleases - administration & dosage | Recombination, Genetic | Nanoparticles - metabolism | Molecular Structure | Genes, Reporter | Genetic Engineering - methods | Bacterial Proteins - genetics | Genes, Synthetic | Ceramides - chemistry | Lipids - administration & dosage | Gene Knockout Techniques | Static Electricity | Nanoparticles - toxicity | Bacterial Proteins - administration & dosage | Animals | Hypothalamus - metabolism | Lipids - chemical synthesis | Green Fluorescent Proteins - biosynthesis | CRISPR-Cas Systems | Luminescent Proteins - genetics | Mice | Nanoparticles - administration & dosage | HeLa Cells | Integrases - genetics | Phosphatidylethanolamines - chemistry | Nanoparticles | Genetic aspects | Nucleotide sequencing | Lipid metabolism | Health aspects | Methods | DNA sequencing | CRISPR | Physical Sciences | Cas9
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2018, Volume 146, Issue 5, pp. 526 - 539
The chemokine CCL5 prevents neuronal cell death mediated both by amyloid β, as well as the human immunodeficiency virus viral proteins gp120 and Tat. Because... 
CXCR4 | AKT | CCR5 | signal transduction | CRISPR‐Cas9 | ERK | CRISPR-Cas9 | NEURONAL APOPTOSIS | ALZHEIMERS-DISEASE | DESENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GP120 | NEUROSCIENCES | PEPTIDE | CELL-DEATH | INTERNALIZATION | MOUSE MODEL | Receptors, G-Protein-Coupled - metabolism | Embryo, Mammalian | Humans | Protein Transport - drug effects | Cerebral Cortex - cytology | CRISPR-Associated Protein 9 - genetics | CRISPR-Associated Protein 9 - metabolism | Antineoplastic Agents - pharmacology | Chemokine CCL5 - metabolism | Neurons - metabolism | Neurons - drug effects | Neuroblastoma - pathology | Pertussis Toxin - pharmacology | Tretinoin - pharmacology | T-Lymphocytes | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mutagenesis - genetics | Gene Expression Regulation - physiology | Rats | Protein Transport - genetics | Animals | Chemokine CCL5 - pharmacology | Signal Transduction - drug effects | Chemokine CCL5 - genetics | Signal Transduction - physiology | Receptors, G-Protein-Coupled - genetics | Synthesis | Viral proteins | Glycogen | Cell death | Cellular signal transduction | Protein kinases | Protein binding | Neuroprotection | CC chemokine receptors | Flow cytometry | Phosphorylation | Viruses | AKT protein | Antagonists | Kinases | Neuroblastoma cells | Proteins | CCR1 protein | Time dependence | Receptors | Human immunodeficiency virus--HIV | CRISPR | CCR5 protein | Extracellular signal-regulated kinase | Glycogen synthase kinase 3 | Pharmacology | Tat protein | Signaling | Internalization | Chemokines | Glycoprotein gp120
Journal Article
Cancer Communications, ISSN 2523-3548, 12/2016, Volume 35, Issue 1, pp. 1 - 3
The regulation of protein stability is a fundamental issue for biophysical processes, but there has not previously been a convenient and unbiased method of... 
Protein stability | Ubiquitination | Acetylation | CRISPR–Cas9 screening | Cdc25A | CRISPR-Cas9 screening | ONCOLOGY | HUMAN-CELLS | Protein Stability | Gene Library | Genome | Proteolysis | Clustered Regularly Interspaced Short Palindromic Repeats | Fluorescence | Genomics | Proteins | Researchers | Rodents | Cell cycle | Cell division | Physiology | Regulation | Genomes | Tumorigenesis
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2020, Volume 109, Issue 1, pp. 62 - 67
Clustered regularly interspaced short palindromic repeats (CRISPR) form the adaptive immune system in archaea and bacteria and have been modified for genome... 
gene therapy | protein delivery | immune response(s) | immunogenicity | clinical trial(s) | CHEMISTRY, MEDICINAL | CRISPR/CAS9 | TOLERANCE | PREVALENCE | CHEMISTRY, MULTIDISCIPLINARY | INHIBITION | LIVER | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | EXPRESSION
Journal Article
Journal Article
Journal Article
Science, ISSN 0036-8075, 12/2018, Volume 362, Issue 6419, pp. 1171 - 1177
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding... 
PROTEIN | GENE | LANDSCAPE | VIRUS ENTRY REQUIRES | INFORMATION | MULTIDISCIPLINARY SCIENCES | GENOMIC ALTERATIONS | CRISPR-CAS9 | RECEPTOR | VECTORS | DROSOPHILA EYE | Loss of Function Mutation | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Antineoplastic Agents - therapeutic use | Pyridazines - pharmacology | Gene Knockdown Techniques | MAP Kinase Signaling System - genetics | Antineoplastic Agents - pharmacology | Gain of Function Mutation | Imidazoles - therapeutic use | Pyridazines - therapeutic use | Proto-Oncogene Proteins p21(ras) - metabolism | Transcription Factors - physiology | Signal Transduction | Imidazoles - pharmacology | Transcription Factors - genetics | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - epidemiology | Drug Resistance, Neoplasm - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Drosophila melanogaster | Ubiquitination - genetics | Leucine zipper | Genetic research | Ras genes | Genetic aspects | Research | Drug resistance | BCR protein | Transcription | Leukemia | Guanosine | Homology | Leucine | Kinases | Inactivation | Genetic screening | Cullin | Proteins | Signal transduction | Ubiquitination | Triphosphatase | Localization | Fusion protein | Protein-tyrosine kinase | Tyrosine | Phenotypes | Deactivation | Sarcoma | Myeloid leukemia | Adapters | Drosophila | MAP kinase | Abl protein | Chronic myeloid leukemia | Leucine zipper proteins | Signaling | Inhibitors | Isoforms | Fruit flies | Mutation | Adapter proteins
Journal Article