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Nature (London), ISSN 1476-4687, 2016, Volume 540, Issue 7632, pp. 236 - 241
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, p. 20254
Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39... 
MESSENGER-RNAS | CANCER-PATIENTS | EXTRACELLULAR VESICLES | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | MICROVESICLES | DIAGNOSTIC BIOMARKERS | INDUCE APOPTOSIS | OVARIAN-CANCER | MODULATION | LYMPHOCYTES | Exosomes - metabolism | Neoplasms - metabolism | CD8-Positive T-Lymphocytes - cytology | T-Lymphocytes, Regulatory - metabolism | T-Lymphocyte Subsets - cytology | Humans | Culture Media, Conditioned - pharmacology | RNA, Messenger - metabolism | Antigens, CD - metabolism | Lectins, C-Type - metabolism | T-Lymphocyte Subsets - drug effects | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Real-Time Polymerase Chain Reaction | Microscopy, Electron, Transmission | CD4-Positive T-Lymphocytes - cytology | Apyrase - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Down-Regulation - drug effects | Up-Regulation - drug effects | T-Lymphocytes, Regulatory - drug effects | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Adenosine - metabolism | Neoplasms - pathology | CD4-Positive T-Lymphocytes - drug effects | Microscopy, Fluorescence | Adenosine | Dendritic cells | CD8 antigen | Gene regulation | Data processing | T cell receptors | Lymphocytes T | Gene expression | Exosomes | Cell surface | CD4 antigen | Polymerase chain reaction | CD69 antigen | Cell activation | Lymphocytes | Down-regulation | Peripheral blood
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 531, Issue 7593, pp. 253 - 257
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 08/2009, Volume 86, Issue 2, pp. 435 - 443
.... IL‐17‐producing CD4+ T lymphocytes (Th17) are currently considered relevant participants in the pathogenesis of psoriasis skin lesions... 
Tc17 cells | IL‐22 | IL‐21 | IL-22 | IL-21 | VULGARIS LESIONS | AUTOIMMUNE INFLAMMATION | DENDRITIC CELLS | IFN-GAMMA | IMMUNOLOGY | IDENTIFICATION | CELL BIOLOGY | CYCLOSPORINE-A | ACCUMULATION | DIFFERENTIATION | HEMATOLOGY | IL-17 PRODUCTION | TH17 | Tumor Necrosis Factor-alpha - metabolism | T-Lymphocytes, Regulatory - metabolism | Humans | Interferon-gamma - metabolism | T-Lymphocytes, Helper-Inducer - secretion | Interleukins - metabolism | Receptors, Retinoic Acid - genetics | T-Lymphocytes, Regulatory - immunology | Receptors, Thyroid Hormone - genetics | T-Lymphocytes, Helper-Inducer - immunology | Psoriasis - metabolism | CD8-Positive T-Lymphocytes - metabolism | Skin - pathology | Skin - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 | Psoriasis - immunology | T-Lymphocytes, Cytotoxic - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | T-Lymphocytes, Regulatory - secretion | Interleukin-17 - secretion | Interferon-gamma - secretion | T-Lymphocytes, Cytotoxic - secretion | Tumor Necrosis Factor-alpha - secretion | Cytokines - secretion | Receptors, Retinoic Acid - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | Receptors, Thyroid Hormone - metabolism | Interleukin-17 - metabolism | CD8-Positive T-Lymphocytes - secretion | T-Lymphocytes, Cytotoxic - metabolism | Lymphocyte Activation - drug effects | Psoriasis - physiopathology | CD3 Complex - immunology | Skin - physiopathology | CD8-Positive T-Lymphocytes - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Cell Lineage - immunology | Interleukins - secretion
Journal Article
Cancer cell, ISSN 1535-6108, 2017, Volume 31, Issue 5, pp. 711 - 723.e4
Effector T cells have the capability of recognizing and killing cancer cells. However, whether tumors can become immune resistant through exclusion of effector... 
T cell-inflamed tumor microenvironment | non-T cell-inflamed tumor microenvironment | immunotherapy resistance | immune escape | adoptive T cell transfer | METASTATIC MELANOMA | RESPONSES | IMMUNITY | MECHANISM | ONCOLOGY | CANCER REGRESSION | REJECTION | ANTIGENS | MICE | BLOCKADE | EXPRESSION | CELL BIOLOGY | Chemotaxis, Leukocyte | Tumor Escape | Basic-Leucine Zipper Transcription Factors - metabolism | Cell Proliferation | Dendritic Cells - immunology | Tumor Microenvironment | T-Lymphocytes - transplantation | Antigens, CD - metabolism | Repressor Proteins - deficiency | T-Lymphocytes - metabolism | Time Factors | Basic-Leucine Zipper Transcription Factors - deficiency | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - metabolism | Repressor Proteins - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Immunotherapy, Adoptive - methods | Signal Transduction | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Repressor Proteins - genetics | Genotype | Integrin alpha Chains - metabolism | Basic-Leucine Zipper Transcription Factors - genetics | Melanoma - pathology | Tumor Burden | beta Catenin - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Phenotype | Animals | Melanoma - immunology | Chemokine CXCL9 - metabolism | Cell Line, Tumor | Immunologic Memory | T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Chemokine CXCL10 - metabolism | Dendritic cells | T cells | Cancer | Immunotherapy | Adoptive T cell transfer
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 537, Issue 7620, pp. 417 - 421
Journal Article
Cancer cell, ISSN 1535-6108, 2012, Volume 21, Issue 6, pp. 822 - 835
Cancer-associated inflammation is thought to be a barrier to immune surveillance, particularly in pancreatic ductal adenocarcinoma (PDA). Gr-1+ CD11b+ cells... 
OVEREXPRESSION | MICROENVIRONMENT | ONCOLOGY | DUCTAL ADENOCARCINOMA | INTERLEUKIN-1-BETA | MICE | SUPPRESSOR-CELLS | INDUCTION | DIFFERENTIATION | MAMMARY CARCINOMAS | MOUSE MODELS | CELL BIOLOGY | Immunohistochemistry | Adenocarcinoma - pathology | CD8-Positive T-Lymphocytes - pathology | Pancreatic Neoplasms - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Inflammation - metabolism | Adenocarcinoma - metabolism | RNA Interference | T-Lymphocytes - metabolism | Myeloid Cells - immunology | CD8-Positive T-Lymphocytes - metabolism | T-Lymphocytes - pathology | Carcinoma, Pancreatic Ductal - immunology | CD11b Antigen - immunology | Adenocarcinoma - immunology | Pancreatic Neoplasms - pathology | Receptors, Chemokine - metabolism | Mice, Transgenic | Inflammation - immunology | Receptors, Chemokine - immunology | Carcinoma, Pancreatic Ductal - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Tumor Microenvironment - immunology | Models, Immunological | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Pancreatic Neoplasms - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Mice | CD11b Antigen - metabolism | Myeloid Cells - pathology | CD8-Positive T-Lymphocytes - immunology | Medical colleges | Analysis | Pancreatic cancer | Oncology, Experimental | Genetically modified organisms | Inflammation | Macrophage colony stimulating factor | Research | T cells | Tumors | Cancer | granulocyte-macrophage colony stimulating factor | myeloid cells | T lymphocyte | carcinoma | pancreas
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2013, Volume 73, Issue 12, pp. 3591 - 3603
Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells. In this study, we document parallel regulation of CD8(+) T... 
DISTINCT MECHANISMS | ONCOLOGY | PROGRAMMED DEATH-1 | IMMUNE ESCAPE | MYELOID-LEUKEMIA | SYNGENEIC MOUSE MODEL | REGULATORY T | GROWTH-FACTOR | CHRONIC VIRAL-INFECTION | ANTITUMOR-ACTIVITY | HUMAN OVARIAN-CANCER | T-Lymphocytes, Regulatory - metabolism | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Blocking - pharmacology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Neoplasms, Experimental - pathology | Flow Cytometry | T-Lymphocytes - metabolism | Neoplasms, Experimental - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Cytokines - immunology | Cytokines - metabolism | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Neoplasms, Experimental - therapy | CTLA-4 Antigen - metabolism | Lymphocytes, Tumor-Infiltrating - transplantation | Programmed Cell Death 1 Receptor - metabolism | Combined Modality Therapy | CTLA-4 Antigen - immunology | B7-H1 Antigen - immunology | Cancer Vaccines - immunology | B7-H1 Antigen - metabolism | Animals | Antibodies, Blocking - immunology | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 7, p. e1003490
The intrahepatic immune environment is normally biased towards tolerance. Nonetheless, effective antiviral immune responses can be induced against hepatotropic... 
HEPATITIS-B-VIRUS | DENDRITIC CELLS | MICROBIOLOGY | CHRONIC VIRAL-INFECTION | PERSISTENCE IN-VIVO | LIVER TOLERANCE | VIROLOGY | EXOGENOUS ANTIGEN | ANTIGEN-PRESENTING CELLS | SINUSOIDAL-ENDOTHELIAL-CELLS | PARASITOLOGY | TRANSGENIC MICE | CROSS-PRESENTATION | Liver - virology | Liver - pathology | Antigens, Viral - metabolism | CD8-Positive T-Lymphocytes - pathology | Cell Proliferation | Hepatitis B - metabolism | Dendritic Cells - immunology | Hepatitis B - virology | Dendritic Cells - pathology | Male | T-Lymphocytes, Cytotoxic - pathology | Hepatitis B - immunology | Liver - immunology | CD40 Antigens - metabolism | Antigen Presentation | CD8-Positive T-Lymphocytes - metabolism | Antigens, Differentiation - metabolism | CD40 Antigens - genetics | Cell Differentiation | Dendritic Cells - virology | Hepatitis B virus - immunology | Dendritic Cells - metabolism | Adaptive Immunity | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | T-Lymphocytes, Cytotoxic - virology | Liver - metabolism | Mice, Inbred C57BL | Hepatitis B - pathology | Programmed Cell Death 1 Receptor - metabolism | Mice, Transgenic | CD40 Antigens - agonists | Hepatitis B virus - physiology | Mice, Knockout | Host-Pathogen Interactions | Animals | T-Lymphocytes, Cytotoxic - metabolism | CD8-Positive T-Lymphocytes - virology | Gene Expression Regulation, Viral | Antigens, Differentiation - genetics | Mice | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | Medical research | Hepatitis | T cell receptors | Immunology | Liver | Rodents
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2013, Volume 190, Issue 9, pp. 4640 - 4649
Dendritic cells (DC) are professional APCs that regulate innate and adaptive immunity. The role of fatty-acid synthesis in DC development and function is... 
CANCER-CELLS | APOPTOSIS | KAPPA-B ACTIVATION | UNFOLDED PROTEIN RESPONSE | CYTOKINE PRODUCTION | SYNTHASE INHIBITION | ER STRESS | MAP KINASE | MACROPHAGES | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | Fatty Acids - immunology | Leukocytes, Mononuclear - metabolism | Chemokine CCL2 - immunology | Dendritic Cells - immunology | Humans | Caspase 3 - metabolism | Male | Cyclin B1 - metabolism | Interferon-gamma - metabolism | PPAR gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Mitogen-Activated Protein Kinase Kinases - metabolism | Liver - immunology | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Liver - metabolism | CD4-Positive T-Lymphocytes - metabolism | Interleukin-12 - metabolism | B7-2 Antigen - metabolism | Cell Differentiation - immunology | Intercellular Adhesion Molecule-1 - metabolism | Proto-Oncogene Proteins c-akt - immunology | T-Lymphocytes, Cytotoxic - metabolism | Endoplasmic Reticulum - immunology | Interleukin-12 - immunology | Mice | Killer Cells, Natural - metabolism | CD8-Positive T-Lymphocytes - immunology | bcl-X Protein - metabolism | Fatty Acids - biosynthesis | Mitogen-Activated Protein Kinase Kinases - immunology | Caspase 3 - immunology | Endoplasmic Reticulum - metabolism | Genes, MHC Class II - immunology | PPAR gamma - immunology | Cyclin B1 - immunology | Leukocytes, Mononuclear - immunology | bcl-X Protein - immunology | Killer Cells, Natural - immunology | Chemokine CCL2 - metabolism | B7-2 Antigen - immunology | Fatty Acids - metabolism | Dendritic Cells - metabolism | T-Lymphocytes, Cytotoxic - immunology | B7-1 Antigen - immunology | Intercellular Adhesion Molecule-1 - immunology | Mice, Inbred C57BL | B7-1 Antigen - metabolism | Animals | Apoptosis - immunology | Interferon-gamma - immunology | Dendritic Cells - cytology | Fatty-acid synthesis | ER stress | NK cells | T cells | Bone marrow dendritic cells
Journal Article