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The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2019, Volume 143, Issue 2, pp. 669 - 680.e12
Chemokine signaling through CCR3 is a key regulatory pathway for eosinophil recruitment into tissues associated with allergic inflammation and asthma. To date,... 
airway hyperresponsiveness | allergic inflammation | biased antagonist | asthma | eosinophil | CCR3 | peptide nanoparticles | ACTIVATION | PROTEIN | CXCR4 ANTAGONIST | CELL-SURFACE | BETA-ARRESTIN | IMMUNOLOGY | CHEMOKINE RECEPTOR CCR3 | ALLERGY | DEGRANULATION | UP-REGULATION | EOTAXIN | EXPRESSION
Journal Article
Nature, ISSN 0028-0836, 07/2009, Volume 460, Issue 7252, pp. 225 - 230
Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD... 
EOSINOPHIL RECRUITMENT | VISUAL FUNCTION | VEGF | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | GENE-EXPRESSION PROFILES | EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION | MODEL | EOTAXIN | ENDOTHELIAL GROWTH-FACTOR | RETINAL-PIGMENT EPITHELIUM | Retina - drug effects | Choroidal Neovascularization - diagnosis | Cell Proliferation | Receptors, CCR3 - immunology | Humans | Chemokine CCL24 - metabolism | Leukocytes | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Chemokine CCL26 | Macular Degeneration - diagnosis | Choroid - cytology | Chemokine CCL11 - antagonists & inhibitors | Receptors, CCR3 - genetics | Disease Models, Animal | Receptors, CCR3 - antagonists & inhibitors | Choroid - metabolism | Chemokine CCL11 - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Choroid - blood supply | Vascular Endothelial Growth Factor A - immunology | Inflammation | Chemokines, CC - antagonists & inhibitors | Macular Degeneration - metabolism | Receptors, CCR3 - metabolism | Animals | Chemokine CCL24 - antagonists & inhibitors | Choroidal Neovascularization - metabolism | Macular Degeneration - therapy | Quantum Dots | Endothelial Cells - cytology | Receptors, CCR3 - analysis | Ligands | Mice | Retina - pathology | Cell Movement | Chemokines, CC - metabolism | Macular degeneration | Physiological aspects | Care and treatment | Genetic aspects | Chemokine receptors | Ophthalmology | Quantum dots | Cells | Index Medicus
Journal Article
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2019, Volume 143, Issue 2, pp. 552 - 553
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 12/2012, Volume 22, Issue 24, pp. 7702 - 7706
The discovery of potent small molecule dual antagonists of the human CCR3 and H receptors is described for the treatment of allergic diseases, for example,... 
Chemokine antagonist | Receptor antagonist | Dual inhibitor | CCR3 | Allergic disease | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC
Journal Article
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