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Neuropsychopharmacology, ISSN 0893-133X, 01/2012, Volume 37, Issue 2, pp. 478 - 486
The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating anxiety-and panic-related responses. Given the cellular and behavioral... 
vanilloid | anxiety | anandamide | cannabinoid | periaqueductal gray | panic | PSYCHIATRY | ENDOCANNABINOID SYSTEM | GREY-MATTER | NEUROSCIENCES | PREFRONTAL CORTEX | DORSOLATERAL PERIAQUEDUCTAL GRAY | ACID AMIDE HYDROLASE | LONG-TERM DEPRESSION | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | BRAIN | Rats, Wistar | Capsaicin - pharmacology | Cinnamates - administration & dosage | Microinjections - methods | Periaqueductal Gray - drug effects | Male | Piperidines - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - physiology | Capsaicin - administration & dosage | TRPV Cation Channels - metabolism | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Arachidonic Acids - administration & dosage | TRPV Cation Channels - antagonists & inhibitors | Electric Stimulation - methods | Pyrazoles - pharmacology | Panic - drug effects | Piperidines - administration & dosage | TRPV Cation Channels - physiology | Rats | Capsaicin - analogs & derivatives | Cinnamates - pharmacology | Arachidonic Acids - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Panic - physiology | Pyrazoles - administration & dosage | Animals | Anilides - administration & dosage | Anilides - pharmacology | Periaqueductal Gray - physiology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Pyrazoles - antagonists & inhibitors | animal models | psychopharmacology | mood | stress disorders | cannabinoids | Original
Journal Article
Brain Research Reviews, ISSN 0165-0173, 2007, Volume 58, Issue 2, pp. 415 - 452
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2015, Volume 470, Issue 2, pp. 181 - 193
Bile acids are primarily synthesized from cholesterol in the liver and have important roles in dietary lipid absorption and cholesterol homoeostasis. Detailed... 
Orphan nuclear receptor | GSK5182 | Bile acid | Oestrogen-related receptor γ (ERRγ ) | Cholesterol 7α-hydroxylase (CYP7A1) | Cannabinoid receptors | Small heterodimer partner (SHP) | HORMONE-RECEPTORS | RAT HEPATOCYTES | bile acid | BIOCHEMISTRY & MOLECULAR BIOLOGY | oestrogen-related receptor gamma (ERR gamma) | ALPHA | orphan nuclear receptor | PREGNANE-X-RECEPTOR | CB1 RECEPTOR | HUMAN HEPATOCYTES | small heterodimer partner (SHP) | cholesterol 7 alpha-hydroxylase (CYP7A1) | INVERSE AGONIST | FATTY LIVER | BILE-ACID BIOSYNTHESIS | CHOLESTEROL 7-ALPHA-HYDROXYLASE | cannabinoid receptors | Promoter Regions, Genetic | Gene Expression | Receptors, Estrogen - metabolism | Receptors, Estrogen - genetics | Humans | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Bile Acids and Salts - metabolism | Hepatocytes - metabolism | Rats, Sprague-Dawley | Mice, Knockout | Cholesterol 7-alpha-Hydroxylase - genetics | Receptor, Cannabinoid, CB1 - metabolism | Ethanol - pharmacology | Glycerides - pharmacology | Animals | Receptor, Cannabinoid, CB1 - agonists | Receptor, Cannabinoid, CB1 - genetics | Drug Inverse Agonism | HEK293 Cells | Cholesterol 7-alpha-Hydroxylase - biosynthesis | Transcription, Genetic | Receptors, Cytoplasmic and Nuclear - metabolism | cholesterol 7α-hydroxylase (CYP7A1) | oestrogen-related receptor γ (ERRγ)
Journal Article
Pharmacological Reviews, ISSN 0031-6997, 09/2011, Volume 63, Issue 3, pp. 461 - 470
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167240 - e0167240
Tamoxifen (Tam) is a selective estrogen receptor (ER) modulator (SERM) that is an essential drug to treat ER-positive breast cancer. Aside from known actions... 
SIGNAL-TRANSDUCTION | IN-VITRO | ALLOSTERIC MODULATORS | HUMAN-BREAST-CANCER | MULTIDISCIPLINARY SCIENCES | INVERSE AGONIST | CELL-GROWTH | RAT-BRAIN | ADENYLATE-CYCLASE | ESTROGEN-RECEPTOR | CB1 RECEPTOR | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Receptor, Cannabinoid, CB2 - agonists | Humans | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Isomerism | Breast Neoplasms - metabolism | Indoles - metabolism | Cyclohexanols - metabolism | Receptor, Cannabinoid, CB1 - agonists | Colforsin - metabolism | Tamoxifen - chemistry | Cannabinoid Receptor Antagonists - pharmacology | Female | Indoles - pharmacology | Cyclohexanols - pharmacology | Cyclic AMP - metabolism | CHO Cells | Binding, Competitive | Tamoxifen - metabolism | Cricetinae | Colforsin - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Adenylyl Cyclases - metabolism | Breast Neoplasms - drug therapy | Selective Estrogen Receptor Modulators - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Cannabinoid Receptor Antagonists - metabolism | Tamoxifen - pharmacology | Tamoxifen - analogs & derivatives | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Selective Estrogen Receptor Modulators - pharmacology | GTP-Binding Proteins - metabolism | Cell receptors | Patient outcomes | Drug metabolism | Development and progression | Genetic aspects | Breast cancer | Tamoxifen | Drug therapy | Health aspects | Cytochrome | Drugs | Estrogens | Estrogen receptors | Drug development | Isomers | Proteins | Osteoporosis | Receptors | Toxicology | Cell growth | Metabolites | Cannabinoid CB2 receptors | Medical treatment | Cytochrome P450 | Pharmacology | Cannabinoid CB1 receptors | FDA approval | Medicine | Studies | Inverse agonists | Affinity | Selective estrogen receptor modulators | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2012, Volume 63, Issue 5, pp. 905 - 915
Mu-opioid and CB1-cannabinoid agonists produce analgesia; however, adverse effects limit use of drugs in both classes. Additive or synergistic effects... 
Analgesia | Morphine | Marijuana | G-protein | Adenylyl cyclase | CB1 receptors | AGONIST MORPHINE | ACTIVATION | PROTEIN-KINASE | CB1 CANNABINOID RECEPTOR | SYNERGISTIC INTERACTIONS | NEUROSCIENCES | INHIBITION | KAPPA | FULL AGONIST | ADENYLYL-CYCLASE | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Pyrazoles - therapeutic use | Receptor, Cannabinoid, CB2 - agonists | Humans | Analgesics, Opioid - pharmacology | Receptors, Opioid, mu - agonists | Piperidines - pharmacology | Cannabinoid Receptor Agonists - therapeutic use | Recombinant Proteins - antagonists & inhibitors | Piperidines - metabolism | Receptors, Opioid, mu - metabolism | Morpholines - metabolism | Analgesics, Non-Narcotic - metabolism | Drug Inverse Agonism | Mice | Analgesics, Opioid - metabolism | Kinetics | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Analgesics, Opioid - antagonists & inhibitors | Cannabinoid Receptor Agonists - metabolism | Cricetulus | Analgesics, Non-Narcotic - pharmacology | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Analgesics, Opioid - adverse effects | Narcotic Antagonists - metabolism | Receptor, Cannabinoid, CB1 - agonists | Analgesics, Non-Narcotic - adverse effects | Cannabinoid Receptor Agonists - adverse effects | Morpholines - adverse effects | CHO Cells | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cricetinae | Morpholines - pharmacology | Narcotic Antagonists - adverse effects | Recombinant Proteins - agonists | Analgesics, Non-Narcotic - therapeutic use | Pyrazoles - metabolism | Mice, Inbred Strains | Receptors, Opioid, mu - antagonists & inhibitors | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Narcotic Antagonists - therapeutic use | Piperidines - therapeutic use | Narcotic Antagonists - pharmacology | Piperidines - adverse effects | Receptors, Opioid, mu - genetics | Index Medicus | Drugs | Pain perception | Opioid receptors | Cyclic AMP | Opioid receptors (type mu) | Antagonists | Cannabinoid CB1 receptors | Guanine nucleotide-binding protein | Antagonism | Cell activation | Side effects | Inverse agonists | CB1 Receptors | Adenylyl Cyclase
Journal Article