BLOOD, ISSN 0006-4971, 06/2017, Volume 129, Issue 25, pp. 3322 - 3331
Transitioning CD19-directed chimeric antigen receptor (CAR) T cells from early-phase trials in relapsed patients to a viable therapeutic approach with...
CD8(+) | B-CELL | HEMATOLOGY | ANTIGEN RECEPTORS | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | CD8-Positive T-Lymphocytes - transplantation | Humans | Neoplasm Recurrence, Local - therapy | Child, Preschool | Infant | Male | Remission Induction | CD4-Positive T-Lymphocytes - immunology | Neoplasm Recurrence, Local - immunology | Young Adult | Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy | CD4-Positive T-Lymphocytes - transplantation | Adolescent | Adult | Female | Receptors, Antigen, T-Cell - immunology | CD8-Positive T-Lymphocytes - immunology | Child | Antigens, CD19 - immunology | 100 | Clinical Trials and Observations
CD8(+) | B-CELL | HEMATOLOGY | ANTIGEN RECEPTORS | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | CD8-Positive T-Lymphocytes - transplantation | Humans | Neoplasm Recurrence, Local - therapy | Child, Preschool | Infant | Male | Remission Induction | CD4-Positive T-Lymphocytes - immunology | Neoplasm Recurrence, Local - immunology | Young Adult | Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy | CD4-Positive T-Lymphocytes - transplantation | Adolescent | Adult | Female | Receptors, Antigen, T-Cell - immunology | CD8-Positive T-Lymphocytes - immunology | Child | Antigens, CD19 - immunology | 100 | Clinical Trials and Observations
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2013, Volume 24, Issue 5, pp. 589 - 602
Inefficient TÂ cell migration is a major limitation of cancer immunotherapy. Targeted activation of the tumor microenvironment may overcome this barrier. We...
DESTRUCTION | MICROENVIRONMENT | ANGIOGENESIS | ONCOLOGY | ENDOTHELIUM | INFLAMMATION | PANCREATIC-CANCER | BONE-MARROW | TUMOR-ASSOCIATED MACROPHAGES | TUMORIGENESIS | INFILTRATION | CELL BIOLOGY | Neoplasm Transplantation | Tumor Escape | CD8-Positive T-Lymphocytes - transplantation | Humans | Pancreatic Neoplasms - blood supply | Vaccination | CD4-Positive T-Lymphocytes - immunology | Insulinoma - blood supply | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Inflammation Mediators - metabolism | Female | Macrophages - radiation effects | Radiotherapy, Adjuvant | Insulinoma - immunology | Cell Differentiation - radiation effects | Macrophages - physiology | Radiotherapy Dosage | Immunotherapy, Adoptive | Cells, Cultured | Mice, Transgenic | Mice, SCID | Insulinoma - therapy | Mice, Inbred C3H | Phenotype | Animals | CD4-Positive T-Lymphocytes - transplantation | Melanoma - immunology | Pancreatic Neoplasms - immunology | Mice, Inbred NOD | Mice | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Nitric Oxide Synthase Type II - metabolism | Pancreatic Neoplasms - therapy
DESTRUCTION | MICROENVIRONMENT | ANGIOGENESIS | ONCOLOGY | ENDOTHELIUM | INFLAMMATION | PANCREATIC-CANCER | BONE-MARROW | TUMOR-ASSOCIATED MACROPHAGES | TUMORIGENESIS | INFILTRATION | CELL BIOLOGY | Neoplasm Transplantation | Tumor Escape | CD8-Positive T-Lymphocytes - transplantation | Humans | Pancreatic Neoplasms - blood supply | Vaccination | CD4-Positive T-Lymphocytes - immunology | Insulinoma - blood supply | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Inflammation Mediators - metabolism | Female | Macrophages - radiation effects | Radiotherapy, Adjuvant | Insulinoma - immunology | Cell Differentiation - radiation effects | Macrophages - physiology | Radiotherapy Dosage | Immunotherapy, Adoptive | Cells, Cultured | Mice, Transgenic | Mice, SCID | Insulinoma - therapy | Mice, Inbred C3H | Phenotype | Animals | CD4-Positive T-Lymphocytes - transplantation | Melanoma - immunology | Pancreatic Neoplasms - immunology | Mice, Inbred NOD | Mice | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Nitric Oxide Synthase Type II - metabolism | Pancreatic Neoplasms - therapy
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 537, Issue 7620, pp. 412 - 416
During chronic viral infection, virus-specific CD8(+) T cells become exhausted, exhibit poor effector function and lose memory potential(1-4). However,...
HIV-1 | VIRUS | REPLICATION | FOLLICLES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TRANSCRIPTION | DIFFERENTIATION | BLOCKADE | EXHAUSTION | SELF-TOLERANCE | Lymphocytic choriomeningitis virus - immunology | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | T-Lymphocyte Subsets - cytology | CD8-Positive T-Lymphocytes - transplantation | Germinal Center - immunology | Humans | Male | Adoptive Transfer | Lymphocytic Choriomeningitis - immunology | HIV Infections - immunology | Basic Helix-Loop-Helix Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Female | Cell Differentiation | Germinal Center - cytology | Lymphocytic Choriomeningitis - virology | Receptors, CXCR5 - metabolism | Signal Transduction | HIV Infections - virology | Receptors, CXCR5 - deficiency | Virus Replication - immunology | T-Lymphocyte Subsets - transplantation | Inhibitor of Differentiation Protein 2 - metabolism | Viral Load - immunology | Lymphocytic choriomeningitis virus - growth & development | Animals | B-Lymphocytes - immunology | T-Lymphocyte Subsets - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | Virus diseases | Physiological aspects | T cells | Health aspects | Membrane proteins
HIV-1 | VIRUS | REPLICATION | FOLLICLES | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TRANSCRIPTION | DIFFERENTIATION | BLOCKADE | EXHAUSTION | SELF-TOLERANCE | Lymphocytic choriomeningitis virus - immunology | T-Lymphocyte Subsets - immunology | CD8-Positive T-Lymphocytes - cytology | T-Lymphocyte Subsets - cytology | CD8-Positive T-Lymphocytes - transplantation | Germinal Center - immunology | Humans | Male | Adoptive Transfer | Lymphocytic Choriomeningitis - immunology | HIV Infections - immunology | Basic Helix-Loop-Helix Transcription Factors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Female | Cell Differentiation | Germinal Center - cytology | Lymphocytic Choriomeningitis - virology | Receptors, CXCR5 - metabolism | Signal Transduction | HIV Infections - virology | Receptors, CXCR5 - deficiency | Virus Replication - immunology | T-Lymphocyte Subsets - transplantation | Inhibitor of Differentiation Protein 2 - metabolism | Viral Load - immunology | Lymphocytic choriomeningitis virus - growth & development | Animals | B-Lymphocytes - immunology | T-Lymphocyte Subsets - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | Virus diseases | Physiological aspects | T cells | Health aspects | Membrane proteins
Journal Article
Science, ISSN 0036-8075, 12/2016, Volume 354, Issue 6316, pp. 1160 - 1165
Blocking Programmed Death-1 (PD-1) can reinvigorate exhausted CD8 Tcells (TEX) andimprove control of chronic infections and cancer. However, whether blocking...
RESPONSES | THERAPY | MEMORY | CHROMATIN | MULTIDISCIPLINARY SCIENCES | INHIBITORY RECEPTOR PD-1 | CHRONIC VIRAL-INFECTION | EXPRESSION | CANCER | CHECKPOINT BLOCKADE | ANTIGEN | CD8-Positive T-Lymphocytes - transplantation | Epigenesis, Genetic | Mice, Inbred C57BL | Gene Regulatory Networks | B7-H1 Antigen - genetics | Cellular Reprogramming - immunology | Animals | B7-H1 Antigen - antagonists & inhibitors | Immunotherapy | Female | Transcription, Genetic | Mice | CD8-Positive T-Lymphocytes - immunology | Cellular Reprogramming - genetics | Cell Lineage - genetics | Immunologic Memory - genetics | Interleukin-7 - metabolism | Cellular proteins | Epigenetic inheritance | Genetic aspects | Immune response | T cells | Health aspects | Epigenetics | Cellular biology | Lymphocytes | Antigens | Control | Rewiring | Exhaustion | Effectors | Durability | Cancer
RESPONSES | THERAPY | MEMORY | CHROMATIN | MULTIDISCIPLINARY SCIENCES | INHIBITORY RECEPTOR PD-1 | CHRONIC VIRAL-INFECTION | EXPRESSION | CANCER | CHECKPOINT BLOCKADE | ANTIGEN | CD8-Positive T-Lymphocytes - transplantation | Epigenesis, Genetic | Mice, Inbred C57BL | Gene Regulatory Networks | B7-H1 Antigen - genetics | Cellular Reprogramming - immunology | Animals | B7-H1 Antigen - antagonists & inhibitors | Immunotherapy | Female | Transcription, Genetic | Mice | CD8-Positive T-Lymphocytes - immunology | Cellular Reprogramming - genetics | Cell Lineage - genetics | Immunologic Memory - genetics | Interleukin-7 - metabolism | Cellular proteins | Epigenetic inheritance | Genetic aspects | Immune response | T cells | Health aspects | Epigenetics | Cellular biology | Lymphocytes | Antigens | Control | Rewiring | Exhaustion | Effectors | Durability | Cancer
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2017, Volume 31, Issue 5, pp. 711 - 723.e4
Effector TÂ cells have the capability of recognizing and killing cancer cells. However, whether tumors can become immune resistant through exclusion of effector...
T cell-inflamed tumor microenvironment | non-T cell-inflamed tumor microenvironment | immunotherapy resistance | immune escape | adoptive TÂ cell transfer | METASTATIC MELANOMA | RESPONSES | IMMUNITY | MECHANISM | ONCOLOGY | CANCER REGRESSION | REJECTION | ANTIGENS | MICE | BLOCKADE | EXPRESSION | CELL BIOLOGY | Chemotaxis, Leukocyte | Tumor Escape | Basic-Leucine Zipper Transcription Factors - metabolism | Cell Proliferation | Dendritic Cells - immunology | Tumor Microenvironment | T-Lymphocytes - transplantation | Antigens, CD - metabolism | Repressor Proteins - deficiency | T-Lymphocytes - metabolism | Time Factors | Basic-Leucine Zipper Transcription Factors - deficiency | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - metabolism | Repressor Proteins - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Immunotherapy, Adoptive - methods | Signal Transduction | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Repressor Proteins - genetics | Genotype | Integrin alpha Chains - metabolism | Basic-Leucine Zipper Transcription Factors - genetics | Melanoma - pathology | Tumor Burden | beta Catenin - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Phenotype | Animals | Melanoma - immunology | Chemokine CXCL9 - metabolism | Cell Line, Tumor | Immunologic Memory | T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Chemokine CXCL10 - metabolism | Dendritic cells | T cells | Cancer | Immunotherapy | Adoptive T cell transfer
T cell-inflamed tumor microenvironment | non-T cell-inflamed tumor microenvironment | immunotherapy resistance | immune escape | adoptive TÂ cell transfer | METASTATIC MELANOMA | RESPONSES | IMMUNITY | MECHANISM | ONCOLOGY | CANCER REGRESSION | REJECTION | ANTIGENS | MICE | BLOCKADE | EXPRESSION | CELL BIOLOGY | Chemotaxis, Leukocyte | Tumor Escape | Basic-Leucine Zipper Transcription Factors - metabolism | Cell Proliferation | Dendritic Cells - immunology | Tumor Microenvironment | T-Lymphocytes - transplantation | Antigens, CD - metabolism | Repressor Proteins - deficiency | T-Lymphocytes - metabolism | Time Factors | Basic-Leucine Zipper Transcription Factors - deficiency | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - metabolism | Repressor Proteins - metabolism | Melanoma - metabolism | Skin Neoplasms - pathology | Immunotherapy, Adoptive - methods | Signal Transduction | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Repressor Proteins - genetics | Genotype | Integrin alpha Chains - metabolism | Basic-Leucine Zipper Transcription Factors - genetics | Melanoma - pathology | Tumor Burden | beta Catenin - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Phenotype | Animals | Melanoma - immunology | Chemokine CXCL9 - metabolism | Cell Line, Tumor | Immunologic Memory | T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Chemokine CXCL10 - metabolism | Dendritic cells | T cells | Cancer | Immunotherapy | Adoptive T cell transfer
Journal Article
Science, ISSN 0036-8075, 12/2016, Volume 354, Issue 6316, pp. 1165 - 1169
Exhausted T cells in cancer and chronic viral infection express distinctive patterns of genes, including sustained expression of programmed cell death protein...
REGULATORY DNA | CHROMATIN | CHRONIC VIRAL-INFECTION | MULTIDISCIPLINARY SCIENCES | CD8-Positive T-Lymphocytes - transplantation | Epigenesis, Genetic | Humans | Mice, Inbred C57BL | Hepatitis C, Chronic - therapy | Lymphocytic Choriomeningitis - therapy | B7-H1 Antigen - genetics | Gene Editing | T-Box Domain Proteins - metabolism | SOXB1 Transcription Factors - metabolism | Animals | B7-H1 Antigen - antagonists & inhibitors | Enhancer Elements, Genetic | Chromatin - immunology | Immunotherapy | HIV Infections - therapy | Transcription, Genetic | Mice | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | Cell Lineage - genetics | Immunologic Memory - genetics | Disease Models, Animal | Epigenetic inheritance | Chromatin | Genetic research | Genetic aspects | Research | T cells | Properties | Gene expression | Health aspects | Epigenetics | Genotype & phenotype | Infections | Lymphocytes | Cancer | Landscapes | Genes | Modules | Editing | Genomes
REGULATORY DNA | CHROMATIN | CHRONIC VIRAL-INFECTION | MULTIDISCIPLINARY SCIENCES | CD8-Positive T-Lymphocytes - transplantation | Epigenesis, Genetic | Humans | Mice, Inbred C57BL | Hepatitis C, Chronic - therapy | Lymphocytic Choriomeningitis - therapy | B7-H1 Antigen - genetics | Gene Editing | T-Box Domain Proteins - metabolism | SOXB1 Transcription Factors - metabolism | Animals | B7-H1 Antigen - antagonists & inhibitors | Enhancer Elements, Genetic | Chromatin - immunology | Immunotherapy | HIV Infections - therapy | Transcription, Genetic | Mice | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | Cell Lineage - genetics | Immunologic Memory - genetics | Disease Models, Animal | Epigenetic inheritance | Chromatin | Genetic research | Genetic aspects | Research | T cells | Properties | Gene expression | Health aspects | Epigenetics | Genotype & phenotype | Infections | Lymphocytes | Cancer | Landscapes | Genes | Modules | Editing | Genomes
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 6, pp. 1809 - 1814
Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer effects; however, the underlying mechanism is poorly understood. Here...
Antitumor immunity | Multifunctionality | Tumor microenvironment | CD8T cells | Immune exhaustion | MULTIDISCIPLINARY SCIENCES | RISK | antitumor immunity | T-CELL EXHAUSTION | CANCER STEM-CELLS | TUMOR REJECTION | MEMORY | INSULIN ANALOGS | IMMUNOTHERAPY | IN-VIVO | immune exhaustion | tumor microenvironment | DIFFERENTIATION | TIM-3 | multifunctionality | Antineoplastic Agents - immunology | Apoptosis - drug effects | CD8-Positive T-Lymphocytes - transplantation | AMP-Activated Protein Kinases - antagonists & inhibitors | Metformin - pharmacology | Mice, Inbred C57BL | Lymphocytes, Tumor-Infiltrating - transplantation | Adoptive Transfer | Lymphocytes, Tumor-Infiltrating - drug effects | Mice, SCID | Neoplasms - drug therapy | Cell Movement - immunology | Tumor Microenvironment - immunology | Animals | Apoptosis - immunology | CD8-Positive T-Lymphocytes - drug effects | Metformin - immunology | Antineoplastic Agents - pharmacology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Cytokines - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Type 2 diabetes | Prevention | Drug interactions | Dosage and administration | Metformin | Drug therapy | Observations | Tumors | Biological Sciences
Antitumor immunity | Multifunctionality | Tumor microenvironment | CD8T cells | Immune exhaustion | MULTIDISCIPLINARY SCIENCES | RISK | antitumor immunity | T-CELL EXHAUSTION | CANCER STEM-CELLS | TUMOR REJECTION | MEMORY | INSULIN ANALOGS | IMMUNOTHERAPY | IN-VIVO | immune exhaustion | tumor microenvironment | DIFFERENTIATION | TIM-3 | multifunctionality | Antineoplastic Agents - immunology | Apoptosis - drug effects | CD8-Positive T-Lymphocytes - transplantation | AMP-Activated Protein Kinases - antagonists & inhibitors | Metformin - pharmacology | Mice, Inbred C57BL | Lymphocytes, Tumor-Infiltrating - transplantation | Adoptive Transfer | Lymphocytes, Tumor-Infiltrating - drug effects | Mice, SCID | Neoplasms - drug therapy | Cell Movement - immunology | Tumor Microenvironment - immunology | Animals | Apoptosis - immunology | CD8-Positive T-Lymphocytes - drug effects | Metformin - immunology | Antineoplastic Agents - pharmacology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Cytokines - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Type 2 diabetes | Prevention | Drug interactions | Dosage and administration | Metformin | Drug therapy | Observations | Tumors | Biological Sciences
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2010, Volume 16, Issue 24, pp. 6122 - 6131
Purpose: Tumor-infiltrating lymphocytes (TIL) and interleukin (IL)-2 administered following lymphodepletion can cause the durable complete regression of bulky...
SURVIVAL | ADOPTIVE TRANSFER | ONCOLOGY | CD8-T-CELL MEMORY | IMMUNOTHERAPY | AUTOIMMUNITY | CD4-T-CELL HELP | PERSISTENCE | CANCER | CD8(+) T-CELLS | TRANSFER THERAPY | Lymphocytes, Tumor-Infiltrating - cytology | CD8-Positive T-Lymphocytes - cytology | Immunotherapy, Adoptive - methods | CD8-Positive T-Lymphocytes - transplantation | Humans | Middle Aged | Cells, Cultured | Lymphocytes, Tumor-Infiltrating - transplantation | Male | Combined Modality Therapy | Cytotoxicity, Immunologic - physiology | Melanoma - pathology | Neoplasm Metastasis | Melanoma - immunology | Aged, 80 and over | Lymphocyte Count | Adult | Female | Aged | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology
SURVIVAL | ADOPTIVE TRANSFER | ONCOLOGY | CD8-T-CELL MEMORY | IMMUNOTHERAPY | AUTOIMMUNITY | CD4-T-CELL HELP | PERSISTENCE | CANCER | CD8(+) T-CELLS | TRANSFER THERAPY | Lymphocytes, Tumor-Infiltrating - cytology | CD8-Positive T-Lymphocytes - cytology | Immunotherapy, Adoptive - methods | CD8-Positive T-Lymphocytes - transplantation | Humans | Middle Aged | Cells, Cultured | Lymphocytes, Tumor-Infiltrating - transplantation | Male | Combined Modality Therapy | Cytotoxicity, Immunologic - physiology | Melanoma - pathology | Neoplasm Metastasis | Melanoma - immunology | Aged, 80 and over | Lymphocyte Count | Adult | Female | Aged | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2008, Volume 118, Issue 1, pp. 294 - 305
The adoptive transfer of antigen-specific T cells that have been expanded ex vivo is being actively pursued to treat infections and malignancy in humans. The T...
MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | IMMUNITY | TCR GENE-TRANSFER | IMMUNOTHERAPY | IN-VIVO PERSISTENCE | SUBSETS | EXPRESSION | TRANSFER THERAPY | TELOMERE LENGTH | LYMPHOCYTES | Macaca nemestrina | Neoplasms - therapy | Animals | Time Factors | CD8-Positive T-Lymphocytes - transplantation | Neoplasms - immunology | Cells, Cultured | Immunologic Memory | Adoptive Transfer | Cell Culture Techniques | CD8-Positive T-Lymphocytes - immunology | Cell Survival - immunology | Infection | Care and treatment | Research | T cells | Health aspects | Cancer
MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | IMMUNITY | TCR GENE-TRANSFER | IMMUNOTHERAPY | IN-VIVO PERSISTENCE | SUBSETS | EXPRESSION | TRANSFER THERAPY | TELOMERE LENGTH | LYMPHOCYTES | Macaca nemestrina | Neoplasms - therapy | Animals | Time Factors | CD8-Positive T-Lymphocytes - transplantation | Neoplasms - immunology | Cells, Cultured | Immunologic Memory | Adoptive Transfer | Cell Culture Techniques | CD8-Positive T-Lymphocytes - immunology | Cell Survival - immunology | Infection | Care and treatment | Research | T cells | Health aspects | Cancer
Journal Article
10.
Full Text
Mapping and Role of the CD8+ T Cell Response During Primary Zika Virus Infection in Mice
Cell Host & Microbe, ISSN 1931-3128, 01/2017, Volume 21, Issue 1, pp. 35 - 46
CD8 T cells may play a dual role in protection against and pathogenesis of flaviviruses, including Zika virus (ZIKV). We evaluated the CD8 T cell response in...
LysMCre+IFNARfl/fl | CD8+ TÂ cell | peptide | Zika virus | mouse model | epitope | LysMCre | CD8 | IFNAR | TÂ cell | ANTIBODIES | WESTERN-HEMISPHERE | DENGUE HEMORRHAGIC-FEVER | MICROBIOLOGY | SEXUAL TRANSMISSION | MOUSE MODELS | PATHOGENESIS | INTERFERON | REPLICATION | VIROLOGY | PROTECTIVE ROLE | DISEASE | PARASITOLOGY | Zika Virus - immunology | CD8-Positive T-Lymphocytes - transplantation | Mice, Inbred C57BL | Adoptive Transfer | Receptor, Interferon alpha-beta - antagonists & inhibitors | Mice, Knockout | Zika Virus Infection - virology | Animals | Receptor, Interferon alpha-beta - immunology | Antibodies, Blocking - immunology | Zika Virus Infection - immunology | Mice | Receptor, Interferon alpha-beta - genetics | Epitopes, T-Lymphocyte - immunology | CD8-Positive T-Lymphocytes - immunology | Disease Models, Animal | LysMCre+IFNARfl | CD8+ T cell
LysMCre+IFNARfl/fl | CD8+ TÂ cell | peptide | Zika virus | mouse model | epitope | LysMCre | CD8 | IFNAR | TÂ cell | ANTIBODIES | WESTERN-HEMISPHERE | DENGUE HEMORRHAGIC-FEVER | MICROBIOLOGY | SEXUAL TRANSMISSION | MOUSE MODELS | PATHOGENESIS | INTERFERON | REPLICATION | VIROLOGY | PROTECTIVE ROLE | DISEASE | PARASITOLOGY | Zika Virus - immunology | CD8-Positive T-Lymphocytes - transplantation | Mice, Inbred C57BL | Adoptive Transfer | Receptor, Interferon alpha-beta - antagonists & inhibitors | Mice, Knockout | Zika Virus Infection - virology | Animals | Receptor, Interferon alpha-beta - immunology | Antibodies, Blocking - immunology | Zika Virus Infection - immunology | Mice | Receptor, Interferon alpha-beta - genetics | Epitopes, T-Lymphocyte - immunology | CD8-Positive T-Lymphocytes - immunology | Disease Models, Animal | LysMCre+IFNARfl | CD8+ T cell
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2010, Volume 184, Issue 6, pp. 3106 - 3116
Ag-specific T cell tolerance plays a critical role in tumor escape. Recent studies implicated myeloid-derived suppressor cells (MDSCs) in the induction of...
IMMUNE-RESPONSE | SIGNAL-TRANSDUCTION MOLECULES | OXIDATIVE-STRESS | TUMOR-BEARING MICE | DOWN-REGULATION | BREAST-TUMORS | RECEPTOR COMPLEX | ZETA-CHAIN | IMMUNOLOGY | CANCER | ANTIGEN | CD8-Positive T-Lymphocytes - pathology | CD8-Positive T-Lymphocytes - transplantation | Transplantation Tolerance - genetics | Adoptive Transfer | Neoplasms, Experimental - pathology | Leukemia, Experimental - immunology | Signal Transduction - immunology | Myeloid Cells - immunology | Neoplasms, Experimental - immunology | Neoplasms, Experimental - genetics | Female | Epitopes, T-Lymphocyte - immunology | Tumor Cells, Cultured | Transplantation Tolerance - immunology | Leukemia, Experimental - genetics | Leukemia, Experimental - pathology | Mice, Inbred C57BL | Antigen Presentation - genetics | Mice, Transgenic | Signal Transduction - genetics | Antigen Presentation - immunology | Genes, T-Cell Receptor beta - immunology | Animals | Cell Line, Tumor | Myeloid Cells - transplantation | Mice | Mice, Inbred BALB C | Myeloid Cells - pathology | CD8-Positive T-Lymphocytes - immunology | Epitopes, T-Lymphocyte - metabolism
IMMUNE-RESPONSE | SIGNAL-TRANSDUCTION MOLECULES | OXIDATIVE-STRESS | TUMOR-BEARING MICE | DOWN-REGULATION | BREAST-TUMORS | RECEPTOR COMPLEX | ZETA-CHAIN | IMMUNOLOGY | CANCER | ANTIGEN | CD8-Positive T-Lymphocytes - pathology | CD8-Positive T-Lymphocytes - transplantation | Transplantation Tolerance - genetics | Adoptive Transfer | Neoplasms, Experimental - pathology | Leukemia, Experimental - immunology | Signal Transduction - immunology | Myeloid Cells - immunology | Neoplasms, Experimental - immunology | Neoplasms, Experimental - genetics | Female | Epitopes, T-Lymphocyte - immunology | Tumor Cells, Cultured | Transplantation Tolerance - immunology | Leukemia, Experimental - genetics | Leukemia, Experimental - pathology | Mice, Inbred C57BL | Antigen Presentation - genetics | Mice, Transgenic | Signal Transduction - genetics | Antigen Presentation - immunology | Genes, T-Cell Receptor beta - immunology | Animals | Cell Line, Tumor | Myeloid Cells - transplantation | Mice | Mice, Inbred BALB C | Myeloid Cells - pathology | CD8-Positive T-Lymphocytes - immunology | Epitopes, T-Lymphocyte - metabolism
Journal Article
Blood, ISSN 0006-4971, 08/2018, Volume 132, Issue 8, pp. 804 - 814
After treatment with chimeric antigen receptor (CAR) T cells, interleukin-15 (IL-15) elevation and CAR T-cell expansion are associated with non-Hodgkin...
LYMPHOMA | HEMATOLOGY | IMMUNOTHERAPY | VACCINE DESIGN | CANCER-THERAPY | Lymphoma, Non-Hodgkin - immunology | CD8-Positive T-Lymphocytes - pathology | CD8-Positive T-Lymphocytes - transplantation | Humans | Middle Aged | Receptors, Antigen, T-Cell - therapeutic use | Male | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Lymphoma, Non-Hodgkin - pathology | CD4-Positive T-Lymphocytes - immunology | Receptors, Chimeric Antigen - therapeutic use | CD4-Positive T-Lymphocytes - transplantation | Lymphoma, Non-Hodgkin - therapy | K562 Cells | Adult | Female | Aged | CD8-Positive T-Lymphocytes - immunology | Cytokines - immunology | Index Medicus | Abridged Index Medicus | Immunobiology and Immunotherapy
LYMPHOMA | HEMATOLOGY | IMMUNOTHERAPY | VACCINE DESIGN | CANCER-THERAPY | Lymphoma, Non-Hodgkin - immunology | CD8-Positive T-Lymphocytes - pathology | CD8-Positive T-Lymphocytes - transplantation | Humans | Middle Aged | Receptors, Antigen, T-Cell - therapeutic use | Male | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Lymphoma, Non-Hodgkin - pathology | CD4-Positive T-Lymphocytes - immunology | Receptors, Chimeric Antigen - therapeutic use | CD4-Positive T-Lymphocytes - transplantation | Lymphoma, Non-Hodgkin - therapy | K562 Cells | Adult | Female | Aged | CD8-Positive T-Lymphocytes - immunology | Cytokines - immunology | Index Medicus | Abridged Index Medicus | Immunobiology and Immunotherapy
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2013, Volume 31, Issue 17, pp. 2152 - 2159
Purpose Adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) and high-dose interleukin-2 (IL-2) administered to lymphodepleted...
REGRESSION | METASTATIC MELANOMA | RAPID EXPANSION | RECOGNITION | EFFICACY | ONCOLOGY | REGULATORY T-CELLS | TRANSFER IMMUNOTHERAPY | CANCER | CULTURES | STANDARD | CD8-Positive T-Lymphocytes - pathology | Prospective Studies | CD8-Positive T-Lymphocytes - transplantation | Humans | Middle Aged | Male | Young Adult | Interleukin-2 - administration & dosage | Adult | Female | Tumor Cells, Cultured | Child | Immunotherapy, Adoptive - adverse effects | Immunotherapy, Adoptive - methods | Lymphocytes, Tumor-Infiltrating - transplantation | Lymphocytes, Tumor-Infiltrating - drug effects | Lymphocytes, Tumor-Infiltrating - pathology | Melanoma - immunology | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Adolescent | Aged | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Original Reports | Mela7 | To6
REGRESSION | METASTATIC MELANOMA | RAPID EXPANSION | RECOGNITION | EFFICACY | ONCOLOGY | REGULATORY T-CELLS | TRANSFER IMMUNOTHERAPY | CANCER | CULTURES | STANDARD | CD8-Positive T-Lymphocytes - pathology | Prospective Studies | CD8-Positive T-Lymphocytes - transplantation | Humans | Middle Aged | Male | Young Adult | Interleukin-2 - administration & dosage | Adult | Female | Tumor Cells, Cultured | Child | Immunotherapy, Adoptive - adverse effects | Immunotherapy, Adoptive - methods | Lymphocytes, Tumor-Infiltrating - transplantation | Lymphocytes, Tumor-Infiltrating - drug effects | Lymphocytes, Tumor-Infiltrating - pathology | Melanoma - immunology | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Adolescent | Aged | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Original Reports | Mela7 | To6
Journal Article