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Progress in Lipid Research, ISSN 0163-7827, 01/2013, Volume 52, Issue 1, pp. 80 - 109
Cannabinoids-endocannaboids are possible preventatives of common diseases including cancers. Cannabinoid receptors (CB1/2, TRPV1) are central components of the... 
DHEA | monoacylglycerol lipase | extracellular signal-regulated kinase | FAAH | JNK | G protein-coupled receptor 55 | HETE | NF-κB | intercellular adhesion molecules | NAPE-PLD | hydroxyeicosatetraenoic acid | PAI-1 | cDNA | long chain poly unsaturated fatty acid | AEA | matrix metalloproteinases | nuclear factor kappa-light-chain-enhancer of activated B cells | c-Jun N-terminal kinase | CLnA | EPEA | CaMKKβ | MAPK | mammalian target of rapamycin (mTOR) complex 1 | conjugated linoleic acid | eicosapentaenoic acid | NAAE | LOX | 2-AG | hydroperoxyeicosatetraenoic acid | adenosine monophosphate-activated protein kinase | AMPK | GPCR | ANG | DHA | mTORC1 | ERK | Bcl-2-associated death promoter | CBD | COX-2 | DNA-binding protein inhibitor 1 | cannabinoid receptor | NAPE | mitogen-activated protein kinase | complementary DNA | lipoxygenase | calcium/calmodulin-dependent protein kinase kinase 2 | fatty acid amide hydrolase | docosahexaenoic acid | docosahexaenoyl ethanolamide | MAGL | ID-1 | B-cell lymphoma 2 | conjugated linolenic acid | eicosapentaenoyl ethanolamide | G protein-coupled receptor | ICAM | BAD | GPR55 | MMPs | N-acylphosphatidyl ethanolamine hydrolizing phospholipid D | N-acylphosphatidyl ethanolamine | anadamide (arachidonoyl ethanolamide) | N-acylethanolamine | 2-arachidonoylglycerol | N-acylethanolamine acid amidase | cannabidiol | plasminogen | LCPUFA | BCl-2 | HPETE | Bcl-2-associated X protein | NAE | EPA | BAX | CLA | Akt protein kinase B | cyclooxygenase 2 | angiopoetins | BREAST-CANCER CELLS | GROWTH-FACTOR RECEPTOR | NUTRITION & DIETETICS | PROSTAGLANDIN E-2 ETHANOLAMIDE | P38 MAPK ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FATTY-ACID AMIDE | CONJUGATED LINOLEIC ACIDS | RECEPTOR-INDEPENDENT MECHANISM | VANILLOID TYPE-1 TRPV1 | NECROSIS-FACTOR-ALPHA | REGULATED KINASE ACTIVATION | Endocannabinoids - metabolism | Neoplasms - metabolism | Receptor, Cannabinoid, CB2 - immunology | Endocannabinoids - pharmacology | Humans | Cannabinoid Receptor Agonists - pharmacology | Arachidonic Acids - pharmacology | Autophagy - drug effects | Cannabinoids - pharmacology | Neoplasms - drug therapy | Receptors, Cannabinoid - metabolism | Animals | Polyunsaturated Alkamides - pharmacology | Cannabinoid Receptor Antagonists - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Cell Death - drug effects | Cannabinoids - metabolism | Medical colleges | RNA | Biochemistry | DNA binding proteins | Genetic transcription | Lipase | Ethanolamines | Proteins | Dehydroepiandrosterone | Cannabinoids | Chemotherapy | Cell death | Prostaglandins E | Linolenic acids | Phenols | Lymphomas | Vascular endothelial growth factor | Health aspects | Protein kinases | Omega-3 fatty acids | Cancer | Index Medicus
Journal Article
Acta Pharmacologica Sinica, ISSN 1671-4083, 03/2019, Volume 40, Issue 3, pp. 374 - 386
With treatment benefits in both the central nervous system and the peripheral system, the medical use of cannabidiol (CBD) has gained increasing popularity.... 
5HT | homology modeling | molecular docking | D | cannabinoid | molecular dynamics simulation | cannabidiol (CBD) | systems pharmacology | simulation 5HT(1A) | VITRO | MAJOR PHYTOCANNABINOIDS | RECEPTOR | PARTICLE MESH EWALD | D-3 | molecular dynamics | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | POLYPHARMACOLOGY | AMBER | RHODOPSIN | PHARMACOLOGY & PHARMACY | MOLECULAR-DYNAMICS SIMULATIONS | MODULATION | Receptors, Opioid, delta - metabolism | Knowledge Bases | Receptors, G-Protein-Coupled - metabolism | Receptors, Opioid, delta - chemistry | Humans | Receptors, Dopamine D3 - chemistry | Receptors, Dopamine D3 - metabolism | Molecular Dynamics Simulation | Sequence Homology, Amino Acid | Algorithms | Hydrogen Bonding | Databases, Chemical | Pharmacology - methods | Protein Binding | Molecular Docking Simulation | Cannabidiol - metabolism | Cannabidiol - chemistry | Receptors, G-Protein-Coupled - chemistry | Binding | Rhodopsin | G protein-coupled receptors | Target recognition | Dopamine | Computer simulation | Serotonin | Computational neuroscience | Central nervous system | Dopamine D3 receptors | Molecular dynamics | Homology | Pharmacology | Systems analysis | Knowledge base | Hydrophobicity | Molecular docking | Opioid receptors (type delta) | Proteins | Simulation | Computation | Network analysis | Chemogenomics | 5HT1A
Journal Article
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 02/2014, Volume 103, Issue 2, pp. 768 - 775
Journal Article
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 11/2019, Volume 10, p. 1284
Background: As a library of cannabinoid (CB) derivatives with (-)-trans-cannabidiol (CBD) or (-)-trans-cannabidivarin (CBDV) scaffold, we synthesized nine... 
CBD | binding | RECEPTOR | CB-receptor | agonist | SYMPTOMS | MODEL | CBDV | cannabidiol | cannabidivarin | CB1 | anti-inflammatory | INVERSE AGONIST | PHARMACOLOGY & PHARMACY
Journal Article
FEBS Letters, ISSN 0014-5793, 2002, Volume 514, Issue 2, pp. 214 - 218
Ciliary neurotrophic factor (CNTF) is a member of the gp130 family of cytokines. The functional receptor complex of CNTF is composed of the CNTF receptor α... 
LIF | Leukemia inhibitory factor receptor | CNTF | Ciliary neurotrophic factor receptor | Cytokine | Interleukin-6 | CBD, cytokine binding domain | Ig, immunoglobulin | IL-11, interleukin-11 | STAT, signal transducer and activator of transcription | CT-1, cardiotrophin-1 | CLC, cardiotrophin-like cytokine | OSM, oncostatin M | sCNTFR, soluble CNTF receptor α | IL-6, interleukin-6 | NT-2, human embryonal carcinoma cell line Ntera/D1 | LIF, leukemia inhibitory factor | CNTF, ciliary neurotrophic factor | LIFR, LIF receptor β | cytokine | leukemia inhibitory factor receptor | STIMULATING FACTOR-RECEPTOR | ciliary neurotrophic factor receptor | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | GP130 | interleukin-6 | FAMILY | CELL BIOLOGY | BIOPHYSICS | CILIARY NEUROTROPHIC FACTOR | Neoplastic Stem Cells - cytology | Humans | Peptide Fragments - pharmacology | PC12 Cells | Recombinant Fusion Proteins - metabolism | Neoplastic Stem Cells - metabolism | Lymphokines - pharmacology | Receptors, Cytokine - metabolism | Growth Inhibitors - pharmacology | Leukemia Inhibitory Factor | Peptide Fragments - genetics | Receptors, Cytokine - genetics | Cell Line | Peptide Fragments - metabolism | Enzyme-Linked Immunosorbent Assay | Receptor, Ciliary Neurotrophic Factor - metabolism | Embryonal Carcinoma Stem Cells | Rats | Leukemia Inhibitory Factor Receptor alpha Subunit | Macromolecular Substances | Animals | Interleukin-6 - pharmacology | Signal Transduction - drug effects | Receptor, Ciliary Neurotrophic Factor - genetics | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Cytokines - pharmacology | Protein Binding - physiology | Protein Structure, Tertiary - physiology | Receptors, OSM-LIF
Journal Article
Nova Biotechnologica et Chimica, ISSN 1338-6905, 12/2015, Volume 14, Issue 2, pp. 117 - 134
Endolysins are bacteriophage-encoded peptidoglycan hydrolases, which are synthesized in the end of phage reproduction cycle, in an infected host cell. Usually,... 
cell wall binding domain (CBD) | ligand/receptor | endolysin | bacteriophage | peptidoglycan (PG)
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2013, Volume 71, Issue 100, pp. 255 - 263
The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI) tract remains unknown. Here we studied... 
Cannabidiol | Gastrointestinal motility | Colon | Cannabinoid | GPR55 | ENDOCANNABINOID SYSTEM | MOUSE COLON | FUNCTIONAL GASTROINTESTINAL DISORDERS | NEUROSCIENCES | PATHOPHYSIOLOGY | IN-VITRO | CANNABINOID RECEPTOR | CB1 | LIGANDS | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | IRRITABLE-BOWEL-SYNDROME | Colon - cytology | Tissue Banks | Receptor, Cannabinoid, CB2 - agonists | Humans | Colon - drug effects | Gastrointestinal Motility - drug effects | Cannabidiol - analogs & derivatives | Colon - innervation | Colonic Diseases, Functional - drug therapy | Male | Neurons - cytology | Myenteric Plexus - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Molecular Targeted Therapy | Receptor, Cannabinoid, CB2 - genetics | Receptors, Cannabinoid - metabolism | Muscle, Smooth - drug effects | Receptor, Cannabinoid, CB1 - agonists | Cannabinoid Receptor Antagonists - pharmacology | Cannabidiol - therapeutic use | Neurons - metabolism | Neurons - drug effects | Receptors, Cannabinoid - chemistry | Receptors, Cannabinoid - genetics | Nerve Tissue Proteins - antagonists & inhibitors | Muscle, Smooth - innervation | Nerve Tissue Proteins - agonists | Gene Expression Regulation | Myenteric Plexus - drug effects | Cannabidiol - pharmacology | Myenteric Plexus - cytology | Muscle, Smooth - metabolism | Mice, Inbred Strains | Nerve Tissue Proteins - genetics | Colon - metabolism | Cannabinoids - pharmacology | Mice, Knockout | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Animals | Receptor, Cannabinoid, CB1 - genetics | Mice | Colonic Diseases, Functional - metabolism | Muscle, Smooth - cytology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Chronic diseases | Physiological aspects | Medical colleges | G proteins | Membrane proteins | G protein-coupled receptors | COX-2, cyclooxygenase-2 | CB2, cannabinoid-2 | GI, gastrointestinal | ECS, endocannabinoid system | cDNA, complementary DNA | MAGL, monoacylglycerol lipase | CBD, cannabidiol | CB1, cannabinoid-1 | GE, gastric emptying | LMMP, longitudinal muscle-myenteric plexus layer | GPR55, G protein-coupled receptor 55 | i.c.v., intracerebroventricular administration | i.p., intraperitoneal | FAAH, fatty acid amide hydrolase | EFS, electrical field stimulation | KRS, Krebs–Ringer solution | RT-PCR, reverse transcription polymerase chain reaction | PPARα, peroxisome proliferator-activated receptor-alpha | TRPV1, transient receptor potential vanilloid 1
Journal Article
FEBS Letters, ISSN 0014-5793, 2005, Volume 579, Issue 6, pp. 1529 - 1533
Though the role of Hedgehog (Hh) signalling in patterning and differentiation during development is well established, the underlying signal transduction... 
Membrane protein | Smoothened | Yeast | Purification | Hedgehog signalling | Heterologous expression | alcohol oxidase 1 | CBD | phenylmethylsulfonyl fluoride | DDM | Patched | CHS | dodecyldimethyl-N-amineoxide | AOX1 | sodium dodecyl sulfate–polyacrylamide gel electrophoresis | polymerase chain reaction | 1-propanesulfonate | cholesteryl hemisuccinate | human Smoothened | calmodulin binding domain | ethylene glycol bis(β-aminoethyl ether) | SDS–PAGE | CHAPS | EGTA | hemagglutinin A | n-dodecyl-β-D-maltoside | DDAO | Hedgehog | PMSF | hSmo | Ptc | PCR | STEM-CELLS | smoothened | SONIC HEDGEHOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | heterologous expression | SACCHAROMYCES-CEREVISIAE | CANCER | yeast | P-GLYCOPROTEIN | CELL BIOLOGY | BIOPHYSICS | purification | PROTEIN EXPRESSION | hedgehog signalling | membrane protein | PICHIA-PASTORIS | MEMBRANE-PROTEINS | BINDING | Recombinant Proteins - metabolism | Gene Expression | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Saccharomyces cerevisiae - genetics | Humans | Solubility | Recombinant Proteins - chemistry | Spectrometry, Fluorescence | Recombinant Proteins - genetics | Hedgehog Proteins | Recombinant Proteins - isolation & purification | Chromatography, Affinity | Smoothened Receptor | Pichia - genetics | Receptors, G-Protein-Coupled - isolation & purification | Protein Conformation | Trans-Activators - metabolism | Receptors, G-Protein-Coupled - genetics | Receptors, G-Protein-Coupled - chemistry | Polymerase chain reaction | Oxidases | Ethylene glycol | Developmental biology | Oncology, Experimental | Lectins | Research | Calmodulin | Cancer | Male | Recombinant Proteins | Cellular Biology | Life Sciences | Time Factors | Fibroblasts | Female | Tretinoin | Cell Behavior | Trans-Activators | Cells, Cultured | Receptors, G-Protein-Coupled | RNA Stability | Pichia | Gene Expression Regulation, Enzymologic | Arthritis, Psoriatic | Saccharomyces cerevisiae | RNA, Messenger | Superoxide Dismutase
Journal Article