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1. Full Text A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects
by Kagoya, Yuki and Tanaka, Shinya and Guo, Tingxi and Anczurowski, Mark and Wang, Chung-Hsi and Saso, Kayoko and Butler, Marcus O and Minden, Mark D and Hirano, Naoto
Nature medicine, ISSN 1078-8956, 03/2018, Volume 24, Issue 3, pp. 352 - 359
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Humans | Receptors, Antigen, T-Cell - therapeutic use | Antigens, CD19 - genetics | Cell Differentiation - genetics | Lymphocyte Activation - genetics | Neoplasms - therapy | CD28 Antigens - genetics | Neoplasms - genetics | T-Lymphocytes - metabolism | Antigens, CD19 - therapeutic use | Interleukin-2 Receptor beta Subunit - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - therapeutic use | Cell Proliferation - genetics | Immunotherapy, Adoptive | Interleukin-2 Receptor beta Subunit - therapeutic use | Janus Kinases - genetics | Signal Transduction | Xenograft Model Antitumor Assays | Receptors, Chimeric Antigen - therapeutic use | Animals | CD28 Antigens - therapeutic use | Cell Line, Tumor | Receptors, Chimeric Antigen - genetics | Receptors, Antigen, T-Cell - genetics | Neoplasms - pathology | Cell receptors | Care and treatment | Immune response | Innovations | Genetic aspects | T cells | Health aspects | Cancer | Cell proliferation | Transcription factors | Toxicity | Interleukin | Stimulation | Lymphocytes T | CD28 antigen | Adoptive transfer | Anticancer properties | T-cell receptor | Cell activation | Lymphocytes | Janus kinase | Biocompatibility | Tyrosine | Interleukin 2 receptors | Antigens | CD19 antigen | Cytokines | Stat3 protein | T cell receptors | Stat5 protein | Chimeric antigen receptors | Signaling | Immunosuppression | Lymphocytes B | Antitumor activity | Solid tumors | Tumors | Glutamine | Index Medicus
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2. Full Text CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir
by Badia, Roger and Ballana, Ester and Castellví, Marc and García-Vidal, Edurne and Pujantell, Maria and Clotet, Bonaventura and Prado, Julia G and Puig, Jordi and Martínez, Miguel A and Riveira-Muñoz, Eva and Esté, José A
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2739 - 10
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Antigens, CD - immunology | Humans | Middle Aged | Lectins, C-Type - immunology | Interleukin-7 - pharmacology | Male | Proviruses - immunology | Lectins, C-Type - genetics | Antigens, CD - genetics | HLA-DR Antigens - genetics | Host-Pathogen Interactions - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Lymphocyte Activation - genetics | Receptors, IgG - genetics | CD3 Complex - genetics | CD28 Antigens - genetics | Proviruses - genetics | Phytohemagglutinins - pharmacology | CD28 Antigens - antagonists & inhibitors | Adult | CD4-Positive T-Lymphocytes - virology | Gene Expression | Antigens, Differentiation, T-Lymphocyte - immunology | Antibodies, Monoclonal - pharmacology | CD3 Complex - antagonists & inhibitors | HIV Infections - genetics | HIV Infections - virology | CD28 Antigens - immunology | Receptors, IgG - immunology | HIV-1 - genetics | Virus Integration | HIV-1 - immunology | Lymphocyte Activation - drug effects | Antigens, Differentiation, T-Lymphocyte - genetics | CD3 Complex - immunology | Interleukin-2 - pharmacology | HLA-DR Antigens - immunology | Primary Cell Culture | CD4-Positive T-Lymphocytes - drug effects | Cell proliferation | Integration | Proviruses | Antibodies | T cell receptors | Lymphocytes T | CD3 antigen | CD28 antigen | CD4 antigen | Interleukin 7 | CD69 antigen | Cell activation | Interleukin 2 | Antiretroviral agents | Lymphocytes | Human immunodeficiency virus--HIV | Histocompatibility antigen HLA | Index Medicus
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3. Full Text Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains
by Alabanza, Leah and Pegues, Melissa and Geldres, Claudia and Shi, Victoria and Wiltzius, Jed J.W and Sievers, Stuart A and Yang, Shicheng and Kochenderfer, James N
Molecular therapy, ISSN 1525-0016, 11/2017, Volume 25, Issue 11, pp. 2452 - 2465
T cell | chimeric antigen receptor | immunotherapy | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Recombinant Fusion Proteins - immunology | Humans | Antigens, CD19 - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | T-Lymphocytes - transplantation | Single-Chain Antibodies - genetics | CD28 Antigens - genetics | Protein Domains | Receptors, Antigen, T-Cell - immunology | Lymphocyte Transfusion | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Antigens, CD19 - immunology | Amino Acid Sequence | Gene Expression | Immunotherapy, Adoptive - methods | Transduction, Genetic | CD28 Antigens - immunology | Recombinant Fusion Proteins - chemistry | Tumor Burden | Plasmids - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | CD8 Antigens - immunology | Xenograft Model Antitumor Assays | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Animals | T-Lymphocytes - cytology | CD8 Antigens - genetics | Plasmids - chemistry | Survival Analysis | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Single-Chain Antibodies - chemistry | Cell proliferation | Flow cytometry | Medical research | Antigens | Bioluminescence | CD19 antigen | Cytokines | Toxicity | Research & development--R&D | Lymphocytes T | Inflammation | CD28 antigen | Patients | Experiments | Chimeric antigen receptors | Cell activation | Lymphocytes B | Cell death | Lymphocytes | Degranulation | Transmembrane domains | Receptor mechanisms | Cancer | Tumors | Index Medicus | Original
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4. Full Text T Cell Retargeting with MHC Class I-Restricted Antibodies: The CD28 Costimulatory Domain Enhances Antigen-Specific Cytotoxicity and Cytokine Production
by Willemsen, Ralph A and Ronteltap, Cees and Chames, Patrick and Debets, Reno and Bolhuis, Reinder L. H
The Journal of immunology (1950), ISSN 0022-1767, 06/2005, Volume 174, Issue 12, pp. 7853 - 7858
Cytotoxicity, Immunologic/genetics | Adjuvants, Immunologic/genetics/metabolism/toxicity | Antigens, CD28/genetics/immunology/physiology | Comparative Study | Receptors, IgE/genetics/metabolism/physiology | Humans | Binding Sites, Antibody/genetics | HLA-A1 Antigen/genetics/immunology/metabolism | Immunoglobulin Variable Region/genetics/metabolism | T-Lymphocytes, Cytotoxic/immunology/metabolism | Transduction, Genetic/methods | Neoplasm Proteins/genetics/immunology/metabolism | Lymphocyte Activation/genetics | Immunoglobulin Fab Fragments/genetics/metabolism/toxicity | Research Support, Non-U.S. Gov't | Protein Structure, Tertiary/genetics | K562 Cells | Signal Transduction/genetics/immunology | Cell Line, Tumor | Receptors, Antigen, T-Cell/biosynthesis/genetics/metabolism | Epitopes, T-Lymphocyte/genetics/immunology/toxicity | Cytokines/biosynthesis | Melanoma/immunology/pathology | Life Sciences & Biomedicine | Immunology | Science & Technology | HLA-A1 Antigen - genetics | Neoplasm Proteins - immunology | Immunoglobulin Variable Region - metabolism | Epitopes, T-Lymphocyte - genetics | Immunoglobulin Fab Fragments - toxicity | Neoplasm Proteins - metabolism | Receptors, Antigen, T-Cell - biosynthesis | Signal Transduction - immunology | Lymphocyte Activation - genetics | CD28 Antigens - genetics | Immunoglobulin Fab Fragments - metabolism | Adjuvants, Immunologic - metabolism | Adjuvants, Immunologic - genetics | Epitopes, T-Lymphocyte - immunology | Neoplasm Proteins - genetics | Transduction, Genetic - methods | HLA-A1 Antigen - metabolism | CD28 Antigens - physiology | T-Lymphocytes, Cytotoxic - immunology | Cytotoxicity, Immunologic - genetics | Melanoma-Specific Antigens | Receptors, IgE - physiology | Antigens, Neoplasm | Binding Sites, Antibody - genetics | Immunoglobulin Fab Fragments - genetics | Receptors, Antigen, T-Cell - metabolism | Adjuvants, Immunologic - toxicity | CD28 Antigens - immunology | Protein Structure, Tertiary - genetics | Signal Transduction - genetics | Melanoma - pathology | Receptors, IgE - genetics | Receptors, IgE - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Melanoma - immunology | Epitopes, T-Lymphocyte - toxicity | Immunoglobulin Variable Region - genetics | HLA-A1 Antigen - immunology | Receptors, Antigen, T-Cell - genetics | Cytokines - biosynthesis | Index Medicus | Abridged Index Medicus
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5. Full Text Target antigen density governs the efficacy of anti-CD20-CD28-CD3 ζ chimeric antigen receptor-modified effector CD8+ T cells
by Watanabe, Keisuke and Terakura, Seitaro and Martens, Anton C and Van Meerten, Tom and Uchiyama, Susumu and Imai, Misa and Sakemura, Reona and Goto, Tatsunori and Hanajiri, Ryo and Imahashi, Nobuhiko and Shimada, Kazuyuki and Tomita, Akihiro and Kiyoi, Hitoshi and Nishida, Tetsuya and Naoe, Tomoki and Murata, Makoto
The Journal of immunology (1950), ISSN 0022-1767, 02/2015, Volume 194, Issue 3, pp. 911 - 920
Humans | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Intracellular Space | Lymphoma, B-Cell - genetics | CD28 Antigens - metabolism | T-Cell Antigen Receptor Specificity - genetics | T-Cell Antigen Receptor Specificity - immunology | Lymphoma, B-Cell - immunology | Antigens, Surface - metabolism | CD8-Positive T-Lymphocytes - metabolism | Gene Order | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Genes, Reporter | Lymphoma, B-Cell - drug therapy | Recombinant Proteins - metabolism | Antigens, CD20 - immunology | T-Lymphocyte Subsets | Gene Expression | Lymphoma, B-Cell - metabolism | Transduction, Genetic | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Lymphocyte Activation | Rituximab | Immunophenotyping | CD28 Antigens - immunology | Recombinant Proteins - genetics | Antigens, CD20 - metabolism | CD3 Complex - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | CD3 Complex - immunology | Cell Line, Tumor | Protein Binding | Receptors, Antigen, T-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | CD8-Positive T-Lymphocytes - immunology | Antigens, Surface - immunology | Cytokines - biosynthesis | Antibodies, Monoclonal, Murine-Derived - therapeutic use | Cytotoxicity, Immunologic | Index Medicus | Abridged Index Medicus
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6. Full Text Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity
by Li, Wenpeng and Guo, Linjie and Rathi, Purva and Marinova, Ekaterina and Gao, Xiuhua and Wu, Meng-Feng and Liu, Hao and Dotti, Gianpietro and Gottschalk, Stephen and Metelitsa, Leonid S and Heczey, Andras
Human gene therapy, ISSN 1043-0342, 05/2017, Volume 28, Issue 5, pp. 437 - 448
Review Articles | hepatoblastoma | immunotherapy | glypican-3 | rhabdoid tumor | chimeric antigen receptor | hepatocellular carcinoma | T-cell therapy | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | T-Lymphocytes, Cytotoxic - immunology | Cell Polarity - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - therapeutic use | Humans | Lymphoma, B-Cell - therapy | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Receptors, Antigen, T-Cell - therapeutic use | Antigens, CD19 - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Lymphoma, B-Cell - genetics | Glypicans - genetics | Glypicans - therapeutic use | Xenograft Model Antitumor Assays | Animals | CD28 Antigens - genetics | CD28 Antigens - therapeutic use | T-Lymphocytes - metabolism | Antigens, CD19 - therapeutic use | Immunotherapy | Lymphoma, B-Cell - immunology | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Malignant rhabdoid tumor | Polarization | Interleukin | Cytotoxicity | Hepatocellular carcinoma | Lymphocytes T | CD28 antigen | Anticancer properties | Receptors | Interleukin 4 | Coding | Lymphocytes | Colony-stimulating factor | Antigens | CD19 antigen | Cytokines | Granulocyte-macrophage colony-stimulating factor | Tumor cell lines | Automobiles | Domains | Chimeric antigen receptors | Lymphocytes B | Interleukin 10 | Heparan sulfate proteoglycans | Antitumor activity | Interferon | Solid tumors | Tumors | Index Medicus | Review
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7. Full Text Efficient Non-Viral T-Cell Engineering by Sleeping Beauty Minicircles Diminishing DNA Toxicity and miRNAs Silencing the Endogenous T-Cell Receptors
by Clauss, Julian and Obenaus, Matthias and Miskey, Csaba and Ivics, Zoltán and Izsvák, Zsuzsanna and Uckert, Wolfgang and Bunse, Mario
Human gene therapy, ISSN 1043-0342, 05/2018, Volume 29, Issue 5, pp. 569 - 584
Research Articles | transposon | minicircle vector | Sleeping Beauty | immunotherapy | T-cell engineering | TCR gene therapy | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Humans | Gene Expression Regulation, Neoplastic | Receptors, Antigen, T-Cell - therapeutic use | Cell Survival - genetics | Flow Cytometry | Interleukin-2 Receptor alpha Subunit - genetics | CD28 Antigens - genetics | Melanoma - genetics | Transposases - genetics | DNA Transposable Elements - genetics | Receptors, Antigen, T-Cell - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Immunotherapy, Adoptive - methods | CD28 Antigens - immunology | Cell Survival - immunology | Genetic Vectors - genetics | CD28 Antigens - therapeutic use | Melanoma - immunology | Cell Line, Tumor | Interferon Type I - genetics | Cell Engineering | T-Lymphocytes - immunology | Interleukin-2 Receptor alpha Subunit - therapeutic use | MicroRNAs - genetics | Receptors, Antigen, T-Cell - genetics | Melanoma - therapy | Toxicity | β-Interferon | Clinical trials | Transgenic | Chains | Stimulation | Lymphocytes T | CD28 antigen | T-cell receptor | Receptors | Transfection | Lymphocytes | Immunotherapy | CD25 antigen | Deoxyribonucleic acid--DNA | Medical research | Antigens | Transposons | T cell receptors | Gene expression | Transposase | Ribonucleic acid--RNA | Delayed response | Genetic engineering | Interferon | Index Medicus
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8. Full Text Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells
by Zhao, Zeguo and Condomines, Maud and van der Stegen, Sjoukje J.C and Perna, Fabiana and Kloss, Christopher C and Gunset, Gertrude and Plotkin, Jason and Sadelain, Michel
Cancer cell, ISSN 1535-6108, 10/2015, Volume 28, Issue 4, pp. 415 - 428
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Hematologic Neoplasms - therapy | Immunotherapy, Adoptive | Receptors, Antigen - immunology | Signal Transduction | Humans | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | CD28 Antigens - immunology | Hematologic Neoplasms - pathology | Recombinant Proteins - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Interferon-gamma - metabolism | Interferon Regulatory Factor-7 - metabolism | Lymphocyte Activation - immunology | CD28 Antigens - genetics | Recombinant Proteins - immunology | CD28 Antigens - biosynthesis | T-Lymphocytes - immunology | Antigens, CD19 - metabolism | Hematologic Neoplasms - immunology | Kinetics | T-Lymphocytes - pathology | Receptors, Antigen - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - biosynthesis | Antigens, CD19 - immunology | T cells | Tumors | Antigens | Index Medicus
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9. Full Text ICOS-based chimeric antigen receptors program bipolar TH17/ TH1 cells
by Guedan, Sonia and Chen, Xi and Madar, Aviv and Carpenito, Carmine and McGettigan, Shannon E and Frigault, Matthew J and Lee, Jihyun and Posey Jr, Avery D and Scholler, John and Scholler, Nathalie and Bonneau, Richard and June, Carl H
Blood, ISSN 0006-4971, 08/2014, Volume 124, Issue 7, pp. 1070 - 1080
Recombinant Fusion Proteins - immunology | Humans | Interleukin-17 - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Th1 Cells - immunology | Recombinant Fusion Proteins - metabolism | Interleukins - metabolism | CD28 Antigens - metabolism | Th1 Cells - metabolism | Signal Transduction - immunology | CD3 Complex - genetics | Flow Cytometry | CD28 Antigens - genetics | Th17 Cells - metabolism | Interleukins - immunology | Receptors, Antigen, T-Cell - immunology | Inducible T-Cell Co-Stimulator Protein - immunology | Immunotherapy, Adoptive - methods | Receptors, Antigen, T-Cell - metabolism | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Cells, Cultured | CD28 Antigens - immunology | Signal Transduction - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism | Mice, SCID | CD3 Complex - metabolism | Interleukin Receptor Common gamma Subunit - genetics | Mice, Knockout | Xenograft Model Antitumor Assays | Interleukin-17 - metabolism | Animals | CD3 Complex - immunology | K562 Cells | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Th17 Cells - immunology | Mice, Inbred NOD | Receptors, Antigen, T-Cell - genetics | Inducible T-Cell Co-Stimulator Protein - metabolism | Index Medicus | Abridged Index Medicus | 12 | Gene Therapy | 9
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10. Full Text Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40
by Foster, Aaron E and Mahendravada, Aruna and Shinners, Nicholas P and Chang, Wei-Chun and Crisostomo, Jeannette and Lu, An and Khalil, Mariam and Morschl, Eva and Shaw, Joanne L and Saha, Sunandan and Duong, MyLinh T and Collinson-Pautz, Matthew R and Torres, David L and Rodriguez, Tania and Pentcheva-Hoang, Tsvetelina and Bayle, J. Henri and Slawin, Kevin M and Spencer, David M
Molecular therapy, ISSN 1525-0016, 09/2017, Volume 25, Issue 9, pp. 2176 - 2188
CD40 | inducible | costimulation | T cell | chimeric antigen receptor | dimerizer | MyD88 | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cell Proliferation | Humans | Gene Expression Profiling | Leukemia - metabolism | Recombinant Fusion Proteins | CD28 Antigens - metabolism | Lymphocyte Activation - immunology | CD40 Antigens - metabolism | CD28 Antigens - genetics | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD40 Antigens - genetics | Toll-Like Receptors - metabolism | Leukemia - genetics | Disease Models, Animal | Immunotherapy, Adoptive - methods | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Cell Survival | Leukemia - therapy | Xenograft Model Antitumor Assays | Animals | Leukemia - immunology | Lymphocyte Activation - drug effects | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Cluster Analysis | Cell proliferation | Antigens | Graft-versus-host reaction | CD40 antigen | Cell survival | Cytokines | CD8 antigen | Cytotoxicity | T cell receptors | Lymphocytes T | Gene expression | Kinases | Adoptive transfer | CD4 antigen | Chimeric antigen receptors | Cell growth | Cell activation | Lymphocytes | Toll-like receptors | MyD88 protein | Tumor necrosis factor-TNF | Ligands | Software | Tumors | Index Medicus | Original
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