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American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 04/2013, Volume 48, Issue 4, pp. 503 - 510
Periostin is an extracellular matrix protein that is up-regulated by T helper cell type 2 cytokines in the asthmatic airway and implicated in mouse studies as... 
CD11b/CD18; Mac-1 | Adhesion | Periostin | Eosinophils | Integrins | integrins | periostin | CD18 | eosinophils | αMβ2 (CD11b | Mac-1 | adhesion
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 09/2018, Volume 138, Issue 9, pp. 1990 - 1998
Although uncontrolled proteolytic activity mediated by activated neutrophils is a major reason for tissue damage, therapeutic approaches using protease... 
EMIGRATION | RECRUITMENT | ACTIVATION | CONTACT | DERMAL-EPIDERMAL SEPARATION | MAC-1 CD11B/CD18 | ELASTASE | EMPHYSEMA | INDUCTION | PROTEASES | DERMATOLOGY
Journal Article
European Respiratory Journal, ISSN 0903-1936, 03/2019, Volume 53, Issue 3
The lung is highly vulnerable during sepsis, yet its functional deterioration accompanied by disturbances in the pulmonary microcirculation is poorly... 
RECRUITMENT | MAC-1 CD11B/CD18 | RESPIRATORY SYSTEM | DEPLETION | SELECTIN | DYSFUNCTION | MODEL | BINDING | LEUKOCYTE SEQUESTRATION
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2017, Volume 114, Issue 13, pp. 3403 - 3408
Recognition by the leukocyte integrins alpha(X)beta(2) and alpha(M)beta(2) of complement iC3b-opsonized targets is essential for effector functions including... 
CD11B/CD18 | ADHESION | ACTIVATION | MULTIDISCIPLINARY SCIENCES | MAC-1 | A-DOMAIN | I-DOMAIN | COMPONENT C3 | BETA-SUBUNIT | BINDING | LEUKOCYTE INTEGRIN
Journal Article
by Ma, JW and Cai, WQ and Zhang, Y and Huang, CM and Zhang, HF and Liu, J and Tang, K and Xu, PW and Katirai, F and Zhang, JM and He, W and Ye, DY and Shen, GX and Huang, B
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2013, Volume 191, Issue 6, pp. 3453 - 3461
Mechanisms by which tumor cells metastasize to distant organs still remain enigmatic. Immune cells have been assumed to be the root of metastasis by their... 
ACTIVATION | FUSION | MAC-1 CD11B/CD18 | DENDRITIC CELLS | DISTINCT ROLES | BONE | MEDIATORS | IMMUNOLOGY | CANCER | PROGRESSION | COMMUNICATION
Journal Article
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ISSN 1073-449X, 08/2009, Volume 180, Issue 4, pp. 311 - 319
Rationale Apoptosis is essential for removal of neutrophils from inflamed tissues and efficient resolution of inflammation. Myeloperoxidase (MPO), abundantly... 
LIPOXIN A | HYPOCHLOROUS ACID | apoptosis | CELL-SURVIVAL | acute lung injury | neutrophil | resolution of inflammation | NEUTROPHIL APOPTOSIS | lipoxins | MACROPHAGE PHAGOCYTOSIS | RESPIRATORY SYSTEM | INFLAMMATION | IN-VIVO | CD11B/CD18 INTEGRINS | NF-KAPPA-B | STABLE ANALOGS | CRITICAL CARE MEDICINE
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 06/2004, Volume 113, Issue 11, pp. 1596 - 1606
The leukocyte integrin alpha(M)beta(2)/Mac-1 appears to support the inflammatory response through multiple ligands, but local engagement of fibrin(ogen) may be... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION | LIGAND-BINDING | CD11B CD18 | CLUMPING FACTOR | MAC-1 | BINDING-SITE | NEUTROPHIL EMIGRATION | DEFICIENT MICE | FIBRINOGEN | GAMMA-C-DOMAIN
Journal Article
by Jin, R and Yu, SY and Song, ZF and Zhu, XL and Wang, CP and Yan, JC and Wu, FS and Nanda, A and Granger, DN and Li, GH
PLOS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6
Recent work has revealed an essential involvement of soluble CD40L (sCD40L) in inflammation and vascular disease. Activated platelets are the major source of... 
CD11B/CD18 | CELLS | ANGIOPLASTY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | P-SELECTIN | RESTENOSIS | ADHESION MOLECULES | WALL INJURY | EXPRESSION | NEOINTIMAL FORMATION
Journal Article
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 12/2015, Volume 195, Issue 11, pp. 5309 - 5317
Microglia play an important role in receptor-mediated phagocytosis in the CNS. In brain abscess and other CNS infections, invading bacteria undergo... 
RESPONSES | ACTIVATION | CR3 CD11B/CD18 | AMYLOID-BETA | APOPTOTIC CELLS | MOUSE MODEL | CENTRAL-NERVOUS-SYSTEM | INNATE IMMUNE-SYSTEM | STAPHYLOCOCCUS-AUREUS | IMMUNOLOGY | IMMUNOGLOBULIN G
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2019, Volume 294, Issue 22, pp. 8834 - 8847
Proteinases are essential drivers of allergic airway disease and innate antifungal immunity in part through their ability cleave the clotting factor fibrinogen... 
AIRWAY EPITHELIAL-CELLS | ACTIVATION | fibrinogen | MAC-1 CD11B/CD18 | MECHANISM | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | allergy | Toll-like receptor 4 (TLR4) | HOUSE-DUST MITE | proteinase | innate immunity | fungi | INFLAMMATION | ASTHMA | MICE | integrin | MOLD
Journal Article
BLOOD, ISSN 0006-4971, 05/2009, Volume 113, Issue 21, pp. 5254 - 5265
Activated platelets express ligands, which are recognized by counterreceptors on neutrophils. Here, we show that the ensuing cell-to-cell interaction programs... 
CD11B/CD18 | PLATELET/POLYMORPHONUCLEAR LEUKOCYTE INTERACTION | ADHESION | POLYMORPHONUCLEAR LEUKOCYTES | ADHERENT PLATELETS | UNSTABLE ANGINA | HEMATOLOGY | CORONARY-ARTERY-DISEASE | TISSUE FACTOR EXPRESSION | FAMILY KINASES MEDIATE | GLYCOPROTEIN LIGAND-1
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2009, Volume 119, Issue 12, pp. 3637 - 3651
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2008, Volume 181, Issue 10, pp. 6829 - 6836
Many patients with colorectal cancer will develop liver metastases, even after successful surgical removal of the primary tumor at a time at which no visible... 
MURINE MODEL | IMMUNITY | MAC-1 CD11B/CD18 | RAT | COLORECTAL-CANCER | KUPFFER CELLS | RECEPTOR | MONOCLONAL-ANTIBODY | TUMOR-CELLS | COLON-CARCINOMA CELLS | IMMUNOLOGY
Journal Article
Cell Reports, ISSN 2211-1247, 03/2015, Volume 10, Issue 10, pp. 1655 - 1664
Leukocyte CD18 integrins increase their affinity for ligand by transmitting allosteric signals to and from their ligand-binding αI domain. Mechanical forces... 
CD11B/CD18 | CELL-SURFACES | DYNAMIC CATCH | DOMAIN | ITGAM | FUNCTION-ASSOCIATED ANTIGEN-1 | LEUKOCYTE ADHESION | CATCH BONDS | ERYTHEMATOSUS | DEFICIENCY | CELL BIOLOGY
Journal Article
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 10/2002, Volume 13, Issue 10, pp. 3369 - 3387
The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins, and in integrin receptors. A number of... 
RNA-POLYMERASE-II | CARTILAGE MATRIX PROTEIN | CLASS-III REGION | COLLAGEN-BINDING SITE | LUNG-TUMOR SUSCEPTIBILITY | ALPHA-INHIBITOR FAMILY | CELL-ADHESION | VON-WILLEBRAND-FACTOR | FACTOR-A DOMAIN | INTEGRIN CR3 CD11B/CD18 | CELL BIOLOGY
Journal Article