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Journal of Experimental & Clinical Cancer Research, ISSN 1756-9966, 02/2019, Volume 38, Issue 1, pp. 50 - 50
Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key... 
Phosphates | Glucose metabolism | Enzymes | Prognosis | Analysis | Cell cycle | Physiological aspects | Hepatoma | Glucose | Health aspects | Dextrose | Proteins | Liver cancer | Phosphorylation | Cell growth | Penicillin | Metabolism | Kinases | Cancer therapies | Index Medicus | Phosphoenolpyruvate carboxykinase 1 | Cell cycle arrest | Hepatocellular carcinoma | AMP-activated protein kinase | CDK/Rb/E2F pathway
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1575 - 10
The mammalian CIP/KIP family proteins are intrinsically disordered proteins (IDPs) that can regulate various cellular processes. However, many reports have... 
CDK INHIBITORS | MULTIDISCIPLINARY SCIENCES | STRUCTURAL DISORDER | SEQUENCE | REGIONS | DEPENDENT-KINASE INHIBITOR | SUBCELLULAR-LOCALIZATION | BINDING | P27(KIP1) | P57(KIP2) | PREDICTION | Proteins | Spacer | Adaptability | Post-translation | Evolution | Kip protein | Amino acid substitution
Journal Article
Clinical Breast Cancer, ISSN 1526-8209, 07/2019
BACKGROUNDAdditional use of cyclin-dependent kinase 4/6 inhibitors with endocrine therapy improves progression-free survival (PFS) in advanced hormone receptor... 
Index Medicus
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2019, Volume 74, Issue 4, pp. 758 - 770.e4
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the... 
docking | cell-cycle regulation | kinase | cyclin | E2F | Cdk | phosphorylation | G1/S
Journal Article
Journal Article
Transcription, ISSN 2154-1264, 03/2019, Volume 10, Issue 2, pp. 111 - 117
Studies of RNA Polymerase II (Pol II) transcription of the HIV-1 genome are of clinical interest, as the insight gained may lead to strategies to selectively... 
CDK9 | CDK | HIV | HIV latency | Tat | P-TEFb | Cyclin-Dependent Kinases - metabolism | RNA Polymerase II - metabolism | Transcription, Genetic - genetics | HIV-1 - genetics | Humans | Polyadenylation | Index Medicus
Journal Article
The FEBS Journal, ISSN 1742-464X, 03/2019, Volume 286, Issue 5, pp. 963 - 974
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 615 - 639
The cyclin-dependent protein kinases (CDKs) are protein-serine/threonine kinases that display crucial effects in regulation of cell cycle and transcription.... 
Inhibitor | Co-crystal structure | Selectivity | CDK | Pharmacological activity | COMPLEX | CHEMISTRY, MEDICINAL | II INHIBITORS | DISCOVERY | CYCLIN-DEPENDENT KINASES | SELECTIVE INHIBITOR | DINACICLIB SCH 727965 | BIOLOGICAL EVALUATION | POTENT CLASS | STRUCTURE-BASED DESIGN | FLAVOPIRIDOL | Drugstores | Structure | Protein kinases | Pharmacy | Analysis | Crystals | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2019, Volume 73, Issue 3, pp. 446 - 457.e6
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 02/2019, Volume 15, Issue 2, pp. 217 - 231
Altered cell cycle reentry has been observed in Alzheimer's disease (AD). was predicted as the top driver of a cell cycle subnetwork associated with AD. We... 
CDT2 | Cell cycle reentry | CDK | Alzheimer's disease | DTL | PROTEIN | DNA-DAMAGE | TAU | P21 | CLINICAL NEUROLOGY | APOLIPOPROTEIN-E | RECEPTOR LR11 | REPLICATION | MOUSE MODEL | GENE-EXPRESSION | DEPENDENT KINASES
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 02/2019, Volume 37, Issue 2, pp. 510 - 521
(i) CDK9 is highly expressed in human synovial sarcomas and elevated expression correlates with the clinicopathological characteristics of sarcoma patients;... 
synovial sarcoma | targeted therapy | cyclin dependent kinase 9 | CDK inhibitors | RNA transcription | FUSION | TRANSCRIPTION | IDENTIFICATION | CANCER | P-TEFB | SYT | SSX | DIFFERENTIATION | ORTHOPEDICS | CDK9 INHIBITION | EXPRESSION | Proteins | RNA | Genetic transcription
Journal Article