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Molecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1676 - 1685
Targeted approaches to treat autoimmune diseases would improve upon current therapies that broadly suppress the immune system and lead to detrimental side... 
tolerance induction mechanism | antigen-specific tolerance | immune tolerance | PLGA | PLG nanoparticles | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | ANTIGENS | IL-10 | IMMUNOLOGICAL-TOLERANCE | DELIVERY | RESPONSES | MULTIPLE-SCLEROSIS | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CROSS-PRESENTATION | B7-2 Antigen - genetics | Myelin Proteolipid Protein - immunology | B7-1 Antigen - genetics | Spleen - immunology | Nanoparticles - chemistry | Ovalbumin - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Delayed-Action Preparations - chemistry | Spleen - drug effects | Polyglactin 910 - metabolism | T-Lymphocytes, Regulatory - pathology | Delayed-Action Preparations - administration & dosage | Myelin Proteolipid Protein - pharmacology | T-Lymphocytes, Regulatory - immunology | Antigen-Presenting Cells - pathology | Immunoconjugates - pharmacology | Female | CD40 Antigens - genetics | Encephalomyelitis, Autoimmune, Experimental - genetics | Polyglactin 910 - chemistry | B7-2 Antigen - immunology | Myelin Proteolipid Protein - chemistry | Spleen - pathology | Ovalbumin - chemistry | Immune Tolerance - drug effects | Gene Expression | Encephalomyelitis, Autoimmune, Experimental - pathology | B7-1 Antigen - immunology | Immunoconjugates - metabolism | Antigen-Presenting Cells - drug effects | Mice, Inbred C57BL | Ovalbumin - pharmacology | Antigen-Presenting Cells - immunology | Immunoconjugates - chemistry | Antigens - chemistry | Particle Size | Encephalomyelitis, Autoimmune, Experimental - therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Antigens - immunology | Mice | Nanoparticles - administration & dosage | Primary Cell Culture | Antigens - pharmacology | CD40 Antigens - immunology | Cell proliferation | Multiple sclerosis | Transcription factors | CD40 antigen | Disease | Peptides | CD86 antigen | Lymphocytes T | Nanoparticles | Myelin proteolipid protein | Lymphocytes | Localization | Immune system | Antigen presentation | Cytokines | Dendritic cells | Myelin | CD80 antigen | Inflammation | T cell receptors | Immunological tolerance | Studies | Major histocompatibility complex | Antigen-presenting cells | Internalization | PD-L1 protein | Proteolipid protein | Poly(lactide-co-glycolide) | Autoimmune diseases | Apoptosis | Index Medicus | Original
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 04/2019, Volume 143, Issue 4, pp. 1616 - 1620.e7
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6029, pp. 600 - 603
Journal Article
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, pp. 1188 - 1188
Recent reports in mice demonstrate that basophils function as antigen presenting cells (APC). They express MHC class II and co-stimulatory molecules CD80 and... 
IMMUNITY | RESPONSES | ASPERGILLUS-FUMIGATUS | PROTEASE-ACTIVATED RECEPTORS | DENDRITIC CELLS | INFLAMMATION | IGE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NEPHRITIS | T-CELLS | Coculture Techniques | Dendritic Cells - immunology | Humans | Monocytes - metabolism | Monocytes - immunology | Recombinant Proteins - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Basophils - immunology | Dendritic Cells - drug effects | HLA-DR Antigens - metabolism | Dendritic Cells - metabolism | Basophils - drug effects | Antigen-Presenting Cells - metabolism | Antigen-Presenting Cells - drug effects | CD4-Positive T-Lymphocytes - cytology | Interleukin-4 - metabolism | Allergens - genetics | B7-1 Antigen - metabolism | Recombinant Proteins - genetics | Antigens, Plant - pharmacology | Fungal Proteins - genetics | Recombinant Proteins - pharmacology | Antigen-Presenting Cells - immunology | Antigens, Plant - genetics | Allergens - metabolism | Monocytes - drug effects | B7-2 Antigen - metabolism | Antigens, Plant - metabolism | Allergens - pharmacology | Fungal Proteins - pharmacology | Basophils - metabolism | Fungal Proteins - metabolism | Cell culture | Antigens | Allergens | Bet v 1 antigen | Dendritic cells | CD86 antigen | Secretion | Immunoglobulin E | CD80 antigen | Lymphocytes T | CD4 antigen | Monocytes | Interleukin 4 | Major histocompatibility complex | Antigen-presenting cells | TLR2 protein | Toll-like receptors | Histocompatibility antigen HLA | Leukocytes (basophilic) | Index Medicus | Life Sciences | Innate immunity | Immunology
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e81777 - e81777
The antigen-presenting abilities of basophils and their role in initiating a Th2 phenotype is a topic of current controversy. We aimed to determine whether... 
B-CELLS | TH2 IMMUNITY | HELMINTH INFECTION | HUMAN EOSINOPHILS | HLA-DR | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | HUMAN IGE SYNTHESIS | ANTIGEN-PRESENTING CELLS | HUMAN BLOOD BASOPHILS | T-CELLS | B7-2 Antigen - genetics | B7-1 Antigen - genetics | Coculture Techniques | Humans | Th2 Cells - immunology | HLA-D Antigens - immunology | Interleukin-3 - pharmacology | Th2 Cells - drug effects | HLA-DR Antigens - genetics | Antigen Presentation | Basophils - immunology | Antigens, Differentiation, B-Lymphocyte - immunology | B7-2 Antigen - immunology | Antigens, Differentiation, B-Lymphocyte - genetics | Basophils - drug effects | Cathepsins - immunology | Gene Expression | HLA-D Antigens - genetics | B7-1 Antigen - immunology | Cells, Cultured | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Th2 Cells - cytology | Basophils - cytology | Histocompatibility Antigens Class II - immunology | Cathepsins - genetics | HLA-DR Antigens - immunology | Histocompatibility Antigens Class II - genetics | Interferon-gamma - pharmacology | Antigens | Cytokines | Analysis | Cathepsins | B cells | T cells | Gene expression | Peptides | CD86 antigen | Stimulation | Lymphocytes T | Cell activation | Cell growth | Immunology | Interleukin 3 | Lymphocytes | Immunotherapy | Food allergies | Antigen presentation | Incubation | Granulocyte-macrophage colony-stimulating factor | CD80 antigen | T cell receptors | Cathepsin S | Ribonucleic acid--RNA | Costimulator | Medicine | Studies | Hospitals | Major histocompatibility complex | Antigen-presenting cells | γ-Interferon | Interferon | Histocompatibility antigen HLA | Leukocytes (basophilic) | Index Medicus | RNA | Ribonucleic acid
Journal Article
Stem Cell Reviews and Reports, ISSN 1550-8943, 12/2012, Volume 8, Issue 4, pp. 1188 - 1198
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2017, Volume 76, Issue Suppl 2, p. 970
Journal Article
Nature, ISSN 0028-0836, 03/2001, Volume 410, Issue 6828, pp. 608 - 611
Optimal immune responses require both an antigen-specific and a co-stimulatory signal. The shared ligands B7-1 and B7-2 on antigen-presenting cells deliver the... 
SYSTEM | ADHESION | RECOGNITION | SOLUBLE FORM | MULTIDISCIPLINARY SCIENCES | T-CELL ACTIVATION | RECEPTOR | CTLA-4 | COSTIMULATION | BLOCKADE | MOLECULAR-BASIS | B7-1 Antigen - genetics | Cricetulus | Humans | Crystallography, X-Ray | Abatacept | B7-1 Antigen - chemistry | CHO Cells | Cricetinae | B7-1 Antigen - immunology | Models, Molecular | Recombinant Proteins - chemistry | Macromolecular Substances | CTLA-4 Antigen | Immunity - physiology | Animals | Antigens, Differentiation - chemistry | Immunoconjugates | T-Lymphocytes - chemistry | Protein Conformation | T-Lymphocytes - immunology | Antigens, Differentiation - genetics | Mice | Mutation | Antigens, CD | Antigens, Differentiation - immunology | Cell culture | Residues | Animal models | Crystal lattices | CD86 antigen | Hydrogen | Central nervous system | Conservation | X-ray diffraction | Amino acids | Lymphocytes T | CD28 antigen | Crystallography | Cell surface | B7 antigen | Light sources | Proteins | T-cell receptor | Cell recognition | Cell activation | Immunology | Lymphocytes | Immunotherapy | Cell adhesion | Genetics | Dimerization | Elbow | Crystal structure | Antigens | Immunoglobulins | Oligomerization | Complementarity | Immune response | CD152 antigen | Macromolecules | Crystals | T cell receptors | Topology | Nitrogen | Computer programs | Interfaces | Diffraction | Antigen-presenting cells | Data collection | Ligands | B7-1 antigen | CD162 antigen | Binding sites | B7-2 antigen | CTLA-4 protein | Index Medicus
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 11/2017, Volume 63, pp. 96 - 109
Anticancer immune responses depend on efficient presentation of tumor antigens and co-stimulatory signals provided by antigen-presenting cells (APCs). However,... 
Tumor microenvironment | Immunomodulation | APCs polarization | Nanotherapy | Colorectal cancer | POLY(GAMMA-GLUTAMIC ACID) | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | GAMMA-GLUTAMIC ACID | DENDRITIC CELLS | ENGINEERING, BIOMEDICAL | CHITOSAN | CANCER-IMMUNOTHERAPY | TUMOR-ASSOCIATED MACROPHAGES | ANTITUMOR IMMUNITY | POLARIZATION | T-CELLS | Inflammation - pathology | Humans | Polyglutamic Acid - administration & dosage | Nanoparticles - adverse effects | Polyglutamic Acid - analogs & derivatives | Antigen-Presenting Cells - pathology | T-Lymphocytes - drug effects | Dendritic Cells - drug effects | Cell Polarity - drug effects | Chitosan - adverse effects | Dendritic Cells - metabolism | Cell Survival - drug effects | Neoplasm Invasiveness | Antigen-Presenting Cells - drug effects | Endocytosis - drug effects | Particle Size | Cell Movement - drug effects | Macrophages - metabolism | Phenotype | T-Lymphocytes - cytology | Cell Differentiation - drug effects | Colonic Neoplasms - pathology | Macrophages - drug effects | Cell Proliferation - drug effects | Interleukin-10 - pharmacology | Polyglutamic Acid - adverse effects | Glutamate | Antigens | Genetic aspects | Dendritic cells | Development and progression | Amino acids | Disease susceptibility | T cells | Macrophages | Prevention | Nanoparticles | Tumor antigens | Cancer | Cell proliferation | Glutamic acid | CD40 antigen | CD86 antigen | CD8 antigen | Colorectal carcinoma | Effector cells | Lymphocytes T | Cancer therapies | Interleukin 6 | Cell activation | Lymphocytes | Antigen presentation | Immunostimulation | Immune response | Cytokines | Secretion | Invasiveness | Interleukin 12 | Inflammation | Cells | CD4 antigen | Immune systems | CD163 antigen | Immunosuppression | Acids | Antigen-presenting cells | Antigen (tumor-associated) | Interleukin 10 | Histocompatibility antigen HLA | Chitosan | Tumors | Index Medicus
Journal Article