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JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 06/2011, Volume 57, Issue 2, pp. 118 - 125
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0158156 - e0158156
Background & Aims Interactions between C-C chemokine receptor types 2 (CCR2) and 5 (CCR5) and their ligands, including CCL2 and CCL5, mediate fibrogenesis by... 
IN-VITRO | PHARMACOKINETICS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | DISEASE | INJURY | NONALCOHOLIC STEATOHEPATITIS | MICE | HEPATIC-FIBROSIS | PHASE 2B | CCR2 | Non-alcoholic Fatty Liver Disease - pathology | CCR5 Receptor Antagonists - pharmacology | Kidney Diseases - pathology | CCR5 Receptor Antagonists - therapeutic use | Mice, Inbred C57BL | Imidazoles - administration & dosage | Kidney Diseases - drug therapy | Rats | CCR5 Receptor Antagonists - administration & dosage | Male | Imidazoles - pharmacology | Chemotaxis | Rats, Sprague-Dawley | Non-alcoholic Fatty Liver Disease - drug therapy | Receptors, CCR2 - antagonists & inhibitors | Monocytes - drug effects | Animals | Fibrosis | Macrophages - drug effects | Mice | Imidazoles - therapeutic use | Inflammation | Analysis | Risk factors | Chemokine receptors | CC chemokine receptors | Animal models | Collagen (type I) | Liver | Collagens | Macrophages | Recruitment | Receptors | Cell activation | Fatty liver | CCR2 protein | Acquired immune deficiency syndrome--AIDS | Rodents | Hepatology | Gastroenterology | Drug therapy | Drug dosages | Peritonitis | Deposition | Carbon-carbon composites | CCR5 protein | Liver diseases | Kidneys | Cytokines | Pharmacology | FDA approval | Gene expression | Disease control | Medicine | Thioacetamide | Monocytes | Collagen | Ligands | Insulin resistance | In vivo methods and tests | Adults | Infiltration | Chemokines | Monocyte chemoattractant protein 1 | Index Medicus | Acquired immune deficiency syndrome | AIDS
Journal Article
Journal Article
Journal Article
Virology, ISSN 0042-6822, 2016, Volume 494, pp. 198 - 214
Abstract The HIV-1 envelope interacts with coreceptors CCR5 and CXCR4 in a dynamic, multi-step process, its molecular details not clearly delineated. Use of... 
Infectious Disease | HIV/AIDS | Coreceptor inhibitor | Tropism shift | Drug resistance | READ ALIGNMENT | SMALL-MOLECULE | ENVELOPE GLYCOPROTEIN | RECEPTOR | VIROLOGY | GP120 V3 LOOP | STRUCTURAL BASIS | CLINICAL-TRIALS | IMMUNODEFICIENCY-VIRUS TYPE-1 | FUNCTIONAL-ANALYSIS | HIV ENTRY | Medical colleges | Analysis | Genomics | Index Medicus | AIDS | HIV
Journal Article
Immunity, ISSN 1074-7613, 06/2017, Volume 46, Issue 6, pp. 1005 - 1017.e5
CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120.... 
maraviroc | V3 loop | CCL5/RANTES | G protein-coupled receptor (GPCR) | Chemokine antagonist | CCR5-gp120 interaction | viral mimicry | membrane protein structure | two-site model | HIV entry inhibitor | CCR5 Receptor Antagonists - chemistry | CCR5 Receptor Antagonists - pharmacology | Triazoles - chemistry | Cyclohexanes - pharmacology | HIV Fusion Inhibitors - chemistry | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Virus Internalization - drug effects | HIV Envelope Protein gp120 - metabolism | Spodoptera | Chemokine CCL5 - chemistry | HIV Infections - immunology | Molecular Mimicry | Receptors, CCR5 - metabolism | Sf9 Cells | HIV-1 - physiology | Cloning, Molecular | Cyclohexanes - chemistry | Chemokine CCL5 - metabolism | HIV Envelope Protein gp120 - chemistry | Models, Molecular | Triazoles - pharmacology | Animals | Protein Binding | Receptors, CCR5 - chemistry | HIV Infections - drug therapy | Protein Conformation | Hydrogen | Analysis | Pharmacy | Therapeutics | Drugstores | HIV (Viruses) | Drug approval | Homeopathy | Materia medica and therapeutics | G proteins | Membrane proteins | Similarity | Molecular structure | Infections | Leukocytes | Hydrogen bonding | Mimicry | Exploitation | Proteins | Hydrogen bonds | Design improvements | Human immunodeficiency virus--HIV | Plasticity | Chemical bonds | Modelling | Binding | CCR5 protein | Diseases | Molecular modelling | Inhibitors | Ligands | Determinants | Plastic properties | Molecular biology | Chemokines | Glycoprotein gp120 | Recognition | Cancer | Index Medicus | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | RANTES | CCL5
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2009, Volume 4, Issue 5, pp. e5683 - e5683
Journal Article
CLINICAL THERAPEUTICS, ISSN 0149-2918, 07/2008, Volume 30, Issue 7, pp. 1228 - 1250
Background: The emergence of viral resistance is one of the greatest challenges in the treatment of HIV infection. Maraviroc is the first member of a new class... 
entry inhibitor | maraviroc | ENTRY INHIBITORS | FUSION | CCR5-receptor antagonist | ANTIRETROVIRALS | CCR5 ANTAGONIST | INDIVIDUALS | CYP3A4 INHIBITORS | HIV-1 infection | PHARMACOKINETICS | RESISTANCE | PHARMACOLOGY & PHARMACY | HEALTHY-VOLUNTEERS | ASSOCIATION
Journal Article
Circulation, ISSN 0009-7322, 05/2013, Volume 127, Issue 21, pp. 2114 - 2124
BACKGROUND—CCR5 plays an important role in atherosclerosis and ischemic cardiovascular diseases, as well as in HIV replication and diffusion. HIV infection is... 
Receptors | Inflammation | Maraviroc | CCR5 | Acquired immunodeficiency syndrome | Atherosclerosis | atherosclerosis | maraviroc | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | MYOCARDIAL-INFARCTION | receptors, CCR5 | acquired immunodeficiency syndrome | HIV-INFECTED PATIENTS | inflammation | PPAR-GAMMA | PERIPHERAL VASCULAR DISEASE | CHEMOKINE RECEPTORS | PROTEASE INHIBITOR RITONAVIR | CORONARY-ARTERY-DISEASE | CARDIOVASCULAR RISK | Tumor Necrosis Factor-alpha - metabolism | Apolipoproteins E - deficiency | Male | Plaque, Atherosclerotic - chemically induced | Cyclohexanes - therapeutic use | Ritonavir - adverse effects | Chemokine CCL2 - metabolism | Chemokine CCL5 - metabolism | CCR5 Receptor Antagonists | Disease Models, Animal | Triazoles - therapeutic use | Macrophages - pathology | Plaque, Atherosclerotic - metabolism | Atherosclerosis - chemically induced | Mice, Inbred C57BL | Plaque, Atherosclerotic - prevention & control | Anti-Retroviral Agents - adverse effects | Treatment Outcome | Atherosclerosis - metabolism | Mice, Knockout | Interleukin-17 - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Apolipoproteins E - genetics | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Atherosclerosis - prevention & control | Cell Movement | Antagonists (Biochemistry) | Animal experimentation | Complications and side effects | Usage | Care and treatment | Atherosclerotic plaque | Ritonavir | Development and progression | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article