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Journal of experimental medicine, ISSN 0022-1007, 2008, Volume 205, Issue 7, pp. 1621 - 1634
Although dendritic cells (DCs) play an important role in mediating protection against influenza virus, the precise role of lung DC subsets, such as CD11b(-)... 
MEDICINE, RESEARCH & EXPERIMENTAL | IIFN-PRODUCING CELLS | INHALED ANTIGEN | IN-VIVO DEPLETION | ANTIGEN PRESENTATION | STEADY-STATE | IMMUNOLOGY | PULMONARY INFECTION | ANTIBODY-RESPONSE | CD8(+) T-CELLS | RESPIRATORY SYNCYTIAL VIRUS | LANGERHANS CELLS | Dendritic Cells - immunology | Lectins, C-Type - immunology | Male | Lectins, C-Type - genetics | CD11c Antigen - immunology | Trachea - virology | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | CD11b Antigen - genetics | Lung - virology | CD11c Antigen - genetics | Female | CD4-Positive T-Lymphocytes - virology | Dendritic Cells - virology | CD11b Antigen - immunology | Plasma Cells - virology | Antigens, Surface - genetics | Intercellular Signaling Peptides and Proteins - genetics | Antigen Presentation - genetics | Mice, Transgenic | Lymph Nodes - virology | Lymph Nodes - immunology | CD8 Antigens - immunology | Trachea - immunology | Heparin-binding EGF-like Growth Factor | Animals | Mannose-Binding Lectins - genetics | Mannose-Binding Lectins - immunology | CD8-Positive T-Lymphocytes - virology | CD8 Antigens - genetics | Dogs | Antibodies, Viral - immunology | Nucleocapsid Proteins - immunology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Antigens, Surface - immunology | Antibody Formation - genetics | Intercellular Signaling Peptides and Proteins - immunology | Lung - immunology | Orthomyxoviridae Infections - immunology | Plasma Cells - immunology | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2014, Volume 15, Issue 10, pp. 929 - 937
The paradigm that macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which... 
HOMEOSTASIS | DENDRITIC CELLS | MICROGLIA | INFLAMMATION | BONE-MARROW | TISSUE-RESIDENT MACROPHAGES | RECEPTOR | STEADY-STATE | IMMUNOLOGY | MYELOID CELLS | LIFE | Receptors, CCR2 - genetics | Intestinal Mucosa - metabolism | Cell Proliferation | Receptors, CCR2 - immunology | Monocytes - metabolism | Intestines - metabolism | Monocytes - immunology | Intestines - immunology | Parabiosis | Intestinal Mucosa - cytology | CD11b Antigen - genetics | Flow Cytometry | Time Factors | Intestinal Mucosa - immunology | Bone Marrow Transplantation | Gene Expression - immunology | Antigens, Differentiation - metabolism | Antigens, Ly - metabolism | Receptors, Chemokine - genetics | Macrophages - immunology | Animals, Newborn | CD11b Antigen - immunology | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Mice, Transgenic | Receptors, Chemokine - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Differentiation - immunology | Macrophages - metabolism | Models, Immunological | Receptors, CCR2 - metabolism | Animals | Antigens, Ly - immunology | Antigens, Differentiation - genetics | CD11b Antigen - metabolism | CX3C Chemokine Receptor 1 | Antigens, Differentiation - immunology | Intestines - cytology | Physiological aspects | Regulation | Immune response | Microbiota (Symbiotic organisms) | Macrophages | Properties | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 09/2015, Volume 6, Issue 1, pp. 8164 - 8164
Autoimmunity and macrophage recruitment into the central nervous system (CNS) are critical determinants of neuroinflammatory diseases. However, the mechanisms... 
INTEGRIN ALPHA(M)BETA | MULTIPLE-SCLEROSIS | WHITE-MATTER | MULTIDISCIPLINARY SCIENCES | IN-VIVO | REGULATORY T-CELLS | BINDING-SITE | CENTRAL-NERVOUS-SYSTEM | MICE | CNS AUTOIMMUNITY | GAMMA-C-DOMAIN | Immunohistochemistry | Myelin-Oligodendrocyte Glycoprotein - immunology | Cell Proliferation | Chemokine CCL2 - immunology | Demyelinating Diseases - genetics | Encephalomyelitis, Autoimmune, Experimental - immunology | Gene Expression Profiling | Brain - metabolism | Autoimmunity - immunology | Demyelinating Diseases - immunology | Fibrinogen - pharmacology | Receptors, Antigen, T-Cell - immunology | Fibrinogen - immunology | Receptors, Chemokine - genetics | DNA-Binding Proteins - immunology | Rats | Antigen Presentation - genetics | Antigen Presentation - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Microglia | Brain - drug effects | Genes, MHC Class II - genetics | Spinal Cord - immunology | Fibrin | Adaptive Immunity - drug effects | Brain - pathology | Mice | CX3C Chemokine Receptor 1 | Blood-Brain Barrier | Spinal Cord - drug effects | Spinal Cord - metabolism | Autoimmunity - genetics | Genes, MHC Class II - immunology | Homeodomain Proteins - immunology | Th1 Cells - immunology | Adaptive Immunity - genetics | CD11b Antigen - genetics | Flow Cytometry | Spinal Cord - pathology | Chemokine CXCL10 - immunology | Adaptive Immunity - immunology | Macrophages - immunology | CD11b Antigen - immunology | Receptors, Chemokine - immunology | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | Chemokine CXCL10 - genetics | Antigen Presentation - drug effects | Brain - immunology | Autoimmunity - drug effects | Chemokines | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 322 - 335
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 718 - 728
Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct lineages: the CD8 alpha(+) (CD103(+)) cDC1 lineage, and the CD11b(+)... 
CLASSICAL DENDRITIC CELLS | HOMEOSTASIS | LYMPHOID-TISSUE | HEMATOPOIETIC STEM-CELLS | MOUSE | DYNAMICS | RECEPTOR | TRANSCRIPTION-FACTOR | IMMUNOLOGY | COMMITTED PROGENITORS | EXPRESSION | Antigens, CD - immunology | Stem Cells - immunology | Oligonucleotide Array Sequence Analysis | Dendritic Cells - immunology | Antigens, Ly - genetics | Transcriptome - immunology | Stem Cells - metabolism | Antigens, CD - metabolism | Lectins - metabolism | Flow Cytometry | Single-Cell Analysis - methods | Bone Marrow Cells - immunology | Integrin alpha Chains - immunology | Antigens, Ly - metabolism | Cell Lineage - genetics | Dendritic Cells - metabolism | Microscopy, Electron, Scanning | CD11b Antigen - immunology | Lectins - immunology | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cell Surface - metabolism | Mice, Transgenic | Integrin alpha Chains - metabolism | Transcriptome - genetics | Receptors, Cell Surface - immunology | CD8 Antigens - immunology | CD8 Antigens - metabolism | Animals | Antigens, Ly - immunology | Dendritic Cells - ultrastructure | Lectins - genetics | CD11b Antigen - metabolism | Bone Marrow Cells - metabolism | Cell Lineage - immunology | Cluster Analysis | Receptors, Cell Surface - genetics | Medical research | Immune response | Dendritic cells | Cell development (Biology) | Bone marrow | Medicine, Experimental | Genetic aspects | Research | Properties | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 15, pp. 2975 - 2987
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been... 
CANCER-PATIENTS | DENDRITIC CELLS | T-REGULATORY CELLS | IMMUNOSUPPRESSION | BONE-MARROW | GROWTH | PERIPHERAL-BLOOD | DIFFERENTIATION | IDENTIFICATION | HEMATOLOGY | PROGRESSION | Cell Proliferation | Reactive Oxygen Species - metabolism | Coculture Techniques | Humans | Sialic Acid Binding Ig-like Lectin 3 - immunology | Multiple Myeloma - immunology | Thalidomide - pharmacology | Lewis X Antigen - metabolism | Lipopolysaccharides - immunology | Thalidomide - analogs & derivatives | Flow Cytometry | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Reactive Oxygen Species - immunology | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | HLA-DR Antigens - metabolism | Sialic Acid Binding Ig-like Lectin 3 - metabolism | Cytokines - immunology | Tumor Microenvironment - drug effects | Bortezomib | CD11b Antigen - immunology | Cytokines - metabolism | Cells, Cultured | Lewis X Antigen - immunology | Multiple Myeloma - metabolism | Tumor Microenvironment - immunology | Multiple Myeloma - pathology | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | HLA-DR Antigens - immunology | CD11b Antigen - metabolism | Pyrazines - pharmacology | Immunologic Factors - pharmacology | Boronic Acids - pharmacology | Tumor Burden - immunology | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Immunity, ISSN 1074-7613, 07/2014, Volume 41, Issue 1, pp. 127 - 140
Memory CD8 T cells are programmed during the primary response for robust secondary responsiveness. Here we show that CD8 T cells responding to different... 
IMMUNODOMINANCE | EFFECTOR | RESPONSES | VIRUS-INFECTION | DENDRITIC CELLS | CD8-T-CELL MEMORY | CD4-T-CELL HELP | CD40 LIGAND | IMMUNOLOGY | VIRAL-INFECTION | CROSS-PRESENTATION | Antigens, CD - immunology | CD40 Antigens - antagonists & inhibitors | Minor Histocompatibility Antigens | Dendritic Cells - immunology | Interleukin-2 Receptor alpha Subunit - biosynthesis | Adoptive Transfer | Signal Transduction - immunology | Lymphocyte Activation - immunology | Interleukin-2 - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Integrin alpha Chains - immunology | Influenza A virus - immunology | CD40 Antigens - genetics | Histocompatibility Antigens Class I - pharmacology | Epitopes, T-Lymphocyte - immunology | Immunologic Memory - immunology | Nucleoproteins - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology | CD11b Antigen - immunology | CD27 Ligand - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | DNA-Directed RNA Polymerases - immunology | Mice, Transgenic | Antigen Presentation - immunology | Animals | Viral Core Proteins - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology | Interferon-gamma - biosynthesis | Orthomyxoviridae Infections - immunology | Flow cytometry | Antigens | Lymphocytes | Ligands | T cell receptors | Infections | Experiments | Immune system | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2012, Volume 109, Issue 46, pp. E3186 - E3195
Although macrophages are widely recognized to have a profibrotic role in inflammation, we have used a highly tractable CCl 4 -induced model of reversible... 
Degradation | Kupffer cell | Proliferation | Collagen | Myofibroblast | Kupffer Cell | LUNG FIBROSIS | proliferation | myofibroblast | MULTIDISCIPLINARY SCIENCES | collagen | degradation | HEPATIC-FIBROSIS | RENAL FIBROSIS | IMMUNE-RESPONSES | APOPTOTIC CELLS | IN-VIVO | MONOCYTE SUBSETS | GENE-EXPRESSION | PULMONARY-FIBROSIS | T-CELLS | Liver Cirrhosis - immunology | Antigens, Ly - genetics | Matrix Metalloproteinase 9 - immunology | Matrix Metalloproteinase 12 - genetics | Insulin-Like Growth Factor I - genetics | Monocytes - immunology | MAP Kinase Signaling System - immunology | Liver Cirrhosis - chemically induced | Insulin-Like Growth Factor I - immunology | CD11b Antigen - genetics | MAP Kinase Signaling System - genetics | Matrix Metalloproteinase 9 - genetics | Monocytes - pathology | Liver Cirrhosis - genetics | Macrophages - immunology | CD11b Antigen - immunology | Macrophages - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Matrix Metalloproteinase 12 - immunology | Mice, Transgenic | Carbon Tetrachloride - toxicity | Carbon Tetrachloride Poisoning - pathology | Gene Expression Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Antigens, Ly - immunology | Carbon Tetrachloride Poisoning - immunology | Liver Cirrhosis - pathology | Carbon Tetrachloride Poisoning - genetics | Mice | Proteins | Genotype & phenotype | Signal transduction | Liver diseases | Gene expression | Rodents | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2014, Volume 15, Issue 1, pp. 98 - 108
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2012, Volume 21, Issue 6, pp. 822 - 835
Cancer-associated inflammation is thought to be a barrier to immune surveillance, particularly in pancreatic ductal adenocarcinoma (PDA). Gr-1 CD11b cells are... 
OVEREXPRESSION | MICROENVIRONMENT | ONCOLOGY | DUCTAL ADENOCARCINOMA | INTERLEUKIN-1-BETA | MICE | SUPPRESSOR-CELLS | INDUCTION | DIFFERENTIATION | MAMMARY CARCINOMAS | MOUSE MODELS | CELL BIOLOGY | Immunohistochemistry | Adenocarcinoma - pathology | CD8-Positive T-Lymphocytes - pathology | Pancreatic Neoplasms - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Inflammation - metabolism | Adenocarcinoma - metabolism | RNA Interference | T-Lymphocytes - metabolism | Myeloid Cells - immunology | CD8-Positive T-Lymphocytes - metabolism | T-Lymphocytes - pathology | Carcinoma, Pancreatic Ductal - immunology | CD11b Antigen - immunology | Adenocarcinoma - immunology | Pancreatic Neoplasms - pathology | Receptors, Chemokine - metabolism | Mice, Transgenic | Inflammation - immunology | Receptors, Chemokine - immunology | Carcinoma, Pancreatic Ductal - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Tumor Microenvironment - immunology | Models, Immunological | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Pancreatic Neoplasms - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Mice | CD11b Antigen - metabolism | Myeloid Cells - pathology | CD8-Positive T-Lymphocytes - immunology | Medical colleges | Analysis | Pancreatic cancer | Oncology, Experimental | Genetically modified organisms | Inflammation | Macrophage colony stimulating factor | Research | T cells | Tumors | Cancer | Index Medicus | granulocyte-macrophage colony stimulating factor | myeloid cells | T lymphocyte | carcinoma | pancreas
Journal Article