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The Journal of experimental medicine, ISSN 1540-9538, 2013, Volume 210, Issue 9, pp. 1695 - 1710
Treatment with monoclonal antibody specific for cytotoxic T lymphocyte–associated antigen 4 (CTLA-4... 
EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | CTLA-4 BLOCKADE | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | CANCER-PATIENTS | IN-VIVO | COMBINATION IMMUNOTHERAPY | MONOCLONAL-ANTIBODY | IMMUNOLOGY | LARGE ESTABLISHED MELANOMA | GAMMA-RIV | ANTITUMOR-ACTIVITY | Fas Ligand Protein - metabolism | Lymph Nodes - pathology | Antibodies, Blocking - pharmacology | Lymphocyte Depletion | Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use | Receptors, IgG - metabolism | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma - prevention & control | Lymph Nodes - drug effects | Cell Membrane - metabolism | Clone Cells | Cell Membrane - drug effects | Tumor Microenvironment - drug effects | Phagocytes - drug effects | Mice, Inbred C57BL | Treatment Outcome | Lymph Nodes - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | Phagocytes - immunology | TNF-Related Apoptosis-Inducing Ligand - metabolism | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocytes, Tumor-Infiltrating - pathology | Signal Transduction - drug effects | Melanoma - immunology | CD8-Positive T-Lymphocytes - drug effects | Antibodies, Blocking - therapeutic use | Lymphocyte Count | Mice | CD11b Antigen - metabolism | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Melanoma - therapy | CD4 Antigens - metabolism | Lymphocytes, Tumor-Infiltrating - immunology
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 25, pp. 6304 - 6314
Interleukin 7 (IL- 7) is a common gamma chain receptor cytokine implicated in thymopoiesis and in peripheral expansion and survival of T lymphocytes... 
INDIVIDUALS | HOMEOSTASIS | CD127 EXPRESSION | DECREASED CD127 | DISEASE | ANTIRETROVIRAL THERAPY | HUMAN-IMMUNODEFICIENCY-VIRUS | HEMATOLOGY | IMMATURE/TRANSITIONAL B-CELLS | INTERLEUKIN-7 RECEPTOR | GAMMA-CHAIN | HIV-1 | Recombinant Proteins - therapeutic use | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | T-Lymphocyte Subsets - cytology | Humans | Middle Aged | Interleukin-7 - pharmacology | Male | Recombinant Proteins - adverse effects | Immunologic Memory - drug effects | Interleukin-7 Receptor alpha Subunit - biosynthesis | Viral Load | Interleukin-7 - administration & dosage | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | T-Lymphocyte Subsets - drug effects | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | Interleukin-7 Receptor alpha Subunit - genetics | Interleukin-7 - blood | Chemical and Drug Induced Liver Injury - etiology | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Recombinant Proteins - administration & dosage | Recombinant Proteins - blood | Maximum Tolerated Dose | T-Lymphocytes, Regulatory - drug effects | CD8-Positive T-Lymphocytes - drug effects | Interleukin-7 - therapeutic use | Lymphocyte Count | HIV Infections - drug therapy | CD8-Positive T-Lymphocytes - immunology | Cell Cycle - drug effects | Interleukin-7 - adverse effects | CD4-Positive T-Lymphocytes - drug effects | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, p. 20254
Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39... 
MESSENGER-RNAS | CANCER-PATIENTS | EXTRACELLULAR VESICLES | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | MICROVESICLES | DIAGNOSTIC BIOMARKERS | INDUCE APOPTOSIS | OVARIAN-CANCER | MODULATION | LYMPHOCYTES | Exosomes - metabolism | Neoplasms - metabolism | CD8-Positive T-Lymphocytes - cytology | T-Lymphocytes, Regulatory - metabolism | T-Lymphocyte Subsets - cytology | Humans | Culture Media, Conditioned - pharmacology | RNA, Messenger - metabolism | Antigens, CD - metabolism | Lectins, C-Type - metabolism | T-Lymphocyte Subsets - drug effects | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Real-Time Polymerase Chain Reaction | Microscopy, Electron, Transmission | CD4-Positive T-Lymphocytes - cytology | Apyrase - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Down-Regulation - drug effects | Up-Regulation - drug effects | T-Lymphocytes, Regulatory - drug effects | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Adenosine - metabolism | Neoplasms - pathology | CD4-Positive T-Lymphocytes - drug effects | Microscopy, Fluorescence | Adenosine | Dendritic cells | CD8 antigen | Gene regulation | Data processing | T cell receptors | Lymphocytes T | Gene expression | Exosomes | Cell surface | CD4 antigen | Polymerase chain reaction | CD69 antigen | Cell activation | Lymphocytes | Down-regulation | Peripheral blood
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 36, pp. 13139 - 13144
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 2014, Volume 9, Issue 3, pp. 1075 - 1088
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2010, Volume 207, Issue 6, pp. 1247 - 1260
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 1, p. e0170814
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a debilitating adverse effect of cancer treatment... 
MACROPHAGE INFILTRATION | PAIN | INDUCED MECHANICAL ALLODYNIA | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | DORSAL-ROOT GANGLIA | SPINAL-CORD | NERVE INJURY | SENSORY NEURONS | SATELLITE GLIAL-CELLS | PACLITAXEL | Hyperalgesia - chemically induced | Neuralgia - genetics | Spleen - immunology | Chemokine CCL2 - immunology | Male | Spleen - drug effects | Activating Transcription Factor 3 - immunology | T-Lymphocytes, Regulatory - pathology | Hyperalgesia - pathology | T-Lymphocytes, Regulatory - immunology | Neurofilament Proteins - genetics | Neuralgia - immunology | Chemokine CCL3 - genetics | Microglia - pathology | Lymph Nodes - drug effects | Activating Transcription Factor 3 - genetics | Receptors, Purinergic P2Y12 - genetics | Gene Expression | Receptors, Purinergic P2Y12 - immunology | Mice, Transgenic | Lymph Nodes - immunology | Spinal Cord - immunology | Hyperalgesia - immunology | T-Lymphocytes, Regulatory - drug effects | Hyperalgesia - genetics | Ganglia, Spinal - pathology | Mice | CD8-Positive T-Lymphocytes - immunology | Ganglia, Spinal - drug effects | CD8-Positive T-Lymphocytes - pathology | Lymph Nodes - pathology | Spinal Cord - drug effects | Chemokine CCL3 - immunology | Sensory Receptor Cells - immunology | Neuralgia - pathology | Microglia - immunology | Antineoplastic Agents - adverse effects | Spinal Cord - pathology | Neuralgia - chemically induced | Neurofilament Proteins - immunology | Spleen - pathology | Ganglia, Spinal - immunology | Sensory Receptor Cells - pathology | Microglia - drug effects | Mice, Inbred C57BL | Paclitaxel - adverse effects | Chemokine CCL2 - genetics | Animals | Sensory Receptor Cells - drug effects | CD8-Positive T-Lymphocytes - drug effects | Organoplatinum Compounds - adverse effects | Usage | Chemotherapy | Care and treatment | Oxalic acid | Polyneuropathies | Research | Diagnosis | T cells | Cancer | Spinal cord | Neurosciences | CD8 antigen | Carbon tetrachloride | Interleukin | Central nervous system | Transgenic | Nervous system | Diabetic neuropathy | Lymphocytes T | Cerebrospinal fluid | Peripheral neuropathy | Macrophages | Lymph nodes | Proteins | Neurotoxicity | Interleukin 4 | Pain | Dorsal root ganglia | Lymphocytes | Rodents | Sensory neurons | Tumor necrosis factor-TNF | Horns | Dorsal horn | Peripheral nervous system | Pain sensitivity | Spleen | Pain perception | Immune response | Cytokines | Granulocyte-macrophage colony-stimulating factor | Hypersensitivity | CCL3 protein | Interleukin 12 | Inflammation | CCL4 protein | Microglia | CD4 antigen | Studies | White blood cells | TNF inhibitors | Infiltration | Chemokines | Monocyte chemoattractant protein 1
Journal Article
Blood, ISSN 1528-0020, 2006, Volume 109, Issue 1, pp. 228 - 234
The molecular mechanisms by which mesenchymal stem cells (MSCs) suppress T-cell proliferation are poorly understood, and whether a soluble factor plays a major... 
SYNTHASE | RESPONSES | ENGRAFTMENT | ACTIVATION | PATHWAY | IMMUNOSUPPRESSION | GROWTH | HEMATOLOGY | MARROW STROMAL CELLS | INHIBIT | TRANSPLANTATION | CD8-Positive T-Lymphocytes - cytology | Dinoprostone - physiology | Humans | B-Lymphocyte Subsets - cytology | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Phosphorylation - drug effects | Macrophages - physiology | B-Lymphocyte Subsets - drug effects | Nitric Oxide - biosynthesis | Signal Transduction | CD4-Positive T-Lymphocytes - metabolism | Cell Division - drug effects | Receptors, Antigen, T-Cell - physiology | Mice, Knockout | B-Lymphocyte Subsets - metabolism | Mice | Tryptophan - pharmacology | HeLa Cells | Interleukin-2 - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology | Nitric Oxide Synthase Type II - metabolism | Tetradecanoylphorbol Acetate - pharmacology | T-Lymphocyte Subsets - cytology | Concanavalin A - pharmacology | Nitric Oxide - pharmacology | STAT5 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Tryptophan - analogs & derivatives | Enzyme Induction - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Mesenchymal Stromal Cells - physiology | NG-Nitroarginine Methyl Ester - pharmacology | Transforming Growth Factor beta - immunology | Cell Line | Antigens, CD19 - analysis | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide - physiology | Cyclooxygenase Inhibitors - pharmacology | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Ionomycin - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interferon-gamma - biosynthesis | Prostaglandin-Endoperoxide Synthases - physiology
Journal Article
Clinical Immunology, ISSN 1521-6616, 2010, Volume 138, Issue 1, pp. 85 - 96
Abstract Cytotoxic T Lymphocyte Antigen 4 (CTLA4) blockade has shown antitumor activity against common cancers... 
Allergy and Immunology | Tremelimumab | T effector cells | CTLA4 | Immune regulation | T regulatory cells | CTLA-4 BLOCKADE | DIFFERENTIAL EXPRESSION | TUMOR | ANTIGENS | IMMUNOLOGY | TRIAL | METASTATIC MELANOMA | IMMUNOTHERAPY | CD28 | ANTITUMOR IMMUNITY | RECEPTORS | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | Leukocytes, Mononuclear - metabolism | T-Lymphocytes, Regulatory - metabolism | T-Lymphocyte Subsets - cytology | Cell Count | Humans | Antibodies, Monoclonal - therapeutic use | Interferon-gamma - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Immunity, Cellular - drug effects | Forkhead Transcription Factors - metabolism | Immune Tolerance - immunology | T-Lymphocyte Subsets - drug effects | T-Lymphocytes - drug effects | Leukocytes, Mononuclear - immunology | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Membrane Glycoproteins - immunology | Immune Tolerance - drug effects | Interleukin-2 - metabolism | Leukocytes, Mononuclear - drug effects | Carcinoembryonic Antigen - immunology | Antibodies, Monoclonal - pharmacology | CD4-Positive T-Lymphocytes - cytology | CD4-Positive T-Lymphocytes - metabolism | Neoplasms - drug therapy | Immunity, Cellular - immunology | T-Lymphocytes, Regulatory - drug effects | Interleukin-2 Receptor alpha Subunit - metabolism | T-Lymphocytes - cytology | Lymphocyte Activation - drug effects | Neoplasms - immunology | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Leukocytes, Mononuclear - cytology | T-Lymphocytes - immunology | Cell Proliferation - drug effects | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects