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Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 596 - 605
T follicular helper (Tfh) cells provide help to B cells and are crucial for establishment of germinal center (GC) reactions, including production of... 
CXC CHEMOKINE RECEPTOR-5 | DENDRITIC CELLS | BCL6 | ANTIBODY-PRODUCTION | IN-VIVO DEPLETION | IMMUNE-RESPONSES | DYNAMICS | GENERATION | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | Ovalbumin - immunology | Germinal Center - immunology | Humans | CD40 Ligand - immunology | CD3 Complex - genetics | CD40 Antigens - metabolism | CD40 Ligand - metabolism | Flow Cytometry | Inducible T-Cell Co-Stimulator Ligand - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Antibodies - immunology | B-Lymphocytes - metabolism | Inducible T-Cell Co-Stimulator Protein - immunology | Inducible T-Cell Co-Stimulator Ligand - immunology | Receptors, CXCR5 - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Receptors, CXCR5 - genetics | Immunization - methods | Mice, Inbred C57BL | Immunophenotyping | Mice, Transgenic | Protein Binding - immunology | CD3 Complex - metabolism | Receptors, CXCR5 - immunology | Mice, Knockout | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Ovalbumin - administration & dosage | CD3 Complex - immunology | Cell Line, Tumor | Lymphocyte Count | Antigens - immunology | Luminescent Proteins - genetics | Mice | Inducible T-Cell Co-Stimulator Protein - metabolism | CD40 Antigens - immunology | Luminescent Proteins - metabolism | Antigen-antibody reactions | Antigens | Genetic aspects | Genotype & phenotype | Rodents | Software | Experiments | Chemokines | Immune system | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 08/2014, Volume 124, Issue 7, pp. 1070 - 1080
Journal Article
Journal Article
Brain, ISSN 0006-8950, 2011, Volume 134, Issue 3, pp. 678 - 692
Inflammation and oxidative stress are thought to promote tissue damage in multiple sclerosis. Thus, novel therapeutics enhancing cellular resistance to free... 
oral therapy | transcription factor | autoimmune demyelination | multiple sclerosis | neuroprotection | astrocyte | oxidative stress | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ENZYME INDUCERS | DIMETHYLFUMARATE | SPINAL-CORD | NEUROSCIENCES | HUMAN ENDOTHELIAL-CELLS | CLINICAL NEUROLOGY | RESPONSE ELEMENT | TRANSCRIPTION FACTOR NRF2 | MULTIPLE-SCLEROSIS | IN-VIVO | Embryo, Mammalian | Antioxidants - metabolism | Humans | Green Fluorescent Proteins - genetics | Neuroprotective Agents - pharmacology | Time Factors | Statistics, Nonparametric | Aldehyde Reductase - metabolism | Nogo Proteins | Sleep - physiology | Tandem Mass Spectrometry - methods | Disease Models, Animal | Fumarates - therapeutic use | Myelin-Oligodendrocyte Glycoprotein | Glycoproteins - adverse effects | CD3 Complex - metabolism | Motor Neurons - metabolism | Signal Transduction - drug effects | Axons - pathology | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Mice | Peptide Fragments - adverse effects | Oxidative Stress - drug effects | Myelin Proteins - metabolism | Neuroprotective Agents - therapeutic use | Chromatography, High Pressure Liquid - methods | Encephalomyelitis, Autoimmune, Experimental - etiology | Transfection | Astrocytes - immunology | Mass Spectrometry | Motor Neurons - cytology | Antigens, Differentiation - metabolism | Female | Spinal Cord - cytology | Motor Neurons - drug effects | Multiple Sclerosis - metabolism | Astrocytes - drug effects | Cytokines - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Hydrogen Peroxide - pharmacology | Axons - metabolism | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | Gene Expression Regulation - drug effects | Animals | Multiple Sclerosis - pathology | NAD(P)H Dehydrogenase (Quinone) - metabolism | Cell Proliferation - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Blood, ISSN 0006-4971, 02/2009, Volume 113, Issue 7, pp. 1526 - 1534
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2012, Volume 18, Issue 7, pp. 1069 - 1076
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2008, Volume 14, Issue 20, pp. 6674 - 6682
Purpose: Immune dysfunction is well documented in renal cell carcinoma (RCC) patients and likely contributes to tumor evasion. This dysfunction includes a... 
Type-1/Type-2 responses | T-regulatory cells | FoxP3 | Immune dysfunction | HEPATOCELLULAR-CARCINOMA | INTERFERON-ALPHA | CANCER-PATIENTS | CYTOKINE PRODUCTION | DENDRITIC CELLS | TUMOR REJECTION | ONCOLOGY | IN-VIVO | PERIPHERAL-BLOOD | ANTITUMOR IMMUNITY | ENDOTHELIAL GROWTH-FACTOR | T-Lymphocytes, Regulatory - metabolism | Humans | Middle Aged | Kidney - immunology | Kidney Neoplasms - immunology | Male | Antineoplastic Agents - therapeutic use | Kidney Neoplasms - metabolism | Th2 Cells - immunology | Interferon-gamma - metabolism | Recombinant Proteins | Th1 Cells - immunology | Th2 Cells - drug effects | Carcinoma, Renal Cell - immunology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Kidney - metabolism | Female | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Th1 Cells - drug effects | Kidney - drug effects | Interleukin-4 - metabolism | CD4-Positive T-Lymphocytes - metabolism | CD3 Complex - metabolism | Th2 Cells - metabolism | Carcinoma, Renal Cell - metabolism | Interleukin-4 - immunology | Immunosuppression | T-Lymphocytes, Regulatory - drug effects | Interferon-gamma - immunology | CD3 Complex - immunology | Indoles - therapeutic use | Kidney Neoplasms - drug therapy | CD4-Positive T-Lymphocytes - drug effects | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 393 - 409
THEMIS is critical for conventional T‐cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates... 
THEMIS | apoptosis | TCR | SHP | negative feedback | SHP1 | ACTIVATION | TCR SIGNALING THRESHOLDS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE PHOSPHATASES | RECEPTOR | SHP-1 | THYMOCYTE POSITIVE SELECTION | CELL BIOLOGY | GENE | PROTEOMICS FACILITIES PIPELINE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Cell Survival - genetics | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Cell Differentiation - genetics | Multiprotein Complexes - metabolism | CD3 Complex - genetics | T-Lymphocytes - metabolism | GRB2 Adaptor Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Jurkat Cells | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | CD3 Complex - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Mice, Knockout | src Homology Domains | Proteins - genetics | Animals | Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | T-Lymphocytes - cytology | Mice | Receptors, Antigen, T-Cell - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | GRB2 Adaptor Protein - metabolism | Ligands | Phosphorylation | T cell receptors | Phosphatase | Immune system | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2015, Volume 112, Issue 19, pp. 6140 - 6145
Journal Article