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Science, ISSN 0036-8075, 2/1993, Volume 259, Issue 5096, pp. 822 - 825
Journal Article
Blood, ISSN 0006-4971, 08/2014, Volume 124, Issue 7, pp. 1070 - 1080
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 393 - 409
THEMIS is critical for conventional T‐cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates... 
SHP1 | THEMIS | apoptosis | TCR | negative feedback | ACTIVATION | TCR SIGNALING THRESHOLDS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE PHOSPHATASES | RECEPTOR | SHP-1 | THYMOCYTE POSITIVE SELECTION | CELL BIOLOGY | GENE | PROTEOMICS FACILITIES PIPELINE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Cell Survival - genetics | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Cell Differentiation - genetics | Multiprotein Complexes - metabolism | CD3 Complex - genetics | T-Lymphocytes - metabolism | GRB2 Adaptor Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Jurkat Cells | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | CD3 Complex - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Mice, Knockout | src Homology Domains | Proteins - genetics | Animals | Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | T-Lymphocytes - cytology | Mice | Receptors, Antigen, T-Cell - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | GRB2 Adaptor Protein - metabolism | Ligands | Phosphorylation | T cell receptors | Phosphatase | Immune system
Journal Article
Nature Genetics, ISSN 1061-4036, 2010, Volume 42, Issue 5, pp. 426 - 429
Journal Article
Leukemia, ISSN 0887-6924, 04/2004, Volume 18, Issue 4, pp. 676 - 684
To develop a therapy for drug-resistant B-lineage acute lymphoblastic leukemia (ALL), we transduced T lymphocytes with anti-CD19 chimeric receptors, consisting... 
T-cell receptor | CD137 | Acute lymphoblastic leukemia | B-cell lymphoma | STEM-CELLS | ALLOGENEIC CELL THERAPY | DONOR LEUKOCYTE INFUSIONS | BONE-MARROW-TRANSPLANTATION | VERSUS-HOST DISEASE | ONCOLOGY | acute lymphoblastic leukemia | IN-VIVO | GENE-TRANSFER | HEMATOLOGY | B-LINEAGE LEUKEMIA | T-CELLS | LYMPHOCYTES | Cytotoxicity Tests, Immunologic | Recombinant Fusion Proteins - pharmacology | CD8 Antigens - pharmacology | Coculture Techniques | Humans | Tumor Necrosis Factor Receptor Superfamily, Member 9 | Receptors, Tumor Necrosis Factor - therapeutic use | Burkitt Lymphoma - pathology | Immunoconjugates - pharmacology | CD3 Complex - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy | T-Lymphocytes - metabolism | Immunotherapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Receptors, Nerve Growth Factor - therapeutic use | Antigens, CD19 - immunology | Receptors, Tumor Necrosis Factor - genetics | Burkitt Lymphoma - therapy | Protein Structure, Tertiary | Transduction, Genetic | CD3 Complex - pharmacology | Receptors, Nerve Growth Factor - genetics | CD8 Antigens - chemistry | T-Lymphocytes - cytology | Immunoconjugates - genetics | CD8 Antigens - genetics | Immunoglobulin Variable Region - pharmacology | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Immunoglobulin Variable Region - genetics | T-Lymphocytes - immunology | CD3 Complex - chemistry | Antigens, CD
Journal Article
Blood, ISSN 0006-4971, 04/2017, Volume 129, Issue 17, pp. 2395 - 2407
We and others previously reported potent antileukemia efficacy of CD123-redirected chimeric antigen receptor (CAR) T cells in preclinical human acute myeloid... 
MULTIPLE-MYELOMA | GEMTUZUMAB OZOGAMICIN | THERAPY | B-CELL | SAFETY | ACUTE LYMPHOBLASTIC-LEUKEMIA | INTERNATIONAL EXPERT PANEL | IN-VIVO | HEMATOLOGY | SUICIDE-GENE | GROUP TRIAL AAML0531 | Recombinant Fusion Proteins - immunology | RNA, Messenger - immunology | Humans | Male | Transplantation, Heterologous | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Leukemia, Myeloid, Acute - immunology | Lymphocyte Depletion | T-Lymphocytes - transplantation | Lentivirus - metabolism | CD3 Complex - genetics | T-Lymphocytes - drug effects | Antibodies, Monoclonal, Humanized - pharmacology | Female | Lentivirus - genetics | Receptors, Antigen, T-Cell - immunology | Leukemia, Myeloid, Acute - therapy | Antigens, CD20 - immunology | Gene Expression | Immunotherapy, Adoptive - methods | Genetic Vectors - chemistry | Leukemia, Myeloid, Acute - pathology | RNA, Messenger - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Genetic Vectors - metabolism | Hematopoietic Stem Cell Transplantation | RNA, Antisense - immunology | Treatment Outcome | Alemtuzumab | Remission Induction | Antigens, CD20 - genetics | Rituximab - pharmacology | Xenograft Model Antitumor Assays | Animals | T-Lymphocytes - cytology | Interleukin-3 Receptor alpha Subunit - genetics | Interleukin-3 Receptor alpha Subunit - immunology | CD3 Complex - immunology | Recombinant Fusion Proteins - genetics | Mice, Inbred NOD | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Interleukin-3 Receptor alpha Subunit - antagonists & inhibitors | Leukemia, Myeloid, Acute - genetics | RNA, Antisense - genetics | Immunobiology
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2005, Volume 11, Issue 23, pp. 8326 - 8331
Purpose: The forkhead box transcription factor FoxP3 is specifically expressed in T cells with regulatory properties (Treg). Recently, high numbers of Treg... 
Regulatory T cells | FoxP3 | Ovarian cancer | B-CELLS | LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | DISEASE | IMMUNOLOGICAL SELF-TOLERANCE | PERIPHERAL-BLOOD | INDUCTION | TUMOR-IMMUNITY | INHIBIT | PROGRESSION | Prognosis | Receptor, ErbB-2 - genetics | Adenocarcinoma, Mucinous - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Receptor, ErbB-2 - metabolism | Suppressor of Cytokine Signaling 1 Protein | Intracellular Signaling Peptides and Proteins - metabolism | Cystadenocarcinoma, Serous - genetics | Interferon-gamma - metabolism | Cystadenocarcinoma, Serous - pathology | RNA, Messenger - metabolism | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | Ovarian Neoplasms - genetics | CD3 Complex - genetics | Forkhead Transcription Factors - metabolism | Biomarkers, Tumor - metabolism | Female | Interferon-gamma - genetics | Cystadenocarcinoma, Serous - immunology | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Repressor Proteins - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Survival Rate | Adenocarcinoma, Mucinous - immunology | Forkhead Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | CD3 Complex - metabolism | Interferon Regulatory Factor-1 - genetics | Nitric Oxide Synthase Type II - genetics | Aged | Biomarkers, Tumor - genetics | Adenocarcinoma, Mucinous - genetics | Suppressor of Cytokine Signaling Proteins - metabolism | Neoplasm Staging | Interferon Regulatory Factor-1 - metabolism | Nitric Oxide Synthase Type II - metabolism | Ovarian Neoplasms - immunology
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 2, pp. 351 - 359.e1
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2015, Volume 194, Issue 7, pp. 3201 - 3212
Journal Article