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cd28-mediated costimulation (35) 35
index medicus (32) 32
immunology (31) 31
animals (24) 24
humans (21) 21
mice (19) 19
phosphatidylinositol 3-kinase (16) 16
cd28 antigens - genetics (14) 14
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phosphorylation (9) 9
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cutting edge (8) 8
lymphocyte activation (8) 8
signal transduction - immunology (8) 8
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in-vivo (7) 7
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phosphatidylinositol 3-kinases - metabolism (7) 7
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expression (6) 6
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mice, inbred c57bl (6) 6
mice, knockout (6) 6
phosphatidylinositol 3-kinase association (6) 6
receptor cd28 (6) 6
amino acid sequence (5) 5
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cell line (5) 5
co-stimulation (5) 5
immunological synapse (5) 5
interleukin-2 - biosynthesis (5) 5
molecular sequence data (5) 5
phosphoinositide 3-kinase (5) 5
receptors, antigen, t-cell - metabolism (5) 5
t-lymphocytes - metabolism (5) 5
b-cells (4) 4
biochemistry & molecular biology (4) 4
cd28 antigen (4) 4
cd28 costimulation (4) 4
cd28-deficient mice (4) 4
cd8-positive t-lymphocytes - immunology (4) 4
cell proliferation (4) 4
ctla-4 (4) 4
immunologic memory (4) 4
lymphocyte activation - immunology (4) 4
mice, inbred balb c (4) 4
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mutation (4) 4
nf-kappa b - metabolism (4) 4
phosphatidylinositol 3-kinases - physiology (4) 4
protein-kinase-c (4) 4
receptor (4) 4
signal transduction - genetics (4) 4
signal-transduction (4) 4
t cells (4) 4
t-cells (4) 4
tyrosine - metabolism (4) 4
wortmannin (4) 4
adaptor proteins, signal transducing - metabolism (3) 3
antibodies, monoclonal - pharmacology (3) 3
antigen receptor (3) 3
antigen-presenting cells - immunology (3) 3
antigens, cd - metabolism (3) 3
b7-1 antigen - metabolism (3) 3
b7-2 antigen (3) 3
bcl-x-l (3) 3
cd28 antigens - biosynthesis (3) 3
cd4-positive t-lymphocytes - immunology (3) 3
cell biology (3) 3
chemical and pharmacologic phenomena (3) 3
chronic disease (3) 3
cycle progression (3) 3
cytoplasmic tail (3) 3
dendritic cells (3) 3
enzyme activation - genetics (3) 3
enzyme activation - immunology (3) 3
extracellular signal-regulated map kinases - metabolism (3) 3
hematology (3) 3
il-2 production (3) 3
male (3) 3
protein structure, tertiary (3) 3
protein-kinase-b (3) 3
survival (3) 3
t-cell-activation (3) 3
t-lymphocyte subsets - immunology (3) 3
tumor cells, cultured (3) 3
tyrosine phosphorylation (3) 3
adapter protein (2) 2
adjuvants, immunologic - physiology (2) 2
adult (2) 2
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BLOOD, ISSN 0006-4971, 02/2008, Volume 111, Issue 3, pp. 1464 - 1471
Activation of PI3K is among the earliest signaling events observed in T cells after conjugate formation with antigen-presenting cells (APCs). The relevant PI3K... 
CYTOPLASMIC DOMAIN | CD28-MEDIATED COSTIMULATION | CD28-DEFICIENT MICE | PHOSPHATIDYLINOSITOL 3-KINASE ASSOCIATION | D-3 PHOSPHOINOSITIDES | SKIN ALLOGRAFT-REJECTION | IMMUNOLOGICAL SYNAPSE | HEMATOLOGY | PHOSPHOINOSITIDE 3-KINASE | ANTIGEN RECEPTOR | CUTTING EDGE
Journal Article
The Journal of Immunology, ISSN 0022-1767, 01/2001, Volume 166, Issue 1, pp. 284 - 292
The optimal activation of cAMP-responsive element binding protein (CREB), similar to the full activation of T lymphocytes, requires the stimulation of both CD3... 
IL-2 PRODUCTION | CAMP INHIBITION | TRANSCRIPTION FACTOR CREB | CD28-MEDIATED COSTIMULATION | PHOSPHATIDYLINOSITOL 3-KINASE | N-TERMINAL KINASE | GENE-EXPRESSION | T-CELL ACTIVATION | KAPPA-B | NUCLEAR FACTOR | IMMUNOLOGY | Phosphorylation | T-Lymphocytes - enzymology | Humans | Transcriptional Activation - immunology | MAP Kinase Signaling System - immunology | Enzyme Activation - immunology | Signal Transduction - immunology | MAP Kinase Signaling System - genetics | Transfection | T-Lymphocytes - metabolism | Tumor Cells, Cultured | p38 Mitogen-Activated Protein Kinases | CD28 Antigens - physiology | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Calcium - pharmacology | Jurkat Cells | CREB-Binding Protein | Enzyme Inhibitors - pharmacology | Nuclear Proteins - metabolism | Signal Transduction - genetics | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Enzyme Activation - drug effects | Serine - metabolism | Drug Synergism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | Signal Transduction - drug effects | CD3 Complex - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | T-Lymphocytes - immunology | Trans-Activators - metabolism | Mice | Enzyme Activation - genetics | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinases - metabolism | CD28 antigen | CRB protein | CD3 antigen | Index Medicus | Abridged Index Medicus
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/1999, Volume 163, Issue 3, pp. 1334 - 1341
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2003, Volume 171, Issue 1, pp. 166 - 174
Ligation of either CD28 or inducible costimulatory protein (ICOS) produces a second signal required for optimal T cell activation and proliferation. One... 
CYTOPLASMIC DOMAIN | NUCLEAR IMPORT | CENTRAL DNA FLAP | CD28-MEDIATED COSTIMULATION | CELL ACTIVATION | LENTIVIRUS VECTOR | RECEPTOR CD28 | INTERLEUKIN-2 SECRETION | IMMUNOLOGY | PHOSPHOINOSITIDE 3-KINASE | MOLECULE ICOS
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 05/2001, Volume 166, Issue 9, pp. 5331 - 5335
CD28 provides an important costimulatory signal in T cell activation that regulates multiple cellular processes including proliferation and survival. Several... 
SURVIVAL | REQUIREMENTS | ACTIVATION | PROTEIN-KINASE-B | MOLECULE CD28 | CD28-MEDIATED COSTIMULATION | PHOSPHATIDYLINOSITOL 3-KINASE ASSOCIATION | IMMUNOLOGY | PHOSPHOINOSITIDE 3-KINASE | EXPRESSION | WORTMANNIN
Journal Article
International Immunology, ISSN 0953-8178, 12/2008, Volume 20, Issue 12, pp. 1507 - 1515
CD28 stimulation contributes to activation of the IL-2 promoter by up-regulating the activity of several transcription factors, including nuclear factor κB... 
Signal transduction | Transcription factors | Co-stimulation | T cells | SIGNAL-TRANSDUCTION | CYTOPLASMIC DOMAIN | REGULATOR | CD28-MEDIATED COSTIMULATION | PHOSPHORYLATION | CARMA1 | T-CELL-ACTIVATION | BCL10 | IMMUNOLOGY | PKC-THETA | REQUIREMENT
Journal Article
Journal Article
TRENDS IN IMMUNOLOGY, ISSN 1471-4906, 09/2001, Volume 22, Issue 9, pp. 490 - 496
Phosphoinositide 3-kinases (PI 3-Ks) phosphorylate the D3-hydroxyl position of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P-2] resulting in the... 
PROTEIN-KINASE-B | CD28-MEDIATED COSTIMULATION | PATHWAY | PHOSPHATIDYLINOSITOL 3-KINASE | CD28 | PTEN | TUMOR-SUPPRESSOR | INTERLEUKIN-2 RECEPTOR | IMMUNOLOGY | PHOSPHOINOSITIDE 3-KINASE | WORTMANNIN
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 10, pp. 2121 - 2130
Journal Article