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Journal of Biological Chemistry, ISSN 0021-9258, 03/2006, Volume 281, Issue 11, pp. 7260 - 7270
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2015, Volume 58, Issue 6, pp. 1028 - 1039
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this disease is not well... 
SELECTIVE-INHIBITION | RECRUITMENT | C/EBP-ALPHA | CREB-BINDING PROTEIN | CHROMATIN | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | C-MYC | P-TEFB | BRD4 | CELL BIOLOGY | Transcriptional Regulator ERG | NIH 3T3 Cells | Oncogene Proteins - genetics | Humans | Leukemia, Myeloid - genetics | Proto-Oncogene Proteins c-myb - genetics | Gene Expression Profiling | Leukemia, Myeloid - pathology | RNA Interference | Proto-Oncogene Protein c-fli-1 - metabolism | Protein Binding - drug effects | Trans-Activators - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Acute Disease | Proto-Oncogene Protein c-fli-1 - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | Proto-Oncogene Proteins c-myb - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Acetylation - drug effects | Animals | Hematopoietic System - metabolism | Leukemia, Myeloid - metabolism | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Trans-Activators - metabolism | Mice | Histones - metabolism | DNA binding proteins | Medicine, Experimental | Medical research | Chromatin | Lysine | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, pp. e39586 - e39586
Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in various neurodegenerative diseases including Parkinson Disease, Alzheimer Disease... 
MITOCHONDRIAL APOPTOSIS | TRANSCRIPTION FACTOR CHOP | UNFOLDED PROTEIN RESPONSE | INDUCED APOPTOSIS | KINASE | BIOLOGY | GENE-EXPRESSION | SYMPATHETIC NEURONS | DEATH | ENDOPLASMIC-RETICULUM STRESS | BH3-ONLY PROTEINS | Transcription Factor CHOP - genetics | Apoptosis - drug effects | Neurons - cytology | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Telencephalon - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - physiology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Tumor Suppressor Proteins - metabolism | Telencephalon - metabolism | Telencephalon - cytology | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Forkhead Box Protein O3 | Transcription Factor CHOP - metabolism | Endoplasmic Reticulum Stress - physiology | Nervous system diseases | Parkinson's disease | Huntington's chorea | Neurons | Tumor proteins | Protein kinases | Apoptosis | Phosphorylation | Transcription factors | Transcription | p53 Protein | Tunicamycin | Homology | AKT protein | CCAAT/enhancer-binding protein | Kinases | Proteins | Signal transduction | Mitochondria | Cell activation | Cell growth | Cascades | Rodents | Forkhead protein | Alzheimer's disease | Movement disorders | Deoxyribonucleic acid--DNA | FOXO3 protein | Stresses | Neurodegenerative diseases | Mortality | Gene expression | Stress | Neurological diseases | Pathology | Signaling | Cell death | Endoplasmic reticulum | CHOP protein | BIM protein | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2012, Volume 14, Issue 7, pp. 753 - 763
It is becoming clear that interconnected functional gene networks, rather than individual genes, govern stem cell self-renewal and differentiation. To identify... 
STEM-CELLS | CHROMATIN | TISSUE | KERATINOCYTES | GENETIC INTERACTION | PHD FINGER | SKIN | P63 | EXPRESSION | MICE LACKING | CELL BIOLOGY | Antigens, Nuclear - metabolism | Epigenesis, Genetic | Humans | Multiprotein Complexes | Integrins - genetics | Gene Regulatory Networks | RNA, Messenger - metabolism | Stem Cells - metabolism | Integrins - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Transfection | RNA Interference | Tumor Suppressor Proteins - genetics | CCAAT-Enhancer-Binding Proteins - genetics | Stem Cell Niche - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Cell Adhesion - genetics | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Cells, Cultured | Gene Expression Regulation | Adenosine Triphosphatases - metabolism | Chromatin Assembly and Disassembly | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Enhancer of Zeste Homolog 2 Protein | Chromosomal Proteins, Non-Histone - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Antigens, Nuclear - genetics | Keratinocytes - metabolism | Bayes Theorem | Adenosine Triphosphatases - genetics | Models, Genetic | Cluster Analysis | Epidermis - cytology | Physiological aspects | Epigenetic inheritance | Genetic aspects | Research | Cell differentiation | Stem cells | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2013, Volume 495, Issue 7442, pp. 524 - 528
Macrophages consist of at least two subgroups, M1 and M2 (refs 1-3). Whereas M1 macrophages are proinflammatory and have a central role in host defence against... 
GLUCOSE-HOMEOSTASIS | OBESITY | TRIBBLES HOMOLOG | INSULIN-RESISTANCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MYELOID LEUKEMOGENESIS | POLARIZATION | ASSOCIATION | ALTERNATIVE ACTIVATION | ADIPOSE-TISSUE | Neutrophils - cytology | Protein-Serine-Threonine Kinases - deficiency | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Eosinophils - metabolism | Hypertriglyceridemia - genetics | Cell Count | Ubiquitin - metabolism | Adipose Tissue - cytology | Diet, High-Fat - adverse effects | Male | Intracellular Signaling Peptides and Proteins - metabolism | Lung - cytology | Intracellular Signaling Peptides and Proteins - deficiency | Adipose Tissue - metabolism | Inflammation Mediators - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Cell Differentiation | Cytokines - genetics | Intracellular Signaling Peptides and Proteins - genetics | Neutrophils - metabolism | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Macrophages - classification | Bone Marrow Cells - cytology | Adipose Tissue - pathology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Cell Cycle Proteins - deficiency | Lipodystrophy - metabolism | Spleen - cytology | Macrophages - cytology | Organ Specificity | Lipolysis | Hypertriglyceridemia - chemically induced | Macrophages - metabolism | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Insulin Resistance - genetics | Lipodystrophy - pathology | Lipodystrophy - chemically induced | Mice | Protein-Serine-Threonine Kinases - chemistry | Eosinophils - cytology | Bone Marrow Cells - metabolism | Proteins | Care and treatment | Metabolic diseases | Cellular signal transduction | Research | Macrophages | Properties | Identification and classification | Testing | Studies | Spleen | Heart attacks | Transplants & implants | Bone marrow | Binding sites | Metabolic disorders | Defects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7307, pp. 714 - 719
Recent genome-wide association studies (GWASs) have identified a locus on chromosome 1p13 strongly associated with both plasma low-density lipoprotein... 
POPULATION | DENSITY-LIPOPROTEIN CHOLESTEROL | TRANSPORT | DESIGN | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | SORTILIN | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Myocardial Infarction - blood | Myocardial Infarction - genetics | Adaptor Proteins, Vesicular Transport - biosynthesis | Humans | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Hepatocytes - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Coronary Artery Disease - blood | Europe - ethnology | Gene Knockdown Techniques | Haplotypes - genetics | Base Sequence | Lipids - blood | Cholesterol, LDL - blood | Transcription, Genetic | Chromosomes, Human, Pair 1 - genetics | Binding Sites | CCAAT-Enhancer-Binding Proteins - metabolism | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Liver - metabolism | Cells, Cultured | Gene Expression Regulation | Phenotype | Animals | Lipoproteins, VLDL - blood | Lipoproteins, VLDL - metabolism | Coronary Artery Disease - genetics | Cholesterol, LDL - metabolism | Polymorphism, Single Nucleotide - genetics | Liver - cytology | Mice | Cohort Studies | Genetic aspects | Genetic variation | Health aspects | Heart attack | Cholesterol | Proteins | Haplotypes | Studies | Plasma | Lipoproteins | Genetics | Cardiovascular disease | Artificial chromosomes | Gene expression | Statins | Index Medicus
Journal Article
Cell Death and Disease, ISSN 2041-4889, 08/2015, Volume 6, Issue 8, pp. e1860 - e1860
alpha-Solanine is a glycoalkaloid found in species of the nightshade family including potato. It was primarily reported to have toxic effects in humans.... 
TARGET | APOPTOSIS | COMPLEX | UNFOLDED PROTEIN RESPONSE | POTATO GLYCOALKALOIDS | PHOSPHORYLATION | MAMMALIAN AUTOPHAGY | MECHANISMS | CLEAVAGE | CELL-DEATH | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | eIF-2 Kinase - metabolism | Humans | Gene Expression Regulation, Neoplastic | Membrane Potential, Mitochondrial - drug effects | Activating Transcription Factor 6 - genetics | Proto-Oncogene Proteins c-akt - genetics | Reactive Oxygen Species - agonists | DNA-Binding Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Chloroquine - pharmacology | TOR Serine-Threonine Kinases - genetics | Macrolides - pharmacology | Microfilament Proteins - metabolism | Solanine - pharmacology | CCAAT-Enhancer-Binding Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Microfilament Proteins - genetics | eIF-2 Kinase - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Signal Transduction | Activating Transcription Factor 4 - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Autophagy-Related Protein 8 Family | Activating Transcription Factor 6 - metabolism | Activating Transcription Factor 4 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | Original
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 03/2017, Volume 8, Issue 1, pp. 14687 - 14687
Journal Article
Molecular Cell, ISSN 1097-2765, 2001, Volume 7, Issue 6, pp. 1165 - 1176
The accumulation of unfolded protein in the endoplasmic reticulum (ER) attenuates protein synthesis initiation through phosphorylation of the α subunit of... 
MOLECULAR MECHANISMS | CELLS | C/EBP-ALPHA | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRESS-RESPONSE | KINASE | ENDOPLASMIC-RETICULUM | WOLCOTT-RALLISON-SYNDROME | REGULATED PROTEINS | TRANSMEMBRANE PROTEIN | CELL BIOLOGY | Phosphorylation | Molecular Chaperones - metabolism | Transcription Factors - chemistry | Protein Biosynthesis - physiology | Endoplasmic Reticulum - metabolism | RNA, Messenger - analysis | Blood Proteins - metabolism | DNA-Binding Proteins - metabolism | Blood Proteins - genetics | Islets of Langerhans - metabolism | Mice, Mutant Strains | Transcription Factor CHOP | Gene Expression - physiology | Islets of Langerhans - cytology | Heat-Shock Proteins | Germ-Line Mutation | CCAAT-Enhancer-Binding Proteins - genetics | Cell Survival - physiology | Activating Transcription Factors | Animals, Newborn | CCAAT-Enhancer-Binding Proteins - metabolism | Hypoglycemia - genetics | Molecular Chaperones - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Hypoglycemia - metabolism | DNA-Binding Proteins - chemistry | Protein Folding | Transcription Factors - metabolism | Carrier Proteins - genetics | Gluconeogenesis - physiology | Homozygote | Animals | Carrier Proteins - metabolism | Homeostasis - physiology | Glucose - metabolism | Mice | Mutagenesis - physiology | Transcriptional Activation - physiology | unfolded protein response | initiation factor eIF-2 | glucose | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 20314 - 20326
Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as... 
FATTY-ACID-SYNTHASE | GLUCOSE-HOMEOSTASIS | CARBOHYDRATE RESPONSE ELEMENT | RAT HEPATOCYTES | STEROL REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | PYRUVATE-KINASE GENE | TRANSCRIPTION FACTOR | CARNITINE-PALMITOYLTRANSFERASE-I | TRANSGENIC MICE | Glucokinase - physiology | Liver - enzymology | Fatty Acid Synthases - metabolism | Immunoblotting | Hepatocytes - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Glycogen - metabolism | Time Factors | CCAAT-Enhancer-Binding Proteins - physiology | Adenoviridae - genetics | Transcription, Genetic | Pentosephosphates - metabolism | RNA - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | DNA-Binding Proteins - physiology | Pyruvate Kinase - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Carbohydrate Metabolism | Cells, Cultured | Gene Expression Regulation | Lipid Metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Nuclear Proteins | Transcription Factors - metabolism | Blotting, Northern | Animals | Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Glucose - metabolism | Mice | Kinetics | Sterol Regulatory Element Binding Protein 1 | Glucose-6-Phosphate - metabolism | Acetyl-CoA Carboxylase - metabolism | Microscopy, Fluorescence | RNA, Small Interfering - metabolism | Index Medicus
Journal Article