Catalogue
Articles
RSS feedX
Search Filters
Format
Subjects
Language
Publication DateThe EMBO Journal, ISSN 0261-4189, 04/2015, Volume 34, Issue 7, pp. 925 - 939
The development and function of B lymphocytes is regulated by numerous signaling pathways, some emanating from the B‐cell antigen receptor (BCR). The spleen...
BAFF receptor | mb1‐CreERT2 | Syk | B‐cell antigen receptor | CD19 | mb1-CreER T 2 | B-cell antigen receptor | LYN | ACTIVATION | mb1-CreER(T2) | MARGINAL ZONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE KINASE | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | RECOMBINASE ACTIVITY | IN-VIVO | DIFFERENTIATION | NF-KAPPA-B | ANTIGEN RECEPTOR | Antigens, CD - immunology | CD40 Antigens - antagonists & inhibitors | Cell Survival - genetics | Intracellular Signaling Peptides and Proteins - immunology | Antigens, CD19 - genetics | Antigens, CD - genetics | Phosphatidylinositol 3-Kinases - immunology | Protein-Tyrosine Kinases - immunology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | ADP-ribosyl Cyclase 1 - immunology | CD40 Antigens - genetics | Interleukin-4 - genetics | Membrane Glycoproteins - immunology | B-Cell Activation Factor Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Antigens, CD19 - immunology | B-Cell Activation Factor Receptor - immunology | B-Lymphocytes - cytology | Interleukin-4 - antagonists & inhibitors | ADP-ribosyl Cyclase 1 - genetics | Signal Transduction - genetics | Cell Survival - immunology | Receptors, Antigen, B-Cell - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Antibodies - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Interleukin-4 - immunology | Animals | B-Lymphocytes - immunology | Lipopolysaccharides - pharmacology | Receptors, Antigen, B-Cell - genetics | Mice | Oligodeoxyribonucleotides - pharmacology | CD40 Antigens - immunology | Lymphocyte receptors | T cell receptors | Kinases | Immune system | mb1-CreERT2
BAFF receptor | mb1‐CreERT2 | Syk | B‐cell antigen receptor | CD19 | mb1-CreER T 2 | B-cell antigen receptor | LYN | ACTIVATION | mb1-CreER(T2) | MARGINAL ZONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE KINASE | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | RECOMBINASE ACTIVITY | IN-VIVO | DIFFERENTIATION | NF-KAPPA-B | ANTIGEN RECEPTOR | Antigens, CD - immunology | CD40 Antigens - antagonists & inhibitors | Cell Survival - genetics | Intracellular Signaling Peptides and Proteins - immunology | Antigens, CD19 - genetics | Antigens, CD - genetics | Phosphatidylinositol 3-Kinases - immunology | Protein-Tyrosine Kinases - immunology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | ADP-ribosyl Cyclase 1 - immunology | CD40 Antigens - genetics | Interleukin-4 - genetics | Membrane Glycoproteins - immunology | B-Cell Activation Factor Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Antigens, CD19 - immunology | B-Cell Activation Factor Receptor - immunology | B-Lymphocytes - cytology | Interleukin-4 - antagonists & inhibitors | ADP-ribosyl Cyclase 1 - genetics | Signal Transduction - genetics | Cell Survival - immunology | Receptors, Antigen, B-Cell - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Antibodies - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Interleukin-4 - immunology | Animals | B-Lymphocytes - immunology | Lipopolysaccharides - pharmacology | Receptors, Antigen, B-Cell - genetics | Mice | Oligodeoxyribonucleotides - pharmacology | CD40 Antigens - immunology | Lymphocyte receptors | T cell receptors | Kinases | Immune system | mb1-CreERT2
Journal Article
Details 
Digital rights
Loading RightsImmunity, ISSN 1074-7613, 06/2015, Volume 42, Issue 6, pp. 1048 - 1061
Thymic antigen-presenting cells (APCs) such as dendritic cells and medullary thymic epithelial cells (mTECs) use distinct strategies of self-antigen expression...
PROMISCUOUS GENE-EXPRESSION | REPERTOIRE | EPITHELIAL-CELLS | DENDRITIC CELLS | AIRE | AUTOIMMUNITY | NEGATIVE SELECTION | CLONAL DELETION | MECHANISMS | IMMUNOLOGY | THYMOCYTES | B7-1 Antigen - genetics | Signal Transduction | Humans | Cells, Cultured | B-Lymphocytes - physiology | Antigen Presentation - genetics | Central Tolerance - genetics | B7-1 Antigen - metabolism | Clonal Selection, Antigen-Mediated - genetics | Transcription Factors - genetics | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Transcription Factors - metabolism | Cell Differentiation - genetics | Animals | CD40 Antigens - metabolism | Autoantigens - immunology | Histocompatibility Antigens Class II - metabolism | Thymus Gland - immunology | CD40 Antigens - genetics | Mice | Mice, Inbred BALB C | Histocompatibility Antigens Class II - genetics | Immunoglobulin Class Switching - genetics | Autoimmunity | Antigens | B cells | Dendritic cells | T cells | Spleen | Flow cytometry | Lymphocytes | Bone marrow | T cell receptors | Gene expression
PROMISCUOUS GENE-EXPRESSION | REPERTOIRE | EPITHELIAL-CELLS | DENDRITIC CELLS | AIRE | AUTOIMMUNITY | NEGATIVE SELECTION | CLONAL DELETION | MECHANISMS | IMMUNOLOGY | THYMOCYTES | B7-1 Antigen - genetics | Signal Transduction | Humans | Cells, Cultured | B-Lymphocytes - physiology | Antigen Presentation - genetics | Central Tolerance - genetics | B7-1 Antigen - metabolism | Clonal Selection, Antigen-Mediated - genetics | Transcription Factors - genetics | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Transcription Factors - metabolism | Cell Differentiation - genetics | Animals | CD40 Antigens - metabolism | Autoantigens - immunology | Histocompatibility Antigens Class II - metabolism | Thymus Gland - immunology | CD40 Antigens - genetics | Mice | Mice, Inbred BALB C | Histocompatibility Antigens Class II - genetics | Immunoglobulin Class Switching - genetics | Autoimmunity | Antigens | B cells | Dendritic cells | T cells | Spleen | Flow cytometry | Lymphocytes | Bone marrow | T cell receptors | Gene expression
Journal Article
Details
Digital rights
Loading RightsJournal of Autoimmunity, ISSN 0896-8411, 2009, Volume 32, Issue 3, pp. 231 - 239
Abstract Autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's thyroiditis (HT) are prevalent autoimmune diseases, affecting up...
Allergy and Immunology | Environment | Graves' Disease | Genes | Hashimoto's thyroiditis | CHRONIC HEPATITIS-C | HCV CHRONIC HEPATITIS | TOXIC NODULAR GOITER | SINGLE-NUCLEOTIDE POLYMORPHISM | IMMUNOLOGY | LYMPHOID TYROSINE PHOSPHATASE | LOW IODINE INTAKE | STRESSFUL LIFE EVENTS | THYROTROPIN RECEPTOR GENE | INTERFERON-ALPHA THERAPY | MHC CLASS-II | Antigens, CD - immunology | Receptors, Thyrotropin - genetics | Thyroiditis, Autoimmune - immunology | Thyroglobulin - metabolism | Humans | Autoimmunity - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | HLA-DR Antigens - genetics | Thyroglobulin - immunology | Thyroiditis, Autoimmune - etiology | CD40 Antigens - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Thyroiditis, Autoimmune - metabolism | CD40 Antigens - genetics | Genetic Predisposition to Disease | Receptors, Thyrotropin - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Receptors, Thyrotropin - immunology | Thyroiditis, Autoimmune - genetics | CTLA-4 Antigen | Thyroglobulin - genetics | HLA-DR Antigens - immunology | CD40 Antigens - immunology | Autoimmunity | Development and progression | Thyroid diseases
Allergy and Immunology | Environment | Graves' Disease | Genes | Hashimoto's thyroiditis | CHRONIC HEPATITIS-C | HCV CHRONIC HEPATITIS | TOXIC NODULAR GOITER | SINGLE-NUCLEOTIDE POLYMORPHISM | IMMUNOLOGY | LYMPHOID TYROSINE PHOSPHATASE | LOW IODINE INTAKE | STRESSFUL LIFE EVENTS | THYROTROPIN RECEPTOR GENE | INTERFERON-ALPHA THERAPY | MHC CLASS-II | Antigens, CD - immunology | Receptors, Thyrotropin - genetics | Thyroiditis, Autoimmune - immunology | Thyroglobulin - metabolism | Humans | Autoimmunity - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | HLA-DR Antigens - genetics | Thyroglobulin - immunology | Thyroiditis, Autoimmune - etiology | CD40 Antigens - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology | Autoimmunity - immunology | Thyroiditis, Autoimmune - metabolism | CD40 Antigens - genetics | Genetic Predisposition to Disease | Receptors, Thyrotropin - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 22 - metabolism | Receptors, Thyrotropin - immunology | Thyroiditis, Autoimmune - genetics | CTLA-4 Antigen | Thyroglobulin - genetics | HLA-DR Antigens - immunology | CD40 Antigens - immunology | Autoimmunity | Development and progression | Thyroid diseases
Journal Article
Details
Digital rights
Loading RightsJournal of Clinical Investigation, ISSN 0021-9738, 05/2017, Volume 127, Issue 5, pp. 1651 - 1663
Mature B cell pools retain a substantial proportion of polyreactive and self-reactive clonotypes, suggesting that activation checkpoints exist to reduce the...
MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON-GAMMA | TOLL-LIKE RECEPTOR-9 | MARGINAL ZONE | ESCAPE TOLERANCE | LYMPHOCYTE STIMULATOR | SOMATIC MUTATION | AUTOANTIBODY PRODUCTION | T-CELLS | CUTTING EDGE | Toll-Like Receptor 9 - genetics | Male | T-Box Domain Proteins - immunology | G1 Phase Cell Cycle Checkpoints - immunology | MAP Kinase Signaling System - immunology | Toll-Like Receptor 9 - immunology | Cell Differentiation - genetics | Interleukins - genetics | MAP Kinase Signaling System - genetics | Interleukins - immunology | B-Cell Activating Factor - immunology | Female | CD40 Antigens - genetics | Interferon-gamma - genetics | Cell Line | DNA - immunology | p38 Mitogen-Activated Protein Kinases - genetics | p38 Mitogen-Activated Protein Kinases - immunology | T-Box Domain Proteins - genetics | G1 Phase Cell Cycle Checkpoints - genetics | Receptors, Antigen, B-Cell - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Lymphocytes - immunology | B-Cell Activating Factor - genetics | Interferon-gamma - immunology | Antigens - immunology | Receptors, Antigen, B-Cell - genetics | Mice | CD40 Antigens - immunology | Antigens | DNA | Cytokine receptors | TLR9 | Cellular signal transduction | Research | B cells | CD27 antigen | CD40 antigen | Laboratories | B-cell receptor | Kinases | Genotype & phenotype | Mitochondria | Cell activation | Lymphocytes | Cell cycle | Interleukin 21 | Toll-like receptors | Deoxyribonucleic acid--DNA | Immunization | Cell survival | Cytokines | Secretion | Cell division | T cell receptors | Survival | TLR9 protein | Immune response (humoral) | Medicine | Lymphocytes B | BLyS protein | Ligands | Interferon | Regulation | Autoimmune diseases | Apoptosis
MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON-GAMMA | TOLL-LIKE RECEPTOR-9 | MARGINAL ZONE | ESCAPE TOLERANCE | LYMPHOCYTE STIMULATOR | SOMATIC MUTATION | AUTOANTIBODY PRODUCTION | T-CELLS | CUTTING EDGE | Toll-Like Receptor 9 - genetics | Male | T-Box Domain Proteins - immunology | G1 Phase Cell Cycle Checkpoints - immunology | MAP Kinase Signaling System - immunology | Toll-Like Receptor 9 - immunology | Cell Differentiation - genetics | Interleukins - genetics | MAP Kinase Signaling System - genetics | Interleukins - immunology | B-Cell Activating Factor - immunology | Female | CD40 Antigens - genetics | Interferon-gamma - genetics | Cell Line | DNA - immunology | p38 Mitogen-Activated Protein Kinases - genetics | p38 Mitogen-Activated Protein Kinases - immunology | T-Box Domain Proteins - genetics | G1 Phase Cell Cycle Checkpoints - genetics | Receptors, Antigen, B-Cell - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Lymphocytes - immunology | B-Cell Activating Factor - genetics | Interferon-gamma - immunology | Antigens - immunology | Receptors, Antigen, B-Cell - genetics | Mice | CD40 Antigens - immunology | Antigens | DNA | Cytokine receptors | TLR9 | Cellular signal transduction | Research | B cells | CD27 antigen | CD40 antigen | Laboratories | B-cell receptor | Kinases | Genotype & phenotype | Mitochondria | Cell activation | Lymphocytes | Cell cycle | Interleukin 21 | Toll-like receptors | Deoxyribonucleic acid--DNA | Immunization | Cell survival | Cytokines | Secretion | Cell division | T cell receptors | Survival | TLR9 protein | Immune response (humoral) | Medicine | Lymphocytes B | BLyS protein | Ligands | Interferon | Regulation | Autoimmune diseases | Apoptosis
Journal Article
Details
Digital rights
Loading RightsJournal of Clinical Investigation, ISSN 0021-9738, 12/2008, Volume 118, Issue 12, pp. 4036 - 4048
infection with influenza A virus (IAV) presents a substantial threat to public health worldwide, with young, elderly, and immunodeficient individuals being...
MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER | IFN-GAMMA PRODUCTION | DENDRITIC CELLS | ALPHA-GALACTOSYLCERAMIDE | IN-VIVO | KILLER T-CELLS | INNATE IMMUNE-RESPONSE | ANTIGEN PRESENTATION | MURINE CYTOMEGALOVIRUS | TUMOR IMMUNOSURVEILLANCE | Influenza A Virus, H1N1 Subtype - immunology | Myeloid Cells - enzymology | Nitric Oxide Synthase - immunology | Influenza, Human - pathology | Antigens, CD1d - immunology | Humans | Arginase - metabolism | Influenza, Human - enzymology | Nitric Oxide Synthase - genetics | Natural Killer T-Cells - enzymology | Arginase - immunology | CD40 Antigens - metabolism | Myeloid Cells - immunology | Natural Killer T-Cells - pathology | Antigens, CD1d - genetics | CD40 Antigens - genetics | Toll-Like Receptors - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Toll-Like Receptors - immunology | Cells, Cultured | Influenza, Human - epidemiology | Arginase - genetics | Antigens, CD1d - metabolism | Mice, Knockout | Animals | Influenza, Human - genetics | Toll-Like Receptors - genetics | Immune Tolerance - genetics | Mice | Nitric Oxide Synthase - metabolism | Myeloid Cells - pathology | CD40 Antigens - immunology | Influenza, Human - immunology | Natural Killer T-Cells - immunology | Immunosuppression | Influenza | Patient outcomes | Physiological aspects | Research | T cells | Health aspects | Risk factors
MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER | IFN-GAMMA PRODUCTION | DENDRITIC CELLS | ALPHA-GALACTOSYLCERAMIDE | IN-VIVO | KILLER T-CELLS | INNATE IMMUNE-RESPONSE | ANTIGEN PRESENTATION | MURINE CYTOMEGALOVIRUS | TUMOR IMMUNOSURVEILLANCE | Influenza A Virus, H1N1 Subtype - immunology | Myeloid Cells - enzymology | Nitric Oxide Synthase - immunology | Influenza, Human - pathology | Antigens, CD1d - immunology | Humans | Arginase - metabolism | Influenza, Human - enzymology | Nitric Oxide Synthase - genetics | Natural Killer T-Cells - enzymology | Arginase - immunology | CD40 Antigens - metabolism | Myeloid Cells - immunology | Natural Killer T-Cells - pathology | Antigens, CD1d - genetics | CD40 Antigens - genetics | Toll-Like Receptors - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Toll-Like Receptors - immunology | Cells, Cultured | Influenza, Human - epidemiology | Arginase - genetics | Antigens, CD1d - metabolism | Mice, Knockout | Animals | Influenza, Human - genetics | Toll-Like Receptors - genetics | Immune Tolerance - genetics | Mice | Nitric Oxide Synthase - metabolism | Myeloid Cells - pathology | CD40 Antigens - immunology | Influenza, Human - immunology | Natural Killer T-Cells - immunology | Immunosuppression | Influenza | Patient outcomes | Physiological aspects | Research | T cells | Health aspects | Risk factors
Journal Article
Details
Digital rights
Loading Rights
6.
Full Text
Signaling by the tumor necrosis factor receptor superfamily in B‐cell biology and disease
Immunological Reviews, ISSN 0105-2896, 11/2011, Volume 244, Issue 1, pp. 115 - 133
Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently in B‐cell maturation and function. In particular, B‐cell activating...
BAFF | B cell | CD40 | BCMA | NF‐κB | TACI | NF-κB | FORKHEAD TRANSCRIPTION FACTOR | SYSTEMIC-LUPUS-ERYTHEMATOSUS | HUMORAL IMMUNE-RESPONSES | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | KINASE-C-DELTA | GERMINAL CENTER FORMATION | NF-?B | ACTIVATING FACTOR-RECEPTOR | NON-HODGKIN-LYMPHOMA | X-LINKED IMMUNODEFICIENCY | NF-KAPPA-B | Cell Proliferation | Humans | NF-kappa B - immunology | NF-kappa B - metabolism | Transmembrane Activator and CAML Interactor Protein - metabolism | Signal Transduction - immunology | CD40 Antigens - metabolism | B-Cell Activating Factor - immunology | B-Lymphocyte Subsets - immunology | CD40 Antigens - genetics | B-Cell Activation Factor Receptor - genetics | B-Lymphocytes - metabolism | B-Cell Activation Factor Receptor - immunology | B-Cell Maturation Antigen - immunology | Tumor Necrosis Factor Ligand Superfamily Member 13 - immunology | Gene Expression | Mice, Transgenic | Cell Survival - immunology | Immunity, Innate | Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism | Transmembrane Activator and CAML Interactor Protein - genetics | B-Cell Activation Factor Receptor - metabolism | Animals | B-Cell Activating Factor - metabolism | B-Cell Maturation Antigen - metabolism | B-Lymphocytes - immunology | B-Lymphocyte Subsets - metabolism | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Neoplasms - immunology | Autoimmune Diseases | Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics | Mice | B-Cell Maturation Antigen - genetics | Transmembrane Activator and CAML Interactor Protein - immunology | CD40 Antigens - immunology | Autoimmunity | Antigens | Tumor necrosis factor | Tumors | Necrosis
BAFF | B cell | CD40 | BCMA | NF‐κB | TACI | NF-κB | FORKHEAD TRANSCRIPTION FACTOR | SYSTEMIC-LUPUS-ERYTHEMATOSUS | HUMORAL IMMUNE-RESPONSES | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | KINASE-C-DELTA | GERMINAL CENTER FORMATION | NF-?B | ACTIVATING FACTOR-RECEPTOR | NON-HODGKIN-LYMPHOMA | X-LINKED IMMUNODEFICIENCY | NF-KAPPA-B | Cell Proliferation | Humans | NF-kappa B - immunology | NF-kappa B - metabolism | Transmembrane Activator and CAML Interactor Protein - metabolism | Signal Transduction - immunology | CD40 Antigens - metabolism | B-Cell Activating Factor - immunology | B-Lymphocyte Subsets - immunology | CD40 Antigens - genetics | B-Cell Activation Factor Receptor - genetics | B-Lymphocytes - metabolism | B-Cell Activation Factor Receptor - immunology | B-Cell Maturation Antigen - immunology | Tumor Necrosis Factor Ligand Superfamily Member 13 - immunology | Gene Expression | Mice, Transgenic | Cell Survival - immunology | Immunity, Innate | Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism | Transmembrane Activator and CAML Interactor Protein - genetics | B-Cell Activation Factor Receptor - metabolism | Animals | B-Cell Activating Factor - metabolism | B-Cell Maturation Antigen - metabolism | B-Lymphocytes - immunology | B-Lymphocyte Subsets - metabolism | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Neoplasms - immunology | Autoimmune Diseases | Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics | Mice | B-Cell Maturation Antigen - genetics | Transmembrane Activator and CAML Interactor Protein - immunology | CD40 Antigens - immunology | Autoimmunity | Antigens | Tumor necrosis factor | Tumors | Necrosis
Journal Article
Details
Digital rights
Loading RightsMolecular Therapy, ISSN 1525-0016, 09/2017, Volume 25, Issue 9, pp. 2176 - 2188
Anti-tumor efficacy of T cells engineered to express chimeric antigen receptors (CARs) is dependent on their specificity, survival, and in vivo expansion...
CD40 | inducible | costimulation | T cell | chimeric antigen receptor | dimerizer | MyD88 | MEDICINE, RESEARCH & EXPERIMENTAL | EFFECTOR FUNCTIONS | TOLL-LIKE RECEPTOR | ANTITUMOR-ACTIVITY | CUTTING EDGE | THERAPY | MEMORY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CPG-OLIGODEOXYNUCLEOTIDES | LYMPHODEPLETION | COSTIMULATION | EXPRESSION | Cell Proliferation | Humans | Gene Expression Profiling | Leukemia - metabolism | Recombinant Fusion Proteins | CD28 Antigens - metabolism | Lymphocyte Activation - immunology | CD40 Antigens - metabolism | CD28 Antigens - genetics | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD40 Antigens - genetics | Toll-Like Receptors - metabolism | Leukemia - genetics | Disease Models, Animal | Immunotherapy, Adoptive - methods | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Cell Survival | Leukemia - therapy | Xenograft Model Antitumor Assays | Animals | Leukemia - immunology | Lymphocyte Activation - drug effects | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Cluster Analysis | Cell proliferation | Antigens | Graft-versus-host reaction | CD40 antigen | Cell survival | Cytokines | CD8 antigen | Cytotoxicity | T cell receptors | Lymphocytes T | Gene expression | Kinases | Adoptive transfer | CD4 antigen | Cell growth | Cell activation | Lymphocytes | Toll-like receptors | MyD88 protein | Tumor necrosis factor-TNF | Ligands | Software | Tumors | Original
CD40 | inducible | costimulation | T cell | chimeric antigen receptor | dimerizer | MyD88 | MEDICINE, RESEARCH & EXPERIMENTAL | EFFECTOR FUNCTIONS | TOLL-LIKE RECEPTOR | ANTITUMOR-ACTIVITY | CUTTING EDGE | THERAPY | MEMORY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CPG-OLIGODEOXYNUCLEOTIDES | LYMPHODEPLETION | COSTIMULATION | EXPRESSION | Cell Proliferation | Humans | Gene Expression Profiling | Leukemia - metabolism | Recombinant Fusion Proteins | CD28 Antigens - metabolism | Lymphocyte Activation - immunology | CD40 Antigens - metabolism | CD28 Antigens - genetics | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD40 Antigens - genetics | Toll-Like Receptors - metabolism | Leukemia - genetics | Disease Models, Animal | Immunotherapy, Adoptive - methods | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Cell Survival | Leukemia - therapy | Xenograft Model Antitumor Assays | Animals | Leukemia - immunology | Lymphocyte Activation - drug effects | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Cluster Analysis | Cell proliferation | Antigens | Graft-versus-host reaction | CD40 antigen | Cell survival | Cytokines | CD8 antigen | Cytotoxicity | T cell receptors | Lymphocytes T | Gene expression | Kinases | Adoptive transfer | CD4 antigen | Cell growth | Cell activation | Lymphocytes | Toll-like receptors | MyD88 protein | Tumor necrosis factor-TNF | Ligands | Software | Tumors | Original
Journal Article
Details
Digital rights
Loading RightsMolecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1676 - 1685
Targeted approaches to treat autoimmune diseases would improve upon current therapies that broadly suppress the immune system and lead to detrimental side...
tolerance induction mechanism | antigen-specific tolerance | immune tolerance | PLGA | PLG nanoparticles | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | ANTIGENS | IL-10 | IMMUNOLOGICAL-TOLERANCE | DELIVERY | RESPONSES | MULTIPLE-SCLEROSIS | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CROSS-PRESENTATION | B7-2 Antigen - genetics | Myelin Proteolipid Protein - immunology | B7-1 Antigen - genetics | Spleen - immunology | Nanoparticles - chemistry | Ovalbumin - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Delayed-Action Preparations - chemistry | Spleen - drug effects | Polyglactin 910 - metabolism | T-Lymphocytes, Regulatory - pathology | Delayed-Action Preparations - administration & dosage | Myelin Proteolipid Protein - pharmacology | T-Lymphocytes, Regulatory - immunology | Antigen-Presenting Cells - pathology | Immunoconjugates - pharmacology | Female | CD40 Antigens - genetics | Encephalomyelitis, Autoimmune, Experimental - genetics | Polyglactin 910 - chemistry | B7-2 Antigen - immunology | Myelin Proteolipid Protein - chemistry | Spleen - pathology | Ovalbumin - chemistry | Immune Tolerance - drug effects | Gene Expression | Encephalomyelitis, Autoimmune, Experimental - pathology | B7-1 Antigen - immunology | Immunoconjugates - metabolism | Antigen-Presenting Cells - drug effects | Mice, Inbred C57BL | Ovalbumin - pharmacology | Antigen-Presenting Cells - immunology | Immunoconjugates - chemistry | Antigens - chemistry | Particle Size | Encephalomyelitis, Autoimmune, Experimental - therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Antigens - immunology | Mice | Nanoparticles - administration & dosage | Primary Cell Culture | Antigens - pharmacology | CD40 Antigens - immunology | Cell proliferation | Multiple sclerosis | Transcription factors | CD40 antigen | Disease | Peptides | CD86 antigen | Lymphocytes T | Nanoparticles | Myelin proteolipid protein | Lymphocytes | Localization | Immune system | Antigen presentation | Cytokines | Dendritic cells | Myelin | CD80 antigen | Inflammation | T cell receptors | Immunological tolerance | Studies | Major histocompatibility complex | Antigen-presenting cells | Internalization | PD-L1 protein | Proteolipid protein | Poly(lactide-co-glycolide) | Autoimmune diseases | Apoptosis | Original
tolerance induction mechanism | antigen-specific tolerance | immune tolerance | PLGA | PLG nanoparticles | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | ANTIGENS | IL-10 | IMMUNOLOGICAL-TOLERANCE | DELIVERY | RESPONSES | MULTIPLE-SCLEROSIS | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CROSS-PRESENTATION | B7-2 Antigen - genetics | Myelin Proteolipid Protein - immunology | B7-1 Antigen - genetics | Spleen - immunology | Nanoparticles - chemistry | Ovalbumin - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Delayed-Action Preparations - chemistry | Spleen - drug effects | Polyglactin 910 - metabolism | T-Lymphocytes, Regulatory - pathology | Delayed-Action Preparations - administration & dosage | Myelin Proteolipid Protein - pharmacology | T-Lymphocytes, Regulatory - immunology | Antigen-Presenting Cells - pathology | Immunoconjugates - pharmacology | Female | CD40 Antigens - genetics | Encephalomyelitis, Autoimmune, Experimental - genetics | Polyglactin 910 - chemistry | B7-2 Antigen - immunology | Myelin Proteolipid Protein - chemistry | Spleen - pathology | Ovalbumin - chemistry | Immune Tolerance - drug effects | Gene Expression | Encephalomyelitis, Autoimmune, Experimental - pathology | B7-1 Antigen - immunology | Immunoconjugates - metabolism | Antigen-Presenting Cells - drug effects | Mice, Inbred C57BL | Ovalbumin - pharmacology | Antigen-Presenting Cells - immunology | Immunoconjugates - chemistry | Antigens - chemistry | Particle Size | Encephalomyelitis, Autoimmune, Experimental - therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Antigens - immunology | Mice | Nanoparticles - administration & dosage | Primary Cell Culture | Antigens - pharmacology | CD40 Antigens - immunology | Cell proliferation | Multiple sclerosis | Transcription factors | CD40 antigen | Disease | Peptides | CD86 antigen | Lymphocytes T | Nanoparticles | Myelin proteolipid protein | Lymphocytes | Localization | Immune system | Antigen presentation | Cytokines | Dendritic cells | Myelin | CD80 antigen | Inflammation | T cell receptors | Immunological tolerance | Studies | Major histocompatibility complex | Antigen-presenting cells | Internalization | PD-L1 protein | Proteolipid protein | Poly(lactide-co-glycolide) | Autoimmune diseases | Apoptosis | Original
Journal Article
Details
Digital rights
Loading RightsThe Journal of Immunology, ISSN 0022-1767, 08/2005, Volume 175, Issue 4, pp. 2340 - 2348
ICOS is a new member of the CD28 family of costimulatory molecules that is expressed on activated T cells. Its ligand B7RP-1 is constitutively expressed on B...
GERMINAL CENTER FORMATION | CXC CHEMOKINE RECEPTOR-5 | OX40 LIGAND | IMMUNE-RESPONSES | ACTIVATION MOLECULE | INDUCIBLE COSTIMULATOR | IMMUNOLOGY | LYMPHOID FOLLICLES | EXPRESSION | MICE LACKING | CUTTING EDGE | Spleen - immunology | Mice, Inbred A | Tumor Necrosis Factor-alpha - genetics | B-Lymphocyte Subsets - cytology | CD28 Antigens - genetics | Mice, Inbred CBA | CD40 Antigens - genetics | CD28 Antigens - physiology | CD40 Antigens - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Membrane Proteins - genetics | Receptors, Cytokine - biosynthesis | Antibodies, Monoclonal - pharmacology | Antigens, Surface - biosynthesis | Spleen - cytology | Mice, Knockout | Cell Differentiation - immunology | Membrane Proteins - biosynthesis | Mice | Mice, Inbred BALB C | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Tumor Necrosis Factor-alpha - biosynthesis | Receptors, CXCR5 | Inducible T-Cell Co-Stimulator Protein | Germinal Center - immunology | Tumor Necrosis Factors | Receptors, OX40 | Tumor Necrosis Factor-alpha - deficiency | Cell Differentiation - genetics | Membrane Proteins - deficiency | Immunization, Secondary | T-Lymphocytes, Helper-Inducer - immunology | Antigens, Differentiation, T-Lymphocyte - physiology | Receptors, Chemokine - biosynthesis | T-Lymphocytes, Helper-Inducer - cytology | B-Lymphocyte Subsets - immunology | Female | Mice, Inbred DBA | Receptors, Tumor Necrosis Factor - deficiency | Membrane Glycoproteins - immunology | Germinal Center - cytology | Receptors, Tumor Necrosis Factor - genetics | B7-1 Antigen - immunology | Mice, Inbred C57BL | Antigens, Surface - genetics | Mice, SCID | Mice, Inbred C3H | Animals | Inducible T-Cell Co-Stimulator Ligand | Spleen - metabolism | Antibodies, Monoclonal - administration & dosage | Antigens, Differentiation, T-Lymphocyte - genetics | Chemokines, CXC - metabolism | Receptors, Tumor Necrosis Factor - biosynthesis
GERMINAL CENTER FORMATION | CXC CHEMOKINE RECEPTOR-5 | OX40 LIGAND | IMMUNE-RESPONSES | ACTIVATION MOLECULE | INDUCIBLE COSTIMULATOR | IMMUNOLOGY | LYMPHOID FOLLICLES | EXPRESSION | MICE LACKING | CUTTING EDGE | Spleen - immunology | Mice, Inbred A | Tumor Necrosis Factor-alpha - genetics | B-Lymphocyte Subsets - cytology | CD28 Antigens - genetics | Mice, Inbred CBA | CD40 Antigens - genetics | CD28 Antigens - physiology | CD40 Antigens - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Membrane Proteins - genetics | Receptors, Cytokine - biosynthesis | Antibodies, Monoclonal - pharmacology | Antigens, Surface - biosynthesis | Spleen - cytology | Mice, Knockout | Cell Differentiation - immunology | Membrane Proteins - biosynthesis | Mice | Mice, Inbred BALB C | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Tumor Necrosis Factor-alpha - biosynthesis | Receptors, CXCR5 | Inducible T-Cell Co-Stimulator Protein | Germinal Center - immunology | Tumor Necrosis Factors | Receptors, OX40 | Tumor Necrosis Factor-alpha - deficiency | Cell Differentiation - genetics | Membrane Proteins - deficiency | Immunization, Secondary | T-Lymphocytes, Helper-Inducer - immunology | Antigens, Differentiation, T-Lymphocyte - physiology | Receptors, Chemokine - biosynthesis | T-Lymphocytes, Helper-Inducer - cytology | B-Lymphocyte Subsets - immunology | Female | Mice, Inbred DBA | Receptors, Tumor Necrosis Factor - deficiency | Membrane Glycoproteins - immunology | Germinal Center - cytology | Receptors, Tumor Necrosis Factor - genetics | B7-1 Antigen - immunology | Mice, Inbred C57BL | Antigens, Surface - genetics | Mice, SCID | Mice, Inbred C3H | Animals | Inducible T-Cell Co-Stimulator Ligand | Spleen - metabolism | Antibodies, Monoclonal - administration & dosage | Antigens, Differentiation, T-Lymphocyte - genetics | Chemokines, CXC - metabolism | Receptors, Tumor Necrosis Factor - biosynthesis
Journal Article
Details
Digital rights
Loading Rights