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Cell Reports, ISSN 2211-1247, 05/2013, Volume 3, Issue 5, pp. 1629 - 1639
c-Myc oncogenic activity is thought to be mediated in part by its ability to generate DNA replication stress and subsequent genomic instability when... 
Cdc45 protein
Journal Article
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 04/2012, Volume 109, Issue 16, pp. 6042 - 6047
In eukaryotes, although the Mcm2-7 complex is a key component of the replicative DNA helicase, its association with Cdc45 and GINS (the CMG complex) is... 
MCM2-7 HELICASE | IN-VITRO | CDC45 | REPLICATION FORKS | BUDDING YEAST | PHOSPHORYLATION | GINS | MULTIDISCIPLINARY SCIENCES | PROTEINS | SLD3 | EPSILON
Journal Article
Journal Article
Cell, ISSN 0092-8674, 2011, Volume 146, Issue 6, pp. 931 - 941
The eukaryotic replicative DNA helicase, CMG, unwinds DNA by an unknown mechanism. In some models, CMG encircles and translocates along one strand of DNA while... 
MCM2-7 HELICASE | HEXAMERIC HELICASE | MINICHROMOSOME MAINTENANCE PROTEIN | COMPLEX | ORIGIN | CDC45 | MECHANISM | STRUCTURAL BASIS | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERSTRAND CROSS-LINK | CELL BIOLOGY | DNA Helicases - metabolism | Animals | Xenopus - metabolism | Models, Biological | DNA, Single-Stranded - metabolism | S Phase | DNA Replication | DNA - metabolism | Amphibians | DNA | Analysis
Journal Article
Cell Cycle, ISSN 1538-4101, 04/2019, Volume 18, Issue 8, pp. 898 - 913
Besides TopBP1, ETAA1 has been identified more recently as an activator of the ATR-ATRIP complex in human cells. We have examined the role of ETAA1 in the... 
ETAA1 | RPA | Xenopus egg extract | TopBP1 | Chk1 | ATRIP | ATR | INITIATION | REPLICATION PROTEIN-A | KINASE | CELL BIOLOGY | CDC45 | BINDING
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 18602 - 18613
The replication fork helicase in eukaryotic cells is comprised of Cdc45, Mcm2-7, and GINS (CMG complex). In budding yeast, Sld3, Sld2, and Dpb11 are required... 
CDC45 | BUDDING YEAST | PHOSPHORYLATION | DPB11 | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHROMOSOME-REPLICATION | S-PHASE PROGRESSION | SACCHAROMYCES-CEREVISIAE | REPLICATION ORIGINS | ASSOCIATION
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 04/2016, Volume 37, pp. 145 - 151
Journal Article
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7695, pp. 265 - 268
The initiation of eukaryotic DNA replication occurs in two discrete stages(1): first, the minichromosome maintenance (MCM) complex assembles as a head-to-head... 
ORIGIN | DNA | MULTIDISCIPLINARY SCIENCES | MCM COMPLEX | ARCHITECTURE | SUGGESTS | CRYO-EM STRUCTURE | BINDING | Observations | DNA replication | Separation | Single-stranded DNA | Replication initiation | Activation | ADP | DNA biosynthesis | DNA helicase | Replication origins | Microscopy | S phase | Cdc45 protein | Replication | ATP | Assembly | Deoxyribonucleic acid--DNA | G1 phase
Journal Article
STRUCTURE, ISSN 0969-2126, 09/2014, Volume 22, Issue 9, pp. 1341 - 1347
The initiation of eukaryotic chromosomal DNA replication requires the formation of an active replicative helicase at the replication origins of chromosomal... 
ACTIVATION | COMPLEX | PHOSPHORYLATION | GINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DDK | CDK | SLD3 | CELL BIOLOGY | REFINEMENT | CDC45 | BIOPHYSICS | S-PHASE
Journal Article
Cellular Oncology, ISSN 2211-3428, 8/2019, Volume 42, Issue 4, pp. 571 - 578
Hub genes are good molecular candidates for targeted cancer therapy. As yet, however, there is little information on the clinical implications and functional... 
Biomedicine, general | Pathology | Hub genes | Biomedicine | CDC45 | Non-small cell lung cancer | Cancer Research | Oncology | Tumorigenesis | WGCNA | Therapeutic targets | ONCOLOGY | PROLIFERATION | PATHOLOGY | CYCLE-ASSOCIATED 5 | CELL BIOLOGY
Journal Article
MicrobiologyOpen, ISSN 2045-8827, 09/2019, Volume 8, Issue 9, pp. e00848 - n/a
The eukaryotic GINS, Cdc45, and minichromosome maintenance proteins form an essential complex that moves with the DNA replication fork. The GINS protein... 
PolD | DNA replication | GAN | GINS | archaea | HYPERTHERMOPHILIC ARCHAEON | EXONUCLEASE | MICROBIOLOGY | FUNCTIONAL INSIGHTS | PYROCOCCUS-FURIOSUS | FAMILY | TERMINAL DOMAINS | REPLICATION | CDC45 | COMPONENT | EXPRESSION | DNA polymerase | Genes | Cloning | Archaea | Homology | Genomes | DNA biosynthesis | Proteins | Polymerase | Exonuclease | Cdc45 protein | Replication | Nuclease | Thermophilic archaea | Deoxyribonucleic acid--DNA | DNA-directed DNA polymerase
Journal Article