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Journal Article
Journal Article
Blood, ISSN 0006-4971, 04/2010, Volume 115, Issue 13, pp. 2619 - 2629
Chronic lymphocytic leukemia (CLL) involves a profound humoral immune defect and tumor-specific humoral tolerance that directly contribute to disease morbidity... 
DEPENDENT CELLULAR CYTOTOXICITY | MULTIPLE-MYELOMA | ACTIVATION | GENE | IMMUNOGLOBULIN REPLACEMENT THERAPY | CHRONIC LYMPHOCYTIC-LEUKEMIA | CD40 LIGAND | SERUM IMMUNOGLOBULINS | HEMATOLOGY | NF-KAPPA-B | T-CELLS | CD40 Ligand - physiology | Adjuvants, Immunologic - pharmacology | Cells, Cultured - cytology | Humans | Neoplasm Proteins - physiology | NFATC Transcription Factors - physiology | Antineoplastic Agents - therapeutic use | BH3 Interacting Domain Death Agonist Protein - genetics | Gene Expression Profiling | RNA Stability - drug effects | Thalidomide - pharmacology | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | BH3 Interacting Domain Death Agonist Protein - biosynthesis | Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis | Thalidomide - analogs & derivatives | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Nuclear Proteins - biosynthesis | Tumor Suppressor Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Adjuvants, Immunologic - therapeutic use | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | B-Lymphocytes - metabolism | Cells, Cultured - drug effects | Neoplasm Proteins - biosynthesis | Gene Expression Regulation, Leukemic - drug effects | CD40 Ligand - biosynthesis | Immunophenotyping | DNA-Binding Proteins - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | B-Lymphocytes - drug effects | Tumor Protein p73 | CD40 Ligand - genetics | Signal Transduction - drug effects | Phosphatidylinositol 3-Kinases - physiology | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Thalidomide - therapeutic use | Tumor Suppressor Proteins - biosynthesis | DNA-Binding Proteins - biosynthesis | Lymphoid Neoplasia
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 03/2007, Volume 115, Issue 12, pp. 1571 - 1580
Background-Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammatory diseases such as atherosclerosis. Despite extensive... 
Mice | Leukocytes | CD40 ligand | Atherosclerosis | Cell adhesion molecules | atherosclerosis | cell adhesion molecules | CARDIAC & CARDIOVASCULAR SYSTEMS | INTERCELLULAR-ADHESION MOLECULE-1 | TRANSENDOTHELIAL MIGRATION | ACUTE CORONARY SYNDROMES | mice | LEUKOCYTE INTEGRIN MAC-1 | VASCULAR SMOOTH-MUSCLE | COUNTER-RECEPTOR | GLYCOPROTEIN IB-ALPHA | ICAM-1 CD54 | CD11B CD18 | ENDOTHELIAL-CELLS | leukocytes | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | CD40 Ligand - physiology | Peroxidase - secretion | Cholesterol, Dietary - toxicity | Tetradecanoylphorbol Acetate - pharmacology | Cricetulus | Atherosclerosis - genetics | Humans | Aorta, Thoracic - chemistry | Chemotaxis, Leukocyte - physiology | Atherosclerosis - etiology | Peritonitis - pathology | Receptors, LDL - deficiency | Macrophage-1 Antigen - physiology | Foam Cells - pathology | Aorta, Thoracic - pathology | Aortic Diseases - pathology | CHO Cells | Receptors, LDL - genetics | Cricetinae | Genetic Predisposition to Disease | CD40 Ligand - deficiency | Macrophages - pathology | Atherosclerosis - physiopathology | Rheology | Mice, Inbred C57BL | Peritonitis - metabolism | Peritonitis - chemically induced | Inflammation - etiology | Mice, Knockout | Monocytes - drug effects | Diet, Atherogenic | Monocytes - enzymology | Animals | Models, Biological | Inflammation - genetics | Lipids - analysis | Aortic Diseases - etiology | Atherosclerosis - prevention & control | Crosses, Genetic | Inflammation - physiopathology | Physiological aspects | Development and progression | Research | CD4 lymphocytes
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2013, Volume 191, Issue 4, pp. 1976 - 1983
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e64631
Recent work has revealed an essential involvement of soluble CD40L (sCD40L) in inflammation and vascular disease. Activated platelets are the major source of... 
CD40 Ligand - physiology | Reactive Oxygen Species - metabolism | Signal Transduction | Respiratory Burst | Mice, Inbred C57BL | Cells, Cultured | Neutrophils - physiology | Cell Communication | Phosphatidylinositol 3-Kinases - metabolism | Protein Kinase C - antagonists & inhibitors | Blood Platelets - physiology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Adhesion | Mice, Knockout | Animals | CD40 Antigens - metabolism | Transcription Factor RelA - metabolism | Macrophage-1 Antigen - genetics | Protein Kinase C - metabolism | Macrophage-1 Antigen - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Active Transport, Cell Nucleus | Transcellular Cell Migration | Oxidative stress | Protein kinase C | CD40 antigen | Leukocyte migration | Laboratories | Pathogenesis | Science | Activation | Biology | Neurosurgery | Kinases | CD40L protein | Recruitment | Proteins | Cell activation | Vascular diseases | Bursting strength | Adhesive strength | Blood platelets | Mac1 protein | Atherosclerosis | Tumor necrosis factor-TNF | Physiology | Cardiology | NF-κB protein | Stroke | Immunoglobulins | CD11b antigen | Neutrophils | Leukocytes (neutrophilic) | Inflammation | Gene expression | Clustering | Adhesion | 1-Phosphatidylinositol 3-kinase | White blood cells | Studies | Hospitals | Ligands | Platelets | Cell migration
Journal Article
Journal Article