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JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 09/2006, Volume 99, Issue 1, pp. 36 - 52
Focal adhesion kinase (FAK) is a non-receptor cytoplasmic tyrosine kinase that plays a key role in the regulation of proliferation and migration of normal and... 
proliferation | TYROSINE PHOSPHORYLATION | CYCLIN D1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEF1 | SERINE PHOSPHORYLATION | CELL BIOLOGY | FAK | CAS | focal adhesion kinase | SIGNALING PATHWAY | DOCKING PROTEIN | CDK INHIBITOR P27 | IN-VIVO | migration | GROWTH-FACTOR | SRC FAMILY KINASES | GLIOBLASTOMA CELLS
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 08/2013, Volume 20, Issue 8, pp. 1055 - 1067
  ZNF313 encoding a zinc-binding protein is located at chromosome 20q13.13, which exhibits a frequent genomic amplification in multiple human cancers. However,... 
CDK inhibitor | Ubiquitin ligase | Differentiation | XAF1 | Apoptosis | ubiquitin ligase | Original Paper | apoptosis | differentiation
Journal Article
Journal Article
Journal Article
Journal Article
CELL DEATH AND DIFFERENTIATION, ISSN 1350-9047, 03/2016, Volume 23, Issue 3, pp. 430 - 441
Cell-cycle inhibitors of the Ink4 and Cip/Kip families are involved in cellular senescence and tumor suppression. These inhibitors are individually dispensable... 
CDK INHIBITORS | STEM-CELLS | P18(INK4C) | BIOCHEMISTRY & MOLECULAR BIOLOGY | PITUITARY | TUMOR-SUPPRESSOR | P16(INK4A) | TUMORIGENESIS | MICE LACKING | P27(KIP1) | DNA-REPLICATION | CELL BIOLOGY
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2018, Volume 158, pp. 896 - 916
Through a structure-guided rational drug design approach, we have discovered a highly selective inhibitor compound (JSH-150), which exhibited an IC of 1 nM... 
CLL | SAR | DMSO | Leukemia | N-bromobutanimide | LDA | DIAD | 4-Dimethylaminopyridine | CDK | Cyclin-dependent kinase | Structure-activity relationship | DMAP | DMF | DME | Diisopropyl azodicarboxylate | NBS | AML | DIPEA | 1,2-Dimethoxyethane | N-dimethylformamide | Lithium diisopropylamide | Kinase inhibitor | DCM | CDK9 | Chronic lymphocytic leukemia | MCL | Mantle cell lymphoma | Dimethyl sulfoxide | Dimethyl chloride | N-diisopropylethylamine | Acute myeloid leukemia | CYCLIN-DEPENDENT KINASES | CELLS | CHEMISTRY, MEDICINAL | DINACICLIB SCH 727965 | CHRONIC LYMPHOCYTIC-LEUKEMIA | TARGETS | CANCER-THERAPY | Neoplasms - metabolism | Nitriles - pharmacology | Apoptosis - drug effects | Humans | Nitriles - pharmacokinetics | Protein Kinase Inhibitors - chemistry | Pyrans - chemistry | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Pyrans - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Antineoplastic Agents - chemistry | Rats, Sprague-Dawley | Neoplasms - drug therapy | Pyrans - pharmacokinetics | Animals | Mice, Nude | Dogs | Nitriles - chemistry | Cell Line, Tumor | Cyclin-Dependent Kinase 9 - metabolism | Mice | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Index Medicus
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 04/2011, Volume 10, Issue 8, pp. 1237 - 1248
Cell cycle inhibitors, such as the cyclin-dependent kinase (Cdk) inhibitor proteins and retinoblastoma (Rb) family members, control exit from the cell cycle... 
Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Auditory | p27 | Cdk inhibitor | Pituitary | Cell cycle | Cochlea | Proliferation | pituitary | cochlea | proliferation | Report | cell cycle | auditory
Journal Article
Journal Article
Current Opinion in Hematology, ISSN 1065-6251, 01/2013, Volume 20, Issue 1, pp. 10 - 15
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2007, Volume 407, Issue 3, pp. 451 - 460
Journal Article