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1. Full Text Recent advances in inflammasome biology
by Place, David E and Kanneganti, Thirumala-Devi
Current Opinion in Immunology, ISSN 0952-7915, 02/2018, Volume 50, pp. 32 - 38
The inflammasome is a complex of proteins that through the activity of caspase-1 and the downstream substrates gasdermin D, IL-1β, and IL-18 execute an... 
AIM2 INFLAMMASOME | ACTIVATION | PROTEIN | PHOSPHORYLATION | CASPASE-1 AUTOPROTEOLYSIS | INFECTION | NLRP3 INFLAMMASOME | NLRC4 | IMMUNOLOGY | PYRIN INFLAMMASOME | CELL-DEATH
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2. Full Text Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
by He, Wan-Ting and Wan, Haoqiang and Hu, Lichen and Chen, Pengda and Wang, Xin and Huang, Zhe and Yang, Zhang-Hua and Zhong, Chuan-Qi and Han, Jiahuai
Cell Research, ISSN 1001-0602, 12/2015, Volume 25, Issue 12, pp. 1285 - 1298
Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of interleukin 1 beta (IL-1... 
GSDMD | pyroptosis | inflammasome | apoptosis | caspase-11 | IL-1β | caspase-1 | PROTEIN | INFLAMMASOME ACTIVATION | IL-1 beta | CASPASE-1 AUTOPROTEOLYSIS | CELL-DEATH | CELL BIOLOGY | ASC | NECROSIS | Interleukin-1beta - secretion | Inflammasomes - metabolism | Pyroptosis | Humans | Mice, Inbred C57BL | Cells, Cultured | Neoplasm Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Apoptosis Regulatory Proteins - deficiency | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Mice | Neoplasm Proteins - deficiency | Neoplasm Proteins - genetics | Original
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3. Full Text The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation
by Sharma, Deepika and Kanneganti, Thirumala-Devi
Journal of Cell Biology, ISSN 0021-9525, 2016, Volume 213, Issue 6, pp. 617 - 629
Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome... 
ANTHRAX LETHAL TOXIN | AIM2 INFLAMMASOME | INNATE IMMUNE RECOGNITION | HOST-DEFENSE | MELANOMA 2 | CASPASE-1 AUTOPROTEOLYSIS | NLRP3 INFLAMMASOME | NALP3 INFLAMMASOME | CUTTING EDGE | PYRIN DOMAIN | CELL BIOLOGY | Pyroptosis - physiology | Inflammasomes - physiology | Animals | Inflammasomes - metabolism | Cell Death - physiology | Interleukin-1beta - metabolism | Humans | Caspase 1 - metabolism | Interleukin-18 - metabolism | Cell research | Research | Enzyme activation | Cellular control mechanisms | Reviews
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4. Full Text Pyroptotic cell death defends against intracellular pathogens
by Jorgensen, Ine and Miao, Edward A
Immunological Reviews, ISSN 0105-2896, 05/2015, Volume 265, Issue 1, pp. 130 - 142
Summary Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. First, caspase‐1... 
pyroptosis | inflammatory caspases | caspase‐1 | inflammasome | caspase‐11 | Inflammatory caspases | Inflammasome | Pyroptosis | Caspase-11 | Caspase-1 | LISTERIA-MONOCYTOGENES | MYCOBACTERIUM-TUBERCULOSIS | AIM2 INFLAMMASOME | CAUSES AUTOINFLAMMATION | NLRC4 INFLAMMASOME | caspase-11 | CASPASE-1 AUTOPROTEOLYSIS | IMMUNOLOGY | NONCANONICAL INFLAMMASOME ACTIVATION | PROTEIN PROMOTES VIRULENCE | INNATE IMMUNE RECOGNITION | MELANOMA 2 | caspase-1 | Interleukin-1 - metabolism | Inflammasomes - metabolism | Infection - immunology | Humans | Caspase 1 - metabolism | DNA Replication | Immunity, Innate | Intracellular Space | Animals | Caspases - metabolism | Immune Evasion | Caspases, Initiator - metabolism | Inflammasomes - immunology | Mice | Interleukin-18 - metabolism | Cell death | Biochemistry | Pathogenic microorganisms
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5. Full Text Mechanisms of inflammasome activation: recent advances and novel insights
by Vanaja, Sivapriya K and Rathinam, Vijay A.K and Fitzgerald, Katherine A
Trends in Cell Biology, ISSN 0962-8924, 2014, Volume 25, Issue 5, pp. 308 - 315
Highlights • New inflammasomes and new microbial triggers of inflammasomes have been identified. • Cytosolic LPS is detected by caspase-11 resulting in its... 
Pathology | ALRs | caspase-11 | NLRs | non-canonical inflammasome | inflammasomes | Inflammasomes | Caspase-11 | Non-canonical inflammasome | ANTHRAX LETHAL TOXIN | AIM2 INFLAMMASOME | MACROPHAGES | CASPASE-1 AUTOPROTEOLYSIS | NLRP3 INFLAMMASOME | CELL-DEATH | CELL BIOLOGY | ASC | HOST-DEFENSE | INFECTION | INTRACELLULAR LPS | Animals | Inflammasomes - metabolism | Signal Transduction | Interleukin-1beta - metabolism | Humans | Cell Death | Caspase 1 - metabolism | Cytosol - metabolism | Mice | Interleukin-18 - metabolism | Proteins | Cysteine | Interleukins | Proteases | Cell death
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6. Full Text Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation
by Yabal, Monica and Calleja, Dale J and Simpson, Daniel S and Lawlor, Kate E
Journal of Leukocyte Biology, ISSN 0741-5400, 02/2019, Volume 105, Issue 2, pp. 377 - 399
Inflammasomes are multimeric protein complexes that induce the cleavage and release of bioactive IL‐1β and cause a lytic form of cell death, termed pyroptosis.... 
metabolism | caspases | inflammasome | mitochondria | reactive oxygen species | INDUCED CELL-DEATH | AIM2 INFLAMMASOME | THIOREDOXIN-INTERACTING PROTEIN | K+ EFFLUX | CASPASE-1 AUTOPROTEOLYSIS | IMMUNOLOGY | INTERLEUKIN-1-BETA MATURATION | NALP3 INFLAMMASOME | CELL BIOLOGY | DIFFERENTIAL REQUIREMENT | GASDERMIN-D | HEMATOLOGY | NF-KAPPA-B
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7. Full Text DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
by Johnson, Darren C and Taabazuing, Cornelius Y and Okondo, Marian C and Chui, Ashley J and Rao, Sahana D and Brown, Fiona C and Reed, Casie and Peguero, Elizabeth and de Stanchina, Elisa and Kentsis, Alex and Bachovchin, Daniel A
Nature Medicine, ISSN 1078-8956, 08/2018, Volume 24, Issue 8, pp. 1151 - 1156
Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | TALABOSTAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASPASE-1 AUTOPROTEOLYSIS | CANCER | ISOINDOLINE | CELL BIOLOGY | POTENT | HEMATOPOIESIS | INFLAMMASOME | EXPRESSION | DIPEPTIDYL PEPTIDASE-IV | Research | Cell death | Health aspects | Serine | Myeloid cells | Animal models | Myeloid leukemia | Leukemia | Caspase | Tumor cell lines | Caspase-1 | Proteins | Monocytes | Inhibitors | Cell lines | Acute myeloid leukemia
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8. Full Text Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy
by Lorenzo Sborgi and Francesco Ravotti and Venkata P. Dandey and Mathias S. Dick and Adam Mazur and Sina Reckel and Mohamed Chami and Sebastian Scherer and Matthias Huber and Anja Böckmann and Edward H. Egelman and Henning Stahlberg and Petr Broz and Beat H. Meier and Sebastian Hiller
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 43, pp. 13237 - 13242
Inflammasomes are multiprotein complexes that control the innate immune response by activating caspase-1, thus promoting the secretion of cytokines in response... 
Inflammation | Protein filament | Innate immune response | Protein structure | ASC speck | PROTEIN | SOLID-STATE NMR | MECHANISM | MOLECULAR-STRUCTURE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | CASPASE-1 AUTOPROTEOLYSIS | BETA-AMYLOID FIBRILS | PYRIN DOMAIN | protein structure | inflammation | innate immune response | DISEASE | protein filament | ASSIGNMENT | Magnetic Resonance Spectroscopy | Inflammasomes - chemistry | Apoptosis Regulatory Proteins - chemistry | Apoptosis Regulatory Proteins - isolation & purification | Inflammasomes - isolation & purification | Models, Molecular | Blotting, Western | Mice, Knockout | Cryoelectron Microscopy | Microscopy, Confocal | Animals | CARD Signaling Adaptor Proteins | Cloning, Molecular | Apoptosis Regulatory Proteins - genetics | Protein Conformation | Mice | Usage | Care and treatment | Rats as laboratory animals | Spectrum analysis | Cryoelectron microscopy | Research | Autoimmune diseases | Risk factors | Biological Sciences
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9. Full Text Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
by Magdalena Matusiak and Nina Van Opdenbosch and Lieselotte Vande Walle and Jean-Claude Sirard and Thirumala-Devi Kanneganti and Mohamed Lamkanfi
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 5, pp. 1541 - 1546
The Nlrc4 inflammasome contributes to immunity against intracellular pathogens that express flagellin and type III secretion systems, and activating mutations... 
Salmonella | BACTERIA | CAUSES AUTOINFLAMMATION | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | CASPASE-1 AUTOPROTEOLYSIS | NLRC4 | IMMUNE RECOGNITION | IPAF | CELL-DEATH | III SECRETION APPARATUS | inflammasome | MUTATION | NEEDLE PROTEIN | flagellin | caspase-1 | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Phosphorylation | Inflammasomes - metabolism | Apoptosis Regulatory Proteins - chemistry | Caspase 1 - metabolism | DNA Primers | Neuronal Apoptosis-Inhibitory Protein - metabolism | Serine - metabolism | Apoptosis Regulatory Proteins - metabolism | Salmonella typhimurium - metabolism | Animals | Base Sequence | Flagellin - metabolism | Yersinia enterocolitica - metabolism | Mice | Enzyme Activation | Real-Time Polymerase Chain Reaction | Physiological aspects | Inflammation | Observations | Flagella (Microbiology) | Health aspects | Life Sciences | Immunology | Biological Sciences
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10. Full Text Bacterial exotoxins and the inflammasome
by Greaney, Allison J and Leppla, Stephen H and Moayeri, Mahtab
Frontiers in Immunology, ISSN 1664-3224, 2015, Volume 6, p. 570
The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of... 
Interleukin-1 | Pyroptosis | Exotoxins | NLRP3 | Nod-like receptors | Inflammasome | Anthrax lethal toxin | Caspase-1 | LISTERIA-MONOCYTOGENES | interleukin-1 | PHENOL-SOLUBLE MODULINS | exotoxins | CASPASE-1 AUTOPROTEOLYSIS | anthrax lethal toxin | NLRP3 INFLAMMASOME | IMMUNOLOGY | CELL-DEATH | pyroptosis | TUMOR-NECROSIS-FACTOR | FAMILIAL MEDITERRANEAN FEVER | inflammasome | TH17 RESPONSES | caspase-1 | PORE-FORMING TOXINS | Bacterial Toxins
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