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Annual Review of Immunology, ISSN 0732-0582, 2009, Volume 27, Issue 1, pp. 199 - 227
Sophisticated genetic tools have made possible the identification of the genes responsible for most well-described immunodeficiencies in the past 15 years.... 
Btk | Common variable immunodeficiency | TACI | X-linked agammaglobulinemia | Hyper-IgM syndrome | DISEASE GENE SH2D1A | INDUCED CYTIDINE DEAMINASE | common variable immunodeficiency | MAJOR HISTOCOMPATIBILITY COMPLEX | IMMUNOLOGY | hyper-IgM syndrome | BRUTONS TYROSINE KINASE | ANTIBODY-DEFICIENCY SYNDROME | CLASS-SWITCH RECOMBINATION | AUTOSOMAL RECESSIVE FORM | Inducible T-Cell Co-Stimulator Protein | CD79 Antigens - immunology | Protein-Tyrosine Kinases - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Precursor Cells, B-Lymphoid - immunology | Antigens, CD19 - genetics | Protein-Tyrosine Kinases - immunology | Transmembrane Activator and CAML Interactor Protein - metabolism | Protein-Tyrosine Kinases - genetics | Adaptor Proteins, Signal Transducing - immunology | Immunologic Deficiency Syndromes - immunology | B-Lymphocytes - metabolism | Antigens, CD19 - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | CD79 Antigens - metabolism | Transmembrane Activator and CAML Interactor Protein - genetics | Animals | B-Lymphocytes - immunology | Adaptor Proteins, Signal Transducing - genetics | Antigens, Differentiation, T-Lymphocyte - genetics | Immunologic Deficiency Syndromes - genetics | Antigens, CD19 - metabolism | CD79 Antigens - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Transmembrane Activator and CAML Interactor Protein - immunology | Genetic aspects | B cells | Properties | Identification and classification | Immunodeficiency | Immunological research
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7277, pp. 88 - 92
Journal Article
Science, ISSN 0036-8075, 6/2012, Volume 336, Issue 6085, pp. 1178 - 1181
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 475 - 488
Follicular B cell survival requires signaling from BAFFR, a receptor for BAFF and the B cell antigen receptor (BCR). This “tonic” BCR survival signal is... 
TACI | AKT | BCMA | IMMUNOLOGY | MATURATION | ACTIVATING FACTOR | AUTOIMMUNE-DISEASE | SYK TYROSINE KINASE | MICE LACKING | FAMILY | ANTIGEN | Oligonucleotide Array Sequence Analysis | Protein-Tyrosine Kinases - metabolism | Cell Survival - genetics | Immunoblotting | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Receptors, Antigen, B-Cell - metabolism | Extracellular Signal-Regulated MAP Kinases - immunology | Phosphatidylinositol 3-Kinases - immunology | Phosphorylation - drug effects | B-Cell Activation Factor Receptor - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | 3-Phosphoinositide-Dependent Protein Kinases | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | B-Cell Activation Factor Receptor - immunology | Cell Survival - drug effects | RNA, Untranslated | Mice, Transgenic | Mice, Knockout | B-Cell Activation Factor Receptor - metabolism | Models, Immunological | B-Lymphocytes - immunology | Signal Transduction - drug effects | Mice | CD79 Antigens - immunology | Intracellular Signaling Peptides and Proteins - immunology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Protein-Tyrosine Kinases - immunology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Flow Cytometry | B-Cell Activating Factor - immunology | Protein-Serine-Threonine Kinases - genetics | Cell Survival - immunology | Proteins - immunology | Receptors, Antigen, B-Cell - immunology | CD79 Antigens - metabolism | Proteins - genetics | Receptor Cross-Talk - immunology | B-Lymphocytes - drug effects | Animals | Proteins - metabolism | Tamoxifen - pharmacology | Protein-Serine-Threonine Kinases - immunology | B-Cell Activating Factor - pharmacology | Proteins | Genetic research | Cells | Bone marrow | Antigens | Kinases | Rodents | Immune system
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2015, Volume 112, Issue 44, pp. 13447 - 13454
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 32, Issue 2, pp. 187 - 199
Early events of B cell activation after B cell receptor (BCR) triggering have been well characterized. However, little is known about the steady state of the... 
MOLIMMUNO | PHOSPHOLIPASE C-GAMMA-2 | UNDERGO HOP DIFFUSION | SINGLE-PARTICLE TRACKING | SYNAPSE FORMATION | TRANSLATIONAL DIFFUSION | IMMUNOLOGY | ANTIGEN RECEPTOR | PLASMA-MEMBRANE | CLASS-II | LATERAL DIFFUSION | SURFACE-IMMUNOGLOBULIN | CD79 Antigens - immunology | Cytoskeleton - immunology | Immunologic Capping - immunology | Actins - metabolism | Actins - immunology | Signal Transduction - immunology | Protein Engineering | Immunologic Capping - drug effects | Cytoskeletal Proteins - metabolism | Cell Membrane - metabolism | B-Lymphocytes - pathology | Thiazolidines - pharmacology | B-Lymphocytes - metabolism | Cell Membrane - drug effects | Mice, Inbred C57BL | Protein Structure, Tertiary - genetics | Signal Transduction - genetics | Mice, Knockout | CD79 Antigens - metabolism | B-Lymphocytes - drug effects | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | B-Lymphocytes - immunology | Cytoskeletal Proteins - immunology | Signal Transduction - drug effects | Cell Line, Tumor | Protein Binding | Cell Membrane - immunology | Mice | CD79 Antigens - genetics | Cytoskeleton - drug effects | Immunologic Capping - genetics | Microscopy, Fluorescence | Oncology, Experimental | Research | Cancer | Proteins | Studies | Medical research | Plasma | Phosphorylation | Microscopy | Rodents | Cytoskeleton | Cameras | Behavior | Kinases | Diffusion
Journal Article
Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 759 - 770
Kinases downstream of B-cell antigen receptor (BCR) represent attractive targets for therapy in non-Hodgkin lymphoma (NHL). As clinical responses vary,... 
SURFACE IGM | BCR | CHRONIC-LYMPHOCYTIC-LEUKEMIA | BRUTONS TYROSINE KINASE | HUMAN FOLLICULAR LYMPHOMA | GENE-EXPRESSION | KINASE INHIBITOR IBRUTINIB | MUTATIONS | TARGETING BTK | HEMATOLOGY | NF-KAPPA-B | Lymphoma, Follicular - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | STAT1 Transcription Factor - metabolism | Lymphoma, Follicular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Single-Cell Analysis | Immunoglobulin M - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | STAT1 Transcription Factor - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Lymphoma, Large B-Cell, Diffuse - diagnosis | Mitogen-Activated Protein Kinase 3 - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Receptors, Antigen, B-Cell - genetics | CD79 Antigens - genetics | src-Family Kinases - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Gene Expression Regulation, Neoplastic | Lymphoma, Follicular - diagnosis | Lymphoma, Large B-Cell, Diffuse - metabolism | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Lymphoma, Mantle-Cell - diagnosis | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Syk Kinase - genetics | Phospholipase C gamma - genetics | src-Family Kinases - metabolism | Lymphoma, Mantle-Cell - genetics | Lymphoma, Mantle-Cell - metabolism | Diagnosis, Differential | Phospholipase C gamma - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Lymphoma, Follicular - pathology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | CD79 Antigens - metabolism | Syk Kinase - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Life Sciences | Human health and pathology | Hematology | Cancer | Lymphoid Neoplasia
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 7, pp. 3207 - 3217
Although the negative selection of self-reactive B cells in the bone marrow of mammals has been clearly demonstrated, it remains unclear in models of... 
SURFACE-IMMUNOGLOBULIN EXPRESSION | THYMUS-LEUKEMIA ANTIGEN | ALLOTYPE SUPPRESSION | V(D)J-ENCODED DETERMINANTS | HOMOZYGOUS CHICKENS | TRANSGENIC MODELS | CLONAL DELETION | IMMUNOLOGY | IG-ALPHA | FABRICIUS | LYMPHOCYTES | Autoantigens - metabolism | CD79 Antigens - immunology | Receptors, Antigen - immunology | Receptors, Fc - metabolism | Receptors, Antigen, B-Cell - metabolism | Immunoglobulin M - immunology | Muramidase - immunology | Immunoglobulin M - metabolism | Signal Transduction - immunology | Flow Cytometry | Receptors, Antigen - genetics | Avian Proteins - immunology | B-Lymphocytes - metabolism | Bursa of Fabricius - metabolism | Fibroblasts - metabolism | Immunoglobulin M - genetics | Avian Proteins - metabolism | Lampreys - immunology | Cells, Cultured | Protein Binding - immunology | Cellular Microenvironment - immunology | Chick Embryo | Receptors, Antigen, B-Cell - immunology | CD8 Antigens - immunology | Lampreys - genetics | CD79 Antigens - metabolism | Bursa of Fabricius - immunology | CD8 Antigens - metabolism | Animals | B-Lymphocytes - immunology | Receptors, Antigen - metabolism | Receptors, Fc - immunology | Bursa of Fabricius - cytology | Autoantigens - immunology | Chickens | CD8 Antigens - genetics | Cell Line, Tumor | Fibroblasts - immunology | Receptors, Antigen, B-Cell - genetics | Receptors, Fc - genetics | Fibroblasts - cytology | Mice | CD79 Antigens - genetics | Avian Proteins - genetics
Journal Article
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2011, Volume 179, Issue 1, pp. 37 - 45
We hypothesized that immune gene-related signatures would predict the presence of unique histological features of lymphoid cell infiltrates in colorectal... 
Pathology | TUMOR-INFILTRATING LYMPHOCYTES | RECRUITMENT | DENDRITIC CELLS | MICROSATELLITE INSTABILITY | INFLAMMATION | REGULATORY T-CELLS | COLON | PATHOLOGY | PROTEINS | CANCER | EXPRESSION | Liver - pathology | Microsatellite Instability | Lymph Nodes - pathology | Prognosis | CD79 Antigens - immunology | Oligonucleotide Array Sequence Analysis | Dendritic Cells - immunology | Germinal Center - immunology | Humans | Middle Aged | Dendritic Cells - pathology | Male | Gene Expression Profiling | Liver Neoplasms - therapy | Colorectal Neoplasms - diagnosis | Immunoenzyme Techniques | Colorectal Neoplasms - therapy | Liver - immunology | T-Lymphocytes - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Female | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Liver Neoplasms - secondary | B-Lymphocytes - metabolism | Dendritic Cells - metabolism | Adenocarcinoma - immunology | Liver - metabolism | RNA, Messenger - genetics | Liver Neoplasms - immunology | Survival Rate | Germinal Center - pathology | Lymph Nodes - immunology | Reverse Transcriptase Polymerase Chain Reaction | Adenocarcinoma - secondary | CD79 Antigens - metabolism | B-Lymphocytes - immunology | Colorectal Neoplasms - immunology | Germinal Center - metabolism | Adenocarcinoma - therapy | T-Lymphocytes - immunology | Aged | Biomarkers, Tumor - genetics | Neoplasm Staging | Regular
Journal Article