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1. Full Text CD63-mediated antigen delivery into extracellular vesicles via DNA vaccination results in robust CD8+ T cell responses
by Kanuma, Tomohiro and Yamamoto, Takuya and Kobiyama, Kouji and Moriishi, Eiko and Masuta, Yuji and Kusakabe, Takato and Ozasa, Koji and Kuroda, Etsushi and Jounai, Nao and Ishii, Ken J
Journal of Immunology, ISSN 0022-1767, 06/2017, Volume 198, Issue 12, pp. 4707 - 4715
DNAvaccines are attractive immunogens for priming humoral and cellular immune responses to the encoded Ag. However, their ability to induce Ag-specific CD8(+)... 
NEOANTIGEN LANDSCAPE | ACTIVATION | MICROENVIRONMENT | MEMBRANE-VESICLES | IMMUNOTHERAPY | IMMUNE-RESPONSES | IN-VIVO | APOPTOTIC CELLS | IMMUNOLOGY | TUMOR-DERIVED EXOSOMES | VACCINES | Immunogenicity, Vaccine | Adjuvants, Immunologic - administration & dosage | Ovalbumin - immunology | Lymphocyte Activation | Mice, Inbred C57BL | Vaccines, DNA - immunology | Antigen Presentation - immunology | Vaccines, DNA - administration & dosage | CD4-Positive T-Lymphocytes - immunology | Tetraspanin 30 - immunology | Cancer Vaccines - immunology | Animals | Extracellular Vesicles - immunology | Immunization, Secondary | Female | Tetraspanin 30 - genetics | Mice | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Membranes | Drug delivery systems | CD8 antigen | Vaccination | Delivery systems | Lymphocytes T | DNA vaccines | Vaccines | Cancer vaccines | Proteins | Vesicles | Transfection | Lymphocytes | Plasmid DNA | Fusion protein | Deoxyribonucleic acid--DNA | Formulations | Immunization | CD63 antigen | Adjuvants | Implantation | Electroporation | Priming | Calnexin | Immune response (humoral) | CD4 antigen | Immunogenicity | Plasmids | Endoplasmic reticulum | Cancer | Index Medicus | Abridged Index Medicus
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2. Full Text Radiogenomics Profiling for Glioblastoma-related Immune Cells Reveals CD49d Expression Correlation with MRI parameters and Prognosis
by Cho, Hye Rim and Jeon, Hyejin and Park, Chul-Kee and Park, Sung-Hye and Choi, Seung Hong
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 16022 - 11
Although there have been a plethora of radiogenomics studies related to glioblastoma (GBM), most of them only used genomic information from tumor cells. In... 
METASTASIS | TUMOR PROGRESSION | MECHANISM | MICROGLIA | GLIOMA | MULTIDISCIPLINARY SCIENCES | MONOCYTES | MICROENVIRONMENTAL REGULATION | FLOW-CYTOMETRY | MYELOID CELLS | MACROPHAGE ACTIVATION | Prognosis | CD8 antigen | Glioblastoma | Cytotoxicity | mRNA | Lymphocytes T | Macrophages | Lymphocytes | CD25 antigen | CD123 antigen | Diffusion coefficient | Lymphoid cells | Myeloid cells | CD11b antigen | Cell survival | CD49d antigen | CD63 antigen | Tumor cells | Microglia | CD4 antigen | Polymerase chain reaction | CD163 antigen | CD83 antigen | Survival analysis | Magnetic resonance imaging | Perfusion | Medical prognosis
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3. Full Text Chronic lymphocytic leukaemia (CLL) and CLL-type monoclonal B-cell lymphocytosis (MBL) show differential expression of molecules involved in lymphoid tissue homing
by Rawstron, Andy C and Shingles, Jane and De Tute, Ruth and Bennett, Fiona and Jack, Andrew S and Hillmen, Peter
Cytometry Part B - Clinical Cytometry, ISSN 1552-4949, 2010, Volume 78, Issue 1, pp. S42 - S46
Introduction: The aim of this study was to screen for cell surface markers that could discriminate CLL-type MBL from CLL or identify CLL cases likely to have... 
CLL | MBL | Lymphoid tissue homing | lymphoid tissue homing | SURVIVAL | L-SELECTIN | DISEASE | CD38 EXPRESSION | MEDICAL LABORATORY TECHNOLOGY | PATHOLOGY | Lymphocytosis - metabolism | Humans | Middle Aged | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Lymphocytosis - genetics | Antigens, CD - metabolism | Flow Cytometry | Lymphocytosis - diagnosis | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Chromosome Deletion | Lymphoid Tissue - metabolism | Immunophenotyping | In Situ Hybridization, Fluorescence | Lymphoid Tissue - pathology | Chromosomes, Human, Pair 17 | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Lymphocyte Count | Aged | Chromosomes, Human, Pair 11 | Cell Movement | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | CD27 antigen | Immunoglobulin M | Flow cytometry | CD86 antigen | Immunoglobulin G | Immunoglobulin D | CD103 antigen | CD23 antigen | CD200 antigen | CXCR5 protein | Lymphocytes | CD38 antigen | CD25 antigen | L-selectin | CD43 antigen | CD11c antigen | Chronic lymphatic leukemia | CD49d antigen | CD63 antigen | CD95 antigen | CD62L protein | Chromosome deletion | Lymphoid tissue | CCR6 protein | CD5 antigen | CD22 antigen | Lymphocytes B | CD81 antigen | Histocompatibility antigen HLA | Cell migration | Index Medicus
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4. Full Text In vitro detection of allergen sensitized basophils by HSA-DNP antigen-anchored liquid crystal microdroplets
by Shin, Hanbyeol and Park, So Jung and Park, Soo-Young and Gupta, Kailash Chandra and Lee, Dong Yun and Kang, Inn-Kyu
Analytical Biochemistry, ISSN 0003-2697, 10/2018, Volume 558, pp. 1 - 11
A simple and easy to handle biosensing technique for detection of HSA-DNP antigen induced allergen reactions in patients has been developed through the... 
HSA-DNP-Antigen | LC microdroplets | Basophils | FcεRI receptor | Allergen | CELLS | CD63 | CHEMISTRY, ANALYTICAL | ACTIVATION | IGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | SENSOR | CYTOKINE | FceRI receptor | IDENTIFICATION | ENZYME AMPLIFICATION | FLOW-CYTOMETRY | REAL-TIME | Antigen-antibody reactions | Allergens | Allergy | Detectors | Immunoglobulin E | Albumin | Nitriles | Health savings accounts | Macrophages | Allergic reaction
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5. Full Text Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera
by Kabe, Yasuaki and Suematsu, Makoto and Sakamoto, Satoshi and Hirai, Miwa and Koike, Ikko and Hishiki, Takako and Matsuda, Atsushi and Hasegawa, Yuichi and Tsujita, Koji and Ono, Masayuki and Minegishi, Naoko and Hozawa, Atsushi and Murakami, Yoshinori and Kubo, Michiaki and Itonaga, Makoto and Handa, Hiroshi
Clinical Chemistry, ISSN 0009-9147, 10/2018, Volume 64, Issue 10, pp. 1463 - 1473
BACKGROUND: Although circulating exosomes in blood play crucial roles in cancer development and progression, difficulties in quantifying exosomes hamper their... 
CELLS | EXTRACELLULAR VESICLES | MARKERS | MEDICAL LABORATORY TECHNOLOGY | PROTEINS | CANCER | MODULATION | BEADS | Cell culture | Flow cytometry | CD9 antigen | Ovarian carcinoma | Surface antigens | Colorectal cancer | Antibodies | CD147 antigen | Exosomes | Ovarian cancer | Proteins | Carcinoembryonic antigen | Epidermal growth factor | Optical properties | Labeling | Growth factors | Enzyme-linked immunosorbent assay | Antigens | Immunoglobulins | CD63 antigen | Cloning | Breast cancer | Roles | Patients | ErbB-2 protein | Disk drives | Blood circulation | Linearity | MicroRNAs | Methods | Counting | Cancer
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6. Full Text Involvement of Class II Phosphoinositide 3-Kinase alpha-Isoform in Antigen-Induced Degranulation in RBL-2H3 Cells
by Nigorikawa, K and Hazeki, K and Guo, Y and Hazeki, O
PLOS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e111698 - e111698
In this study, we present findings that suggest that PI3K-C2 alpha, a member of the class II phosphoinositide 3-kinase (PI3K) subfamily, regulates the process... 
GRANULE EXOCYTOSIS | ACTIVATION | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | C2-BETA | MEMBRANE | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | C2 DOMAIN | C2-ALPHA | SECRETION | MAMMALIAN-CELLS | Calcium - pharmacology | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Isoenzymes - genetics | beta-N-Acetylhexosaminidases - metabolism | Humans | RNA, Messenger - genetics | Rats | RNA, Messenger - metabolism | Gene Knockdown Techniques | Neuropeptide Y - metabolism | Animals | Transfection | Receptors, IgE - metabolism | Isoenzymes - metabolism | Cell Line, Tumor | Class II Phosphatidylinositol 3-Kinases - genetics | RAW 264.7 Cells | Mice | Antigens - pharmacology | Cell Degranulation - drug effects | RNA, Small Interfering - metabolism | Health sciences | Antigens | Enzymes | Calcium mobilization | Calcium (intracellular) | CD63 antigen | Leukemia | siRNA | Exocytosis | Mammals | Kinases | 1-Phosphatidylinositol 3-kinase | Proteins | Vesicles | Secretory vesicles | Degranulation | Protein expression | Localization | Calcium ions | Index Medicus
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7. Full Text microRNA modified tumor‐derived exosomes as novel tools for maturation of dendritic cells
by Taghikhani, Adeleh and Hassan, Zuhair Mohammad and Ebrahimi, Marzieh and Moazzeni, Seyyed‐Mohammad
Journal of Cellular Physiology, ISSN 0021-9541, 06/2019, Volume 234, Issue 6, pp. 9417 - 9427
Tumor‐derived exosomes (TEX) are known by their immune suppression effects as well as initiation mediators in cancer progression and metastasis. Meanwhile,... 
microRNA | tumor‐derived exosomes (TEX) | dendritic cell maturation | tumor-derived exosomes (TEX) | MIR-142 | PHYSIOLOGY | PATHWAY | DCS | ANTIGENS | EXPRESSION | DELIVERY | CELL BIOLOGY | Antigens | MicroRNA | Interleukins | Dendritic cells | Development and progression | Metastasis | Macrophage colony stimulating factor | Transforming growth factors | Mitogens | Cancer | Flow cytometry | CD40 antigen | Genes | Interleukin | Vaccines | Exosomes | Macrophages | Immunity | Metastases | Lipopolysaccharides | Cancer vaccines | Proteins | Bone marrow | Toll-like receptors | Maturation | CD63 antigen | Tumor cells | Markers | MiRNA | Electroporation | CD80 antigen | Breast cancer | TLR4 protein | Ribonucleic acid--RNA | Gene expression | Morphology | MicroRNAs | Antigen (tumor-associated) | γ-Interferon | CD81 antigen | Leukocytes (granulocytic) | Tumors
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8. Full Text The role of tetraspanin CD63 in antigen presentation via MHC class II
by Petersen, Sven H and Odintsova, Elena and Haigh, Tracey A and Rickinson, Alan B and Taylor, Graham S and Berditchevski, Fedor
European Journal of Immunology, ISSN 0014-2980, 09/2011, Volume 41, Issue 9, pp. 2556 - 2561
Interactions between MHC class II (MHC II)-positive APCs and CD4(+) T cells are central to adaptive immune responses. Using an Epstein-Barr virus... 
Antigen presentation | CD63 | CD4 | MHC class II | T cell | DENDRITIC CELLS | VESICLES | COMPLEXES | ALPHA | IMMUNOLOGY | PEPTIDE | MOLECULES | RESPONSES | SURFACE | TYPE-1 | ASSOCIATION | Exosomes - metabolism | RNA, Small Interfering - genetics | Antigens, Viral - metabolism | Humans | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | Tetraspanin 30 - immunology | Lymphocyte Activation - genetics | Exosomes - immunology | B-Lymphocytes - virology | Histocompatibility Antigens Class II - metabolism | Tetraspanin 30 - genetics | Clone Cells | CD4-Positive T-Lymphocytes - virology | B-Lymphocytes - metabolism | B-Lymphocytes - ultrastructure | Exosomes - ultrastructure | Adaptive Immunity | CD4-Positive T-Lymphocytes - metabolism | Herpesvirus 4, Human - immunology | Antigen Presentation - genetics | Microscopy, Electron | Antigens, Viral - immunology | B-Lymphocytes - immunology | Histocompatibility Antigens Class II - immunology | Tetraspanin 30 - metabolism | Cell Line, Transformed | Medical research | Antigens | Immune system | Index Medicus
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9. Full Text Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia
by Blair, Thomas A and Michelson, Alan D and Frelinger, Andrew L
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 10300 - 13
Mass cytometry (MC) uses mass spectrometry to simultaneously detect multiple metal-conjugated antibodies on single cells, thereby enabling the detailed study... 
ALPHA-GRANULE | HETEROGENEITY | ACTIVATION | INHIBITION | CLOPIDOGREL | MULTICOLOR FLOW-CYTOMETRY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | RECEPTOR | EXPRESSION | AGGREGATION | Cadmium | Subpopulations | Flow cytometry | CD9 antigen | CD63 antigen | Antibodies | Mass spectroscopy | Glycoproteins | CD36 antigen | CD29 antigen | Dimensional analysis | CD154 antigen | Platelets | Surface markers
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10. Full Text Decrease in antigen‐specific CD63 basophil expression is associated with the development of tolerance to egg by SOTI in children
by Vila, Leticia and Moreno, Ana and Gamboa, Pedro M and Martínez‐Aranguren, Rubén and Sanz, Maria L
Pediatric Allergy and Immunology, ISSN 0905-6157, 08/2013, Volume 24, Issue 5, pp. 463 - 468
BackgroundIn the last decade, there have been an increasing number of studies on achieving tolerance to foods by specific oral tolerance induction (SOTI).... 
specific oral tolerance induction | basophil activation | egg allergy | CD63 | Specific oral tolerance induction | Basophil activation | Egg allergy | DIAGNOSIS | TESTS | MARKER | IGE | INDUCTION | IMMUNOLOGY | ALLERGY | ORAL IMMUNOTHERAPY | PEDIATRICS | Allergens - therapeutic use | Skin Tests | Humans | Mouth - immunology | Child, Preschool | Immune Tolerance | Egg Hypersensitivity - diagnosis | Treatment Outcome | Egg Proteins | Egg Hypersensitivity - immunology | Tetraspanin 30 - immunology | Immunoglobulin E - immunology | Allergens - immunology | Adolescent | Basophils - immunology | Female | Egg Hypersensitivity - therapy | Biomarkers, Pharmacological - metabolism | Child | Desensitization, Immunologic - methods | Immunoglobulin E | Antigens | Children | Eggs | Index Medicus
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11. Full Text Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma
by Cocozza, Federico and Menay, Florencia and Tsacalian, Rodrigo and Elisei, Analía and Sampedro, Pura and Soria, Ivana and Waldner, Claudia and Gravisaco, María José and Mongini, Claudia
Vaccine, ISSN 0264-410X, 03/2019, Volume 37, Issue 12, pp. 1565 - 1576
Exosomes are 60–150 nm small extracellular vesicles (EVs) released by most cells. Tumor-cell-derived exosomes, used as a vaccine, elicit a specific cytotoxic... 
Extracellular vesicles | Tumor-vaccine | Exosomes | T-cell lymphoma | VITRO | MEDICINE, RESEARCH & EXPERIMENTAL | HEAT-SHOCK-PROTEIN-70 | ACTIVATION | ASCITES-DERIVED EXOSOMES | MICROVESICLES | PROLIFERATION | IMMUNOLOGY | MICROENVIRONMENT | BIOGENESIS | EFFICIENT INDUCTION | EXPRESSION | Proteins | Antigens | Cyclophosphamide | Immune response | Vaccination | Radiation | Non-Hodgkin's lymphomas | T cells | Cancer | Cell culture | CD9 antigen | CD8 antigen | Cytotoxicity | Lymphocytes T | Vaccines | Immunosuppressive agents | Anticancer properties | Cancer vaccines | Lysates | Drug dosages | Culture | Immune system | Immunization | Dendritic cells | CD63 antigen | Secretion | Tumor cells | Lymphoma | Immune response (humoral) | CD4 antigen | Immune systems | Immunogenicity | γ-Interferon | Cell lines | Hypoxia | CD81 antigen | Lymphomas | Acidosis | Tumors
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12. Full Text Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy
by Chettimada, Sukrutha and Lorenz, David R and Misra, Vikas and Dillon, Simon T and Reeves, R. Keith and Manickam, Cordelia and Morgello, Susan and Kirk, Gregory D and Mehta, Shruti H and Gabuzda, Dana
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 16
Exosomes are nanovesicles released from most cell types including immune cells. Prior studies suggest exosomes play a role in HIV pathogenesis, but little is... 
C-REACTIVE PROTEIN | PLASMACYTOID DENDRITIC CELLS | TRYPTOPHAN | TRANSMISSION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | NOTCH | MICROVESICLES | FATTY-ACIDS | INFECTION | DIFFERENTIATION | Oxidative stress | Antiretroviral drugs | Myeloid cells | CD9 antigen | Immune response | CD63 antigen | Immunomodulation | Pathogenesis | Immunoblotting | Inflammation | Electron microscopy | CD14 antigen | Exosomes | Patients | Antiretroviral therapy | Nanoparticles | Monocytes | Human immunodeficiency virus--HIV | Proteomics | Histocompatibility antigen HLA | CD81 antigen | Interferon
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13. Full Text Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples
by Belov, Larissa and Matic, Kieran J and Hallal, Susannah and Best, O. Giles and Mulligan, Stephen P and Christopherson, Richard I
Journal of Extracellular Vesicles, ISSN 2001-3078, 01/2016, Volume 5, Issue 1, pp. 25355 - 12
Extracellular vesicles (EV) are membranous particles (30-1,000 nm in diameter) secreted by cells. Important biological functions have been attributed to 2... 
luminescence | chronic lymphocytic leukaemia | microvesicles | exosomes | CD antigen | CELL BIOLOGY | WORKING GROUP | MELANOMA | ANTIBODY MICROARRAY | COLORECTAL-CANCER | DISEASE | CHRONIC LYMPHOCYTIC-LEUKEMIA | CIRCULATING MICROPARTICLES | STROMAL CELLS | EXPRESSION | Membranes | Leukemia | Colorectal carcinoma | Colorectal cancer | Exosomes | Proteins | Vesicles | CD44 antigen | Fibroblasts | Bone marrow | Antigens | Immunoglobulins | Chronic lymphatic leukemia | CD19 antigen | CD63 antigen | Antibody microarrays | Melanoma | CD62L protein | Chemiluminescence | Tumor cell lines | CD5 antigen | Body fluids | Lymphocytes B | Medical prognosis | Cell lines | Plasma membranes | Histocompatibility antigen HLA
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14. Full Text The fbpA/sapM double knock out strain of Mycobacterium tuberculosis is highly attenuated and immunogenic in macrophages
by Saikolappan, Sankaralingam and Estrella, Jaymie and Sasindran, Smitha J and Khan, Arshad and Armitige, Lisa Y and Jagannath, Chinnaswamy and Dhandayuthapani, Subramanian
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, pp. e36198 - e36198
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death due to bacterial infections in mankind, and BCG, an attenuated... 
PHAGOSOME MATURATION | TUBERCLE-BACILLI | PROTECTIVE IMMUNITY | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | MURINE MACROPHAGES | BALB/C MOUSE MODEL | VACCINE EFFICACY | PROGRESSIVE PULMONARY TUBERCULOSIS | ANTIGEN 85B | PANTOTHENATE AUXOTROPH | Acyltransferases - deficiency | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Acyltransferases - immunology | Gene Knockout Techniques | Acyltransferases - genetics | Antigens, Bacterial - genetics | Phagosomes - immunology | Vaccines, Attenuated - immunology | Animals | Mice | Mutation | Lysosomes - immunology | Macrophages - immunology | Mycobacterium tuberculosis - genetics | Vaccines, Attenuated - genetics | Antigens | Tuberculosis vaccines | Tuberculosis | Phosphatases | Bacterial infections | Vaccination | Comparative analysis | T cells | Macrophages | Health aspects | Peptides | Laboratories | Antigen 85B | Genes | Oxidizing agents | Antigen processing | Science | Lysosomes | Phagosomes | Acidification | Lymphocytes T | Infections | Vaccines | Proteins | Immunology | Oxidants | Lymphocytes | Bacteria | Attenuation | Strains (organisms) | Deoxyribonucleic acid--DNA | Antigen presentation | Maturation | CD63 antigen | BCG | Medicine | Pathology | DNA fingerprints | Immunogenicity | Antigen-presenting cells | Molecular biology | Acid phosphatase | Index Medicus | Phorbol esters | Helper cells | Infection | Deoxyribonucleic acid | DNA
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