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Blood, ISSN 0006-4971, 06/2011, Volume 117, Issue 23, pp. 6287 - 6296
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and... 
B-CELLS | CLL | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | APOPTOTIC CELL-DEATH | RITUXIMAB | SURVIVAL SIGNALS | LYMPHOMA | DRUG-RESISTANCE | INHIBITOR | HEMATOLOGY | EXPRESSION | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | B-Cell Activating Factor - metabolism | CD40 Ligand - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Receptors, Antigen, B-Cell - genetics | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Leukemic - genetics | Protein-Tyrosine Kinases - genetics | CD40 Ligand - metabolism | MAP Kinase Signaling System - genetics | Female | Interleukin-4 - genetics | Protein-Tyrosine Kinases - biosynthesis | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Neoplasm Proteins - biosynthesis | Interleukin-4 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Cell Proliferation - drug effects | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
by Ma, Cindy S., PhD and Wong, Natalie, BSc Hons and Rao, Geetha, MSc and Avery, Danielle T., BApplSci and Torpy, James, MPhil and Hambridge, Thomas, BSc Hons and Bustamante, Jacinta, MD, PhD and Okada, Satoshi, MD, PhD and Stoddard, Jennifer L., BS and Deenick, Elissa K., PhD and Pelham, Simon J., MSc and Payne, Kathryn, BSc Hons and Boisson-Dupuis, Stéphanie, PhD and Puel, Anne, PhD and Kobayashi, Masao, MD, PhD and Arkwright, Peter D., FRCPCH, DPhil and Kilic, Sara Sebnem, MD and El Baghdadi, Jamila, PhD and Nonoyama, Shigeaki, MD, PhD and Minegishi, Yoshiyuki, MD, PhD and Mahdaviani, Seyed Alireza, MD and Mansouri, Davood, MD and Bousfiha, Aziz, MD and Blincoe, Annaliesse K., BHB, MBChB and French, Martyn A., MB ChB, MD, FRACP, FRCPath, FRCP and Hsu, Peter, FRACP, PhD and Campbell, Dianne E., FRACP, PhD and Stormon, Michael O., MBBS, FRACP and Wong, Melanie, MBBS, PhD, FRACP, FRCPA and Adelstein, Stephen, MBBCh, PhD, FRACP, FRCPA and Smart, Joanne M., MBBS, FRACP and Fulcher, David A., MBBS, PhD, FRACP, FRCPA and Cook, Matthew C., MBBS, PhD, FRACP, FRCPA and Phan, Tri Giang, MBBS, PhD, FRACP, FRCPA and Stepensky, Polina, MD and Boztug, Kaan, MD and Kansu, Aydan, MD and İkincioğullari, Aydan, MD and Baumann, Ulrich, MD and Beier, Rita, MD and Roscioli, Tony, FRACP, PhD and Ziegler, John B., MD, FRACP and Gray, Paul, FRACP and Picard, Capucine, MD, PhD and Grimbacher, Bodo, MD and Warnatz, Klaus, MD, PhD and Holland, Steven M., MD and Casanova, Jean-Laurent, MD, PhD and Uzel, Gulbu, MD and Tangye, Stuart G., PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 4, pp. 993 - 1006.e1
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2011, Volume 12, Issue 6, pp. 536 - 543
The transcription factor BATF controls the differentiation of interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) by regulating expression of the... 
FOLLICULAR-HELPER-CELLS | DENDRITIC CELLS | GENE-REGULATION | DIFFERENTIATION | IMMUNOLOGY | PROMOTER | C-MAF | EXPRESSION | DIVISION | IL-21 | NEGATIVE REGULATOR | Basic-Leucine Zipper Transcription Factors - metabolism | Oligonucleotide Array Sequence Analysis | Germinal Center - immunology | Immunoglobulin Class Switching - immunology | Basic-Leucine Zipper Transcription Factors - immunology | Male | Gene Expression Profiling | Mice, 129 Strain | CD40 Ligand - immunology | Lymphocyte Activation - immunology | CD40 Ligand - metabolism | Flow Cytometry | T-Lymphocytes - metabolism | Recombination, Genetic | Proto-Oncogene Proteins c-bcl-6 - metabolism | Female | B-Lymphocytes - metabolism | Carrier Proteins - immunology | Cytidine Deaminase - genetics | Mice, Inbred C57BL | Cells, Cultured | Basic-Leucine Zipper Transcription Factors - genetics | Mice, Inbred Strains | Mice, Knockout | Proto-Oncogene Proteins c-bcl-6 - genetics | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Animals | B-Lymphocytes - immunology | Carrier Proteins - metabolism | Germinal Center - metabolism | CD40 Ligand - genetics | Cytidine Deaminase - metabolism | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Immunoglobulin Class Switching - genetics | Proto-Oncogene Proteins c-bcl-6 - immunology | Physiological aspects | Transcription factors | B cells | Research | Gene expression | T cells | Index Medicus
Journal Article
Journal Article
Blood, ISSN 0006-4971, 04/2010, Volume 115, Issue 13, pp. 2619 - 2629
Chronic lymphocytic leukemia (CLL) involves a profound humoral immune defect and tumor-specific humoral tolerance that directly contribute to disease morbidity... 
DEPENDENT CELLULAR CYTOTOXICITY | MULTIPLE-MYELOMA | ACTIVATION | GENE | IMMUNOGLOBULIN REPLACEMENT THERAPY | CHRONIC LYMPHOCYTIC-LEUKEMIA | CD40 LIGAND | SERUM IMMUNOGLOBULINS | HEMATOLOGY | NF-KAPPA-B | T-CELLS | CD40 Ligand - physiology | Adjuvants, Immunologic - pharmacology | Cells, Cultured - cytology | Humans | Neoplasm Proteins - physiology | NFATC Transcription Factors - physiology | Antineoplastic Agents - therapeutic use | BH3 Interacting Domain Death Agonist Protein - genetics | Gene Expression Profiling | RNA Stability - drug effects | Thalidomide - pharmacology | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | BH3 Interacting Domain Death Agonist Protein - biosynthesis | Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis | Thalidomide - analogs & derivatives | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Nuclear Proteins - biosynthesis | Tumor Suppressor Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Adjuvants, Immunologic - therapeutic use | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | B-Lymphocytes - metabolism | Cells, Cultured - drug effects | Neoplasm Proteins - biosynthesis | Gene Expression Regulation, Leukemic - drug effects | CD40 Ligand - biosynthesis | Immunophenotyping | DNA-Binding Proteins - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | B-Lymphocytes - drug effects | Tumor Protein p73 | CD40 Ligand - genetics | Signal Transduction - drug effects | Phosphatidylinositol 3-Kinases - physiology | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Thalidomide - therapeutic use | Tumor Suppressor Proteins - biosynthesis | DNA-Binding Proteins - biosynthesis | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Annals of Oncology, ISSN 0923-7534, 10/2013, Volume 24, Issue 10, pp. 2686 - 2693
Journal Article
Journal Article
BLOOD, ISSN 0006-4971, 07/2014, Volume 124, Issue 4, pp. 546 - 554
Journal Article
Journal Article
Journal Article