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Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7257, pp. 904 - 908
Acquired uniparental disomy(aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function... 
TRANSFORMATION | PROTEIN | RETROVIRAL VECTOR GCDNSAP | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC STEM-CELLS | V-CBL | MUTATIONS | UBIQUITIN LIGASES | MYELODYSPLASTIC SYNDROMES | P53 | NIH 3T3 Cells | Neoplasm Transplantation | ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Humans | Leukemia, Myeloid - genetics | Molecular Sequence Data | ras Proteins - metabolism | Male | Leukemia, Myeloid - pathology | Allelic Imbalance | Ubiquitination | Base Sequence | Female | Proto-Oncogene Proteins c-cbl - deficiency | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-cbl - genetics | Amino Acid Sequence | Oncogenes - genetics | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Chromosomes, Human, Pair 11 - genetics | Proto-Oncogene Proteins c-cbl - chemistry | Mice, Knockout | Animals | Uniparental Disomy - genetics | Leukemia, Myeloid - metabolism | Mice, Nude | Mutant Proteins - chemistry | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Protein Conformation | Mice | Mutation | Gene mutations | Myelocytic leukemia | Physiological aspects | Tumor suppressor genes | Development and progression | Genetic aspects | Nonlymphoid leukemia | Research | Protein kinases | Proteins | Genes | Amino acids | Kinases | Cells | Clinical outcomes | Crystal structure
Journal Article
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 05/2013, Volume 5, Issue 5, pp. 723 - 736
We found that basal‐like breast cancer (BLBC) cells use Cdc42 to inhibit function of the redox/Fyn/c‐Cbl (RFC) pathway, which normally functions to convert... 
redox/Fyn/c‐Cbl pathway | basal‐like breast cancer | cancer stem cell | tamoxifen | c‐Cbl | Cancer stem cell | Tamoxifen | Redox/Fyn/c-Cbl pathway | C-Cbl | Basal-like breast cancer | basal-like breast cancer | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | INDUCED APOPTOSIS | DOWN-REGULATION | c-Cbl | CELLULAR TARGETS | ESTROGEN-RECEPTOR | redox | HIGH-DOSE TAMOXIFEN | INDUCED RAPID DEATH | THERAPEUTIC TARGET | c-Cbl pathway | Fyn | RHO-GTPASES | Neoplastic Stem Cells - cytology | Proto-Oncogene Proteins c-cbl - metabolism | Neoplastic Stem Cells - drug effects | Humans | Transplantation, Heterologous | cdc42 GTP-Binding Protein - metabolism | Breast Neoplasms - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | cdc42 GTP-Binding Protein - antagonists & inhibitors | Estrogen Receptor alpha - metabolism | Female | Proto-Oncogene Proteins c-cbl - genetics | Cell Survival - drug effects | Oxidation-Reduction | Mice, SCID | Breast Neoplasms - drug therapy | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Signal Transduction - drug effects | cdc42 GTP-Binding Protein - genetics | Tamoxifen - therapeutic use | Tamoxifen - pharmacology | Cell Line, Tumor | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Breast Neoplasms - mortality | Mice, Inbred NOD | Mice | RNA, Small Interfering - metabolism | Proteins | Breast cancer | Stem cells | Cancer cells | Estrogen | Cdc42 protein | Medical research | Metastasis | Kinases | Hypotheses | Cell death | Laboratory animals | Fyn protein | Tumors | Apoptosis
Journal Article
Oncogene, ISSN 0950-9232, 12/2012, Volume 31, Issue 50, pp. 5123 - 5131
Casitas B-lineage lymphoma (CBL) protein family functions as multifunctional adaptor proteins and E3 ubiquitin ligases that are implicated as regulators of... 
smad | breast cancer | TGF-β | tumorigenesis | CBL | NUCLEAR IMPORT | SMAD3 | CANCER CELLS | C-CBL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TYROSINE KINASES | CELL BIOLOGY | TGF-beta | GROWTH-FACTOR-BETA | ONCOLOGY | II RECEPTOR | GENETICS & HEREDITY | ACQUIRED UNIPARENTAL DISOMY | MUTATIONS | Proto-Oncogene Proteins c-cbl - metabolism | Cyclin-Dependent Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Transplantation, Heterologous | Smad3 Protein - metabolism | Gene Knockdown Techniques - methods | Breast Neoplasms - metabolism | Proto-Oncogene Proteins c-cbl - biosynthesis | Smad3 Protein - genetics | Plasminogen Activator Inhibitor 1 - metabolism | Cell Transformation, Neoplastic - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Female | Transcription, Genetic | Plasminogen Activator Inhibitor 1 - genetics | Cyclin-Dependent Kinases - genetics | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-cbl - genetics | Signal Transduction | Cell Transformation, Neoplastic - metabolism | Protein Transport | Animals | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Protein Binding | Mice | Cell Transformation, Neoplastic - pathology | Transforming Growth Factor beta - metabolism | Index Medicus | Cbl protein | Transcription | Breast cancer | Smad3 protein | Transforming growth factor- beta | adaptor proteins | Carcinogenesis | Lymphoma | Smad4 protein | Nuclear transport | Cyclin-dependent kinase | Signal transduction | Cyclin-dependent kinase inhibitor p21 | Cbl-b protein | Tumor suppressor genes | Tumorigenesis | Mutation | Ubiquitin-protein ligase
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2005, Volume 391, Issue 2, pp. 153 - 166
The activation of signalling pathways by ligand engagement with transmembrane receptors is responsible for determining many aspects of cellular function and... 
T-cell receptor | Ubiquitin | Receptor tyrosine kinase | E3 ligase | Cbl | Thymocyte | BIOCHEMISTRY & MOLECULAR BIOLOGY | thymocyte | receptor tyrosine kinase | ubiquitin | Protein Structure, Tertiary | Proto-Oncogene Proteins c-cbl - genetics | Proto-Oncogene Proteins c-cbl - metabolism | Animals | Signal Transduction | Substrate Specificity | Proto-Oncogene Proteins c-cbl - chemistry | Proto-Oncogene Proteins c-cbl - immunology | PLC, phospholipase C | SH, Src homology | TCR, T-cell receptor | IL-2, interleukin 2 | PI3K, phosphoinositide 3-kinase | PTK, protein tyrosine kinase | EGF, epidermal growth factor | TKB, tyrosine-kinase-binding | Review | Sli-1, suppressor of lineage defect-1 | UBA, ubiquitin-associated | WASP, Wiskott–Aldrich syndrome protein | PTB, phosphotyrosine-binding | Ubc, ubiquitin-conjugating | GLUT4, glucose transporter 4 | BMMC, bone-marrow-derived mast cell | KPD, Komeda diabetes-prone | HECT, homologous with E6AP C-terminus | SLAP, Src-like adaptor protein | CIN85, Cbl-interacting protein of 85 kDa | CTLA-4, cytotoxic T-lymphocyte-associated protein 4 | PKC, protein kinase C | ZAP-70, ζ-associated protein of 70 kDa | SLP-76, SH2 domain-containing leucocyte protein of 76 kDa | FcεRI, high-affinity IgE receptor | NFAT, nuclear factor of activated T-cells | GRAIL, gene related to anergy in lymphocytes | RIP-gp, rat insulin promoter glycoprotein | hSpry2, human Sprouty 2 | RTK, receptor tyrosine kinase | SEM-5, sex muscle abnormal 5 | DP, double positive | LAT, linker for activation of T-cells | APS, adaptor molecule containing pleckstrin homology and Src homology 2 domains | MAIDS, murine AIDS | PDGF, platelet-derived growth factor | BLNK, B-cell linker
Journal Article
11/2009
Erythropoietin (EPO) is the primary cytokine regulator of erythropoiesis. Fundamental to this action is the ability of EPO to bind the EPO receptor (EPO-R),... 
0379 | Erythropoietin | Cbl | 0307
Dissertation
Journal Article