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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2018, Volume 9, Issue 10, pp. 953 - 955
Recruitment of naturally occurring suppressive CD4+, CD25+, and FOXP3+ regulatory T cells (Treg) to the tumor microenvironment (TME) has the potential to... 
migration | CCR4 | CCR4 antagonist
Journal Article
Clinical Laboratory, ISSN 1433-6510, 2018, Volume 64, Issue 6, pp. 907 - 913
Myocardial infarction (MI) is an irreversible damage of myocardial tissue caused by prolonged ischemia and hypoxia. A local hypoxia-induced inflammation causes... 
CCR4 | Heart attack | CCL22
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 05/2013, Volume 104, Issue 5, pp. 647 - 650
We report an adult T-cell leukemia/lymphoma patient suffering from StevensJohnson Syndrome (SJS) during mogamulizumab (humanized anti-CCR4 monoclonal antibody)... 
LEUKEMIA-LYMPHOMA | ONCOLOGY | MONOCLONAL-ANTIBODY KW-0761 | TOXIC EPIDERMAL NECROLYSIS | CCR4
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6190 - 6213
Recruitment of suppressive CD4(+) FOXP3(+) regulatory T cells (T-reg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in... 
CELLS | CD4 | CHEMISTRY, MEDICINAL | THERAPY | CHEMOKINE RECEPTOR CCR4 | CCL22/CCR4
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 685 - 685
Conference Proceeding
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 10/2006, Volume 177, Issue 7, pp. 4488 - 4494
CD4(+)CD25(+) T regulatory cells (Treg) are thought to be important in the peripheral tolerance. Recent evidence suggests that human peripheral blood... 
IN-VITRO | ACTIVATION | RESIDENT | E-SELECTIN | IMMUNOLOGY | SUPPRESSION | EXPRESSION | CCR4 | 2 SUBSETS | PSORIASIS | LYMPHOCYTES
Journal Article
JOURNAL OF THORACIC ONCOLOGY, ISSN 1556-0864, 11/2017, Volume 12, Issue 11, pp. S2420 - S2421
Conference Proceeding
日本臨床免疫学会会誌, ISSN 0911-4300, 2016, Volume 39, Issue 3, pp. 207 - 212
... 
CXCL10 | HAM | CXCR3 | CCR4 | astrocyte
Journal Article
BioEssays, ISSN 0265-9247, 10/2016, Volume 38, Issue 10, pp. 1048 - 1058
The CCR4‐NOT complex, a master regulator in the control of protein expression, is involved in the regulation of RNA metabolism at many steps, from synthesis to... 
structural biology | CCR4‐NOT | protein expression | protein degradation | Proteins | Gene expression
Journal Article
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 762 - 762
Post Kala-azar dermal leishmaniasis (PKDL), caused by Leishmania donovani is the dermal sequel of Visceral Leishmaniasis and importantly, is the proposed... 
CUTANEOUS LEISHMANIASIS | INDIVIDUALS | CHEMOKINES | MULTIDISCIPLINARY SCIENCES | HALLMARKS | CCR4 | EXHAUSTION | LYMPHOCYTES
Journal Article
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 18, pp. 5340 - 5348
CCR8 is a chemokine receptor expressed principally on regulatory T cells (Treg) and is known to be critical for CCR8(+) Treg-mediated immunosuppression. Recent... 
BREAST-CANCER | EFFECTOR | ONCOLOGY | CHEMOKINE RECEPTORS CCR4 | DISEASE | REGULATORY T-CELLS | BLOCKADE | EXPRESSION | TUMOR-IMMUNITY | CUTTING EDGE | LYMPHOCYTES
Journal Article
Japanese Journal of Clinical Immunology, ISSN 0911-4300, 2016, Volume 39, Issue 3, pp. 207 - 212
Journal Article
The Journal of Urology, ISSN 0022-5347, 04/2018, Volume 199, Issue 4, pp. 896 - 896
Journal Article
Trends in Immunology, ISSN 1471-4906, 09/2015, Volume 36, Issue 9, pp. 556 - 564
During infection, a subset of effector T cells seeds the lymphoid and non-lymphoid tissues and gives rise to tissue-resident memory T cells (T RM ). Recent... 
MULTIPLE ROLES | SIMPLEX-VIRUS TYPE-2 | IMMUNE PROTECTION | RESIDENT MEMORY | ENDOTHELIAL-CELLS | INFECTION | IMMUNOLOGY | CHEMOKINE RECEPTOR CCR4 | EXPRESSION | CUTTING EDGE | LYMPHOCYTE TRAFFICKING
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 07/2019, Volume 25, Issue 14, pp. 4388 - 4399
Purpose: The anti-CCR4 mAb, mogamulizumab, offers therapeutic benefit to patients with adult T-cell leukemialymphoma (ATL), but skin-related adverse events... 
IMMUNE DYSREGULATION | MOLECULAR TARGET | ENTEROPATHY | ONCOLOGY | IMMUNOTHERAPY | LINKED SYNDROME IPEX | MONOCLONAL-ANTIBODY KW-0761 | POLYENDOCRINOPATHY | AUTOREACTIVE B-CELLS | CCR4 | ANTI-CCR4
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 2017, Volume 8, Issue 9, pp. 981 - 986
-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide was identified as a hit in a CCR4 receptor antagonist high-throughput screen (HTS) of a subset... 
TARC | Chemokine receptor 4 | antagonist | CCR4 | MDC
Journal Article
日本内科学会雑誌, ISSN 0021-5384, 2017, Volume 106, Issue 7, pp. 1404 - 1409
HTLV-1関連脊髄症(HTLV-1-associated myelopathy:HAM)は,ヒトT細胞白血病ウイルス1型(human T-cell leukemia virus type... 
clinical trial | CXCL10 | HAM | disease activity | CCR4
Journal Article
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