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Journal of Leukocyte Biology, ISSN 0741-5400, 08/2009, Volume 86, Issue 2, pp. 435 - 443
Lytic CD8+ T cells at the psoriasis plaque’s epidermis secrete IL‐17, IL‐21 and IL‐22 and depends on autocrine TNFalpha production. IL‐17‐producing CD4+ T... 
Tc17 cells | IL‐22 | IL‐21 | IL-22 | IL-21 | VULGARIS LESIONS | AUTOIMMUNE INFLAMMATION | DENDRITIC CELLS | IFN-GAMMA | IMMUNOLOGY | IDENTIFICATION | CELL BIOLOGY | CYCLOSPORINE-A | ACCUMULATION | DIFFERENTIATION | HEMATOLOGY | IL-17 PRODUCTION | TH17 | Tumor Necrosis Factor-alpha - metabolism | T-Lymphocytes, Regulatory - metabolism | Humans | Interferon-gamma - metabolism | T-Lymphocytes, Helper-Inducer - secretion | Interleukins - metabolism | Receptors, Retinoic Acid - genetics | T-Lymphocytes, Regulatory - immunology | Receptors, Thyroid Hormone - genetics | T-Lymphocytes, Helper-Inducer - immunology | Psoriasis - metabolism | CD8-Positive T-Lymphocytes - metabolism | Skin - pathology | Skin - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 | Psoriasis - immunology | T-Lymphocytes, Cytotoxic - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | T-Lymphocytes, Regulatory - secretion | Interleukin-17 - secretion | Interferon-gamma - secretion | T-Lymphocytes, Cytotoxic - secretion | Tumor Necrosis Factor-alpha - secretion | Cytokines - secretion | Receptors, Retinoic Acid - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | Receptors, Thyroid Hormone - metabolism | Interleukin-17 - metabolism | CD8-Positive T-Lymphocytes - secretion | T-Lymphocytes, Cytotoxic - metabolism | Lymphocyte Activation - drug effects | Psoriasis - physiopathology | CD3 Complex - immunology | Skin - physiopathology | CD8-Positive T-Lymphocytes - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Cell Lineage - immunology | Interleukins - secretion
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7486, pp. 52 - 57
Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable responses in a subset of cancer patients, despite advanced... 
SURVIVAL | IMMUNE CELLS | MELANOMA | CD8+ T-CELLS | PROGNOSTIC-FACTORS | SUPPRESSORS | PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | PROTEINS | CANCER | LYMPHOCYTES | CD8-Positive T-Lymphocytes - cytology | RNA, Small Interfering - genetics | Immunotherapy - methods | Cell Proliferation | Molecular Targeted Therapy | Gene Knockdown Techniques | CD4-Positive T-Lymphocytes - immunology | Melanoma, Experimental - immunology | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Cytokines - immunology | Lymphocytes, Tumor-Infiltrating - cytology | Reproducibility of Results | Antigens, Neoplasm - immunology | Mice, Inbred C57BL | Cytokines - secretion | Protein Phosphatase 2 - genetics | Protein Phosphatase 2 - deficiency | Tumor Microenvironment - immunology | Animals | Apoptosis - immunology | CD8-Positive T-Lymphocytes - secretion | Protein Phosphatase 2 - metabolism | High-Throughput Nucleotide Sequencing | Lymphocytes, Tumor-Infiltrating - secretion | Mice | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Immune response | Gene targeting | Immunotherapy | Physiological aspects | Genetic research | Research | T cells | Tumors | Spleen | Genes | Melanoma | Cytotoxicity | T cell receptors | Infections | Kinases | Cell growth | Lymphocytes | Rodents | Medical prognosis | Immune system
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31318
Background: Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, is the major component of many plants including apples, basil, cranberries,... 
SIGNAL-TRANSDUCTION | RESPONSES | ACTIVATION | CYCLOSPORINE-A | CELL-RECEPTOR STIMULATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FACTOR-ALPHA GENE | INHALED CORTICOSTEROIDS | T-CELLS | OLEANOLIC ACID | CD8-Positive T-Lymphocytes - cytology | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Mitogens - pharmacology | Concanavalin A - pharmacology | NF-kappa B - metabolism | CD4-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - immunology | Transcription Factor AP-1 - metabolism | Lymphocyte Activation - genetics | Macrophages - secretion | B-Lymphocytes - secretion | Oxidation-Reduction - drug effects | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Anti-Inflammatory Agents - pharmacology | Antibodies, Monoclonal - pharmacology | CD4-Positive T-Lymphocytes - cytology | NFATC Transcription Factors - metabolism | Cytokines - secretion | CD28 Antigens - immunology | Antioxidants - pharmacology | Macrophages - cytology | CD8-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - pathology | Up-Regulation - drug effects | B-Lymphocytes - drug effects | Animals | CD4-Positive T-Lymphocytes - secretion | CD8-Positive T-Lymphocytes - secretion | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | CD3 Complex - immunology | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | CD4-Positive T-Lymphocytes - drug effects | Mitogen-Activated Protein Kinases - metabolism | Graft-versus-host reaction | Transcription factors | Oregano | Cancer therapies | Cranberries | Anticancer properties | Proteins | Antioxidants | Cell activation | Cell growth | Inhibition | Enzymes | NF-κB protein | Cytokines | Albinism | Immunoregulation | Activator protein 1 | Peppermint | Prunes | JNK protein | T cell receptors | Carboxylic acids | Serum levels | Apples | γ-Interferon | Rosemary | Ursolic acid | Cell proliferation | Health sciences | Phosphorylation | Ordination | Homeostasis | Lymphocytes T | Transplantation | Biology | Activation | NF-AT protein | Kinases | Macrophages | Inflammatory diseases | Interleukin 6 | Lymphocytes | Transcription activation | Cell cycle | Tumor necrosis factor-TNF | Statistical analysis | Antiinflammatory agents | Secretion | Extracellular signal-regulated kinase | Inflammation | Pharmacology | Acids | Lymphocytes B | Interferon | Alzheimers disease | Apoptosis | Anti-inflammatory agents
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2009, Volume 182, Issue 6, pp. 3469 - 3481
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4746 - 4757
Solid tumors are complex masses with a local microenvironment, or stroma, that supports tumor growth and progression. Among the diverse tumor-supporting... 
MEDICINE, RESEARCH & EXPERIMENTAL | CD8(+) | IMMUNOTHERAPY | INFILTRATING LYMPHOCYTES | INTERLEUKIN-12 | SUPPRESSOR-CELLS | ANTITUMOR IMMUNITY | GENE-TRANSFER | ANTIGEN-LOSS VARIANTS | CANCER | T-CELLS | CD8-Positive T-Lymphocytes - transplantation | Interleukin-12 - genetics | Stromal Cells - pathology | Myeloid Cells - physiology | Interleukin-12 - physiology | Neoplasm Proteins - immunology | Recombinant Fusion Proteins - physiology | Gene Expression Profiling | Lymphocyte Subsets - immunology | Antigen-Presenting Cells - pathology | Melanoma, Experimental - immunology | Antigen Presentation | Bone Marrow Cells - immunology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Interleukin-12 - secretion | Lymphocyte Subsets - pathology | Tumor Escape - immunology | Macrophages - physiology | Immunotherapy, Adoptive | Antigens, Neoplasm - immunology | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - therapy | Bone Marrow Cells - pathology | Interferon-gamma - physiology | Melanoma, Experimental - pathology | Gene Expression Regulation, Neoplastic - immunology | Radiation Chimera | Antigen-Presenting Cells - immunology | Tumor Microenvironment - immunology | Animals | CD8-Positive T-Lymphocytes - secretion | Inflammation - genetics | Mice | Stromal Cells - physiology | Care and treatment | Interleukin-12 | Cancer cells | Genetic aspects | Research | Properties | Cancer
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 17, pp. 4339 - 4346
Journal Article