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Neuropsychopharmacology, ISSN 0893-133X, 01/2012, Volume 37, Issue 2, pp. 478 - 486
The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating anxiety-and panic-related responses. Given the cellular and behavioral... 
vanilloid | anxiety | anandamide | cannabinoid | periaqueductal gray | panic | PSYCHIATRY | ENDOCANNABINOID SYSTEM | GREY-MATTER | NEUROSCIENCES | PREFRONTAL CORTEX | DORSOLATERAL PERIAQUEDUCTAL GRAY | ACID AMIDE HYDROLASE | LONG-TERM DEPRESSION | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | BRAIN | Rats, Wistar | Capsaicin - pharmacology | Cinnamates - administration & dosage | Microinjections - methods | Periaqueductal Gray - drug effects | Male | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - physiology | Capsaicin - administration & dosage | TRPV Cation Channels - metabolism | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Arachidonic Acids - administration & dosage | TRPV Cation Channels - antagonists & inhibitors | Electric Stimulation - methods | Pyrazoles - pharmacology | Panic - drug effects | Piperidines - administration & dosage | TRPV Cation Channels - physiology | Rats | Capsaicin - analogs & derivatives | Cinnamates - pharmacology | Arachidonic Acids - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Panic - physiology | Pyrazoles - administration & dosage | Animals | Anilides - administration & dosage | Anilides - pharmacology | Periaqueductal Gray - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Pyrazoles - antagonists & inhibitors | Index Medicus | animal models | psychopharmacology | mood | stress disorders | cannabinoids | Original
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167240 - e0167240
Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator (SERM) that is an essential drug to treat ER-positive breast cancer. Aside from known actions... 
SIGNAL-TRANSDUCTION | IN-VITRO | ALLOSTERIC MODULATORS | HUMAN-BREAST-CANCER | MULTIDISCIPLINARY SCIENCES | INVERSE AGONIST | CELL-GROWTH | RAT-BRAIN | ADENYLATE-CYCLASE | ESTROGEN-RECEPTOR | CB1 RECEPTOR | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Receptor, Cannabinoid, CB2 - agonists | Humans | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Isomerism | Breast Neoplasms - metabolism | Indoles - metabolism | Cyclohexanols - metabolism | Receptor, Cannabinoid, CB1 - agonists | Colforsin - metabolism | Tamoxifen - chemistry | Cannabinoid Receptor Antagonists - pharmacology | Female | Indoles - pharmacology | Cyclohexanols - pharmacology | Cyclic AMP - metabolism | CHO Cells | Binding, Competitive | Tamoxifen - metabolism | Cricetinae | Colforsin - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Adenylyl Cyclases - metabolism | Breast Neoplasms - drug therapy | Selective Estrogen Receptor Modulators - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Cannabinoid Receptor Antagonists - metabolism | Tamoxifen - pharmacology | Tamoxifen - analogs & derivatives | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Selective Estrogen Receptor Modulators - pharmacology | GTP-Binding Proteins - metabolism | Cell receptors | Patient outcomes | Drug metabolism | Development and progression | Genetic aspects | Breast cancer | Tamoxifen | Drug therapy | Health aspects | Cytochrome | Drugs | Estrogens | Estrogen receptors | Drug development | Isomers | Proteins | Adenylate cyclase | Osteoporosis | Receptors | Toxicology | Cell growth | Metabolites | Cannabinoid CB2 receptors | Cannabinoid receptors | Medical treatment | Cytochrome P450 | Pharmacology | Cannabinoid CB1 receptors | FDA approval | Medicine | Studies | Inverse agonists | Affinity | Selective estrogen receptor modulators | Cancer | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2012, Volume 63, Issue 5, pp. 905 - 915
Mu-opioid and CB1-cannabinoid agonists produce analgesia; however, adverse effects limit use of drugs in both classes. Additive or synergistic effects... 
Analgesia | Morphine | Marijuana | G-protein | Adenylyl cyclase | CB1 receptors | AGONIST MORPHINE | ACTIVATION | PROTEIN-KINASE | CB1 CANNABINOID RECEPTOR | SYNERGISTIC INTERACTIONS | NEUROSCIENCES | INHIBITION | KAPPA | FULL AGONIST | ADENYLYL-CYCLASE | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Pyrazoles - therapeutic use | Receptor, Cannabinoid, CB2 - agonists | Humans | Analgesics, Opioid - pharmacology | Receptors, Opioid, mu - agonists | Piperidines - pharmacology | Cannabinoid Receptor Agonists - therapeutic use | Recombinant Proteins - antagonists & inhibitors | Piperidines - metabolism | Receptors, Opioid, mu - metabolism | Morpholines - metabolism | Analgesics, Non-Narcotic - metabolism | Drug Inverse Agonism | Mice | Analgesics, Opioid - metabolism | Kinetics | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Analgesics, Opioid - antagonists & inhibitors | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Analgesics, Non-Narcotic - pharmacology | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Analgesics, Opioid - adverse effects | Narcotic Antagonists - metabolism | Receptor, Cannabinoid, CB1 - agonists | Analgesics, Non-Narcotic - adverse effects | Cannabinoid Receptor Agonists - adverse effects | Morpholines - adverse effects | CHO Cells | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cricetinae | Morpholines - pharmacology | Narcotic Antagonists - adverse effects | Recombinant Proteins - agonists | Analgesics, Non-Narcotic - therapeutic use | Pyrazoles - metabolism | Mice, Inbred Strains | Receptors, Opioid, mu - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Narcotic Antagonists - therapeutic use | Piperidines - therapeutic use | Narcotic Antagonists - pharmacology | Piperidines - adverse effects | Receptors, Opioid, mu - genetics | Index Medicus | Drugs | Pain perception | Opioid receptors | Cyclic AMP | Opioid receptors (type mu) | Antagonists | Cannabinoid CB1 receptors | Guanine nucleotide-binding protein | Antagonism | Cell activation | Side effects | Inverse agonists | CB1 Receptors | Adenylyl Cyclase
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2013, Volume 71, Issue 100, pp. 255 - 263
The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI) tract remains unknown. Here we studied... 
Cannabidiol | Gastrointestinal motility | Colon | Cannabinoid | GPR55 | ENDOCANNABINOID SYSTEM | MOUSE COLON | FUNCTIONAL GASTROINTESTINAL DISORDERS | NEUROSCIENCES | PATHOPHYSIOLOGY | IN-VITRO | CANNABINOID RECEPTOR | CB1 | LIGANDS | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | IRRITABLE-BOWEL-SYNDROME | Colon - cytology | Tissue Banks | Receptor, Cannabinoid, CB2 - agonists | Humans | Colon - drug effects | Gastrointestinal Motility - drug effects | Cannabidiol - analogs & derivatives | Colon - innervation | Colonic Diseases, Functional - drug therapy | Male | Neurons - cytology | Myenteric Plexus - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Molecular Targeted Therapy | Receptor, Cannabinoid, CB2 - genetics | Receptors, Cannabinoid - metabolism | Muscle, Smooth - drug effects | Receptor, Cannabinoid, CB1 - agonists | Cannabinoid Receptor Antagonists - pharmacology | Cannabidiol - therapeutic use | Neurons - metabolism | Neurons - drug effects | Receptors, Cannabinoid - chemistry | Receptors, Cannabinoid - genetics | Nerve Tissue Proteins - antagonists & inhibitors | Muscle, Smooth - innervation | Nerve Tissue Proteins - agonists | Gene Expression Regulation | Myenteric Plexus - drug effects | Cannabidiol - pharmacology | Myenteric Plexus - cytology | Muscle, Smooth - metabolism | Mice, Inbred Strains | Nerve Tissue Proteins - genetics | Colon - metabolism | Cannabinoids - pharmacology | Mice, Knockout | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Animals | Receptor, Cannabinoid, CB1 - genetics | Mice | Colonic Diseases, Functional - metabolism | Muscle, Smooth - cytology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Chronic diseases | Physiological aspects | Medical colleges | G proteins | Membrane proteins | Index Medicus | G protein-coupled receptors | COX-2, cyclooxygenase-2 | CB2, cannabinoid-2 | GI, gastrointestinal | ECS, endocannabinoid system | cDNA, complementary DNA | MAGL, monoacylglycerol lipase | CBD, cannabidiol | CB1, cannabinoid-1 | GE, gastric emptying | LMMP, longitudinal muscle-myenteric plexus layer | GPR55, G protein-coupled receptor 55 | i.c.v., intracerebroventricular administration | i.p., intraperitoneal | FAAH, fatty acid amide hydrolase | EFS, electrical field stimulation | KRS, Krebs–Ringer solution | RT-PCR, reverse transcription polymerase chain reaction | PPARα, peroxisome proliferator-activated receptor-alpha | TRPV1, transient receptor potential vanilloid 1
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2015, Volume 77, Issue 5, pp. 475 - 487
Abstract Background Mixed cannabinoid receptor 1 and 2 (CB1 and CB2 ) agonists such as Δ9 -tetrahydrocannabinol (Δ9 -THC) can produce tolerance, physical... 
Psychiatry | Tolerance | CB2 | Precipitated withdrawal | Chemotherapy-induced neuropathic pain | Knockout mouse | Side effect | DORSAL-HORN NEURONS | MECHANICAL ALLODYNIA | PSYCHIATRY | VENTRAL ROOT TRANSECTION | CB2 RECEPTOR | INDUCED PERIPHERAL NEUROPATHY | SPINAL-CORD | NECROSIS-FACTOR-ALPHA | NERVE INJURY | NEUROSCIENCES | ACID AMIDE HYDROLASE | PRIMARY SENSORY NEURONS | Hyperalgesia - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Spinal Cord - drug effects | Receptor, Cannabinoid, CB2 - agonists | Male | Cannabinoid Receptor Agonists - pharmacology | RNA, Messenger - metabolism | Receptor, Cannabinoid, CB2 - genetics | Paclitaxel - toxicity | Receptor, Cannabinoid, CB1 - agonists | Cannabinoid Receptor Antagonists - pharmacology | Female | Indoles - pharmacology | Chemokine CCL2 - metabolism | Chromones - pharmacology | Dronabinol - pharmacology | Disease Models, Animal | Mice, Inbred C57BL | Random Allocation | Hyperalgesia - physiopathology | Mice, Knockout | Antineoplastic Agents, Phytogenic - toxicity | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Hyperalgesia - drug therapy | Spinal Cord - physiopathology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Cannabinoids | Neurosciences | Paclitaxel | Index Medicus
Journal Article