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by Balachandran, Vinod P and Luksza, Marta and Zhao, Julia N and Makarov, Vladimir and Moral, John Alec and Remark, Romain and Herbst, Brian and Askan, Gokce and Bhanot, Umesh and Senbabaoglu, Yasin and Wells, Daniel K and Cary, Charles Ian Ormsby and Grbovic-Huezo, Olivera and Attiyeh, Marc and Medina, Benjamin and Zhang, Jennifer and Loo, Jennifer and Saglimbeni, Joseph and Abu-Akeel, Mohsen and Zappasodi, Roberta and Riaz, Nadeem and Smoragiewicz, Martin and Kelley, Z. Larkin and Basturk, Olca and Gönen, Mithat and Levine, Arnold J and Allen, Peter J and Fearon, Douglas T and Merad, Miriam and Gnjatic, Sacha and Iacobuzio-Donahue, Christine A and Wolchok, Jedd D and DeMatteo, Ronald P and Chan, Timothy A and Greenbaum, Benjamin D and Merghoub, Taha and Leach, Steven D and Australian Pancreatic Canc Genom and Garvan Institute of Medical Research and Bankstown Hospital and St Vincent’s Hospital and Royal Adelaide Hospital and Royal North Shore Hospital and Envoi Pathology and QIMR Berghofer Medical Research Institute and Prince of Wales Hospital and University of Melbourne, Centre for Cancer Research and University of Queensland, Institute for Molecular Bioscience and Royal Prince Alfred Hospital, Chris O’Brien Lifehouse and Princess Alexandria Hospital and Fremantle Hospital and Liverpool Hospital and Austin Hospital and University of Glasgow and Johns Hopkins Medical Institutes and Flinders Medical Centre and Westmead Hospital and St John of God Healthcare and ARC-Net Centre for Applied Research on Cancer and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. S12 - S16
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2724 - 13
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that... 
TGF-BETA | MELANOMA | THERAPY | MEMORY | CANCER REGRESSION | INFILTRATING LYMPHOCYTES | MULTIDISCIPLINARY SCIENCES | PD-1 | EXPRESSION | EXHAUSTION | ANTIGEN | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Adenocarcinoma of Lung - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Squamous Cell Carcinoma of Head and Neck - pathology | Ovarian Neoplasms - pathology | Transcriptome | Male | Receptors, Antigen, T-Cell, alpha-beta - immunology | Squamous Cell Carcinoma of Head and Neck - mortality | Ovarian Neoplasms - mortality | Antigens, CD - genetics | Squamous Cell Carcinoma of Head and Neck - immunology | Ovarian Neoplasms - genetics | Adenocarcinoma of Lung - mortality | Adenocarcinoma of Lung - genetics | Carcinoma, Squamous Cell - mortality | Melanoma - genetics | Integrin alpha Chains - immunology | Female | Adenocarcinoma of Lung - immunology | Apyrase - immunology | Immunophenotyping | Melanoma - pathology | Carcinoma, Squamous Cell - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | CD8 Antigens - immunology | Squamous Cell Carcinoma of Head and Neck - genetics | Lymphocytes, Tumor-Infiltrating - pathology | Melanoma - immunology | Apyrase - genetics | CD8 Antigens - genetics | Survival Analysis | CD8-Positive T-Lymphocytes - immunology | Integrin alpha Chains - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Melanoma - mortality | Ovarian Neoplasms - immunology | Head | Phenotypes | Tumor cells | CD8 antigen | T cell receptors | Lymphocytes T | Patients | Metastases | T-cell receptor | CD103 antigen | Major histocompatibility complex | Lymphocytes | Immunotherapy | Head and neck cancer | Neck | Solid tumors | Cancer | Tumors | BASIC BIOLOGICAL SCIENCES
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2003, Volume 100, Issue 15, pp. 8856 - 8861
Ig-like transcript 4 (ILT4) (also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is a cell surface receptor expressed mainly on myelomonocytic... 
T lymphocytes | Molecules | Biological Sciences | Receptors | Epithelial cells | Protein refolding | Alleles | Cell lines | Natural killer cells | Leukocytes | T cell antigen receptors | Leukocyte Ig-like receptors | Natural killer cell | Surface plasmon resonance | Major histocompatibility complex | Coreceptor | CRYSTALLIZATION | G ANTIGEN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LIR-1 | coreceptor | major histocompatibility complex | CYTOMEGALOVIRUS | CUTTING EDGE | MOLECULES | G EXPRESSION | leukocyte Ig-like receptors | surface plasmon resonance | COMPLEX CLASS-I | natural killer cell | MYELOMONOCYTIC CELLS | Surface Plasmon Resonance | Receptors, Immunologic - chemistry | Humans | DNA, Complementary - genetics | Molecular Sequence Data | HLA Antigens - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | Base Sequence | Killer Cells, Natural - immunology | Antigens, CD - chemistry | Membrane Glycoproteins | Binding Sites | Binding, Competitive | Recombinant Proteins - metabolism | Amino Acid Sequence | Leukocyte Immunoglobulin-like Receptor B1 | Models, Molecular | Recombinant Proteins - chemistry | Histocompatibility Antigens Class I - genetics | Recombinant Proteins - genetics | HLA-G Antigens | HLA Antigens - chemistry | HLA Antigens - metabolism | Histocompatibility Antigens Class I - chemistry | Sequence Homology, Amino Acid | CD8 Antigens - metabolism | Protein Conformation | Kinetics | CD8-Positive T-Lymphocytes - immunology | In Vitro Techniques | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Physiological aspects | Killer cells | Research | Antigens, CD8 | Killer Cells, Natural | Histocompatibility Antigens Class I | Recombinant Proteins | CD8-Positive T-Lymphocytes | Life Sciences | Immunology | Receptors, Immunologic | HLA Antigens | Antigens, CD | DNA, Complementary
Journal Article
by Nejentsev, Sergey and Howson, Joanna M. M and Walker, Neil M and Szeszko, Jeffrey and Field, Sarah F and Stevens, Helen E and Reynolds, Pamela and Hardy, Matthew and King, Erna and Masters, Jennifer and Hulme, John and Maier, Lisa M and Smyth, Deborah and Bailey, Rebecca and Cooper, Jason D and Ribas, Gloria and Campbell, R. Duncan and Clayton, David G and Todd, John A and Burton, Paul R and Cardon, Lon R and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P and McCarthy, Mark I and Ouwehand, Willem H and Samani, Nilesh J and Donnelly, Peter and Barrett, Jeffrey C and Davison, Dan and Easton, Doug and Evans, David and Leung, Hin-Tak and Marchini, Jonathan L and Morris, Andrew P and Spencer, Chris C. A and Tobin, Martin D and Attwood, Antony P and Boorman, James P and Cant, Barbara and Everson, Ursula and Hussey, Judith M and Jolley, Jennifer D and Knight, Alexandra S and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V and Taylor, Niall C and Walters, Graham R and Watkins, Nicholas A and Winzer, Thilo and Jones, Richard W and McArdle, Wendy L and Ring, Susan M and Strachan, David P and Pembrey, Marcus and Breen, Gerome and St Clair, David and Caesar, Sian and Gordon-Smith, Katherine and Jones, Lisa and Fraser, Christine and Green, Elaine K and Grozeva, Detelina and Hamshere, Marian L and Holmans, Peter A and Jones, Ian R and Kirov, George and Moskvina, Valentina and Nikolov, Ivan and O'Donovan, Michael C and Owen, Michael J and Collier, David A and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and Young, Allan H and Ferrier, I. Nicol and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jennifer H and Bishop, D. Timothy and Iles, Mark M and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S and Braund, Peter S and Dixon, Richard J and Mangino, Massimo and Stevens, Suzanne and Thompson, John R and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and Drummond, Hazel and Lees, Charles W and Nimmo, Elaine R and ... and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium and The Wellcome Trust Case Control Consortium
Nature, ISSN 0028-0836, 12/2007, Volume 450, Issue 7171, pp. 887 - 892
Journal Article
Molecular Therapy, ISSN 1525-0016, 11/2017, Volume 25, Issue 11, pp. 2452 - 2465
Anti-CD19 chimeric antigen receptor (CAR) T cells have caused remissions of B cell malignancies, but problems including cytokine-mediated toxicity and short... 
T cell | chimeric antigen receptor | immunotherapy | MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | MATURATION ANTIGEN | CRYSTAL-STRUCTURE | ANTITUMOR-ACTIVITY | REMISSIONS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GENETICS & HEREDITY | B-CELL MALIGNANCIES | CAR-T-CELLS | LYMPHOMA | LYMPHOCYTES | Recombinant Fusion Proteins - immunology | Humans | Antigens, CD19 - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | T-Lymphocytes - transplantation | Single-Chain Antibodies - genetics | CD28 Antigens - genetics | Protein Domains | Receptors, Antigen, T-Cell - immunology | Lymphocyte Transfusion | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Antigens, CD19 - immunology | Amino Acid Sequence | Gene Expression | Immunotherapy, Adoptive - methods | Transduction, Genetic | CD28 Antigens - immunology | Recombinant Fusion Proteins - chemistry | Tumor Burden | Plasmids - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | CD8 Antigens - immunology | Xenograft Model Antitumor Assays | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Animals | T-Lymphocytes - cytology | CD8 Antigens - genetics | Plasmids - chemistry | Survival Analysis | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Single-Chain Antibodies - chemistry | Cell proliferation | Flow cytometry | Medical research | Antigens | Bioluminescence | CD19 antigen | Cytokines | Toxicity | Research & development--R&D | Lymphocytes T | Inflammation | CD28 antigen | Patients | Experiments | Cell activation | Lymphocytes B | Cell death | Lymphocytes | Degranulation | Transmembrane domains | Receptor mechanisms | Cancer | Tumors | Original
Journal Article
Cell, ISSN 0092-8674, 06/2018, Volume 173, Issue 7, pp. 1755 - 1769.e22
High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We... 
metastatic | clonal evolution | high-grade serous ovarian cancer | human leukocyte antigen | intratumoral heterogeneity | tumor-infiltrating lymphocyte | clone | foldback inversion | HLA | HGSC | mutation signature | immunoediting | BREAST-CANCER | GENOMIC INSTABILITY | REPERTOIRE | REPAIR | PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | MUTATIONS | SEQUENCING DATA | INFERENCE | CD8(+) T-CELLS | CELL BIOLOGY | Humans | Middle Aged | Ovarian Neoplasms - pathology | HLA Antigens - genetics | Loss of Heterozygosity | Young Adult | Ovarian Neoplasms - classification | Neoplasm Grading | BRCA1 Protein - metabolism | Aged, 80 and over | Antigens, Neoplasm - metabolism | Adult | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Lymphocytes, Tumor-Infiltrating - cytology | Antigens, Neoplasm - genetics | Receptors, Antigen, T-Cell - metabolism | HLA Antigens - metabolism | Whole Genome Sequencing | BRCA1 Protein - genetics | CD8 Antigens - metabolism | BRCA2 Protein - metabolism | Aged | Polymorphism, Single Nucleotide | Receptors, Antigen, T-Cell - genetics | BRCA2 Protein - genetics | Cluster Analysis | Lymphocytes, Tumor-Infiltrating - immunology | Ovarian Neoplasms - immunology | Immunohistochemistry | Yuan (China) | Medical research | Immune response | Genomics | HLA histocompatibility antigens | Development and progression | Metastasis | T cells | Gene expression | Epidemiology | Ovarian cancer | Histocompatibility antigens | Analysis | Tumor antigens | Medicine, Experimental
Journal Article
Journal Article
Journal of experimental medicine, ISSN 0022-1007, 2008, Volume 205, Issue 7, pp. 1621 - 1634
Although dendritic cells (DCs) play an important role in mediating protection against influenza virus, the precise role of lung DC subsets, such as CD11b(-)... 
MEDICINE, RESEARCH & EXPERIMENTAL | IIFN-PRODUCING CELLS | INHALED ANTIGEN | IN-VIVO DEPLETION | ANTIGEN PRESENTATION | STEADY-STATE | IMMUNOLOGY | PULMONARY INFECTION | ANTIBODY-RESPONSE | CD8(+) T-CELLS | RESPIRATORY SYNCYTIAL VIRUS | LANGERHANS CELLS | Dendritic Cells - immunology | Lectins, C-Type - immunology | Male | Lectins, C-Type - genetics | CD11c Antigen - immunology | Trachea - virology | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Movement - immunology | CD11b Antigen - genetics | Lung - virology | CD11c Antigen - genetics | Female | CD4-Positive T-Lymphocytes - virology | Dendritic Cells - virology | CD11b Antigen - immunology | Plasma Cells - virology | Antigens, Surface - genetics | Intercellular Signaling Peptides and Proteins - genetics | Antigen Presentation - genetics | Mice, Transgenic | Lymph Nodes - virology | Lymph Nodes - immunology | CD8 Antigens - immunology | Trachea - immunology | Heparin-binding EGF-like Growth Factor | Animals | Mannose-Binding Lectins - genetics | Mannose-Binding Lectins - immunology | CD8-Positive T-Lymphocytes - virology | CD8 Antigens - genetics | Dogs | Antibodies, Viral - immunology | Nucleocapsid Proteins - immunology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Antigens, Surface - immunology | Antibody Formation - genetics | Intercellular Signaling Peptides and Proteins - immunology | Lung - immunology | Orthomyxoviridae Infections - immunology | Plasma Cells - immunology
Journal Article