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Progress in Neuro-Psychopharmacology and Biological Psychiatry, ISSN 0278-5846, 01/2016, Volume 64, pp. 200 - 208
Inflammation is an important pathogenic factor in Parkinson's disease (PD), so that it can contribute to kill dopaminergic neurons of the substantia nigra and... 
Cannabinoids | Glial activation | Parkinson's disease | Inflammation | CB 2 receptors | LPS
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 11/2016, Volume 43, Issue 12, pp. 2219 - 2227
The cannabinoid type 2 receptor (CB2R) is expressed by immune cells such as monocytes and macrophages. In the brain, CB2R is primarily found on microglia. CB2R... 
Medicine & Public Health | PET imaging | Alzheimer’s disease | CB 2 R | Orthopedics | Cannabinoid type 2 receptor | Oncology | Neuroinflammation | Nuclear Medicine | Imaging / Radiology | Cardiology
Journal Article
Experimental Neurology, ISSN 0014-4886, 07/2015, Volume 269, pp. 133 - 141
The cannabinoid CB 2 receptor has recently emerged as a potential anti-inflammatory target to break the self-sustaining cycle of neuroinflammation and... 
Endocannabinoid system | Parkinson's disease | Neuroinflammation | CB 2 receptors | Microglia
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2015, Volume 101, pp. 651 - 667
Abstract During the last years, there has been a continuous interest in the development of cannabinoid receptor ligands that may serve as therapeutic agents... 
CB 2 antagonism | Docking studies | Bioisosterism | Synthesis | Cannabinoid receptors
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2006, Volume 149, Issue 2, pp. 145 - 154
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2008, Volume 153, Issue 2, pp. 226 - 239
Journal Article
Inflammation Research, ISSN 1023-3830, 11/2016, Volume 65, Issue 11, pp. 869 - 879
Journal Article
Molecular Immunology, ISSN 0161-5890, 2011, Volume 49, Issue 3, pp. 453 - 461
► There is negative correlation of CB R expression in CNS and periphery during EAE. ► SR2 suppressed CB R while up-regulated CB R in the time-dependent manner.... 
Experimental autoimmune encephalomyelitis | Inflammatory responses | Cannabinoid receptor | Selective CB 2R antagonist | Selective CB | R antagonist
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2016, Volume 112, pp. 66 - 80
Previous studies have investigated the relevance and structure-activity relationships (SARs) of pyrazole derivatives in relation with cannabinoid receptors,... 
Molecular modelling | Synthesis | antagonism | Tricyclic pyrazoles | Cannabinoid receptors | CB
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 01/2016, Volume 99, pp. 60 - 72
The activator of G protein signalling AGS2 (Tctex-1) forms protein complexes with Gβγ, and controls cell proliferation by regulating cell cycle progression. A... 
G protein-coupled receptor (GPCR) | Cannabinoid receptor (CB2) | Tctex-1 | Protein degradation | G protein subunit | Cannabinoid receptor (CB
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 05/2012, Volume 39, Issue 4, pp. 593 - 600
Introduction: The cannabinoid receptor type 2 (CB ) is an important target for development of drugs and imaging agents for diseases, such as neuroinflammation,... 
F]-2-oxoquinoline derivatives | Cannabinoid receptor CB | Positron emission tomography
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2005, Volume 145, Issue 4, pp. 441 - 448
Journal Article
Neuroscience Letters, ISSN 0304-3940, 05/2015, Volume 595, pp. 1 - 6
Clinical trials investigating the analgesic efficacy of cannabinoids in multiple sclerosis have yielded mixed results, possibly due to psychotropic side... 
JWH-133 | Multiple sclerosis | Pain | CB 2 receptor | AM-630
Journal Article
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