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Science, ISSN 0036-8075, 6/2012, Volume 336, Issue 6085, pp. 1150 - 1153
Protein phosphorylation is a fundamental mechanism regulating nearly every aspect of cellular life. Several secreted proteins are phosphorylated, but the... 
Proteins | T lymphocytes | Phosphorylation | Biomineralogy | Secretion | Phosphoproteins | REPORTS | Immunoblotting | Cellular immunity | Physiological regulation | Siblings | OSTEOPONTIN | INHIBITION | MULTIDISCIPLINARY SCIENCES | PHOSPHOPROTEOME | PURIFICATION | SEQUENCE | GOLGI-APPARATUS | SPECIFICITY DETERMINANTS | MASS-SPECTROMETRY | APPARATUS CASEIN KINASE | LACTATING MAMMARY-GLAND | Abnormalities, Multiple - metabolism | Golgi Apparatus - enzymology | Microcephaly - genetics | Humans | Secretory Pathway | Caseins - metabolism | Glycoproteins - metabolism | Molecular Sequence Data | Substrate Specificity | Cleft Palate - genetics | Casein Kinase I | Recombinant Fusion Proteins - metabolism | Extracellular Matrix Proteins - secretion | Cattle | Exophthalmos - genetics | HEK293 Cells | Osteosclerosis - metabolism | Osteosclerosis - genetics | Abnormalities, Multiple - genetics | Extracellular Matrix Proteins - metabolism | Amino Acid Sequence | Extracellular Matrix Proteins - chemistry | Milk - enzymology | Extracellular Matrix Proteins - genetics | Microcephaly - metabolism | Osteopontin | Recombinant Fusion Proteins - chemistry | Protein Sorting Signals | Amino Acid Motifs | Animals | Calcification, Physiologic | Casein Kinases - metabolism | Exophthalmos - metabolism | Cell Line, Tumor | Recombinant Fusion Proteins - secretion | Cleft Palate - metabolism | HeLa Cells | Mutation | Physiological aspects | Biomineralization | Extracellular matrix | Research | Phosphotransferases | Mineralogy | Cells | Index Medicus | Mutations | Casein | Genes | Bones | Kinases
Journal Article
Journal Article
Biological & Pharmaceutical Bulletin, ISSN 0918-6158, 2004, Volume 27, Issue 1, pp. 109 - 112
The physiological correlation between casein kinase I (CK-I) and an isoform η of protein kinase C (C-kinase η) was investigated in vitro, since it has been... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 26, pp. 10574 - 10579
Journal Article
Plant Physiology, ISSN 0032-0889, 3/2009, Volume 149, Issue 3, pp. 1478 - 1492
Journal Article
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 06/2009, Volume 66, Issue 11-12, pp. 1868 - 1889
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Cancer Research, ISSN 0008-5472, 12/2010, Volume 70, Issue 24, pp. 10288 - 10298
Journal Article
Journal Article
Journal Article