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International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 12/2016, Volume 81, Issue Pt B, pp. 254 - 270
. CCM proteins play pleiotropic roles in distinct redox-sensitive pathways by modulating the fine-tuned crosstalk between redox signaling and autophagy.... 
Cerebral cavernous malformation (CCM) | Oxidative stress | Vascular homeostasis | Inflammation | Redox signaling | Autophagy | Angiogenesis | Antioxidant response | CCM3/PDCD10 | Blood-brain barrier dysfunction | CCM2 | CCM1/KRIT1 | Vascular permeability | Cerebrovascular disease | IMMUNE-RESPONSE | RHO-KINASE | VASCULAR-PERMEABILITY | BETA-CATENIN | CELL BIOLOGY | ENDOTHELIAL-CELLS | SHEAR-STRESS | NF-KAPPA-B | NADPH OXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOOD-BRAIN-BARRIER | TO-MESENCHYMAL TRANSITION | Hemangioma, Cavernous, Central Nervous System - physiopathology | Neovascularization, Pathologic - genetics | Neovascularization, Pathologic - physiopathology | Oxidative Stress | Humans | Prevention | Proteins | Brain | Medical colleges | Endothelium | Antioxidants | Blood circulation disorders | Medical research | Endothelial growth factors | Medicine, Experimental | Development and progression | Bone morphogenetic proteins | Disease susceptibility | KLF, Kruppel-like factor | COX-2, cycloxygenase-2 | NVU, neurovascular unit | ICH, intracerebral hemorrhage | PDCD10 | KRIT1 | ROS, reactive oxygen species | BMP, bone morphogenetic protein | fCCM, familial form of CCM | EndMT, endothelial-to-mesenchymal transition | VEGF, vascular endothelial growth factor | TGFβ, transforming growth factor beta | AJ, adherens junction | CCM, cerebral cavernous malformation | sCCM, sporadic form of CCM | CCM3 | CCM1
Journal Article
Experimental Cell Research, ISSN 0014-4827, 2009, Volume 315, Issue 2, pp. 285 - 303
is a disease gene responsible for Cerebral Cavernous Malformations (CCM). It encodes for a protein containing distinct protein–protein interaction domains,... 
Rap1A | Yeast two-hybrid interaction | Head-to-tail protein interaction | Nucleocytoplasmic shuttling | Homology modeling | KRIT1 | Ligand docking | CCM | ICAP1 | FERM domain | PTB DOMAINS | MERLIN | CRYSTAL-STRUCTURE | BINDING-PROTEIN | ANKYRIN REPEAT | CELL BIOLOGY | ENCODING KRIT1 | CEREBRAL CAVERNOUS MALFORMATIONS | PROTEIN INTERACTIONS | ONCOLOGY | NEUROFIBROMATOSIS TYPE-2 | Microtubule-Associated Proteins - chemistry | KRIT1 Protein | Microtubule-Associated Proteins - genetics | rap1 GTP-Binding Proteins - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Cercopithecus aethiops | Central Nervous System Vascular Malformations - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Proto-Oncogene Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Hemangioma, Cavernous, Central Nervous System - genetics | Protein Interaction Domains and Motifs - genetics | Protein Isoforms - chemistry | Computer Simulation | Microfilament Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Microfilament Proteins - genetics | Peptide Fragments - genetics | Cell Line | rap1 GTP-Binding Proteins - metabolism | Peptide Fragments - metabolism | Protein Structure, Secondary | Hemangioma, Cavernous, Central Nervous System - physiopathology | Models, Molecular | Rats | Proto-Oncogene Proteins - genetics | Recombinant Fusion Proteins - chemistry | Protein Isoforms - physiology | Microtubule-Associated Proteins - physiology | Point Mutation | Two-Hybrid System Techniques | Peptide Fragments - chemistry | Animals | Proto-Oncogene Proteins - physiology | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | Central Nervous System Vascular Malformations - physiopathology | HeLa Cells | COS Cells | rap1 GTP-Binding Proteins - genetics | Protein Isoforms - genetics | Proteins | Models | Genetic disorders | Cellular biology | Binding sites | PROTEIN STRUCTURE | HYBRIDIZATION | IN VIVO | SIMULATION | 60 APPLIED LIFE SCIENCES | PATHOGENESIS | SPLICING | MALFORMATIONS | LIGANDS | STRUCTURE FUNCTIONS | BIOLOGY | YEASTS | PROTEINS
Journal Article
Frontiers in surgery, ISSN 2296-875X, 2017, Volume 4, p. 31
[This corrects the article on p. 60 in vol. 3, PMID: 27896269.]. 
KRIT1 | cavernous malformation | CCM3 | CCM2 | CCM1 | CCM
Journal Article
Frontiers in surgery, ISSN 2296-875X, 2016, Volume 3, p. 60
Mutations in the genes , and are known to result in the formation of cerebral cavernous malformations (CCMs). CCMs are intracranial lesions composed of... 
Brain | Gene mutations | Molecular genetics | Hemorrhage | Analysis | Protein-protein interactions | molecular genetics | Krit1 | CCM2 | CCM1 | CCM | gene
Journal Article
Neurosurgery, ISSN 0148-396X, 05/2017, Volume 80, Issue 5, pp. 665 - 680
Journal Article
Circulation, ISSN 0009-7322, 2015, Volume 131, Issue 3, pp. 289 - 299
Journal Article
Journal Article
Journal Article
Cold Spring Harbor perspectives in biology, ISSN 1943-0264, 10/2018, Volume 10, Issue 10
Endothelial cell - cell adherens junctions (AJs) supervise fundamental vascular functions, such as the control of permeability and transmigration of... 
CELL-CELL JUNCTIONS | CEREBRAL CAVERNOUS MALFORMATIONS | PHOSPHATASE VE-PTP | FLUID SHEAR-STRESS | TRANSENDOTHELIAL MIGRATION | LEUKOCYTE EXTRAVASATION | PERMEABILITY IN-VIVO | BLOOD-BRAIN-BARRIER | CCM PATHOGENESIS | MECHANOSENSORY COMPLEX | CELL BIOLOGY
Journal Article