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Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2015, Volume 25, Issue 17, pp. 3420 - 3435
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 10/2006, Volume 25, Issue 47, pp. 6304 - 6318
Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the... 
Caspase | Indirubin | Cell death | Protein kinase | Autophagy | Cancer | CANCER-CELLS | autophagy | cell death | INDIRUBIN DERIVATIVES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATOMA-CELLS | NEUROBLASTOMA-CELLS | protein kinase | PROTEIN-KINASES | caspase | CELL BIOLOGY | CYCLIN-DEPENDENT KINASES | indirubin | CDK INHIBITORY DRUGS | ONCOLOGY | ARYL-HYDROCARBON RECEPTOR | GENETICS & HEREDITY | SELECTIVE INHIBITORS | cancer | Caspases - physiology | Phosphorylation | Proto-Oncogene Proteins c-bcl-2 - physiology | Humans | Indoles - chemical synthesis | Male | Cell Line, Tumor - drug effects | Structure-Activity Relationship | Quinolines - pharmacology | Spodoptera | Tumor Suppressor Protein p53 - physiology | Recombinant Fusion Proteins - antagonists & inhibitors | Amino Acid Chloromethyl Ketones - pharmacology | Swine | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Indoles - pharmacology | Starfish | Cell Death - drug effects | Cyclin-Dependent Kinases - antagonists & inhibitors | STAT3 Transcription Factor - metabolism | Cell Line | CDC2 Protein Kinase - antagonists & inhibitors | Cell Line, Tumor - enzymology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Oximes - chemical synthesis | Cell Nucleus - ultrastructure | Oximes - chemistry | Animals | Cysteine Proteinase Inhibitors - pharmacology | bcl-X Protein - physiology | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Protein Processing, Post-Translational | Cell Cycle - drug effects | Indoles - chemistry | Proteins | Inhibitor drugs | Kinases | Leukemia | Apoptosis | Oximes | Quinolines | CDC2 Protein Kinase | Glycogen Synthase Kinase 3 | Recombinant Fusion Proteins | Life Sciences | Cell Death | Cyclin-Dependent Kinases | Indoles | bcl-X Protein | Cyclin-Dependent Kinase Inhibitor p21 | Biochemistry, Molecular Biology | Protein Kinase Inhibitors | Tumor Suppressor Protein p53 | Cell Cycle | Cysteine Proteinase Inhibitors | Amino Acid Chloromethyl Ketones | Cell Line, Tumor | STAT3 Transcription Factor | Proto-Oncogene Proteins c-bcl-2 | Caspases | Cell Nucleus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018, Volume 62, Issue 9, pp. 4233 - 4251
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal... 
POTENT ANTITUMOR-ACTIVITY | IN-VITRO | CHEMISTRY, MEDICINAL | DINACICLIB SCH 727965 | X-RAY CRYSTALLOGRAPHY | STRUCTURE-BASED DISCOVERY | DISTINCT ACTIVATION PATHWAYS | CELL-CYCLE | CDK INHIBITOR | CDK2-DEPENDENT PHOSPHORYLATION | STRUCTURE-BASED DESIGN
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2017, Volume 25, Issue 12, pp. 3018 - 3033
Journal Article
Current Drug Targets, ISSN 1389-4501, 03/2010, Volume 11, Issue 3, pp. 291 - 302
Poor therapeutic outcomes and serious side effects, together with acquired resistance to multiple drugs, are common problems of current cancer therapies.... 
Resistance | Therapy | Protein kinase | DNA damage | Oncology | Inhibitor | CDK | P53 | RNA-POLYMERASE-II | WILD-TYPE P53 | therapy | DOWN-REGULATION | TUMOR-CELLS | RIBOSOMAL-PROTEIN L11 | MULTIPLE-MYELOMA CELLS | protein kinase | oncology | resistance | p53 | BREAST-CANCER CELLS | inhibitor | CYC202 R-ROSCOVITINE | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Current Oncology Reports, ISSN 1523-3790, 5/2015, Volume 17, Issue 5, pp. 1 - 5
Dysregulation of the cell cycle is a classic hallmark of cancer growth and metastatic potential. Re-establishing cell cycle control through CDK inhibition has... 
Abemaciclib | Medicine & Public Health | CDK inhibition | Cell cycle | Palbociclib | LEE011 | Oncology | Breast cancer | Hormone-receptor positive | DEPENDENT KINASE INHIBITOR | ANTITUMOR-ACTIVITY | LY2835219 | ESTROGEN-RECEPTOR | PD0332991 | ONCOLOGY | SCHEDULE | PD 0332991 | PHASE-I | EXPRESSION | CYCLIN | Medical colleges | Development and progression | Analysis | Index Medicus
Journal Article