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cyclin-dependent kinase 2 (429) 429
cdc2-cdc28 kinases (376) 376
humans (312) 312
cyclin-dependent kinases - metabolism (233) 233
animals (223) 223
protein-serine-threonine kinases - metabolism (217) 217
cell cycle (146) 146
phosphorylation (145) 145
cyclin-dependent kinase inhibitor p27 (131) 131
cyclin-dependent kinase inhibitor p21 (117) 117
mice (116) 116
cyclins - biosynthesis (115) 115
biochemistry & molecular biology (113) 113
cell cycle proteins (113) 113
oncology (111) 111
cyclin-dependent kinases - biosynthesis (109) 109
tumor cells, cultured (109) 109
cyclins - metabolism (103) 103
protein-serine-threonine kinases - biosynthesis (102) 102
cyclin-dependent kinase 4 (101) 101
cell biology (100) 100
tumor suppressor proteins (97) 97
proto-oncogene proteins (95) 95
cyclin-dependent kinases - antagonists & inhibitors (92) 92
retinoblastoma protein - metabolism (85) 85
dna - biosynthesis (82) 82
cells, cultured (79) 79
cell line (78) 78
protein-serine-threonine kinases - antagonists & inhibitors (76) 76
expression (74) 74
cell division - drug effects (73) 73
cell cycle - drug effects (69) 69
female (67) 67
rats (67) 67
g1 phase (62) 62
transfection (60) 60
cyclin e - metabolism (59) 59
cell cycle - physiology (57) 57
cell division (57) 57
enzyme inhibitors - pharmacology (56) 56
cyclins - genetics (55) 55
cyclin-dependent kinases (54) 54
blotting, western (53) 53
male (50) 50
apoptosis (49) 49
cyclin-dependent kinases - genetics (49) 49
cell-cycle (48) 48
cdc2-cdc28 kinases - metabolism (46) 46
retinoblastoma protein (46) 46
protein-serine-threonine kinases - genetics (45) 45
s phase (45) 45
cell cycle proteins - metabolism (44) 44
g1 phase - drug effects (44) 44
s-phase (44) 44
cell cycle proteins - biosynthesis (43) 43
microtubule-associated proteins - metabolism (43) 43
microtubule-associated proteins - biosynthesis (42) 42
protein-kinase (40) 40
molecular sequence data (38) 38
p27 (38) 38
cyclin e - biosynthesis (37) 37
enzyme activation (37) 37
kinetics (37) 37
e2f transcription factors (36) 36
protein (36) 36
time factors (36) 36
dependent kinases (35) 35
gene expression (35) 35
p21 (35) 35
protein kinases - metabolism (34) 34
cancer (33) 33
cdk2 (33) 33
cell division - physiology (32) 32
cell line, tumor (32) 32
proliferation (32) 32
proteins (32) 32
transcription factors - metabolism (32) 32
flow cytometry (31) 31
gene-expression (31) 31
genetics & heredity (31) 31
signal transduction (31) 31
3t3 cells (30) 30
cyclin d1 (30) 30
cyclin d1 - metabolism (30) 30
growth (30) 30
activation (29) 29
cdc2 protein kinase - biosynthesis (29) 29
gene (29) 29
rna, messenger - biosynthesis (29) 29
rna, messenger - metabolism (29) 29
base sequence (28) 28
cdc2 protein kinase - metabolism (28) 28
cyclin a - metabolism (28) 28
dna-replication (28) 28
protein biosynthesis (28) 28
dna-binding proteins (27) 27
immunohistochemistry (27) 27
amino acid sequence (26) 26
cyclin d1 - biosynthesis (26) 26
down-regulation (26) 26
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Genetics, ISSN 0016-6731, 10/2016, Volume 204, Issue 2, pp. 807 - 819
The CKS1B gene located on chromosome 1q21 is frequently amplified in breast, lung, and liver cancers. CKS1B codes for a conserved regulatory subunit of... 
Cyclin-dependent kinase | CKS1 | Polo-like kinase | Synthetic dosage lethal | FISSION YEAST | BUDDING YEAST | CRYSTAL-STRUCTURE | synthetic dosage lethal | SACCHAROMYCES-CEREVISIAE | HEPATOCELLULAR-CARCINOMA | CYCLE CONTROL | polo-like kinase | GENETICS & HEREDITY | REGULATORY PROTEIN CKS1 | cyclin-dependent kinase | MORPHOGENESIS CHECKPOINT | SCHIZOSACCHAROMYCES-POMBE | Neoplasms - metabolism | Synthetic Lethal Mutations - genetics | Conserved Sequence - genetics | Saccharomyces cerevisiae - genetics | Humans | Gene Expression Regulation, Neoplastic | CDC2-CDC28 Kinases - biosynthesis | Saccharomyces cerevisiae Proteins - biosynthesis | Mitosis - genetics | Proto-Oncogene Proteins - biosynthesis | Saccharomyces cerevisiae - metabolism | Protein-Tyrosine Kinases - genetics | Neoplasms - genetics | Nuclear Proteins - biosynthesis | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Protein-Tyrosine Kinases - biosynthesis | Gene Expression Regulation, Fungal | Protein-Serine-Threonine Kinases - genetics | CDC28 Protein Kinase, S cerevisiae - genetics | Proto-Oncogene Proteins - genetics | Cell Cycle Proteins - biosynthesis | Saccharomyces cerevisiae Proteins - genetics | CDC28 Protein Kinase, S cerevisiae - biosynthesis | Protein Interaction Mapping | Protein-Serine-Threonine Kinases - biosynthesis | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | CDC2-CDC28 Kinases - genetics | Lethal mutation | Yeast | Research | Chromosomes | Cancer cells | Medical research | Phosphorylation | Cyclin-dependent kinases | Singers | Genomes | Kinases | Academic libraries | Studies | AACR | Gene amplification | Cell cycle | Mutation | Cancer | Apoptosis | Crystal structure | Investigations
Journal Article
Cancer Research, ISSN 0008-5472, 12/2003, Volume 63, Issue 23, pp. 8323 - 8329
Notch signaling plays a critical role in maintaining the balance between cell proliferation, differentiation, and apoptosis; hence, perturbed Notch signaling... 
ACTIVATED PROTEIN-KINASE | HUMAN HEPATOMA-CELLS | CANCER CELLS | GENE | ONCOLOGY | TRANSFECTION | GRANULOCYTIC DIFFERENTIATION | TUMOR-SUPPRESSOR | HIGH-TITER | HUMAN LIVER | EXPRESSION | Cyclin A - biosynthesis | Mitogen-Activated Protein Kinase Kinases - genetics | Phosphorylation | Tumor Suppressor Protein p53 - biosynthesis | Humans | Cyclins - genetics | Gene Expression Regulation, Neoplastic | CDC2-CDC28 Kinases - biosynthesis | Cyclin A - genetics | Cyclin E - genetics | Tumor Suppressor Protein p53 - genetics | MAP Kinase Signaling System | Cyclin-Dependent Kinase 2 | Cyclins - biosynthesis | MAP Kinase Kinase 4 | Carcinoma, Hepatocellular - genetics | JNK Mitogen-Activated Protein Kinases | Female | Liver Neoplasms - pathology | Receptors, Cell Surface - physiology | Gene Transfer Techniques | Liver Neoplasms - genetics | Signal Transduction | Cyclin-Dependent Kinase Inhibitor p21 | Retinoblastoma Protein - metabolism | Cyclin A1 | Mitogen-Activated Protein Kinase Kinases - biosynthesis | Animals | Mice, Nude | Carcinoma, Hepatocellular - pathology | Cyclin E - biosynthesis | Liver Neoplasms - metabolism | Cell Cycle - physiology | Cell Line, Tumor | Growth Inhibitors - physiology | Mice | Transcription Factors | Apoptosis - physiology | Receptor, Notch1 | CDC2-CDC28 Kinases - genetics | Carcinoma, Hepatocellular - metabolism | Receptors, Cell Surface - genetics
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/1999, Volume 19, Issue 7, pp. 4672 - 4683
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
TARGETED HOMOLOGOUS RECOMBINATION | DNA-BINDING | E GENE | CDK-ACTIVATING KINASE | RETINOBLASTOMA PROTEIN | GROWTH ARREST | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBCELLULAR-LOCALIZATION | DEPENDENT KINASE INHIBITOR | TRANSCRIPTION FACTOR | FUNCTIONAL INACTIVATION | CELL BIOLOGY | Cyclin A - biosynthesis | Phosphorylation | Cyclin-Dependent Kinases - metabolism | Microtubule-Associated Proteins - genetics | Humans | Proto-Oncogene Proteins c-fos - biosynthesis | E2F Transcription Factors | Retinoblastoma-Like Protein p107 | Phosphoproteins - metabolism | Proteins | Cyclin-Dependent Kinase 2 | Proto-Oncogene Proteins c-myc - physiology | Cyclins - metabolism | Cell Division | Calcium-Calmodulin-Dependent Protein Kinases - biosynthesis | Proto-Oncogene Proteins | Cyclin D | Protein-Serine-Threonine Kinases - metabolism | Carrier Proteins | DNA-Binding Proteins | Mitogen-Activated Protein Kinases | Cell Line | CDC2-CDC28 Kinases | Retinoblastoma Protein - metabolism | Rats | Cyclin-Dependent Kinases - biosynthesis | Nuclear Proteins - metabolism | Transcription Factors - biosynthesis | Cyclin-Dependent Kinase 4 | Cyclin-Dependent Kinase 6 | Cyclin-Dependent Kinase Inhibitor p27 | Protein-Serine-Threonine Kinases - biosynthesis | Transcription Factor DP1 | Animals | Cyclin E - biosynthesis | Retinoblastoma-Like Protein p130 | Cell Cycle - physiology | Proto-Oncogene Proteins c-myc - genetics | Enzyme Activation | Retinoblastoma-Binding Protein 1 | Mitogen-Activated Protein Kinase 1 | Cell Cycle Proteins | Mitogen-Activated Protein Kinase 3 | Tumor Suppressor Proteins | Cell Growth and Development
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2017, Volume 135, pp. 35 - 49
The model of our working hypothesis shows potential mechanisms by which 3-COA overcomes -induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK... 
Hsp90 | MEK1/2 | Lung cancer | Cks1b | Chemoresistance | 3-COA | DRUG-RESISTANCE | ANTITUMOR-ACTIVITY | REGULATOR | THERAPY | A549 CELLS | MEK/ERK | CKS1 | TARGETS | PHARMACOLOGY & PHARMACY | EXPRESSION | MYELOMA | Lung Neoplasms - drug therapy | MAP Kinase Signaling System - physiology | Follow-Up Studies | Humans | Lung Neoplasms - metabolism | Middle Aged | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - pharmacology | CDC2-CDC28 Kinases - biosynthesis | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Tumor Burden - physiology | Dose-Response Relationship, Drug | Adult | Female | Antineoplastic Agents - pharmacology | Purines - therapeutic use | Retrospective Studies | Benzodioxoles - therapeutic use | Oleanolic Acid - therapeutic use | Tumor Cells, Cultured | MAP Kinase Kinase Kinases - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - pathology | Purines - pharmacology | Carcinoma, Non-Small-Cell Lung - metabolism | MAP Kinase Kinase Kinases - metabolism | Animals | MAP Kinase Signaling System - drug effects | Tumor Burden - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Mice, Nude | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Aged | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Drug Resistance, Neoplasm - physiology | Benzodioxoles - pharmacology | Drug Resistance, Neoplasm - drug effects | Medical colleges | Care and treatment | Anthracyclines | Heat shock proteins | Development and progression | Protein kinases | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/1996, Volume 93, Issue 7, pp. 2735 - 2740
The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for studying inhibitory molecules that can modify... 
Molecules | Enzymes | Phenyls | Hydrogen bonds | Flavones | Crystals | Cell cycle | Atoms | Ligands | Biochemistry | cancer | cyclin-dependent kinase | drug design | protein kinase inhibitors | flavopiridol | CRYSTALLIZATION | CATALYTIC SUBUNIT | DEPENDENT KINASE-2 | PROTEIN-KINASE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | P21 | Chemical inhibitors | Ligand binding (Biochemistry) | Research
Journal Article
Anticancer Research, ISSN 0250-7005, 03/2005, Volume 25, Issue 2A, pp. 971 - 979
Journal Article
Oncology Reports, ISSN 1021-335X, 5/2014, Volume 31, Issue 5, pp. 1986 - 1992
Cyclin-dependent kinase subunit 2 (CKS2) is a cyclin-dependent kinase subunit (CKS) family member that participates in cell cycle regulation. Few studies have... 
esophageal squamous cell carcinoma | biomarker | prognosis | cyclin-dependent kinase subunit 2 | Esophageal squamous cell carcinoma | Biomarker | Prognosis | Cyclin-dependent kinase subunit 2 | BLADDER-CANCER | PROTEIN | PROGNOSTIC-FACTORS | IDENTIFICATION | OLIGONUCLEOTIDE MICROARRAY | OVEREXPRESSION | LYMPH-NODE METASTASIS | ONCOLOGY | GASTRIC-CANCER | GENE-EXPRESSION | CKS1 | Immunohistochemistry | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | CDC2-CDC28 Kinases - biosynthesis | Male | Esophageal Neoplasms - pathology | Carcinoma, Squamous Cell - mortality | RNA Interference | Lymphatic Metastasis - pathology | Aged, 80 and over | Cell Cycle Proteins - genetics | Esophageal Neoplasms - mortality | Female | Esophagus - cytology | Esophageal Squamous Cell Carcinoma | Cell Proliferation - genetics | Carrier Proteins - biosynthesis | Cell Cycle Proteins - biosynthesis | Carrier Proteins - genetics | Esophagus - pathology | Esophageal Neoplasms - genetics | Lymphatic Metastasis - genetics | Cell Line, Tumor | Aged | Biomarkers, Tumor - genetics | RNA, Small Interfering | CDC2-CDC28 Kinases - genetics | Proteins | Antigens | Lymphatic system | Medical prognosis | Cyclin-dependent kinases | Cell cycle | Protein expression | Metastasis | Multivariate analysis | Kinases | Phase transitions | Esophageal cancer
Journal Article
Cancer Research, ISSN 0008-5472, 08/2001, Volume 61, Issue 16, pp. 6137 - 6144
Trans-3,4 ' ,5-trihydroxystilbene (resveratrol), a polyphenolic compound found in the human diet, was reported recently to serve as an estrogen agonist with... 
BREAST-CANCER CELLS | GRAPES | EPITHELIAL-CELLS | ONCOLOGY | ESTROGEN-RECEPTOR-ALPHA | GENE-EXPRESSION | S-PHASE | RED WINE | PHYTOESTROGENS | INHIBITOR | BETA | Cyclin A - biosynthesis | Receptors, Estrogen - metabolism | Antigens, CD - biosynthesis | Humans | Transcriptional Activation - drug effects | Alkaline Phosphatase - metabolism | Endometrial Neoplasms - metabolism | Stilbenes - metabolism | Receptors, Progesterone - genetics | Cyclin A - genetics | Stilbenes - pharmacology | Antigens, CD - genetics | Cyclin E - genetics | RNA, Messenger - biosynthesis | Cyclin-Dependent Kinase 2 | Adenocarcinoma - metabolism | Drug Interactions | Estrogen Receptor alpha | Endometrial Neoplasms - genetics | Female | Adenocarcinoma - genetics | Antineoplastic Agents, Phytogenic - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Cyclin-Dependent Kinases - genetics | Estradiol - pharmacology | Cell Survival - drug effects | CDC2-CDC28 Kinases | Receptors, Estrogen - genetics | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Receptors, Estrogen - antagonists & inhibitors | Cyclin-Dependent Kinases - biosynthesis | Down-Regulation - drug effects | Adenocarcinoma - drug therapy | Estrogen Receptor Modulators - pharmacology | Protein-Serine-Threonine Kinases - biosynthesis | Alkaline Phosphatase - biosynthesis | Cyclin E - biosynthesis | Endometrial Neoplasms - drug therapy | S Phase - drug effects | Estrogen Receptor Modulators - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Estrogen Receptor beta | Integrin alpha1 | Receptors, Progesterone - biosynthesis
Journal Article
The Oncologist, ISSN 1083-7159, 10/2011, Volume 16, Issue 10, pp. 1440 - 1450
Journal Article
Journal Article