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Nature (London), ISSN 1476-4687, 2012, Volume 487, Issue 7408, pp. 482 - 485
.... Here we isolated the circulating resting CD4(+) T cells of patients in whom viraemia was fully suppressed by antiretroviral therapy, and directly studied the effect of VOR on this latent reservoir... 
CELLS | ACTIVATION | SUBEROYLANILIDE HYDROXAMIC ACID | MULTIDISCIPLINARY SCIENCES | IN-VIVO | VALPROIC ACID | INFECTION | HISTONE DEACETYLASE INHIBITORS | TYPE-1 | EXPRESSION | PCR | Gene Expression Regulation, Viral - drug effects | Humans | Hydroxamic Acids - adverse effects | Histone Deacetylase Inhibitors - administration & dosage | RNA, Viral - blood | Virus Latency - drug effects | Proviruses - drug effects | HIV-1 - growth & development | Proviruses - genetics | Hydroxamic Acids - administration & dosage | Anti-HIV Agents - therapeutic use | CD4-Positive T-Lymphocytes - virology | Hydroxamic Acids - pharmacology | Biomarkers - metabolism | HIV Infections - blood | Risk Assessment | HIV-1 - drug effects | CD4-Positive T-Lymphocytes - cytology | HIV Infections - virology | RNA, Viral - biosynthesis | CD4-Positive T-Lymphocytes - metabolism | Viremia - drug therapy | HIV-1 - genetics | Proviruses - growth & development | Histones - drug effects | Up-Regulation - drug effects | Acetylation - drug effects | Viremia - virology | HIV Infections - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Histone Deacetylase Inhibitors - adverse effects | Physiological aspects | Antiviral agents | HIV patients | Health aspects | Vorinostat | Antiretroviral drugs | Plasma | Cell culture | Lymphocytes | Human immunodeficiency virus--HIV | Genomes | Drug therapy | Drug dosages
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 47, Issue 4, pp. 776 - 788.e5
Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals but does not eliminate the reservoir of latently infected cells. Recent... 
SIV | animal models | HIV | latent viral reservoir | regulatory T cells | co-inhibitory receptors | CTLA-4 | T follicular helper cells | PD-1 | regulatory T cells | TGF-BETA | REPLICATION | RESERVOIR | REGULATORY CELLS | IMMUNE ACTIVATION | GENE-EXPRESSION | IMMUNODEFICIENCY VIRUS-INFECTION | IMMUNOLOGY | CHRONIC HIV-INFECTION | FOLLICULAR HELPER-CELLS | Humans | Host-Pathogen Interactions - drug effects | Macaca mulatta | Immunologic Memory - drug effects | Host-Pathogen Interactions - immunology | T-Lymphocytes, Helper-Inducer - virology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - drug effects | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | HIV-1 - physiology | In Situ Hybridization | T-Lymphocytes, Helper-Inducer - immunology | Lymph Nodes - drug effects | CD4-Positive T-Lymphocytes - virology | Immunologic Memory - immunology | Simian Immunodeficiency Virus - immunology | Anti-Retroviral Agents - therapeutic use | HIV-1 - drug effects | HIV Infections - virology | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Lymph Nodes - virology | Lymph Nodes - immunology | CTLA-4 Antigen - immunology | Simian Immunodeficiency Virus - physiology | Microscopy, Confocal | HIV-1 - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | HIV Infections - drug therapy | Programmed Cell Death 1 Receptor - immunology | Simian Immunodeficiency Virus - drug effects | CD4-Positive T-Lymphocytes - drug effects | T-Lymphocytes, Regulatory - virology | Therapy | PD-1 protein | Memory | Viruses | Infections | Lymphocytes T | Lymph nodes | CTLA-4 protein | Lymphocytes | Antiretroviral agents | Immunotherapy | Human immunodeficiency virus--HIV | Drug therapy | Deoxyribonucleic acid--DNA | Spleen | Antiretroviral drugs | Immunological memory | Memory cells | Immunoregulation | Latent infection | Monkeys & apes | Antiretroviral therapy | CD4 antigen | Lymphocytes B | Replication
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 36, pp. 13139 - 13144
Journal Article
Blood, ISSN 1528-0020, 2006, Volume 109, Issue 1, pp. 228 - 234
The molecular mechanisms by which mesenchymal stem cells (MSCs) suppress T-cell proliferation are poorly understood, and whether a soluble factor plays a major... 
SYNTHASE | RESPONSES | ENGRAFTMENT | ACTIVATION | PATHWAY | IMMUNOSUPPRESSION | GROWTH | HEMATOLOGY | MARROW STROMAL CELLS | INHIBIT | TRANSPLANTATION | CD8-Positive T-Lymphocytes - cytology | Dinoprostone - physiology | Humans | B-Lymphocyte Subsets - cytology | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Phosphorylation - drug effects | Macrophages - physiology | B-Lymphocyte Subsets - drug effects | Nitric Oxide - biosynthesis | Signal Transduction | CD4-Positive T-Lymphocytes - metabolism | Cell Division - drug effects | Receptors, Antigen, T-Cell - physiology | Mice, Knockout | B-Lymphocyte Subsets - metabolism | Mice | Tryptophan - pharmacology | HeLa Cells | Interleukin-2 - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology | Nitric Oxide Synthase Type II - metabolism | Tetradecanoylphorbol Acetate - pharmacology | T-Lymphocyte Subsets - cytology | Concanavalin A - pharmacology | Nitric Oxide - pharmacology | STAT5 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Tryptophan - analogs & derivatives | Enzyme Induction - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Mesenchymal Stromal Cells - physiology | NG-Nitroarginine Methyl Ester - pharmacology | Transforming Growth Factor beta - immunology | Cell Line | Antigens, CD19 - analysis | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide - physiology | Cyclooxygenase Inhibitors - pharmacology | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Ionomycin - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interferon-gamma - biosynthesis | Prostaglandin-Endoperoxide Synthases - physiology
Journal Article
Clinical Immunology, ISSN 1521-6616, 2010, Volume 138, Issue 1, pp. 85 - 96
Abstract Cytotoxic T Lymphocyte Antigen 4 (CTLA4) blockade has shown antitumor activity against common cancers... 
Allergy and Immunology | Tremelimumab | T effector cells | CTLA4 | Immune regulation | T regulatory cells | CTLA-4 BLOCKADE | DIFFERENTIAL EXPRESSION | TUMOR | ANTIGENS | IMMUNOLOGY | TRIAL | METASTATIC MELANOMA | IMMUNOTHERAPY | CD28 | ANTITUMOR IMMUNITY | RECEPTORS | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | Leukocytes, Mononuclear - metabolism | T-Lymphocytes, Regulatory - metabolism | T-Lymphocyte Subsets - cytology | Cell Count | Humans | Antibodies, Monoclonal - therapeutic use | Interferon-gamma - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Immunity, Cellular - drug effects | Forkhead Transcription Factors - metabolism | Immune Tolerance - immunology | T-Lymphocyte Subsets - drug effects | T-Lymphocytes - drug effects | Leukocytes, Mononuclear - immunology | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Membrane Glycoproteins - immunology | Immune Tolerance - drug effects | Interleukin-2 - metabolism | Leukocytes, Mononuclear - drug effects | Carcinoembryonic Antigen - immunology | Antibodies, Monoclonal - pharmacology | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Neoplasms - drug therapy | Immunity, Cellular - immunology | T-Lymphocytes, Regulatory - drug effects | Interleukin-2 Receptor alpha Subunit - metabolism | T-Lymphocytes - cytology | Lymphocyte Activation - drug effects | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Leukocytes, Mononuclear - cytology | T-Lymphocytes - immunology | Cell Proliferation - drug effects | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | T cells | Tumor antigens | Immune response
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