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Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 24, pp. 4751 - 4760
Natural killer (NK) cells are lymphocytes that play an important role in the immune response to infection and malignancy. Recent studies in mice have shown... 
INNATE | NATURAL-KILLER-CELLS | INFECTION | HEMATOLOGY | EXPANSION | Receptors, Interleukin-12 - immunology | Antigens, CD - immunology | Interleukin-18 - immunology | Humans | Lectins, C-Type - immunology | Interferon-gamma - metabolism | Interleukin-15 - immunology | Antigens, CD - metabolism | NK Cell Lectin-Like Receptor Subfamily D - immunology | Lectins, C-Type - metabolism | NK Cell Lectin-Like Receptor Subfamily C - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Time Factors | Killer Cells, Natural - immunology | Receptors, Interleukin-12 - genetics | Interferon-gamma - genetics | CD56 Antigen - immunology | Immunologic Memory - immunology | Cytokines - immunology | Interleukin-12 - pharmacology | Receptors, Interleukin-18 - metabolism | CD56 Antigen - metabolism | NK Cell Lectin-Like Receptor Subfamily C - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-15 - pharmacology | Receptors, Interleukin-12 - metabolism | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Interleukin-12 - immunology | K562 Cells | Receptors, Interleukin-18 - genetics | Receptors, Interleukin-18 - immunology | Cell Proliferation - drug effects | Interleukin-18 - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Cytokines - pharmacology | Immunobiology
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e76781
Natural killer (NK) cells are important mediators of anti-tumor immunity and are active against several hematologic malignancies, including multiple myeloma... 
EX-VIVO EXPANSION | MULTIPLE-MYELOMA | NK CELLS | UNRELATED DONOR | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | AUTOLOGOUS TRANSPLANTATION | TERM-FOLLOW-UP | IMMUNOLOGICAL SYNAPSE FORMATION | ANTITUMOR-ACTIVITY | T-LYMPHOCYTES | Cell Proliferation | Coculture Techniques | Humans | Multiple Myeloma - immunology | Interleukin Receptor Common gamma Subunit - immunology | NK Cell Lectin-Like Receptor Subfamily D - immunology | NK Cell Lectin-Like Receptor Subfamily C - immunology | Multiple Myeloma - therapy | Interleukin-2 - immunology | Killer Cells, Natural - immunology | Cell Culture Techniques | CD56 Antigen - immunology | Cytotoxicity, Immunologic - drug effects | CD56 Antigen - metabolism | Fetal Blood - immunology | NK Cell Lectin-Like Receptor Subfamily C - metabolism | Cells, Cultured | Fetal Blood - cytology | Fetal Blood - metabolism | Mice, SCID | Xenograft Model Antitumor Assays - methods | Antigen-Presenting Cells - immunology | CD3 Complex - metabolism | Interleukin Receptor Common gamma Subunit - genetics | Mice, Knockout | Interleukin Receptor Common gamma Subunit - deficiency | Microscopy, Confocal | Multiple Myeloma - pathology | Animals | CD3 Complex - immunology | K562 Cells | Cell Line, Tumor | Interleukin-2 - pharmacology | Mice, Inbred NOD | Mice | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic - immunology | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Antigens | Killer cells | Cell culture | Pediatrics | Transcription factors | Transplants & implants | Toxicity | Leukemia | Multiple myeloma | Cytotoxicity | Immunological synapses | Immunity | Blood | NKG2 antigen | Receptors | Interleukin 2 | Cord blood | Cryopreservation | Immunotherapy | Bone marrow | Biocompatibility | Natural killer cells | CD56 antigen | Expansion | Immunoglobulins | Cytokines | CD3 antigen | Permeability | Medicine | Studies | Stem cells | Ligands | Umbilical cord | Gene therapy | Synapses | Cancer
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 06/2013, Volume 73, Issue 12, pp. 3499 - 3510
Cancer immunosurveillance relies on effector/memory tumor-infiltrating CD8(+) T cells with a T-helper cell 1 (T(H)1) profile. Evidence for a natural killer... 
NATURAL-KILLER-CELLS | INHIBITION | EFFICACY | ONCOLOGY | C-KIT | MUTATIONS | CYTOTOXIC ACTIVITY | CANCER | EXPRESSION | IMATINIB MESYLATE | PREDICTION | Forkhead Transcription Factors - immunology | Immunohistochemistry | Multivariate Analysis | Pyrimidines - immunology | Prognosis | Humans | Middle Aged | Male | Benzamides - therapeutic use | Flow Cytometry | T-Lymphocytes - metabolism | Forkhead Transcription Factors - metabolism | Protein Kinase Inhibitors - immunology | T-Lymphocytes - drug effects | Aged, 80 and over | Killer Cells, Natural - immunology | Adult | Female | Lymphocytes, Tumor-Infiltrating - metabolism | CD56 Antigen - immunology | Natural Cytotoxicity Triggering Receptor 1 - immunology | Gastrointestinal Stromal Tumors - immunology | CD56 Antigen - metabolism | Kaplan-Meier Estimate | Treatment Outcome | Piperazines - therapeutic use | Lymphocytes, Tumor-Infiltrating - drug effects | Benzamides - immunology | CD3 Complex - metabolism | Imatinib Mesylate | Gastrointestinal Stromal Tumors - drug therapy | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | CD3 Complex - immunology | Piperazines - immunology | Gastrointestinal Stromal Tumors - metabolism | Natural Cytotoxicity Triggering Receptor 1 - metabolism | T-Lymphocytes - immunology | Aged | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology
Journal Article
JOURNAL OF AUTOIMMUNITY, ISSN 0896-8411, 01/2016, Volume 66, pp. 40 - 50
Journal Article
Journal Article
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 12, pp. 3301 - 3310
CD3(+)CD56(+) cytokine-induced killer (CIK) cells display a potent cytolytic activity. The adhesion molecule lymphocyte function-associated antigen-1 plays a... 
IMMUNOLOGICAL EFFECTOR-CELLS | SEVERE COMBINED IMMUNODEFICIENCY | NKG2D | DENDRITIC CELLS | IN-VIVO | ANTITUMOR-ACTIVITY | NECTIN-2 CD112 | HEMATOLOGY | PHASE-I | INDUCED KILLER-CELLS | CELIAC-DISEASE | Neoplasms - metabolism | T-Lymphocyte Subsets - immunology | T-Lymphocyte Subsets - cytology | Humans | Natural Cytotoxicity Triggering Receptor 3 - metabolism | NK Cell Lectin-Like Receptor Subfamily K - immunology | Lymphocyte Function-Associated Antigen-1 - metabolism | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - metabolism | Lymphocyte Function-Associated Antigen-1 - immunology | Signal Transduction - immunology | T-Lymphocytes, Cytotoxic - drug effects | Flow Cytometry | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Neoplasms - genetics | Cytomegalovirus Infections - virology | Killer Cells, Natural - immunology | Cytomegalovirus Infections - pathology | Natural Cytotoxicity Triggering Receptor 3 - immunology | CD56 Antigen - immunology | Cytotoxicity, Immunologic - drug effects | Antibodies, Monoclonal - immunology | T-Lymphocytes, Cytotoxic - immunology | Cytokine-Induced Killer Cells - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Antibodies, Monoclonal - pharmacology | Antigens, Differentiation, T-Lymphocyte - metabolism | Cytokine-Induced Killer Cells - immunology | Cytomegalovirus - growth & development | Cytomegalovirus - immunology | Killer Cells, Natural - cytology | Signal Transduction - drug effects | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | CD3 Complex - immunology | Cell Line, Tumor | Cytokine-Induced Killer Cells - cytology | Killer Cells, Natural - metabolism | Primary Cell Culture | Neoplasms - pathology
Journal Article
Plos One, ISSN 1932-6203, 2012, Volume 7, Issue 12, pp. e51851 - e51851
Dendritic cells (DCs) are the quintessential antigen-presenting cells of the human immune system and play a prime role in coordinating innate and adaptive... 
NATURAL-KILLER-CELLS | IN-VITRO | INTERFERON-ALPHA | ACTIVATION | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | CYTOTOXICITY | EXPRESSION | CD8(+) T-CELLS | GRANZYME-B | Neoplasms - metabolism | Monocytes - cytology | Dendritic Cells - immunology | Granzymes - metabolism | Humans | Monocytes - immunology | Antigen-Presenting Cells - immunology | Interleukin-15 - immunology | Flow Cytometry | Myeloid Cells - immunology | Neoplasms - immunology | Killer Cells, Natural - immunology | Cell Differentiation | Dendritic Cells - cytology | Granzymes - immunology | CD56 Antigen - immunology | Cytotoxicity, Immunologic - immunology | Neoplasms - pathology | Cell culture | Health sciences | Adaptive systems | Fas antigen | Laboratories | Toxicity | Interleukin | Cytotoxicity | Lymphocytes T | Genotype & phenotype | Granzyme B | Immunology | Lymphocytes | Immunotherapy | Tumor necrosis factor-TNF | Life sciences | Natural killer cells | Perforin | CD56 antigen | Immune system | Antigen presentation | Immune response | Immunostimulation | Cytokines | Hematology | Dendritic cells | CD95 antigen | Data processing | Breast cancer | Tumor necrosis factor-α | Interleukin 15 | Medicine | Monocytes | Hospitals | Infectious diseases | FasL protein | Immunogenicity | Cell death | Antigen-presenting cells | Ligands | TRAIL protein | Apoptosis | Cancer
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2013, Volume 121, Issue 14, pp. 2669 - 2677
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2010, Volume 185, Issue 2, pp. 1311 - 1320
Daclizumab (Dac), an Ab against the IL-2R alpha-chain, inhibits brain inflammation in patients with multiple sclerosis, while expanding CD56(bright)... 
NATURAL-KILLER-CELLS | REMITTING MULTIPLE-SCLEROSIS | IN-VIVO | DISEASE | DACLIZUMAB | RECEPTOR-ALPHA-CHAIN | ANTIBODY | PERIPHERAL-BLOOD | INTERFERON-BETA | IMMUNOLOGY | EXPRESSION | Forkhead Transcription Factors - immunology | Leukocytes, Mononuclear - metabolism | T-Lymphocytes, Regulatory - metabolism | Humans | Interleukin-7 Receptor alpha Subunit - immunology | Lewis X Antigen - metabolism | T-Lymphocytes, Regulatory - immunology | Antibodies, Monoclonal, Humanized | Signal Transduction - immunology | Flow Cytometry | Interleukin-2 - immunology | T-Lymphocytes - metabolism | Forkhead Transcription Factors - metabolism | T-Lymphocytes - drug effects | Leukocytes, Mononuclear - immunology | Immunoglobulin G - pharmacology | Killer Cells, Natural - immunology | CD56 Antigen - immunology | Cytotoxicity, Immunologic - drug effects | Immunosuppressive Agents - pharmacology | Interleukin-7 - metabolism | Interleukin-2 Receptor alpha Subunit - immunology | Interleukin-2 - metabolism | CD56 Antigen - metabolism | Cell Line | Antibodies, Monoclonal - pharmacology | Cells, Cultured | Lewis X Antigen - immunology | T-Lymphocytes, Regulatory - drug effects | Interleukin-7 - immunology | Interleukin-2 Receptor alpha Subunit - metabolism | Signal Transduction - drug effects | Interleukin-7 Receptor alpha Subunit - metabolism | Lewis X Antigen - pharmacology | K562 Cells | Interleukin-2 - pharmacology | Leukocytes, Mononuclear - cytology | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic - immunology
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2602 - 2610
The interaction between clonally distributed inhibitory receptors and their activating counterparts on NK cells and HLA class I molecules defines NK cell... 
RESPONSES | TAP DEFICIENCY SYNDROME | BARE LYMPHOCYTE SYNDROME | RECOGNITION | KIR | TOLERANCE | SURFACE EXPRESSION | SELF | IMMUNOLOGY | TAP1-DEFICIENT PATIENT | CD8-ALPHA-ALPHA | Humans | Middle Aged | Male | Interferon-gamma - metabolism | HLA-A Antigens - metabolism | Histocompatibility Antigens Class I - metabolism | ATP-Binding Cassette Transporters - deficiency | Cell Differentiation - genetics | NK Cell Lectin-Like Receptor Subfamily C - immunology | Flow Cytometry | ATP-Binding Cassette Transporters - genetics | HLA-C Antigens - immunology | Receptors, KIR - metabolism | Lysosomal-Associated Membrane Protein 1 - immunology | Killer Cells, Natural - immunology | Adult | Female | CD56 Antigen - immunology | HLA-B Antigens - genetics | CD57 Antigens - metabolism | HLA-C Antigens - metabolism | CD56 Antigen - metabolism | NK Cell Lectin-Like Receptor Subfamily C - metabolism | CD57 Antigens - immunology | Receptors, KIR - genetics | HLA-B Antigens - immunology | Histocompatibility Antigens Class I - immunology | Genotype | Histocompatibility Antigens Class I - genetics | CD8 Antigens - immunology | HLA-B Antigens - metabolism | Cell Differentiation - immunology | CD8 Antigens - metabolism | HLA-A Antigens - immunology | Interferon-gamma - immunology | HLA-A Antigens - genetics | Lysosomal-Associated Membrane Protein 1 - metabolism | HLA-C Antigens - genetics | Killer Cells, Natural - metabolism | Mutation | ATP-Binding Cassette Sub-Family B Member 2 | ATP-Binding Cassette Transporters - immunology | Receptors, KIR - immunology
Journal Article