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chemokines, cc (27) 27
gene expression (27) 27
cloning (26) 26
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chemotaxis, leukocyte - drug effects (25) 25
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murine model (25) 25
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tissue eosinophilia (24) 24
chemokine ccl26 (23) 23
hyperresponsiveness (23) 23
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receptors, ccr5 - metabolism (23) 23
enzyme-linked immunosorbent assay (22) 22
piperidines - pharmacology (22) 22
receptors, chemokine - biosynthesis (22) 22
chemokines, cc - antagonists & inhibitors (21) 21
chemokines, cc - genetics (21) 21
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1. Full Text Chemokine receptor antagonists: Part 1
by Pease, James E and Horuk, Richard
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 01/2009, Volume 19, Issue 1, pp. 39 - 58
Background: Chemokines were originally defined as host defense proteins, however, their biological role goes well beyond this simple description of their... 
chemokine receptors | antagonism | chemokines | GPCRs | Antagonism | Chemokine receptors | Chemokines | RHEUMATOID-ARTHRITIS | ALLOGRAFT-REJECTION | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | PROTEIN-COUPLED RECEPTORS | POTENT CCR2 ANTAGONISTS | BIPIPERIDINE AMIDE COMPOUNDS | PIPERIDINE-DERIVATIVES | FUNCTIONAL EXPRESSION | IN-VIVO | PHARMACOLOGY & PHARMACY | SMALL-MOLECULE ANTAGONISTS | Animals | Humans | Drug Design | Patents as Topic | Chemokines, CC - metabolism | Drug Delivery Systems | Receptors, CCR1 - antagonists & inhibitors | Receptors, CCR2 - antagonists & inhibitors | Receptors, CCR3 - antagonists & inhibitors | Receptors, CCR4 - antagonists & inhibitors
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2. Full Text Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness
by Grozdanovic, Milica and Laffey, Kimberly G and Abdelkarim, Hazem and Hitchinson, Ben and Harijith, Anantha and Moon, Hyung-Geon and Park, Gye Young and Rousslang, Lee K and Masterson, Joanne C and Furuta, Glenn T and Tarasova, Nadya I and Gaponenko, Vadim and Ackerman, Steven J
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2019, Volume 143, Issue 2, pp. 669 - 680.e12
Chemokine signaling through CCR3 is a key regulatory pathway for eosinophil recruitment into tissues associated with allergic inflammation and asthma. To date,... 
airway hyperresponsiveness | allergic inflammation | biased antagonist | asthma | eosinophil | CCR3 | peptide nanoparticles | ACTIVATION | PROTEIN | CXCR4 ANTAGONIST | CELL-SURFACE | BETA-ARRESTIN | IMMUNOLOGY | CHEMOKINE RECEPTOR CCR3 | ALLERGY | DEGRANULATION | UP-REGULATION | EOTAXIN | EXPRESSION
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3. Full Text Small molecule antagonists for chemokine CCR3 receptors
by Willems, Lianne I and IJzerman, Ad P
Medicinal Research Reviews, ISSN 0198-6325, 09/2010, Volume 30, Issue 5, pp. 778 - 817
The chemokine receptor CCR3 is believed to play a role in the development of allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis.... 
antagonists | allergic disease | CCR3 | chemokine receptor | low‐molecular‐weight | Antagonists | Chemokine receptor | Low-molecular-weight | Allergic disease | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | low-molecular-weight | DISCOVERY | BIPIPERIDINE AMIDE COMPOUNDS | RIGID CYCLIC TEMPLATES | INTERNATIONAL UNION | IN-VIVO | ASTHMA | PHARMACOLOGY & PHARMACY | PART 1 | AIRWAY HYPERRESPONSIVENESS | STABILIZED ACYCLIC SCAFFOLDS | Amino Acid Sequence | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | Animals | Humans | Molecular Sequence Data | Structure-Activity Relationship | Receptors, CCR3 - chemistry | Receptors, CCR3 - antagonists & inhibitors | Patents | amides | Calcium (intracellular) | Phenylalanine | Hypersensitivity | Leukocytes (eosinophilic) | piperazine | Allergic diseases | Inflammation | Structure-activity relationships | Chemotaxis | Chemokine receptors | Asthma | Urea | Atopic dermatitis | Allergic rhinitis
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4. Full Text CCR3 is a target for age-related macular degeneration diagnosis and therapy
by Takeda, Atsunobu and Baffi, Judit Z and Kleinman, Mark E and Cho, Won Gil and Nozaki, Miho and Yamada, Kiyoshi and Kaneko, Hiroki and Albuquerque, Romulo J. C and Dridi, Sami and Saito, Kuniharu and Raisler, Brian J and Budd, Steven J and Geisen, Pete and Munitz, Ariel and Ambati, Balamurali K and Green, Martha G and Ishibashi, Tatsuro and Wright, John D and Humbles, Alison A and Gerard, Craig J and Ogura, Yuichiro and Pan, Yuzhen and Smith, Justine R and Grisanti, Salvatore and Hartnett, M. Elizabeth and Rothenberg, Marc E and Ambati, Jayakrishna
Nature, ISSN 0028-0836, 07/2009, Volume 460, Issue 7252, pp. 225 - 230
Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD... 
EOSINOPHIL RECRUITMENT | VISUAL FUNCTION | VEGF | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | GENE-EXPRESSION PROFILES | EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION | MODEL | EOTAXIN | ENDOTHELIAL GROWTH-FACTOR | RETINAL-PIGMENT EPITHELIUM | Retina - drug effects | Choroidal Neovascularization - diagnosis | Cell Proliferation | Receptors, CCR3 - immunology | Humans | Chemokine CCL24 - metabolism | Leukocytes | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Chemokine CCL26 | Macular Degeneration - diagnosis | Choroid - cytology | Chemokine CCL11 - antagonists & inhibitors | Receptors, CCR3 - genetics | Disease Models, Animal | Receptors, CCR3 - antagonists & inhibitors | Choroid - metabolism | Chemokine CCL11 - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Choroid - blood supply | Vascular Endothelial Growth Factor A - immunology | Inflammation | Chemokines, CC - antagonists & inhibitors | Macular Degeneration - metabolism | Receptors, CCR3 - metabolism | Animals | Chemokine CCL24 - antagonists & inhibitors | Choroidal Neovascularization - metabolism | Macular Degeneration - therapy | Quantum Dots | Endothelial Cells - cytology | Receptors, CCR3 - analysis | Ligands | Mice | Retina - pathology | Cell Movement | Chemokines, CC - metabolism | Macular degeneration | Physiological aspects | Care and treatment | Genetic aspects | Chemokine receptors | Ophthalmology | Quantum dots | Cells | Index Medicus
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5. Full Text Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists
by Nitta, Aiko and Iura, Yosuke and Inoue, Hideki and Sato, Ippei and Morihira, Koichiro and Kubota, Hirokazu and Morokata, Tatsuaki and Takeuchi, Makoto and Ohta, Mitsuaki and Tsukamoto, Shin-ichi and Imaoka, Takayuki and Takahashi, Toshiya
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2012, Volume 22, Issue 22, pp. 6876 - 6881
Optimization starting with our lead compound (IC = 4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward... 
Pyrrolidinyl phenylurea derivatives | Allergic diseases | CCR3 antagonists | POTENT | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | PART 1 | UREA DERIVATIVES | DISCOVERY | Administration, Oral | Pyrrolidines - pharmacokinetics | Half-Life | Macaca fascicularis | Biological Availability | Pyrrolidines - chemistry | Receptors, CCR3 - metabolism | Animals | Phenylurea Compounds - chemical synthesis | Pyrrolidines - chemical synthesis | Phenylurea Compounds - chemistry | Phenylurea Compounds - pharmacokinetics | Receptors, CCR3 - antagonists & inhibitors
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6. Full Text Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo‐controlled clinical trial
by Neighbour, H and Boulet, L.‐P and Lemiere, C and Sehmi, R and Leigh, R and Sousa, A. R and Martin, J and Dallow, N and Gilbert, J and Allen, A and Hall, D and Nair, P
Clinical & Experimental Allergy, ISSN 0954-7894, 04/2014, Volume 44, Issue 4, pp. 508 - 516
Summary Background Several chemokines, notably eotaxin, mediate the recruitment of eosinophils into tissues via the CCR3 receptor. Objective In this study, we... 
clinical trial | sputum eosinophils | eotaxin | asthma | CCR3 | Clinical trial | Sputum eosinophils | Eotaxin | Asthma | PROGENITORS | EOTAXIN RECEPTOR CCR3 | SPUTUM | MAST-CELLS | ALLERGEN | IMMUNOLOGY | INTERLEUKIN-5 | HYPERRESPONSIVENESS | PATHOGENESIS | ALLERGY | ACCUMULATION | EXPRESSION | Sputum - cytology | Humans | Middle Aged | Male | Eosinophils - immunology | Young Adult | Sputum - immunology | Benzamides - therapeutic use | Adult | Bronchitis - complications | Female | Benzamides - pharmacology | Eosinophils - pathology | Leukocyte Count | Receptors, CCR3 - antagonists & inhibitors | Asthma - physiopathology | Treatment Outcome | Bronchitis - physiopathology | Asthma - drug therapy | Methylurea Compounds - pharmacology | Methylurea Compounds - therapeutic use | Bronchitis - drug therapy | Pulmonary Eosinophilia - complications | Aged | Respiratory Function Tests | Chemotaxis, Leukocyte - immunology | Clinical trials | Bronchitis
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7. Full Text Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability
by Nagai, Nori and Ju, Meihua and Izumi-Nagai, Kanako and Robbie, Scott J and Bainbridge, James W and Gale, David C and Pierre, Esaie and Krauss, Achim H.P and Adamson, Peter and Shima, David T and Ng, Yin-Shan
American Journal of Pathology, The, ISSN 0002-9440, 2015, Volume 185, Issue 9, pp. 2534 - 2549
Choroidal neovascularization (CNV) is a defining feature of wet age-related macular degeneration. We examined the functional role of CCR3 in the development of... 
Pathology | TARGET | SYSTEMIC ABSORPTION | MACULAR DEGENERATION | PATHOLOGY | VEGF-A | RANIBIZUMAB | EOTAXIN | DELIVERY | Wet Macular Degeneration - pathology | Mice, Inbred C57BL | Capillary Permeability - drug effects | Capillary Permeability - immunology | Vascular Endothelial Growth Factor A - metabolism | Animals | Wet Macular Degeneration - drug therapy | Choroidal Neovascularization - drug therapy | Choroidal Neovascularization - pathology | Angiogenesis Inhibitors - therapeutic use | Mice | Choroid - pathology | Disease Models, Animal | Receptors, CCR3 - antagonists & inhibitors | Regular
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8. Full Text Tipping the balance: A biased nanobody antagonist of CCR3 with potential for the treatment of eosinophilic inflammation
by Pease, James E and Williams, Timothy J
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2019, Volume 143, Issue 2, pp. 552 - 553
biased antagonist | asthma | Allergic inflammation | eosinophil | inflammation | CCR3 | INHIBITION | ALLERGY | CHEMOKINE | IMMUNOLOGY | EOTAXIN
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9. Full Text A small molecule antagonist of chemokine receptors CCR1 and CCR3: Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry
by Sabroe, Ian and Peck, Michael J and Van Keulen, Berend Jan and Jorritsma, Annelies and Simmons, Graham and Clapham, Paul R and Williams, Timothy J and Pease, James E
Journal of Biological Chemistry, ISSN 0021-9258, 08/2000, Volume 275, Issue 34, pp. 25985 - 25992
We describe a small molecule chemokine receptor antagonist, UCB35625 (the trans-isomer J113863 published by Banyu Pharmaceutical Co., patent WO98/04554), which... 
CHEMOATTRACTANT CYTOKINE | MESSENGER-RNA | CHEMOTACTIC CYTOKINES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | IN-VIVO | BONE-MARROW | CROSS-DESENSITIZATION | EOTAXIN RECEPTOR | MONOCLONAL-ANTIBODY | GUINEA-PIG MODEL | Chemokine CCL4 | HIV-1 - pathogenicity | Monocyte Chemoattractant Proteins - pharmacology | Chemokine CCL3 | Eosinophils - drug effects | Models, Chemical | Humans | Receptors, Chemokine - metabolism | Chemokine CCL11 | Chemokines, CC | Eosinophils - physiology | Animals | Drug Interactions | Flow Cytometry | Transfection | Mice | Receptors, CCR3 | Receptors, Chemokine - antagonists & inhibitors | Receptors, CCR1 | Receptors, Chemokine - drug effects | Cytokines - pharmacology | Xanthenes - pharmacology | Macrophage Inflammatory Proteins - pharmacology
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10. Full Text Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: Insights from a receptor model
by Kriegl, Jan M and Martyres, Domnic and Grundl, Marc A and Anderskewitz, Ralf and Dollinger, Horst and Rast, Georg and Schmid, Bernhard and Seither, Peter and Tautermann, Christofer S
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2015, Volume 25, Issue 2, pp. 229 - 235
Rodent selectivity data of piperidine-4-yl-1 -indoles, a series of CC chemokine receptor-3 (CCR3) antagonists, are presented and discussed as part of an... 
Chemokine | Receptor model | Piperidine-4-yl-1H-indoles | hERG | Rodent selectivity | CCR3 | Rodent selectivity hERG | CHEMISTRY, MEDICINAL | INHIBITION | CHEMISTRY, ORGANIC | MARAVIROC | DISCOVERY | Protein Structure, Tertiary | Piperidines - chemistry | Protein Structure, Secondary | Species Specificity | Piperidines - metabolism | Humans | Models, Molecular | Rats | Receptors, CCR3 - metabolism | Indoles - metabolism | Animals | Piperidines - pharmacology | Indoles - pharmacology | Mice | Indoles - chemistry | Receptors, CCR3 - antagonists & inhibitors | HERG
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11. Full Text Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4
by Pease, James Edward and Horuk, Richard
Expert Opinion on Drug Discovery, ISSN 1746-0441, 05/2014, Volume 9, Issue 5, pp. 467 - 483
Introduction: The chemokine receptors CCR3 and CCR4 have been shown to be important therapeutic targets for the treatment of a variety of diseases. Although... 
antagonists | chemokine | autoimmune | inflammation | asthma | CCR4 | CCR3 | Chemokine | Antagonists | Autoimmune | Inflammation | Asthma | INDAZOLE ARYLSULFONAMIDES | GENE-RELATED PEPTIDE | DIFFERENTIAL EXPRESSION | MACROPHAGE-DERIVED CHEMOKINE | INDUCED AIRWAY INFLAMMATION | CELLS IN-VITRO | MACULAR DEGENERATION | ACTIVATION-REGULATED CHEMOKINE | EPITHELIAL-CELLS | PHARMACOLOGY & PHARMACY | SMALL-MOLECULE ANTAGONISTS | Anti-Asthmatic Agents - pharmacology | Humans | Hypersensitivity, Immediate - drug therapy | Anti-Allergic Agents - pharmacology | Asthma - drug therapy | Receptors, CCR3 - antagonists & inhibitors | Receptors, CCR4 - antagonists & inhibitors
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12. Full Text Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3
by Morikawa, Toshio and Hachiman, Ikuko and Matsuo, Kazuhiko and Nishida, Eriko and Ninomiya, Kiyofumi and Hayakawa, Takao and Yoshie, Osamu and Muraoka, Osamu and Nakayama, Takashi
Journal of Natural Products, ISSN 0163-3864, 08/2016, Volume 79, Issue 8, pp. 2005 - 2013
CC chemokine receptor 3 (CCR3) is expressed selectively in eosinophils, basophils, and some Th2 cells and plays a major role in allergic diseases. A methanol... 
ABSOLUTE-CONFIGURATION ASSIGNMENT | CHEMISTRY, MEDICINAL | ENANTIOSELECTIVE SYNTHESIS | ANTIALLERGIC ACTIVITIES | MACHILUS-THUNBERGII | EOSINOPHIL EOTAXIN RECEPTOR | PLANT SCIENCES | FUNCTIONAL LIGAND | NITRIC-OXIDE PRODUCTION | STELLARIA-DICHOTOMA | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | BIOACTIVE CONSTITUENTS | Eosinophils - metabolism | Lignans - chemistry | Stereoisomerism | Furans - pharmacology | Humans | Myristica fragrans - chemistry | Molecular Structure | Chemotaxis - drug effects | Lignans - pharmacology | Lignans - isolation & purification | Receptors, CCR3 - antagonists & inhibitors
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13. Full Text Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists
by Nitta, Aiko and Iura, Yosuke and Tomioka, Hiroki and Sato, Ippei and Morihira, Koichiro and Kubota, Hirokazu and Morokata, Tatsuaki and Takeuchi, Makoto and Ohta, Mitsuaki and Tsukamoto, Shin-ichi and Imaoka, Takayuki and Takahashi, Toshiya
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2012, Volume 22, Issue 15, pp. 4951 - 4954
The synthesis and structure–activity relationships of ureas as CCR3 antagonists are described. Optimization starting with lead compound (IC = 190 nM) derived... 
Urea derivatives | Allergic diseases | Proline moiety | CCR3 antagonists | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | ASTHMA | PART 1 | Naphthalenes - chemical synthesis | Naphthalenes - chemistry | Humans | Structure-Activity Relationship | Urea - chemical synthesis | Pyrrolidines - chemistry | Proline - chemistry | Receptors, CCR3 - metabolism | Pyrrolidines - chemical synthesis | Urea - analogs & derivatives | Pyrrolidines - metabolism | Protein Binding | Urea - metabolism | Drug Evaluation, Preclinical | Naphthalenes - metabolism | Receptors, CCR3 - antagonists & inhibitors | Urea
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14. Full Text Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists
by Sato, Ippei and Morihira, Koichiro and Inami, Hiroshi and Kubota, Hirokazu and Morokata, Tatsuaki and Suzuki, Keiko and Hamada, Noritaka and Iura, Yosuke and Nitta, Aiko and Imaoka, Takayuki and Takahashi, Toshiya and Takeuchi, Makoto and Ohta, Mitsuaki and Tsukamoto, Shin-ichi
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 1, pp. 144 - 156
The 6-fluoro-2-naphthylmethyl derivatives were prepared, and their inhibitory activities against CCR3 were evaluated. A novel class of potent CCR3 receptor... 
6-fluoro-2-naphthylmethyl moiety | Allergic diseases | Nortropane derivatives | CCR3 antagonists | MURINE MODEL | CELLS | SELECTIVE ANTAGONIST | POTENT | CHEMISTRY, MEDICINAL | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CHEMOKINE RECEPTORS | EXPRESSION | EOTAXIN | DISCOVERY | Calcium - metabolism | Small Molecule Libraries | Humans | Inhibitory Concentration 50 | Chemokine CCL11 | Benzamides - pharmacology | Structure-Activity Relationship | Benzamides - chemical synthesis | Precursor Cells, B-Lymphoid | Receptors, CCR3 - antagonists & inhibitors
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15. Full Text Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H 1 antagonists. Part i
by Furber, Mark and Alcaraz, Lilian and Luckhurst, Christopher and Bahl, Ash and Beaton, Haydn and Bowers, Keith and Collington, John and Denton, Rebecca and Donald, David and Kinchin, Elizabeth and MacDonald, Cathy and Rigby, Aaron and Riley, Rob and Soars, Matt and Springthorpe, Brian and Webborn, Peter
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 12/2012, Volume 22, Issue 24, pp. 7702 - 7706
The discovery of potent small molecule dual antagonists of the human CCR3 and H receptors is described for the treatment of allergic diseases, for example,... 
Chemokine antagonist | Receptor antagonist | Dual inhibitor | CCR3 | Allergic disease | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC
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16.