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by Yuan, Y and Sun, HB and Ge, SC and Wang, MJ and Zhao, HX and Wang, L and An, LN and Zhang, J and Zhang, HF and Hu, B and Wang, JF and Liang, GL
ACS NANO, ISSN 1936-0851, 01/2015, Volume 9, Issue 1, pp. 761 - 768
Compared to H-1 MRI, F-19 MRI provides higher selectivity but lower sensitivity. Therefore, the need to inject high doses of the 19F probe to improve its... 
CELLS | NANOPROBES | disassembly | CONTRAST AGENTS | MOLECULE | MATERIALS SCIENCE, MULTIDISCIPLINARY | F-19 MRI | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | Casp3/7 | self-assembly | NMR | BIOCOMPATIBLE CONDENSATION REACTION | IN-VIVO | T-1 | zebrafish | PROBE
Journal Article
ACS Nano, ISSN 1936-0851, 01/2015, Volume 9, Issue 1, pp. 761 - 768
Compared to (1)H MRI, (19)F MRI provides higher selectivity but lower sensitivity. Therefore, the need to inject high doses of the (19)F probe to improve its... 
F MRI | self-assembly | zebrafish | disassembly | Casp3/7 | Caspase 7 - metabolism | Nanoparticles - chemistry | Fluorine-19 Magnetic Resonance Imaging - methods | Glutathione - metabolism | Nanotechnology - methods | Humans | Molecular Conformation | Caspase 3 - metabolism | Models, Molecular | Zebrafish | Hep G2 Cells | Animals | Intracellular Space - metabolism | Index Medicus
Journal Article
Pathology and Oncology Research, ISSN 1219-4956, 2018, pp. 1 - 6
Despite advances in our understanding of the biology of chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma (RO), the differential diagnosis among... 
Ki-67 | p16 | CASP3 | Caspase 3 | Oncocytoma | CD138 | Survivin | Cyclin D1 | ChRCC | Chromophobe | Kidney cancer | Caspase | Staining | Differential diagnosis | Immunoreactivity | Stains | Caspase-3 | Neoplasms | Clear cell-type renal cell carcinoma | Tumors
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2208 - 2222
Dysregulation of autophagy contributes to neuronal cell death in several neurodegenerative and lysosomal storage diseases. Markers of autophagy are also... 
β; AIF1/IBA1, allograft inflammatory factor 1 | SPTAN1, spectrin, α, non-erythrocytic 1 | LAMP1, lysosomal-associated membrane protein 1 | LC3, microtubule associated protein 1 light chain 3 | ACTB, actin | APC, adenomatous polyposis coli | ATG7, autophagy-related 7 | ULK1, unc-51 like autophagy activating kinase 1 | AIFM1, apoptosis-inducing factor, mitochondrion-associated, 1 | ATG5, autophagy-related 5 | autophagy flux | CASP3, caspase 3 | GFP, green fluorescent protein | autophagy | traumatic brain injury | CSPG4, chondroitin sulfate proteoglycan 4 | CAPS12, caspase 12 | neuronal cell death | ATG12, autophagy-related 12 | SQSTM1, sequestosome 1 | CD68, CD68 molecule | CCI, controlled cortical impact | RBFOX3, RNA binding protein, fox-1 homolog (C. elegans) 3 | LAMP2, lysosomal-associated membrane protein 2 | TBI, traumatic brain injury | lysosome | CTSD, cathepsin D | Traumatic brain injury | Autophagy | Neuronal cell death | Autophagy flux | Lysosome | NEURODEGENERATIVE DISEASE | UBIQUITIN | LYSOSOMAL STORAGE DISORDERS | CEREBRAL-CORTEX | RAT MODEL | CELL BIOLOGY | PATHWAY | DEGRADATION | MICE | EXPRESSION | PARKINSONS-DISEASE | Sequestosome-1 Protein | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Phagosomes - metabolism | Neurons - cytology | Autophagy - physiology | Brain Injuries - metabolism | Apoptosis Regulatory Proteins - metabolism | Brain - metabolism | Animals | Cell Death - physiology | Neurons - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Brain Injuries - pathology | Disease Models, Animal | Index Medicus
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 05/2019, Volume 120, Issue 5, pp. 7199 - 7210
Journal Article
Autophagy, ISSN 1554-8627, 02/2015, Volume 11, Issue 2, pp. 314 - 331
An active medicinal component of plant origin with an ability to overcome autophagy by inducing apoptosis should be considered a therapeutically active lead... 
BECN1 | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 β | apoptosis | 3-azido withaferin A | ATG, autophagy-related | HSPA5/GRP78, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | AVOs, acidic vesicular organelles | EIF2AK3/PERK, eukaryotic initiation translation factor 2-α kinase 3 | PARP1, poly (ADP-ribose) polymerase 1 | CaP, prostate cancer cells | PRKCZ/PKCζ, protein kinase C, zeta | DAPI, 4'6-diamidino-2-phenylindole | AO, acridine orange | BCL2, B-cell CLL/lymphoma 2 | CASP3, caspase 3 | NAC, N-acetyl-L-cysteine | MTOR, mechanistic target of rapamycin | autophagy | SQSTM1/p62, sequestosome 1 | DDIT3/CHOP, DNA-damage-inducible transcript 3 | PAWR/Par-4, PRKC, apoptosis, WT1, regulator | PAWR | MMPψ, mitochondrial membrane potential | BECN1, Beclin 1, autophagy-related | myrAKT1, myristoylated v-akt murine thymoma viral oncogene homolog 1 | 3-AWA, 3-azido withaferin A | CQ, chloroquine | BAF A1, bafilomycin A | DCF, dichlorofluorescein | CASP9, caspase 9 | MDC, monodansylcadaverine | BCL2 | WT1, Wilms tumor 1 | BAD, BCL2-associated agonist of cell death | MEFs, mouse embryonic fibroblasts | CYCS, cytochrome c, somatic | ER, endoplasmic reticulum | Autophagy | Apoptosis | MAMMALIAN TARGET | SURVIVAL | BECLIN 1 | TARGETING AUTOPHAGY | ENDOPLASMIC-RETICULUM STRESS | PAR-4 | CELL BIOLOGY | THERAPY | INHIBITION | GROWTH | SENSITIZES | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Endoplasmic Reticulum Stress - drug effects | Apoptosis - drug effects | Humans | Male | Autophagy - physiology | Autophagy - drug effects | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Signal Transduction - drug effects | Withanolides - pharmacology | Cell Line, Tumor | Index Medicus
Journal Article
Journal Article
Journal Article
Biochemistry (Moscow), ISSN 0006-2979, 10/2018, Volume 83, Issue 10, pp. 1245 - 1254
Here, we studied the effect of the mitochondria-targeted antioxidant SkQ1 (plastoquinone cationic derivative) on the CASP3 gene expression and caspase-3... 
Life Sciences | Biochemistry, general | Biomedicine, general | Microbiology | hyperoxia | mitochondria | brain | mitochondria-targeted antioxidant | Bioorganic Chemistry | CASP3 gene expression | caspase-3 | Brain | Mitochondria | Mitochondria-targeted antioxidant | Caspase-3 | Hyperoxia | APOPTOSIS | ERYTHROPOIETIN | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBRAL-CORTEX | CELL-DEATH | PATHWAY | ANTIOXIDANT | CASPASES | MITOCHONDRIA-TARGETED PLASTOQUINONE | Superoxide Dismutase - genetics | Gene Expression - drug effects | Catalase - genetics | Glutathione - metabolism | Glutathione Reductase - metabolism | Caspase 3 - metabolism | Rats | Male | Mitochondria - metabolism | RNA, Messenger - metabolism | Glutathione Reductase - genetics | Brain - metabolism | Catalase - metabolism | Plastoquinone - pharmacology | Animals | Caspase 3 - genetics | Lipid Peroxidation - drug effects | Oxidative Stress - drug effects | Hyperbaric Oxygenation | Superoxide Dismutase - metabolism | Plastoquinone - analogs & derivatives | Oxidative stress | Genetic aspects | Gene expression | Observations | Stresses | Enzymes | Cerebral cortex | Enzyme activity | Cortex | Lipid peroxidation | Caspase | Stimulation | Lipids | Antioxidants | Enzymatic activity | Glutathione reductase | Cerebrum | Oxygenation | Glutathione | Peroxidation | Reductase | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 2006 - 2020
Silver nanoparticles (Ag NPs) are cytotoxic to cancer cells and possess excellent potential as an antitumor agent. A variety of nanoparticles have been shown... 
CASP3, caspase 3, apoptosis-related cysteine peptidase | PI3K, phosphoinositide 3-kinase | silver nanoparticles (Ag NPs) | autophagy inhibition | s.c., subcutaneously | tumor therapy | ANXA5, annexin A5 | RPS6KB, ribosomal protein S6 kinase, 70 kDa | XRD, X-ray diffraction | I-MEF, immortalized mouse embryonic fibroblast | PVP, polyvinylpyrrolidone | MTOR, mechanistic target of rapamycin | autophagy | PI, propidium iodide | EGFP-LC3, enhanced green fluorescent protein-tagged LC3 | DMEM, Dulbecco's Modified Eagle's medium | TUNEL, terminal deoxyribonucleotidyl transferase (TDT)-mediated dUTP-digoxigenin nick end labeling | PtdIns3K, phosphatidylinositol 3-kinase | DLS, dynamic light scattering | TEM, transmission electron microscopy | lysosomal function | CTSB, cathepsin B | SQSTM1, sequestosome 1 | ICP-MS, inductively coupled plasma-mass spectrometry | MDC, monodansylcadaverine | P-MEF, primary mouse embryonic fibroblast | UV-Vis, ultraviolet visible | Silver nanoparticles (Ag NPs) | Autophagy | Lysosomal function | Tumor therapy | Autophagy inhibition | CANCER-CELLS | IONS | MECHANISMS | TOXICITY | INDUCTION | MODEL | PVP | QUANTUM DOTS | CELL BIOLOGY | THERAPY | EARTH-OXIDE NANOCRYSTALS | Neoplasms - metabolism | Cell Survival | Humans | Metal Nanoparticles - chemistry | Mice, Inbred C57BL | Silver - chemistry | Ions | Male | Antineoplastic Agents - chemistry | Androstadienes - chemistry | Animals | Lysosomes - metabolism | Melanoma, Experimental | Cell Line, Tumor | Mice | HeLa Cells | Neoplasms - pathology | Apoptosis | Fibroblasts - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 07/2015, Volume 11, Issue 7, pp. 1130 - 1145
The glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while... 
sclerosis | endothelial cells | autophagy | podocytes | proteinuria | diabetic nephropathy | Podocytes | Diabetic nephropathy | Autophagy | Endothelial cells | Sclerosis | Proteinuria | apoptosis-related cysteine peptidase | LC3A | sequestosome 1 | caspase 3 | mechanistic target of rapamycin | CELL BIOLOGY | Cdh5 | MAP1LC3A | CASP3 | STZ | NITRIC-OXIDE | Nphs2 | transmission electron microscopy | GLYCEMIC CONTROL | OXIDATIVE STRESS | GEC | TUBA | cadherin 5 | end-stage renal disease | NEPHROPATHY | streptozotocin | Wilms tumor 1 | DISEASE | GROWTH-FACTOR | SQSTM1 | ESRD | GFB | diabetes mellitus | blood urea nitrogen | microtubule-associated protein 1 light chain 3 | GBM | GENE-EXPRESSION | BUN | glomerular endothelial cells | nephrosis 2 | glomerular filtration barrier | podocin | tubulin | RENAL BIOPSY SPECIMENS | KNOCKOUT MICE | MTOR | WT1 | glomerular basement membrane | TEM | TRANSGENIC MICE | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Autophagy - drug effects | Mesangial Cells - drug effects | Endothelial Cells - ultrastructure | Glomerular Filtration Rate - drug effects | Diabetic Nephropathies - physiopathology | Gene Deletion | Mesangial Cells - ultrastructure | Integrases - metabolism | Microtubule-Associated Proteins - deficiency | Diabetic Nephropathies - prevention & control | Diabetic Nephropathies - pathology | Mice, Inbred C57BL | Cells, Cultured | Glucose - pharmacology | Podocytes - pathology | Phenotype | Podocytes - ultrastructure | Animals | Autophagy-Related Protein 5 | Podocytes - drug effects | Mesangial Cells - pathology | Endothelial Cells - pathology | Endothelial Cells - drug effects | Index Medicus | Life Sciences | Development Biology
Journal Article
Autophagy, ISSN 1554-8627, 04/2015, Volume 11, Issue 4, pp. 670 - 684
Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and proteins. Impaired autophagic activity is involved in... 
CASP3, caspase 3, apoptosis-related cysteine peptidase | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 β | TUBB4, tubulin, β 4, class IV | DRAM2, DNA-damage regulated autophagy modulator 2 | IL13, interleukin 13 | CAV1, caveolin 1, caveolae protein, 22kDa | CCL3, chemokine (C-C motif) ligand 3 | ATG9B, autophagy-related 9B | RELA, v-rel reticuloendotheliosis viral oncogene homolog A | TGFB1, transforming growth factor, β 1 | ATG4B, autophagy-related 4B | epithelial cell | ATG3, autophagy-related 3 | CXCR2, chemokine (C-X-C motif) receptor 2 | lung fibrosis | IFNG, interferon, gamma | ATG7, autophagy-related 7 | ATG5, autophagy-related 5 | CXCL1, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity α) | autophagin-1 | GFP-LC3B, green fluorescent protein-LC3B | TGFBR2, transforming growth factor, β receptor II (70/80kDa) | autophagy | TNF, tumor necrosis factor | IL12B, interleukin 12B | WT, wild type | idiopathic pulmonary fibrosis | IPF, idiopathic pulmonary fibrosis | SQSTM1, sequestosome 1 | ACTA2, actin, α 2, smooth muscle, aorta | BAX, BCL2-associated X protein | ATG4B | cysteine peptidase | Epithelial cell | Autophagin-1 | Autophagy | Idiopathic pulmonary fibrosis | Lung fibrosis | APOPTOSIS | LUNG INJURY | RECEPTOR | CELL BIOLOGY | DISEASES | EPITHELIAL-CELLS | IL-17A PROMOTES | INFLAMMATION | MICE | EXPRESSION | CAVEOLIN-1 | Autophagy-Related Proteins | Cytokines - metabolism | Gene Expression - drug effects | Epithelial Cells - drug effects | Apoptosis - genetics | Autophagy - physiology | Idiopathic Pulmonary Fibrosis - chemically induced | Autophagy - drug effects | Idiopathic Pulmonary Fibrosis - metabolism | Mice, Knockout | Animals | Cysteine Endopeptidases - metabolism | Cysteine Endopeptidases - genetics | Bleomycin - pharmacology | Homeostasis - drug effects | Epithelial Cells - cytology | Cytokines - genetics | Index Medicus
Journal Article
Neuroscience Letters, ISSN 0304-3940, 06/2015, Volume 597, pp. 176 - 182
GAP43 is a protein involved in neurite outgrowth during development and axon regeneration reflecting its presynaptic localization in developing neurons.... 
Brain ischemia | GAP43 | Bioluminescence | CASP3 | tMCAO | TMCAO | RAT | GAP-43 | GENE-EXPRESSION | INJURY | NEUROSCIENCES | DEFICIENCY | Brain - metabolism | Animals | Time Factors | GAP-43 Protein - metabolism | Mice, Inbred C57BL | Caspase 3 - metabolism | Brain Ischemia - metabolism | Mice, Transgenic | Neurons - metabolism | Astrocytes - metabolism | Brain damage | Neurophysiology | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 02/2015, Volume 11, Issue 2, pp. 239 - 252
PTEN (phosphatase and tensin homolog), a tumor suppressor frequently mutated in human cancer, has various cytoplasmic and nuclear functions. PTEN translocates... 
SESN2, sestrin 2 | CASP3, caspase 3, apoptosis-related cysteine peptidase | PPase, protein phosphatase | YFP, yellow fluorescent protein | bafilomycin A | PTEN | ATG, autophagy-related | CITED1/p300/CBP, Cbp/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 1 | member X | RAD51, RAD51 recombinase | topotecan | TPT, topotecan | DSBs, DNA double-strand breaks | autophagy | GST, glutathione S-transferase | TUBA4A, tubulin, α, 4a | H2AFX | MVP, major vault protein | TP53, tumor protein p53 | NEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | Baf.A | CCND1, cyclin D1 | ATM, ATM serine/threonine kinase | AKT/PKB, v-akt murine thymoma viral oncogene homolog | PtdIns(3, 4, 5)P | CDDP, cisplatin | NC, normal control | PMSF, phenylmethanesulfonyl fluoride | PI3K, phosphoinositide 3-kinase | DNA damage | PARP, poly (ADP-ribose) polymerase 1 | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | SDS, sodium dodecyl sulfate | H2A histone family | GLTSCR2/PICT-1, glioma tumor suppressor candidate region gene 2 | MTORC1, mechanistic target of rapamycin complex 1 | PAGE, polyacrylamide gel electrophoresis | CENPC/CENP-C, centromere protein C | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | AMPK, protein kinase, AMP-activated | GFP, green fluorescent protein | JUN | SQSTM1/p62, sequestosome 1 | phosphatidylinositol (3, 4, 5)-trisphosphate | WT, wild type | ribosomal protein S6 kinase, 70kDa | RPS6KB/p70S6K | siRNA, small interfering RNA | CSNK2/CK2, casein kinase 2 | GSK3B, glycogen synthase kinase 3 β | ATM | jun proto-oncogene | PTEN, phosphatase and tensin homolog | Topotecan | Autophagy | LOCALIZATION | PROTEIN | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | PHOSPHATASE | CYCLE ARREST | CHROMOSOME-10 PTEN | CELL BIOLOGY | HISTONE H2AX PHOSPHORYLATION | PROSTATE-CANCER | TUMOR-SUPPRESSOR | EXPRESSION | Tumor Suppressor Proteins - metabolism | Topotecan - pharmacology | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | PTEN Phosphohydrolase - metabolism | Autophagy - physiology | Signal Transduction - genetics | Cisplatin - pharmacology | Autophagy - drug effects | Topoisomerase I Inhibitors - pharmacology | Signal Transduction - drug effects | Active Transport, Cell Nucleus - drug effects | Antineoplastic Agents - pharmacology | DNA Damage | Phosphorylation - drug effects | Index Medicus
Journal Article