X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
cddo-im (22) 22
index medicus (16) 16
oleanolic acid - analogs & derivatives (14) 14
oleanolic acid - pharmacology (11) 11
imidazoles - pharmacology (10) 10
oxidative stress (10) 10
animals (9) 9
humans (9) 9
nrf2 (9) 9
2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (6) 6
apoptosis (6) 6
biochemistry & molecular biology (6) 6
mice (6) 6
oncology (6) 6
pharmacology & pharmacy (6) 6
article (5) 5
cytoprotection (5) 5
dose-response relationship, drug (5) 5
nf-e2-related factor 2 - genetics (5) 5
oxidative stress - drug effects (5) 5
antioxidants (4) 4
gene expression (4) 4
gene expression regulation - drug effects (4) 4
glutathione (4) 4
heme oxygenase-1 (4) 4
keap1 (4) 4
liver (4) 4
liver - pathology (4) 4
male (4) 4
nf-e2-related factor 2 - metabolism (4) 4
oleanolic acid (4) 4
transcription factor nrf2 (4) 4
60 applied life sciences (3) 3
acid phenethyl ester (3) 3
activation (3) 3
acute myelogenous leukemia (3) 3
antioxidant (3) 3
cell line, tumor (3) 3
cell survival - drug effects (3) 3
cysteine (3) 3
cytoprotection - drug effects (3) 3
digestive system (3) 3
environment and public health (3) 3
heme (3) 3
imidazolide (3) 3
in-vivo (3) 3
inflammation (3) 3
ligases (3) 3
liver - drug effects (3) 3
mice, inbred c57bl (3) 3
mice, knockout (3) 3
nadh dehydrogenase (3) 3
oleanolic acid - therapeutic use (3) 3
proteins (3) 3
respiratory system (3) 3
signal transduction - drug effects (3) 3
toxicity (3) 3
toxicology (3) 3
transcription factors (3) 3
2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid cddo (2) 2
analysis (2) 2
antioxidants - metabolism (2) 2
antioxidants - pharmacology (2) 2
apoptosis - drug effects (2) 2
benzoquinones (2) 2
biology (2) 2
biophysics (2) 2
cancer (2) 2
cape (2) 2
cddo (2) 2
cddo-me (2) 2
cell differentiation - drug effects (2) 2
cells (2) 2
cells, cultured (2) 2
cytoprotection - genetics (2) 2
exposure (2) 2
expression (2) 2
gene expression profiling (2) 2
glutamate-cysteine ligase - metabolism (2) 2
hematology (2) 2
hematology, oncology and palliative medicine (2) 2
heme oxygenase-1 - metabolism (2) 2
hepatocellular carcinoma (2) 2
human umbilical vein endothelial cells - drug effects (2) 2
human umbilical vein endothelial cells - metabolism (2) 2
hydroquinones - pharmacology (2) 2
imidazole (2) 2
induction (2) 2
inflammatory response (2) 2
injury (2) 2
insulin-resistance (2) 2
kelch-like ech-associated protein 1 (2) 2
kinases (2) 2
liver - metabolism (2) 2
lung (2) 2
macrophages (2) 2
mirna (2) 2
mitogen-activated protein kinase 1 - metabolism (2) 2
mitogen-activated protein kinase 3 - metabolism (2) 2
mouse macrophages (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Free Radical Biology and Medicine, ISSN 0891-5849, 08/2012, Volume 53, Issue 4, pp. 817 - 827
The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine... 
Keap1 | Reactive cysteine | Stress response | Nrf2 | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CDDO-IM | PHASE-2 RESPONSE | ANTIOXIDANT | COVALENT MODIFICATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NITRIC-OXIDE | CYSTEINE RESIDUES | Oxidants - pharmacology | Maleates - pharmacology | Cytoskeletal Proteins - genetics | Humans | Oleanolic Acid - analogs & derivatives | Transcriptional Activation - drug effects | Oleanolic Acid - pharmacology | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Organoselenium Compounds - pharmacology | HEK293 Cells | Cytoskeletal Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Dimethyl Fumarate | Kelch-Like ECH-Associated Protein 1 | Macrophages, Peritoneal - drug effects | Isothiocyanates - pharmacology | Gene Expression | Mice, Transgenic | Imidazoles - pharmacology | Antioxidants - pharmacology | Azoles - pharmacology | Gene Expression Regulation - drug effects | Animals | Fumarates - pharmacology | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Glutamate-Cysteine Ligase - genetics | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | Amino Acid Substitution | Purines | Cysteine | Dimethylformamide | Ligases | Quinone | Transplantation of organs, tissues, etc | Universities and colleges | Macrophages | Cystine | Index Medicus | stress response | reactive cysteine
Journal Article
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 11/2017, Volume 56, Issue 11, pp. 2382 - 2390
Aflatoxin B1 (AFB1) is a potent human and animal hepatocarcinogen. To investigate the effects of aflatoxin on miRNA expression during the initiation phase of... 
RNA sequencing | miRNA | CDDO‐Im | aflatoxin B | hepatocellular carcinoma | CDDO-Im | Prevention | Epigenetic inheritance | MicroRNA | Analysis | Cancer | Dosing | Carcinogens | Liver | Animal tissues | Rodents | MiRNA | Aflatoxin B1 | Rats | Exposure | Carcinogenesis | Index Medicus | aflatoxin B1
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2007, Volume 6, Issue 1, pp. 154 - 162
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2006, Volume 5, Issue 12, pp. 3232 - 3239
The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im) is a multifunctional agent with potent anti-inflammatory,... 
CDDO-Im | IKK | Redox | NF-κB | Triterpenoid | BREAST-CANCER CELLS | TUMOR-NECROSIS-FACTOR | NITRIC-OXIDE PRODUCTION | RECEPTOR-GAMMA | ONCOLOGY | ACUTE MYELOGENOUS LEUKEMIA | IKK-BETA | INDUCE APOPTOSIS | MOUSE MACROPHAGES | 2-CYANO-3,12-DIOXOOLEANA-1,9-DIEN-28-OIC ACID CDDO | 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 236, Issue 1, pp. 109 - 114
CDDO-Im is a synthetic triterpenoid recently shown to induce cytoprotective genes through the Nrf2–Keap1 pathway, an important mechanism for the induction of... 
CDDO-Im | Oxidative stress | Nrf2 | Acetaminophen | Liver | LUNG | OXIDANT STRESS | SENSITIVITY | OLEANOLIC ACID | IMIDAZOLIDE | LIVER-INJURY | PHARMACOLOGY & PHARMACY | MICE | TOXICOLOGY | INFLAMMATORY RESPONSE | EXPRESSION | Heme Oxygenase-1 - metabolism | Liver - pathology | NADPH Dehydrogenase - metabolism | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - pharmacology | Male | Alanine Transaminase - blood | Nuclear Transfer Techniques | RNA, Messenger - metabolism | Necrosis | Dose-Response Relationship, Drug | Liver - drug effects | Time Factors | NF-E2-Related Factor 2 - genetics | Glutamate-Cysteine Ligase - metabolism | Membrane Proteins - metabolism | Disease Models, Animal | Liver Diseases - genetics | Response Elements | Liver - metabolism | Liver Diseases - prevention & control | Mice, Inbred C57BL | Imidazoles - pharmacology | Antioxidants - pharmacology | NF-E2-Related Factor 2 - deficiency | NAD(P)H Dehydrogenase (Quinone) | Mice, Knockout | Animals | NF-E2-Related Factor 2 - metabolism | Cytoprotection - genetics | Chemical and Drug Induced Liver Injury | Mice | Liver Diseases - metabolism | Cysteine | Thiols | Sarcoma | Quinone | Glutamate | Antioxidants | Messenger RNA | Aminotransferases | Ligases | Heme | Genetic research | Glutathione | Protein binding | Index Medicus | OXIDATION | TRANSCRIPTION FACTORS | INJURIES | ANTIOXIDANTS | FIBROSARCOMAS | DMSO | CYSTEINE | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | NAD | HEME | ALANINES | GLUTATHIONE | PROMOTERS | GENES | LIVER | LIGASES | OXYGENASES | TIME DEPENDENCE | AMINOTRANSFERASES | acetaminophen | liver | oxidative stress
Journal Article
Gene Regulation and Systems Biology, ISSN 1177-6250, 04/2017, Volume 2017, Issue 11, pp. 1177625017701106 - 1177625017701106
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2008, Volume 231, Issue 3, pp. 364 - 373
The iron chelate, ferric nitrilotriacetate (FeNTA), induces acute proximal tubular necrosis as a consequence of lipid peroxidation and oxidative tissue damage.... 
2,6-dichlorophenolindophenol | Oxidative stress | glutathione-S-transferase | DCPIP | HO-1 | Mrp | glutamate cysteine ligase catalytic subunit | relative light units | Kidney | 4-HNE | Multidrug resistance-associated protein | Nrf2 | 1-[2-cyano-3-,12-dioxooleana-1,9-dien-28-oyl]imidazole | NF-E2-related factor 2 | RLU | branched DNA signal amplification | ferric nitrilotriacetate | NQO1 | Kelch-like ECH-associated protein 1 | CDDO-Im | GST | heme oxygenase-1 | NAD(P)H:quinone oxidoreductase 1 | 4-hydroxynonenal | GCLC | FeNTA | bDNA | Keap1 | FERRIC NITRILOTRIACETATE | PROXIMAL TUBULES | HEME OXYGENASE-1 GENE | RESISTANCE-ASSOCIATED PROTEINS | kidney | TRANSCRIPTION FACTOR NRF2 | INDUCED RENAL CARCINOGENESIS | NF-E2-RELATED FACTOR-2 | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CDDO-IMIDAZOLIDE | BINDING-SITES | oxidative stress | Ferric Compounds - toxicity | Kidney Diseases - prevention & control | Mice, Inbred C57BL | Oxidative Stress - physiology | Gene Expression Regulation - physiology | Male | Nitrilotriacetic Acid - toxicity | Nitrilotriacetic Acid - analogs & derivatives | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Animals | Kidney Diseases - chemically induced | NF-E2-Related Factor 2 - genetics | Mice | Oxidative Stress - drug effects | NF-E2-Related Factor 2 - biosynthesis | Kidney Diseases - metabolism | Gene expression | Index Medicus | OXIDATION | TRANSCRIPTION FACTORS | TUBULES | CYSTEINE | IRON | TOXICITY | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | ECR HEATING | HEME | GLUTATHIONE | CARCINOMAS | CREATININE | LIGASES | MICE | OXYGENASES | UREA
Journal Article