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Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 16, pp. 4540 - 4544
Wee1 is a protein kinase that regulates the G2 checkpoint and prevents entry into mitosis in response to DNA damage. Cyclindependent kinases (CDK) are a family... 
DNA-DAMAGING AGENTS | IN-VITRO | INHIBITOR AZD1775 | THERAPY | ONCOLOGY | P53-DEFICIENT TUMOR-CELLS | OVARIAN-CANCER | G CHECKPOINT | S-PHASE CHECKPOINT | MK-1775 | CYCLE | Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | CDC2 Protein Kinase - metabolism | Carboplatin - adverse effects | Cell Cycle Proteins - antagonists & inhibitors | G2 Phase Cell Cycle Checkpoints - drug effects | Phosphorylation - drug effects | Pyrazoles - adverse effects | Pyrimidines - administration & dosage | Cell Cycle Proteins - metabolism | Carboplatin - administration & dosage | Nuclear Proteins - metabolism | Clinical Trials as Topic | Neoplasms - drug therapy | Pyrazoles - administration & dosage | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Nuclear Proteins - antagonists & inhibitors | Pyrimidines - adverse effects | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors | Cdc2 protein | Schedules | Phosphorylation | Mitosis | p53 Protein | DNA damage | Serine | Kinases | Damage prevention | DNA repair | Anticancer properties | Proteins | Cyclin B | Cell cycle | Inhibition | Deoxyribonucleic acid--DNA | Threonine | CHK1 protein | Cyclin-dependent kinases | Poly(ADP-ribose) polymerase | Side effects | Protein kinase | Carboplatin | Antitumor activity | Tumors | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 01/2002, Volume 62, Issue 1, pp. 188 - 199
Interactions between the kinase inhibitor STI571 and pharmacological antagonists of the mitogen-activated protein/extracellular signal-regulated kinase kinase... 
CHRONIC MYELOGENOUS LEUKEMIA | IN-VITRO | POSITIVE CELLS | 1-BETA-D-ARABINOFURANOSYLCYTOSINE-INDUCED APOPTOSIS | GENE | ONCOLOGY | ABL TYROSINE KINASE | PHILADELPHIA-CHROMOSOME | BCR-ABL | DNA-DAMAGE | RESISTANCE | MAP Kinase Signaling System - physiology | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase Kinases - physiology | G1 Phase - drug effects | K562 Cells - drug effects | Fusion Proteins, bcr-abl - biosynthesis | HL-60 Cells - pathology | MAP Kinase Kinase 2 | MAP Kinase Kinase 1 | CDC2 Protein Kinase - metabolism | DNA-Binding Proteins - metabolism | Protein-Tyrosine Kinases - physiology | K562 Cells - pathology | Milk Proteins | Protein-Serine-Threonine Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | U937 Cells - enzymology | Protein-Serine-Threonine Kinases - physiology | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | HL-60 Cells - drug effects | Pyrimidines - pharmacology | Down-Regulation - drug effects | Imatinib Mesylate | Piperazines - pharmacology | K562 Cells - enzymology | Drug Synergism | MAP Kinase Signaling System - drug effects | STAT5 Transcription Factor | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | Activating Transcription Factor 1 | Cyclic AMP Response Element-Binding Protein - metabolism | MAP Kinase Kinase Kinases - physiology | Resting Phase, Cell Cycle - drug effects | Trans-Activators - metabolism | U937 Cells - pathology | Transcription Factors | Apoptosis - physiology | HL-60 Cells - enzymology | Mitogen-Activated Protein Kinases - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | U937 Cells - drug effects
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2001, Volume 276, Issue 1, pp. 251 - 260
Journal Article
Oncology Reports, ISSN 1021-335X, 06/2018, Volume 39, Issue 6, pp. 2829 - 2836
The protein kinase, membrane-associated tyrosine/threonine 1 (PKMYT1) is known to inhibit precocious entry into mitosis by phosphorylating CDK1 at Thr14 and... 
Prognosis | Metastasis | PKMYT1 | Colorectal cancer | CELLS | COMPLEX | colorectal cancer | PHOSPHORYLATES CDC2 | prognosis | MYT1 | INHIBITORY KINASE | EPITHELIAL-MESENCHYMAL TRANSITION | WEE1 | ONCOLOGY | metastasis | GROWTH | INSIGHTS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2016, Volume 113, Issue 30, pp. 8466 - 8471
Journal Article
Journal of Medical Genetics, ISSN 0022-2593, 01/2018, Volume 55, Issue 1, pp. 28 - 38
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e102097
Zinc is an extremely important trace element that plays important roles in several biological processes. However, the function of zinc in meiotic division of... 
IN-VITRO | ACTIVATION | PIG OOCYTES | MEIOSIS-II | MULTIDISCIPLINARY SCIENCES | MATURATION-PROMOTING FACTOR | MOUSE OOCYTES | GERMINAL VESICLE | CUMULUS CELLS | CELL-CYCLE | MAMMALIAN OOCYTES | Meiosis - physiology | Zinc - metabolism | Cyclin B1 - metabolism | Chelating Agents - pharmacology | Ethylenediamines - pharmacology | CDC2 Protein Kinase - metabolism | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Swine - physiology | Meiosis - drug effects | Animals | Oocytes - physiology | Protein Kinase C - metabolism | Female | Proto-Oncogene Proteins c-mos - metabolism | Signal Transduction - physiology | Chelating Agents - metabolism | In Vitro Techniques | Ethylenediamines - metabolism | Real-Time Polymerase Chain Reaction | Mitogen-Activated Protein Kinases - metabolism | Tetradecanoylphorbol Acetate - metabolism | Zinc - deficiency | Zinc in the body | Zinc compounds | Cytokinins | Protein kinases | In vitro fertilization | Cdc2 protein | Phosphorylation | Protein kinase C | Maturation-promoting factor | Kinases | Oocytes | Proteins | Ethylenediamine | Cell cycle | Polyvinyl alcohol | Maturation | Animal sciences | MAP kinase | Meiosis | Mammals | Gene expression | Substrates | Zinc | Biological activity | Depletion | Trace elements | Acetic acid | Phorbol 12-myristate 13-acetate | Cytoplasm
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 11/2002, Volume 22, Issue 22, pp. 7831 - 7841
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0119346
Protein kinase D (PKD) has been implicated in many aspects of tumorigenesis and progression, and is an emerging molecular target for the development of... 
ACTIVATION LOOP SER | APOPTOSIS | POTENT | BOMBESIN | MULTIDISCIPLINARY SCIENCES | CHEMISTRY | MOLECULAR-CLONING | DNA-SYNTHESIS | PHORBOL ESTERS | EXPRESSION | CONTRIBUTES | Prostatic Neoplasms - pathology | M Phase Cell Cycle Checkpoints - drug effects | Pteridines - pharmacology | Pteridines - chemistry | Humans | Neoplasms, Experimental - enzymology | Male | Neoplasm Proteins - antagonists & inhibitors | Protein Kinase C - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms, Experimental - pathology | Xenograft Model Antitumor Assays | Animals | G2 Phase Cell Cycle Checkpoints - drug effects | Mice, Nude | Protein Kinase C - metabolism | Protein Kinase C - chemistry | Prostatic Neoplasms - enzymology | Cell Proliferation - drug effects | Mice | Neoplasms, Experimental - drug therapy | Prostatic Neoplasms - drug therapy | Cell cycle | Physiological aspects | Development and progression | Genetic aspects | Research | Protein kinases | Prostate cancer | Cell proliferation | Cdc2 protein | Phosphorylation | Biology | Kinases | Cancer therapies | Proteins | Cell growth | Bcl-x protein | Xenografts | Tumorigenesis | Inhibition | Pharmaceutical sciences | Cell survival | Cyclin-dependent kinases | Pharmacology | Survivin | Chemistry | Androgens | Inhibitors | Protein kinase | Biomarkers | In vivo methods and tests | Prostate | Cancer | Apoptosis
Journal Article
Journal Article