X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (1897) 1897
humans (1789) 1789
life sciences & biomedicine (1687) 1687
ccr5 receptor antagonists (907) 907
animals (772) 772
receptors, ccr5 - metabolism (733) 733
hiv (587) 587
ccr5 (537) 537
hiv infections - drug therapy (520) 520
immunology (514) 514
male (481) 481
female (475) 475
ccr5 protein (467) 467
hiv-1 - drug effects (463) 463
receptors, ccr5 - genetics (450) 450
virology (449) 449
pharmacology & pharmacy (445) 445
infectious diseases (425) 425
hiv infections - virology (401) 401
virus diseases (399) 399
viruses (392) 392
hiv-1 - physiology (383) 383
anti-hiv agents - pharmacology (373) 373
chemokines (341) 341
mice (326) 326
adult (301) 301
human immunodeficiency virus--hiv (298) 298
hiv-1 - genetics (260) 260
middle aged (256) 256
maraviroc (251) 251
cell line (242) 242
microbiology (242) 242
research (236) 236
hiv-1 (231) 231
aids/hiv (224) 224
antiviral agents (224) 224
health aspects (221) 221
cells, cultured (218) 218
receptors, cxcr4 - metabolism (217) 217
biochemistry & molecular biology (214) 214
anti-hiv agents - therapeutic use (212) 212
multidisciplinary sciences (204) 204
science & technology - other topics (204) 204
research article (191) 191
hiv infection (189) 189
infections (189) 189
molecular sequence data (184) 184
chemokine receptors (183) 183
aids (181) 181
hiv infections - immunology (181) 181
cyclohexanes - therapeutic use (180) 180
triazoles - therapeutic use (180) 180
cell biology (179) 179
receptors, ccr5 - immunology (177) 177
amino acid sequence (174) 174
analysis (172) 172
medicine (171) 171
receptors, ccr5 - physiology (169) 169
receptors, cxcr4 - antagonists & inhibitors (169) 169
human immunodeficiency virus (166) 166
chemistry, medicinal (165) 165
ligands (165) 165
triazoles - pharmacology (165) 165
inflammation (164) 164
cyclohexanes - pharmacology (163) 163
hiv-1 - metabolism (163) 163
cxcr4 protein (155) 155
proteins (151) 151
hiv fusion inhibitors - pharmacology (149) 149
hiv envelope protein gp120 - metabolism (147) 147
cd4 antigen (145) 145
receptors, ccr5 - chemistry (143) 143
cxcr4 (142) 142
science (142) 142
structure-activity relationship (142) 142
tropism (141) 141
mutation (140) 140
chemistry (139) 139
hiv envelope protein gp120 - genetics (138) 138
physical sciences (134) 134
genotype (133) 133
hiv-1 - pathogenicity (129) 129
lymphocytes (128) 128
mice, inbred c57bl (127) 127
virus replication - drug effects (127) 127
flow cytometry (126) 126
macrophages (126) 126
acquired immune deficiency syndrome--aids (123) 123
t cells (122) 122
abridged index medicus (121) 121
protein binding (121) 121
chemokine (118) 118
lymphocytes t (118) 118
viral load (117) 117
anti-hiv agents - chemistry (116) 116
biology (116) 116
hiv fusion inhibitors - therapeutic use (116) 116
rats (116) 116
viral tropism (114) 114
hiv infections - metabolism (113) 113
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2430) 2430
Japanese (24) 24
French (23) 23
Spanish (18) 18
Chinese (16) 16
German (9) 9
Portuguese (4) 4
Russian (3) 3
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


PloS one, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0158156 - e0158156
...) is an oral, dual CCR2/CCR5 antagonist with nanomolar potency against both receptors. CVC's anti-inflammatory and antifibrotic effects were evaluated in a range of preclinical models of inflammation and fibrosis... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Non-alcoholic Fatty Liver Disease - pathology | CCR5 Receptor Antagonists - pharmacology | Kidney Diseases - pathology | CCR5 Receptor Antagonists - therapeutic use | Mice, Inbred C57BL | Imidazoles - administration & dosage | Kidney Diseases - drug therapy | Rats | CCR5 Receptor Antagonists - administration & dosage | Male | Imidazoles - pharmacology | Chemotaxis | Rats, Sprague-Dawley | Non-alcoholic Fatty Liver Disease - drug therapy | Receptors, CCR2 - antagonists & inhibitors | Monocytes - drug effects | Animals | Fibrosis | Macrophages - drug effects | Mice | Imidazoles - therapeutic use | Inflammation | Analysis | Risk factors | Chemokine receptors | CC chemokine receptors | Animal models | Collagen (type I) | Liver | Collagens | Macrophages | Recruitment | Receptors | Cell activation | Fatty liver | CCR2 protein | Acquired immune deficiency syndrome--AIDS | Rodents | Hepatology | Gastroenterology | Drug therapy | Drug dosages | Peritonitis | Deposition | Carbon-carbon composites | CCR5 protein | Liver diseases | Kidneys | Cytokines | Pharmacology | FDA approval | Gene expression | Disease control | Medicine | Thioacetamide | Monocytes | Collagen | Ligands | Insulin resistance | In vivo methods and tests | Adults | Infiltration | Chemokines | Monocyte chemoattractant protein 1 | Index Medicus | Acquired immune deficiency syndrome | AIDS
Journal Article
PloS one, ISSN 1932-6203, 05/2009, Volume 4, Issue 5, pp. e5683 - e5683
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 05/2013, Volume 127, Issue 21, pp. 2114 - 2124
.... Maraviroc, a CCR5 antagonist antiretroviral drug, might provide benefit for patients with M-tropic HIV infections at high risk for cardiovascular diseases... 
Receptors | Inflammation | Maraviroc | CCR5 | Acquired immunodeficiency syndrome | Atherosclerosis | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Apolipoproteins E - deficiency | Male | Plaque, Atherosclerotic - chemically induced | Cyclohexanes - therapeutic use | Ritonavir - adverse effects | Chemokine CCL2 - metabolism | Chemokine CCL5 - metabolism | CCR5 Receptor Antagonists | Disease Models, Animal | Triazoles - therapeutic use | Macrophages - pathology | Plaque, Atherosclerotic - metabolism | Atherosclerosis - chemically induced | Mice, Inbred C57BL | Plaque, Atherosclerotic - prevention & control | Anti-Retroviral Agents - adverse effects | Treatment Outcome | Atherosclerosis - metabolism | Mice, Knockout | Interleukin-17 - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Apolipoproteins E - genetics | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Atherosclerosis - prevention & control | Cell Movement | Antagonists (Biochemistry) | Animal experimentation | Complications and side effects | Usage | Care and treatment | Atherosclerotic plaque | Ritonavir | Development and progression | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 06/2017, Volume 46, Issue 6, pp. 1005 - 1017.e5
.... To guide the design of improved therapeutics, we solved the structure of CCR5 in complex with chemokine antagonist [5P7]CCL5... 
maraviroc | V3 loop | CCL5/RANTES | G protein-coupled receptor (GPCR) | Chemokine antagonist | CCR5-gp120 interaction | viral mimicry | membrane protein structure | two-site model | HIV entry inhibitor | CCR5 Receptor Antagonists - chemistry | CCR5 Receptor Antagonists - pharmacology | Triazoles - chemistry | Cyclohexanes - pharmacology | HIV Fusion Inhibitors - chemistry | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Virus Internalization - drug effects | HIV Envelope Protein gp120 - metabolism | Spodoptera | Chemokine CCL5 - chemistry | HIV Infections - immunology | Molecular Mimicry | Receptors, CCR5 - metabolism | Sf9 Cells | HIV-1 - physiology | Cloning, Molecular | Cyclohexanes - chemistry | Chemokine CCL5 - metabolism | HIV Envelope Protein gp120 - chemistry | Models, Molecular | Triazoles - pharmacology | Animals | Protein Binding | Receptors, CCR5 - chemistry | HIV Infections - drug therapy | Protein Conformation | Hydrogen | Analysis | Pharmacy | Therapeutics | Drugstores | HIV (Viruses) | Drug approval | Homeopathy | Materia medica and therapeutics | G proteins | Membrane proteins | Similarity | Molecular structure | Infections | Leukocytes | Hydrogen bonding | Mimicry | Exploitation | Proteins | Hydrogen bonds | Design improvements | Human immunodeficiency virus--HIV | Plasticity | Chemical bonds | Modelling | Binding | CCR5 protein | Diseases | Molecular modelling | Inhibitors | Ligands | Determinants | Plastic properties | Molecular biology | Chemokines | Glycoprotein gp120 | Recognition | Cancer | Index Medicus | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | RANTES | CCL5
Journal Article
Journal Article