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Immunology, ISSN 0019-2805, 01/2018, Volume 153, Issue 1, pp. 42 - 50
Summary The T‐cell receptor (TCR)–CD3 complex, expressed on T cells, determines the outcome of a T‐cell response... 
protein–protein interaction | T‐cell receptor–CD3 complex | T‐cell activation | signal transduction | T-cell activation | T-cell receptor–CD3 complex | TCR | ACTIVATION | ADAPTER PROTEINS | PHOSPHORYLATION | TYROSINE KINASE | IMMUNOLOGY | ALDRICH-SYNDROME PROTEIN | ZAP-70 | CONFORMATIONAL-CHANGES | LCK | PROLINE-RICH SEQUENCE | protein-protein interaction | T-cell receptor-CD3 complex | T-Lymphocyte Subsets - immunology | Receptors, Antigen, T-Cell - chemistry | Humans | Receptor-CD3 Complex, Antigen, T-Cell - chemistry | Receptor-CD3 Complex, Antigen, T-Cell - metabolism | CD3 Complex - genetics | Wiskott-Aldrich Syndrome Protein - metabolism | ZAP-70 Protein-Tyrosine Kinase - metabolism | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Oncogene Proteins - metabolism | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | CD3 Complex - metabolism | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | T-Lymphocyte Subsets - metabolism | Protein Binding | Receptors, Antigen, T-Cell - genetics | CD3 Complex - chemistry | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Cellular signal transduction | T cells | Protein-protein interactions | Drugs | Antigens | Immunomodulation | Transplants | T cell receptors | Lymphocytes T | CD3 antigen | ZAP-70 protein | Drug development | Cytosol | Recruitment | T-cell receptor | Signaling | Major histocompatibility complex | Lymphocytes | Lck protein | NUMB protein | Dimers | Autoimmune diseases | Review
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 393 - 409
.... This complex requires the adapter GRB2, which bridges SHP to THEMIS in a Tyr‐phosphorylation‐independent fashion. Rather, SHP1 and THEMIS engage with the N... 
SHP1 | THEMIS | apoptosis | TCR | negative feedback | ACTIVATION | TCR SIGNALING THRESHOLDS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE PHOSPHATASES | RECEPTOR | SHP-1 | THYMOCYTE POSITIVE SELECTION | CELL BIOLOGY | GENE | PROTEOMICS FACILITIES PIPELINE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Cell Survival - genetics | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Cell Differentiation - genetics | Multiprotein Complexes - metabolism | CD3 Complex - genetics | T-Lymphocytes - metabolism | GRB2 Adaptor Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Jurkat Cells | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | CD3 Complex - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Mice, Knockout | src Homology Domains | Proteins - genetics | Animals | Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | T-Lymphocytes - cytology | Mice | Receptors, Antigen, T-Cell - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | GRB2 Adaptor Protein - metabolism | Ligands | Phosphorylation | T cell receptors | Phosphatase | Immune system
Journal Article
The Journal of Physiology, ISSN 0022-3751, 2004, Volume 556, Issue 3, pp. 983 - 1000
Muscular adaptation to physical exercise has previously been described as a repair process following tissue damage. Recently, evidence has been published to... 
INDUCED INJURY | PHYSIOLOGY | IMMUNOREACTIVITY | ECCENTRIC EXERCISE | REGENERATION | LEUKEMIA INHIBITORY FACTOR | DENERVATED HUMAN MUSCLE | SATELLITE CELLS | STRENGTH | FACTOR-I | EXPRESSION | NEUROSCIENCES | Immunohistochemistry | Granulocytes - cytology | Cytokines - analysis | Humans | Middle Aged | DNA-Binding Proteins - analysis | Ki-67 Antigen - metabolism | Male | Muscle, Skeletal - metabolism | Proteins - analysis | Pain - metabolism | fas Receptor - metabolism | Fascia - chemistry | Oxygen Consumption - physiology | fas Receptor - analysis | Antigens, CD - metabolism | Antigens, CD - analysis | Running - physiology | C-Reactive Protein - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator | CD11b Antigen - analysis | Receptors, Cytokine - metabolism | Testosterone - blood | C-Reactive Protein - analysis | Hormones - blood | Leukocytes - chemistry | Interleukin-6 - metabolism | Lymphocytes - metabolism | CD56 Antigen - analysis | Lymphocytes - cytology | Insulin-Like Growth Factor I - analysis | Muscle, Skeletal - physiology | CD3 Complex - metabolism | Leukemia Inhibitory Factor Receptor alpha Subunit | Regression Analysis | Pain - physiopathology | Receptors, Cytokine - analysis | Adolescent | Antigens, Differentiation, Myelomonocytic - analysis | Creatine Kinase - metabolism | Transcription Factors - analysis | Leukocytes - metabolism | Insulin-Like Growth Factor I - metabolism | Receptors, OSM-LIF | Interleukin-6 - analysis | Monocytes - cytology | Receptors, Cell Surface - analysis | Monocytes - metabolism | Receptors, Aryl Hydrocarbon - analysis | DNA-Binding Proteins - metabolism | Testosterone - metabolism | Flow Cytometry | Interleukin-6 - blood | Exercise Test - methods | Muscle, Skeletal - chemistry | Fascia - metabolism | Heart Rate - physiology | Receptors, Aryl Hydrocarbon - metabolism | Adult | Female | Leukocyte Count | Leukemia Inhibitory Factor | Isometric Contraction - physiology | Cytokines - blood | Leukocytes - cytology | CD56 Antigen - metabolism | Creatine Kinase - blood | Cytokines - metabolism | Receptors, Cell Surface - metabolism | Transcription Factors - metabolism | CD3 Complex - analysis | Ki-67 Antigen - analysis | Proteins - metabolism | Hormones - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | CD11b Antigen - metabolism | Growth Substances - metabolism | Pain - diagnosis | Research Papers
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 38, Issue 3, pp. 596 - 605
T follicular helper (Tfh) cells provide help to B cells and are crucial for establishment of germinal center (GC) reactions, including production of... 
CXC CHEMOKINE RECEPTOR-5 | DENDRITIC CELLS | BCL6 | ANTIBODY-PRODUCTION | IN-VIVO DEPLETION | IMMUNE-RESPONSES | DYNAMICS | GENERATION | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | Ovalbumin - immunology | Germinal Center - immunology | Humans | CD40 Ligand - immunology | CD3 Complex - genetics | CD40 Antigens - metabolism | CD40 Ligand - metabolism | Flow Cytometry | Inducible T-Cell Co-Stimulator Ligand - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Antibodies - immunology | B-Lymphocytes - metabolism | Inducible T-Cell Co-Stimulator Protein - immunology | Inducible T-Cell Co-Stimulator Ligand - immunology | Receptors, CXCR5 - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Receptors, CXCR5 - genetics | Immunization - methods | Mice, Inbred C57BL | Immunophenotyping | Mice, Transgenic | Protein Binding - immunology | CD3 Complex - metabolism | Receptors, CXCR5 - immunology | Mice, Knockout | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Ovalbumin - administration & dosage | CD3 Complex - immunology | Cell Line, Tumor | Lymphocyte Count | Antigens - immunology | Luminescent Proteins - genetics | Mice | Inducible T-Cell Co-Stimulator Protein - metabolism | CD40 Antigens - immunology | Luminescent Proteins - metabolism | Antigen-antibody reactions | Antigens | Genetic aspects | Genotype & phenotype | Rodents | Software | Experiments | Chemokines | Immune system
Journal Article
Blood, ISSN 0006-4971, 02/2009, Volume 113, Issue 7, pp. 1526 - 1534
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 04/2010, Volume 30, Issue 7, pp. 1660 - 1672
Journal Article
Clinical and experimental immunology, ISSN 0009-9104, 2010, Volume 162, Issue 1, pp. 100 - 107
Summary Pyoderma gangrenosum (PG) is a rare, immune‐mediated inflammatory skin disease presenting with painful ulcers having undermined edges. Less commonly,... 
cytokines | pyoderma gangrenosum | matrix metalloproteinases | neutrophilic dermatoses | Sweet's syndrome | INTERLEUKIN-17 | PYODERMA-GANGRENOSUM | SWEETS-SYNDROME | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | EXPRESSION | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Humans | Middle Aged | Male | Vascular Endothelial Growth Factor A - metabolism | Antigens, CD - metabolism | Young Adult | Matrix Metalloproteinase 9 - metabolism | Sweet Syndrome - metabolism | Inflammation Mediators - metabolism | Adult | Female | Interleukin-8 - metabolism | Neutrophils - metabolism | Neutrophils - pathology | Pyoderma Gangrenosum - metabolism | Cytokines - metabolism | Matrix Metalloproteinase 2 - metabolism | Receptors, Cell Surface - metabolism | Sweet Syndrome - pathology | CD3 Complex - metabolism | Pyoderma Gangrenosum - pathology | Interleukin-17 - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Adolescent | Aged | Matrix Metalloproteinases - metabolism | Peroxidase - metabolism | Skin diseases | Cytokines | T cells | Macrophages | Vascular endothelial growth factor | Wounds | CD3 antigen | Inflammation | Leukocytes (neutrophilic) | Lymphocytes T | Matrix metalloproteinase | Gelatinase B | Inflammatory diseases | Interleukin 17 | Gelatinase A | CD163 antigen | Ulcers | Peroxidase | Immunoreactivity | Chemokines | Interleukin 8 | Tumor necrosis factor- alpha | Translational Studies
Journal Article
International immunology, ISSN 1460-2377, 2007, Volume 19, Issue 4, pp. 345 - 354
Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4+CD25+ T regulatory cells (nTregs). In mice, expression... 
INTERLEUKIN-2 | TGF-BETA | T cell activation | transcription factors | INDUCTION | IMMUNOLOGY | T cells | REGULATORY-CELLS | TRANSCRIPTION FACTOR FOXP3 | COSTIMULATION | GENERATION | FLOW-CYTOMETRY | DIFFERENTIATION | human | EXPRESSION | tolerance | T-Lymphocyte Subsets - immunology | Cysteine - analogs & derivatives | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Coculture Techniques | Humans | Clonal Anergy | Receptors, Nerve Growth Factor - metabolism | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flagellin - pharmacology | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | T-Lymphocyte Subsets - drug effects | Cysteine - pharmacology | Antigens, Differentiation - metabolism | Interleukin-2 - metabolism | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Cytokines - metabolism | Lectins, C-Type | Toll-Like Receptors - immunology | CD4-Positive T-Lymphocytes - metabolism | Glucocorticoid-Induced TNFR-Related Protein | Antigens, Differentiation, T-Lymphocyte - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | CTLA-4 Antigen | T-Lymphocytes, Regulatory - drug effects | Interleukin-2 Receptor alpha Subunit - metabolism | Lipoproteins - pharmacology | T-Lymphocyte Subsets - metabolism | Interleukin-7 Receptor alpha Subunit - metabolism | CD3 Complex - immunology | Interleukin-2 - pharmacology | CD4-Positive T-Lymphocytes - drug effects
Journal Article