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Molecular Biology of the Cell, ISSN 1059-1524, 04/2011, Volume 22, Issue 8, pp. 1191 - 1206
Mitosis requires precise coordination of multiple global reorganizations of the nucleus and cytoplasm. Cyclin-dependent kinase 1 (Cdk1) is the primary upstream... 
ANAPHASE-PROMOTING COMPLEX | XENOPUS EGG EXTRACTS | PROTEIN PHOSPHATASES | CYCLE-DEPENDENT PHOSPHORYLATION | UBIQUITIN LIGASE | M-PHASE | CHROMOSOME ALIGNMENT | CELL-CYCLE | TUMOR-CELLS | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Cyclin-Dependent Kinases - metabolism | Gene Expression - drug effects | Xenopus Proteins - genetics | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | Phosphoprotein Phosphatases - metabolism | G2 Phase - drug effects | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Cyclin B - genetics | cdc25 Phosphatases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Prometaphase - drug effects | Female | Cyclin-Dependent Kinases - antagonists & inhibitors | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Cyclin-Dependent Kinases - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CDC2 Protein Kinase - genetics | Protein Phosphatase 2 - antagonists & inhibitors | CDC2 Protein Kinase - antagonists & inhibitors | Xenopus laevis | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Phosphoprotein Phosphatases - antagonists & inhibitors | cdc25 Phosphatases - genetics | Xenopus Proteins - antagonists & inhibitors | Membrane Proteins | Animals | Phosphoprotein Phosphatases - genetics | Nuclear Proteins - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Cyclin B - metabolism | Feedback, Physiological - drug effects | Xenopus Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | S Phase - drug effects | HeLa Cells | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 01/2012, Volume 12, Issue 1, pp. 62 - 73
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2016, Volume 62, Issue 2, pp. 307 - 313
Journal Article
Molecules, ISSN 1420-3049, 03/2017, Volume 22, Issue 3, p. 446
Cell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are... 
Cytogenetics | CDC25 inhibitors | Leukemic cell differentiation | Gene expression | Acute myeloid leukemia | PHASE INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOGENOUS LEUKEMIA | PROLIFERATION | cytogenetics | leukemic cell differentiation | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | CELL-DIVISION | AML CELLS | THERAPY | acute myeloid leukemia | CD34 EXPRESSION | DIVISION CYCLE 25 | gene expression | DUAL-SPECIFICITY PHOSPHATASES | Small Molecule Libraries - pharmacology | Cytoskeletal Proteins - genetics | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Profiling | cdc25 Phosphatases - antagonists & inhibitors | Nitro Compounds - pharmacology | Cytoskeletal Proteins - metabolism | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | Microtubule Proteins - genetics | cdc25 Phosphatases - metabolism | Cell Survival - drug effects | Pharmacogenetics | Ethylamines - pharmacology | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Computational Biology | Enzyme Inhibitors - pharmacology | Microtubule Proteins - metabolism | Naphthoquinones - pharmacology | cdc25 Phosphatases - genetics | Gene Expression Regulation, Leukemic | Genetic Heterogeneity | Myeloid Cells - metabolism | Myeloid Cells - pathology | Primary Cell Culture | Biomarkers, Pharmacological - metabolism | Leukemia, Myeloid, Acute - genetics | Chromatin | Profiling | Transcription | Leukemia | Gene regulation | Differentiation (biology) | Kinases | Heterogeneity | Genetic abnormalities | Cell cycle | Inhibition | Myeloid leukemia | Abnormalities | Cyclin-dependent kinases | Cell division | Cultures | Cell differentiation | Patients | Inhibitors | Microtubules | Cytoskeleton | Viability | In vitro methods and tests
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 03/2016, Volume 16, Issue 5, pp. 358 - 369
Journal Article
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 12/2006, Volume 119, Issue 12, pp. 2784 - 2794
The majority of cancer therapeutics induces DNA damage to kill cells. Normal proliferating cells undergo cell cycle arrest in response to DNA damage, thus... 
topoisomerase inhibitors | camptothecin | cell cycle checkpoint | Chk1 | doxorubicin | Cdc25A | small molecule inhibitor | Camptothecin | Topoisomerase inhibitors | Cell cycle checkpoint | Doxorubicin | Small molecule inhibitor | DEATH | P53 | DNA-DAMAGE CHECKPOINT | ONCOLOGY | PATHWAY | KINASES | CYCLE | Neoplasms - metabolism | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Protein Kinases - genetics | Humans | CDC2 Protein Kinase - immunology | Tumor Suppressor Protein p53 - genetics | Urea - chemistry | CDC2 Protein Kinase - metabolism | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Caspases - metabolism | Time Factors | Urea - analogs & derivatives | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Molecular Structure | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | cdc25 Phosphatases - genetics | Tumor Suppressor Protein p53 - deficiency | Cell Survival - radiation effects | Blotting, Western | Neoplasms - drug therapy | Antibodies - pharmacology | Drug Synergism | Protein Kinases - immunology | Cell Line, Tumor | Checkpoint Kinase 1 | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | DNA Damage | HeLa Cells | Cell Cycle - drug effects | Neoplasms - pathology | Camptothecin - pharmacology | Doxorubicin - pharmacology | Urea - pharmacology | Cell Proliferation - radiation effects
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 11/2014, Volume 9, Issue 11, pp. 2471 - 2478
SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase (PKMT) known to monomethylate lysine 20 of histone H4 in vivo. SETD8’s methyltransferase... 
PR-SET7 HISTONE METHYLTRANSFERASE | PROTEIN METHYLTRANSFERASES | SELECTIVE-INHIBITION | CELLS | METHYLATION | CDC25 | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | S-PHASE | CYCLE PROGRESSION | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | High-Throughput Screening Assays | Humans | HEK293 Cells | Letters
Journal Article