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1. Full Text Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma
by Palumbo, Antonio and Chanan-Khan, Asher and Weisel, Katja and Nooka, Ajay K and Masszi, Tamas and Beksac, Meral and Spicka, Ivan and Hungria, Vania and Munder, Markus and Mateos, Maria V and Mark, Tomer M and Qi, Ming and Schecter, Jordan and Amin, Himal and Qin, Xiang and Deraedt, William and Ahmadi, Tahamtan and Spencer, Andrew and Sonneveld, Pieter and CASTOR Investigators
The New England journal of medicine, ISSN 0028-4793, 08/2016, Volume 375, Issue 8, pp. 754 - 766
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Recurrence | Dexamethasone - administration & dosage | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Dexamethasone - adverse effects | Drug Resistance, Neoplasm | Male | ADP-ribosyl Cyclase 1 - antagonists & inhibitors | Disease-Free Survival | Multiple Myeloma - drug therapy | Bortezomib - administration & dosage | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Bortezomib - adverse effects | Adult | Female | Aged | Infusions, Intravenous | Care and treatment | Usage | Bortezomib | Dexamethasone | Diagnosis | Multiple myeloma | Thrombocytopenia | Body weight | CD38 antigen | Monoclonal antibodies | Cytotoxicity | Drug therapy | Survival | Patients | Neutropenia | Index Medicus | Abridged Index Medicus
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2. Full Text Targeting of CD38 by the Tumor Suppressor miR-26a Serves as a Novel Potential Therapeutic Agent in Multiple Myeloma
by Hu, Yi and Liu, Huimin and Fang, Chuanfeng and Li, Chen and Xhyliu, Fjorela and Dysert, Hayley and Bodo, Juraj and Habermehl, Gabriel and Russell, Benjamin E and Li, Wenjun and Chappell, Marcia and Jiang, Xiaofeng and Ondrejka, Sarah L and Hsi, Eric D and Maciejewski, Jaroslaw P and Yi, Qing and Anderson, Kenneth C and Munshi, Nikhil C and Ao, Geyou and Valent, Jason N and Lin, Jianhong and Zhao, Jianjun
Cancer research (Chicago, Ill.), ISSN 0008-5472, 05/2020, Volume 80, Issue 10, pp. 2031 - 2044
Index Medicus | CD38 | multiple myeloma | miR-26a
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3. Full Text A cytosolic chaperone complex controls folding and degradation of type III CD38
by Wu, Yang and Zhang, Jingzi and Fang, Lei and Lee, Hon Cheung and Zhao, Yong Juan
The Journal of biological chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 11, pp. 4247 - 4258
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | ADP-ribosyl Cyclase 1 - metabolism | Cytosol - metabolism | Membrane Glycoproteins - metabolism | Humans | Protein Folding | HEK293 Cells | Index Medicus | cyclic ADP ribose (cADPR) | heat shock protein 90 (Hsp90) | lysosomal degradation | Hsp70-interacting protein (Hip) | Protein Synthesis and Degradation | cytosolic soluble CD38 | heat shock protein (HSP) | hsp70 | chaperone | CD38 | protein folding | protein degradation | type III CD38
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4. Full Text The ecto-enzyme CD38 is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells
by Cosker, François and Cheviron, Nathalie and Yamasaki, Michiko and Menteyne, Alexis and Lund, Frances E and Moutin, Marie-Jo and Galione, Antony and Cancela, Jose-Manuel
The Journal of biological chemistry, ISSN 0021-9258, 12/2010, Volume 285, Issue 49, pp. 38251 - 38259
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Cholagogues and Choleretics - pharmacology | ADP-ribosyl Cyclase 1 - genetics | Membrane Glycoproteins - metabolism | Calcium - metabolism | Calcium Signaling - physiology | Lysosomes - genetics | ADP-ribosyl Cyclase | Cholecystokinin - pharmacology | Lysosomes - enzymology | Rats | NADP - biosynthesis | Pancreas, Exocrine - enzymology | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Calcium Signaling - drug effects | NADP - analogs & derivatives | Nucleotidyltransferases - genetics | ADP-ribosyl Cyclase 1 - metabolism | Mice | Nucleotidyltransferases - metabolism | NADP - genetics | Index Medicus | Antigens, CD38 | Calcium | Biochemistry, Molecular Biology | Lysosomes | Pancreas, Exocrine | Life Sciences | Nucleotidyltransferases | Cholagogues and Choleretics | NADP | Cholecystokinin | Membrane Glycoproteins | Calcium Signaling | Enzymes | NAADP | Signal Transduction | CD38 | Calcium Intracellular Release | Pancreas
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5. Full Text CD38 and Anti-CD38 Monoclonal Antibodies in AL Amyloidosis: Targeting Plasma Cells and beyond
by Roccatello, Dario and Fenoglio, Roberta and Sciascia, Savino and Naretto, Carla and Rossi, Daniela and Ferro, Michela and Barreca, Antonella and Malavasi, Fabio and Baldovino, Simone
International journal of molecular sciences, ISSN 1422-0067, 06/2020, Volume 21, Issue 11, p. 4129
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Neonates | Immunomodulation | Fibrils | Multiple myeloma | Antibodies | Cytotoxicity | Chains | FDA approval | Cell surface | Investigations | Modulators | Fc receptors | Medical prognosis | Light chains | CD38 antigen | Plasma cells | Monoclonal antibodies | Amyloidosis | Natural killer cells | Immune system | Index Medicus | AL amyloidosis | CD38 | Isatuximab | anti-CD38 MoAb | Daratumumab
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6. Full Text Targeting CD38 suppresses induction and function of T regulatory cells to mitigate immunosuppression in multiple myeloma
by Feng, Xiaoyan and Zhang, Li and Acharya, Chirag and An, Gang and Wen, Kenneth and Qiu, Lugui and Munshi, Nikhil C and Tai, Yu-Tzu and Anderson, Kenneth C
Clinical cancer research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4290 - 4300
Life Sciences & Biomedicine | Oncology | Science & Technology | Plasma | CD8 antigen | Multiple myeloma | Bone marrow transplantation | Recovery of function | Leukocytes (mononuclear) | Lymphocytes T | Immunosuppressive agents | Killer cells | Lymphocytes | CD38 antigen | Interleukin 1 | Bone marrow | Peripheral blood mononuclear cells | CD25 antigen | Foxp3 protein | Inhibition | Natural killer cells | Immunoregulation | Patients | CD4 antigen | Immunosuppression | Experimental design | Interleukin 10 | Lysis | Monoclonal antibodies | Health risk assessment | Cancer | Index Medicus | IFNγ | CD107a | bone marrow stromal cells (BMSCs) | natural occurring Tregs (nTregs) | regulatory T (Treg) | CD38 | Isatuximab (Isa) (SAR650984) | PD1 | multiple myeloma (MM) | conventional T (Tcon) | tumor-induced Treg (iTregs)
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7. Full Text HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: Results of a randomized phase II exploratory clinical trial
by Ensoli, Fabrizio and Cafaro, Aurelio and Casabianca, Anna and Tripiciano, Antonella and Bellino, Stefania and Longo, Olimpia and Francavilla, Vittorio and Picconi, Orietta and Sgadari, Cecilia and Moretti, Sonia and Cossut, Maria Pavone R and Arancio, Angela and Orlandi, Chiara and Sernicola, Leonardo and Maggiorella, Maria T and Paniccia, Giovanni and Mussini, Cristina and Lazzarin, Adriano and Sighinolfi, Laura and Palamara, Guido and Gori, Andrea and Angarano, Gioacchino and Di Pietro, Massimo and Galli, Massimo and Mercurio, Vito S and Castelli, Francesco and Di Perri, Giovanni and Monini, Paolo and Magnani, Mauro and Garaci, Enrico and Ensoli, Barbara
Retrovirology, ISSN 1742-4690, 04/2015, Volume 12, Issue 1, pp. 33 - 33
HIV-1 | Tat protein | Proviral DNA | HLA-DR | CD8 | Antibodies | CD38 | Vaccine | T cells | HAART | Neutralization | Life Sciences & Biomedicine | Science & Technology | Virology | HIV Antibodies - blood | Follow-Up Studies | Immunoglobulin G - blood | Humans | Middle Aged | AIDS Vaccines - immunology | Acquired Immunodeficiency Syndrome - therapy | Male | Treatment Outcome | CD4 Lymphocyte Count | AIDS Vaccines - adverse effects | Viral Load | Leukocytes - immunology | Young Adult | Acquired Immunodeficiency Syndrome - immunology | Immunoglobulin M - blood | Adult | Female | Italy | tat Gene Products, Human Immunodeficiency Virus - immunology | AIDS Vaccines - administration & dosage | Antiretroviral Therapy, Highly Active - methods | Antibodies, Neutralizing - blood | Antiviral agents | Dendritic cells | Lymphocytes | Vaccination | DNA | Clinical trials | Homeostasis | HIV (Viruses) | Index Medicus
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8. Full Text Novel Insights in Anti-CD38 Therapy Based on CD38-Receptor Expression and Function: The Multiple Myeloma Model
by Zannetti, Beatrice Anna and Faini, Angelo Corso and Massari, Evita and Geuna, Massimo and Maffini, Enrico and Poletti, Giovanni and Cerchione, Claudio and Martinelli, Giovanni and Malavasi, Fabio and Lanza, Francesco
Cells (Basel, Switzerland), 12/2020, Volume 9, Issue 12, p. 2666
Antigens | Flow cytometry | Autografts | Enzymes | Adenosine | Dendritic cells | Immunomodulation | Leukemia | Multiple myeloma | Stem cell transplantation | Cytotoxicity | T cell receptors | Hematological diseases | Cell surface | Immunosuppressive agents | Proteasome inhibitors | Cell adhesion & migration | Chemotherapy | Lymphocytes | CD38 antigen | Monoclonal antibodies | Bone marrow | Index Medicus | plasmacells | CD38 | multiple myeloma | anti-CD38 monoclonal antibodies | bone marrow microenvironment | CD38 antigen expression in various tissues
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9. Full Text 2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships
by Deaton, David N and Haffner, Curt D and Henke, Brad R and Jeune, Michael R and Shearer, Barry G and Stewart, Eugene L and Stuart, J. Darren and Ulrich, John C
Bioorganic & medicinal chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 8, pp. 2107 - 2150
NAD | CD38 inhibitor | Nicotinamide adenine dinucleotide | CD38 | NAD glycohydrolase | Medicine, Experimental | Quinoline | Medical research | Analysis | Index Medicus
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10. Full Text Class 1 HDAC and HDAC6 inhibition inversely regulates CD38 induction in myeloma cells via interferon‐α and ATRA
by Bat‐Erdene, Ariunzaya and Nakamura, Shingen and Oda, Asuka and Iwasa, Masami and Teramachi, Jumpei and Ashtar, Mohannad and Harada, Takeshi and Miki, Hirokazu and Tenshin, Hirofumi and Hiasa, Masahiro and Fujii, Shiro and Sogabe, Kimiko and Oura, Masahiro and Udaka, Kengo and Kagawa, Kumiko and Yoshida, Sumiko and Aihara, Ken‐ichi and Kurahashi, Kiyoe and Endo, Itsuro and Abe, Masahiro
British journal of haematology, ISSN 0007-1048, 06/2019, Volume 185, Issue 5, pp. 969 - 974
CD38 | multiple myeloma | HDAC inhibition | ATRA | interferon‐α | interferon-α | Life Sciences & Biomedicine | Hematology | Science & Technology | Histone deacetylase | Interferon | Myeloma | CD38 antigen | Index Medicus
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11. Full Text Trogocytosis represents a novel mechanism of action of daratumumab in multiple myeloma
by Krejcik, Jakub and Van De Donk, Niels W.C.J
Oncotarget, ISSN 1949-2553, 09/2018, Volume 9, Issue 72, pp. 33621 - 33622
CD38 | Trogocytosis | Daratumumab | Immunotherapy | Multiple myeloma
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12. Full Text Daratumumab With Cetrelimab, an Anti–PD-1 Monoclonal Antibody, in Relapsed/Refractory Multiple Myeloma
by Cohen, Yael C and Oriol, Albert and Wu, Ka Lung and Lavi, Noa and Vlummens, Philip and Jackson, Carolyn and Garvin, Wendy and Carson, Robin and Crist, Wendy and Fu, Jiayu and Feng, Huaibao and Xie, Hong and Schecter, Jordan and San-Miguel, Jesús and Lonial, Sagar
Clinical lymphoma, myeloma and leukemia, ISSN 2152-2650, 08/2020
CD38 | Efficacy | Safety | Programmed death receptor-1 | RRMM
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13. Full Text A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization
by Drent, Esther and Themeli, Maria and Poels, Renée and de Jong-Korlaar, Regina and Yuan, Huipin and de Bruijn, Joost and Martens, Anton C.M and Zweegman, Sonja and van de Donk, Niels W.C.J and Groen, Richard W.J and Lokhorst, Henk M and Mutis, Tuna
Molecular therapy, ISSN 1525-0016, 08/2017, Volume 25, Issue 8, pp. 1946 - 1958
CAR design | multiple myeloma | off-target effects | scFV | CD38 | chimeric antigen receptor | affinity | Molecular Biology | Genetics | Molecular Medicine | Pharmacology | Drug Discovery | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptors, Antigen, T-Cell - chemistry | Humans | Antibody Affinity - immunology | Multip