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Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7195, pp. 662 - 666
Phosphoinositide 3- kinases ( PI3Ks) signal downstream of multiple cell- surface receptor types. Class IA PI3K isoforms(1) couple to tyrosine kinases and... 
CATALYTIC SUBUNIT | P110-DELTA | P110 DELTA | B-CELL | PHOSPHATIDYLINOSITOL 3-KINASE | MULTIDISCIPLINARY SCIENCES | EMBRYONIC LETHALITY | MICE | GROWTH-FACTOR | PHOSPHOINOSITIDE 3-KINASE | EXPRESSION
Journal Article
Nature, ISSN 0028-0836, 08/2008, Volume 454, Issue 7205, pp. 776 - 779
On activation by receptors, the ubiquitously expressed class IA isoforms (p110 alpha and p110 beta) of phosphatidylinositol-3-OH kinase (PI(3)K) generate lipid... 
BETA-GAMMA | CATALYTIC SUBUNIT | PHOSPHATIDYLINOSITOL 3-KINASES | LYSOPHOSPHATIDIC ACID | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | TUMOR-SUPPRESSOR GENE | EMBRYONIC LETHALITY | PI 3-KINASE | PHOSPHOINOSITIDE 3-KINASE | P110-ALPHA SUBUNIT
Journal Article
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 2019, Volume 104, Issue 11, pp. 5651 - 5657
Context: Prolonged adrenal stimulation by corticotropin, as in long-standing Cushing disease (CD), leads to diffuse to nodular hyperplasia. Adrenal functional... 
CATALYTIC SUBUNIT | ACTIVATION | REMOVAL | DISEASE | ENDOCRINOLOGY & METABOLISM | ADRENOCORTICOTROPIN | RECURRENT HYPERCORTISOLISM | HYPERPLASIA | ADENOMAS
Journal Article
Hypertension, ISSN 0194-911X, 01/2019, Volume 73, Issue 1, pp. 92 - 101
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and increases the risk of stroke, heart failure, and death. Ang II (angiotensin II)... 
AT1R associated protein | atrial fibrillation | immunoproteasome | catalytic subunit β5 | mice | angiotensin II
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 03/2017, Volume 18, Issue 3, pp. 175 - 186
Journal Article
SCIENCE SIGNALING, ISSN 1945-0877, 12/2012, Volume 5, Issue 253
Synergistic activation by heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) and receptor tyrosine kinases distinguishes... 
CATALYTIC SUBUNIT | P110-ALPHA | ISOFORMS | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | PURIFICATION | GROWTH | PHOSPHOINOSITIDE 3-KINASE P110-BETA | CANCER | BINDING | CELL BIOLOGY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1803 - 1816
CK2 is a ubiquitous Ser/Thr protein kinase involved in the control of various signaling pathways and is known to be constitutively active. In the present... 
CATALYTIC SUBUNIT | CK2-ALPHA | DESIGN | NMR | CHEMISTRY, MEDICINAL | COMPLEXES | INHIBITORS | LIGAND | MAP | DISCOVERY
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 12/2019, Volume 137, pp. 34 - 45
Hypertensive cardiac remodeling is a major cause of heart failure. The immunoproteasome is an inducible form of the proteasome and its catalytic subunit β5i... 
PTEN | β5i | Cardiac remodeling | DOCA-salt | Immunoproteasome catalytic subunit
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 14, pp. 5922 - 5933
Biophysical parameters can accelerate drug development; e.g., rigid ligands may reduce entropic penalty and improve binding affinity. We studied systematically... 
CATALYTIC SUBUNIT | COMPLEX | FASUDIL | CHEMISTRY, MEDICINAL | THERMODYNAMICS | CALORIMETRY | ASSIGNMENT | DYNAMICS | DEPENDENT PROTEIN-KINASE | INHIBITOR | HYDRATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1817 - 1836
Protein CK2 has gained much interest as an anticancer drug target in the past decade. We had previously described the identification of a new allosteric site... 
REGULATORY SUBUNIT | CATALYTIC SUBUNIT | CK2-ALPHA | ACTIVATION | CHEMISTRY, MEDICINAL | RECOGNITION | PHOSPHORYLATION | DYNAMICS | INHIBITORS | BINDING | RELEVANT
Journal Article