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Molecular cell, ISSN 1097-2765, 2015, Volume 58, Issue 6, pp. 1028 - 1039
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this disease is not well understood... 
SELECTIVE-INHIBITION | RECRUITMENT | C/EBP-ALPHA | CREB-BINDING PROTEIN | CHROMATIN | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | C-MYC | P-TEFB | BRD4 | CELL BIOLOGY | Transcriptional Regulator ERG | NIH 3T3 Cells | Oncogene Proteins - genetics | Humans | Leukemia, Myeloid - genetics | Proto-Oncogene Proteins c-myb - genetics | Gene Expression Profiling | Leukemia, Myeloid - pathology | RNA Interference | Proto-Oncogene Protein c-fli-1 - metabolism | Protein Binding - drug effects | Trans-Activators - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Acute Disease | Proto-Oncogene Protein c-fli-1 - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | Proto-Oncogene Proteins c-myb - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Acetylation - drug effects | Animals | Hematopoietic System - metabolism | Leukemia, Myeloid - metabolism | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Trans-Activators - metabolism | Mice | Histones - metabolism | DNA binding proteins | Medicine, Experimental | Medical research | Chromatin | Lysine
Journal Article
Biochemical journal, ISSN 0264-6021, 01/2010, Volume 425, Issue 1, pp. 215 - 223
The transcription factor SREBP1c (sterol-regulatory-element-binding protein 1c) is highly expressed in adipose tissue and plays a central role in several aspects of adipocyte development including the induction of PPAR gamma... 
Adipocyte | CCAAT/enhancer-binding protein(C/EBP) | Sterol-regulatory-element-binding protein 1c(SREBP1c) | Transcription | Lipid | Adipogenesis | transcription | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | ALPHA | sterol-regulatory-element-binding protein 1c (SREBP1c) | lipid | BETA | adipogenesis | INSULIN-RESISTANCE | adipocyte | LIPODYSTROPHY | ADIPOCYTE DIFFERENTIATION | PPAR-GAMMA | ADD1/SREBP1 | CCAAT/enhancer-binding protein (C/EBP) | MICE | ADIPOSE-TISSUE | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Humans | Adipocytes - cytology | DNA-Binding Proteins - metabolism | Chromatin Immunoprecipitation | RNA Interference | CCAAT-Enhancer-Binding Protein-delta - metabolism | CCAAT-Enhancer-Binding Proteins - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Promoter Regions, Genetic | CCAAT-Enhancer-Binding Protein-beta - genetics | Cells, Cultured | Gene Expression Regulation | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | 3T3-L1 Cells | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | RUNX1 Translocation Partner 1 Protein | Transcription Factors - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | CCAAT-Enhancer-Binding Protein-delta - genetics | Adipocytes - metabolism | CCAAT-Enhancer-Binding Protein-alpha - genetics | Protein Binding | Mice
Journal Article
Biochemical journal, ISSN 1470-8728, 2011, Volume 434, Issue 3, pp. 365 - 381
.... Iron metabolism is controlled at different... 
Ferroportin | Iron-sulfur cluster (ISC) | Transferrin receptor (TfR) | Iron-regulatory protein 2 (IRP2) | Ferritin | Iron-regulatory protein 1 (IRP1) | ferritin | iron-sulfur cluster (ISC) | transferrin receptor (TfR) | OXIDATIVE STRESS | MAMMALIAN IRON | MITOCHONDRIAL IRON | iron-regulatory protein 2 (IRP2) | HEME-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | iron-regulatory protein 1 (IRP1) | ferroportin | AMYLOID PRECURSOR PROTEIN | RESPONSIVE ELEMENT | TRANSFERRIN-BOUND IRON | RNA-BINDING | H-FERRITIN | HEPCIDIN EXPRESSION | Neoplasms - metabolism | Oxidation-Reduction | Response Elements | Humans | RNA, Messenger - genetics | RNA, Messenger - physiology | Mitochondria - metabolism | Iron - metabolism | Iron-Regulatory Proteins - genetics | Animals | Ferritins - metabolism | Biological Transport | Iron-Regulatory Proteins - physiology | Transferrin - metabolism | DHBA, dihydroxybenzoic acid | IRP, iron-regulatory protein | UTR, untranslated region | SLC, solute carrier | iron–sulfur cluster (ISC) | MRCKα, myotonic dystrophy kinase-related Cdc42 (cell division cycle 42)-binding kinase α | LIP, labile iron pool | Lcn2, lipocalin 2 | FLVCR, feline leukaemia virus, subgroup C, receptor | CIA, cytosolic ISC assembly | Cfd1, cytosolic Fe–S cluster-deficient protein 1 | BMP, bone morphogenetic protein | PCBP1, poly(rC)-binding protein 1 | Abcb, ATP-binding cassette, subfamily B | STAT3, signal transducer and activator of transcription 3 | SDH, succinate dehydrogenase | TfR, Tf receptor | c-aconitase, cytosolic aconitase | HIF, hypoxia-inducible factor | HO-1, haem oxygenase 1 | IRIDA, iron-refractory iron deficiency anaemia | ISC, iron–sulfur cluster | m-aconitase, mitochondrial aconitase | DMT1, divalent metal transporter 1 | Review | EBPα, CCAAT | IRE, iron-responsive element | IOP1, iron-only hydrogenase-like protein 1 | Nbp35, nucleotide-binding protein 35 | Skp1, S-phase kinase-associated protein 1 | Nfs, nitrogen fixation homologue | FBXL5, F-box and leucine-rich repeat protein 5 | ROS, reactive oxygen species | Tf, transferrin | enhancer-binding protein α | H, heavy | Isu, iron–sulfur cluster scaffold homologue | Rbx1, Ring-box 1 | β-APP, β-amyloid precursor protein | Dcytb, duodenal cytochrome b | Nar1, nuclear architecture-related protein 1 | ALAS, ALA synthase | NTBI, non-transferrin-bound iron | ALA, 5-aminolevulinic acid | Hpx, haemopexin | Cul1, Cullin 1 | Grx, glutaredoxin | ER, endoplasmic reticulum | L, light
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2016, Volume 17, Issue 1, pp. 124 - 124
...), and the CCAAT/enhancer binding proteins (C/EBPs) such as C/EBP alpha, beta and delta are considered the key early regulators of adipogenesis, while fatty acid binding protein 4 (FABP4... 
C/EBPα | Obesity | Adipose tissue | PPARγ | Adipogenesis | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | C/EBP alpha | adipose tissue | BINDING-PROTEIN | PEROXISOMAL BETA-OXIDATION | DIET-INDUCED OBESITY | PPAR gamma | CHEMISTRY, MULTIDISCIPLINARY | MESENCHYMAL STEM-CELLS | adipogenesis | GENE-EXPRESSION | PPAR-GAMMA | ADIPOCYTE DIFFERENTIATION | obesity | RECEPTOR-GAMMA EXPRESSION | GREEN TEA POLYPHENOL | Fatty Acid Synthase, Type I - genetics | Obesity - drug therapy | Stilbenes - therapeutic use | Adipogenesis - drug effects | Humans | Adipocytes - drug effects | Fatty Acid-Binding Proteins - metabolism | PPAR gamma - metabolism | Obesity - genetics | Adipose Tissue - metabolism | Protein Isoforms - metabolism | Adiponectin - genetics | Adiponectin - metabolism | Genistein - therapeutic use | CCAAT-Enhancer-Binding Protein-delta - metabolism | CCAAT-Enhancer-Binding Proteins - genetics | Adipogenesis - genetics | PPAR gamma - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Signal Transduction | Adipose Tissue - pathology | Gene Expression Regulation | Adipocytes - pathology | Fatty Acid Synthase, Type I - metabolism | Fatty Acid-Binding Proteins - genetics | Obesity - metabolism | Obesity - pathology | Hydroxycholesterols - therapeutic use | Animals | CCAAT-Enhancer-Binding Protein-delta - genetics | Adipocytes - metabolism | Mice | Adipose Tissue - drug effects | Protein Isoforms - genetics | Molecules | Stem cells | Adipocytes
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 6, p. e39586
... death, independent of p53. CHOP (C/EBP homologous protein also known as GADD153; gene name Ddit3), a critical initiator of ER stress-induced apoptosis, was found... 
MITOCHONDRIAL APOPTOSIS | TRANSCRIPTION FACTOR CHOP | UNFOLDED PROTEIN RESPONSE | INDUCED APOPTOSIS | KINASE | BIOLOGY | GENE-EXPRESSION | SYMPATHETIC NEURONS | DEATH | ENDOPLASMIC-RETICULUM STRESS | BH3-ONLY PROTEINS | Transcription Factor CHOP - genetics | Apoptosis - drug effects | Neurons - cytology | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Telencephalon - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - physiology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Tumor Suppressor Proteins - metabolism | Telencephalon - metabolism | Telencephalon - cytology | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Forkhead Box Protein O3 | Transcription Factor CHOP - metabolism | Endoplasmic Reticulum Stress - physiology | Nervous system diseases | Parkinson's disease | Huntington's chorea | Neurons | Tumor proteins | Protein kinases | Apoptosis | Phosphorylation | Transcription factors | Transcription | p53 Protein | Tunicamycin | Homology | AKT protein | CCAAT/enhancer-binding protein | Kinases | Proteins | Signal transduction | Mitochondria | Cell activation | Cell growth | Cascades | Rodents | Forkhead protein | Alzheimer's disease | Movement disorders | Deoxyribonucleic acid--DNA | FOXO3 protein | Stresses | Neurodegenerative diseases | Mortality | Gene expression | Stress | Neurological diseases | Pathology | Signaling | Cell death | Endoplasmic reticulum | CHOP protein | BIM protein | Deoxyribonucleic acid | DNA
Journal Article
Cell death & disease, ISSN 2041-4889, 2015, Volume 6, Issue 8, pp. e1860 - e1860
alpha-Solanine is a glycoalkaloid found in species of the nightshade family including potato. It was primarily reported to have toxic effects in humans.... 
TARGET | APOPTOSIS | COMPLEX | UNFOLDED PROTEIN RESPONSE | POTATO GLYCOALKALOIDS | PHOSPHORYLATION | MAMMALIAN AUTOPHAGY | MECHANISMS | CLEAVAGE | CELL-DEATH | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | eIF-2 Kinase - metabolism | Humans | Gene Expression Regulation, Neoplastic | Membrane Potential, Mitochondrial - drug effects | Activating Transcription Factor 6 - genetics | Proto-Oncogene Proteins c-akt - genetics | Reactive Oxygen Species - agonists | DNA-Binding Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Chloroquine - pharmacology | TOR Serine-Threonine Kinases - genetics | Macrolides - pharmacology | Microfilament Proteins - metabolism | Solanine - pharmacology | CCAAT-Enhancer-Binding Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Microfilament Proteins - genetics | eIF-2 Kinase - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Signal Transduction | Activating Transcription Factor 4 - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Autophagy-Related Protein 8 Family | Activating Transcription Factor 6 - metabolism | Activating Transcription Factor 4 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | Original
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2012, Volume 338, Issue 6114, pp. 1599 - 1603
.... Epicardial activation of these enhancers depends on a combinatorial transcriptional code centered on CCAAT/enhancer binding protein (C/EBP... 
Heart | Transcription factors | HEK293 cells | Transgenic animals | RESEARCH ARTICLES | Neutrophils | Epicardium | Physical trauma | Gene expression | Embryos | Transgenic plants | CELLS | IMMUNITY | RETINOIC ACID | ZEBRAFISH | GRAINY-HEAD | MOUSE HEART | INTEGRITY | REGENERATION | MULTIDISCIPLINARY SCIENCES | BINDING PROTEIN | DROSOPHILA | Myocardial Infarction - genetics | WT1 Proteins - metabolism | Oligonucleotide Array Sequence Analysis | Heart - embryology | Male | Pericardium - metabolism | Neutrophil Infiltration | Ventricular Remodeling | Gene Expression Regulation, Developmental | Uroplakin III - genetics | Pericardium - embryology | Female | CCAAT-Enhancer-Binding Protein-delta - metabolism | CCAAT-Enhancer-Binding Proteins - genetics | Binding Sites | Myocardial Reperfusion Injury - genetics | WT1 Proteins - genetics | Organ Culture Techniques | CCAAT-Enhancer-Binding Proteins - metabolism | Heart - physiopathology | Myocardial Contraction | Signal Transduction | CCAAT-Enhancer-Binding Protein-beta - genetics | Gene Expression Regulation | Mice, Transgenic | Aldehyde Oxidoreductases - genetics | Myocardial Infarction - metabolism | CCAAT-Enhancer-Binding Protein-beta - metabolism | Pericardium - cytology | Aldehyde Oxidoreductases - metabolism | Myocardial Reperfusion Injury - metabolism | Animals | Enhancer Elements, Genetic | CCAAT-Enhancer-Binding Protein-delta - genetics | Mice | Models, Genetic | Uroplakin III - metabolism | Cellular signal transduction | Genetic aspects | Research | Genetic transcription | Regeneration (Biology) | Properties | Observations | Proteins | Signal transduction | Cardiovascular disease | Embryology | Rodents | Injury prevention | Activation | Mathematical models | Adults | Heart function | Protective | Injuries
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2015, Volume 290, Issue 17, pp. 11177 - 11187
.... A trigger of muscle protein loss is the Jak/Stat pathway, and indeed, we found that conditioned medium from C26 colon carcinoma (C26... 
TRANSCRIPTION FACTORS | SKELETAL-MUSCLE | PROTEIN-DEGRADATION | MYOSTATIN GENE | PATHWAY | ATROPHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | KAPPA-B | UP-REGULATION | EXPRESSION | CATABOLIC CONDITIONS | Colonic Neoplasms - genetics | SKP Cullin F-Box Protein Ligases - genetics | Caspase 3 - metabolism | Ubiquitin - metabolism | Muscle, Skeletal - metabolism | Colonic Neoplasms - metabolism | Tripartite Motif Proteins | Proteolysis | Caspase 3 - genetics | Muscle Proteins - metabolism | Myostatin - genetics | CCAAT-Enhancer-Binding Protein-delta - metabolism | Myostatin - metabolism | Cachexia - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cachexia - genetics | Ubiquitin-Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Ubiquitin - genetics | Carcinoma, Lewis Lung - metabolism | Mice, Knockout | Muscle Proteins - genetics | Proteasome Endopeptidase Complex - genetics | Animals | Carcinoma, Lewis Lung - genetics | CCAAT-Enhancer-Binding Protein-delta - genetics | Cachexia - pathology | Colonic Neoplasms - pathology | Carcinoma, Lewis Lung - pathology | Cell Line, Tumor | Mice | Muscle, Skeletal - pathology | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Signal Transduction | STAT3 | Caspase | Cancer Cachexia | Cancer Biology | Muscle Atrophy | Caspase-3
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 14687
Journal Article