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DRUG DESIGN DEVELOPMENT AND THERAPY, ISSN 1177-8881, 2018, Volume 12, pp. 321 - 330
Although early breast cancer ( BC) is highly curable, advanced or metastatic disease poses numerous challenges in terms of medical management and treatment... 
CHEMISTRY, MEDICINAL | abemaciclib | RETINOBLASTOMA TUMOR-SUPPRESSOR | breast cancer | PHASE-II | ANTITUMOR-ACTIVITY | RIBOCICLIB LEE011 | COMBINATION | CDK4/6 inhibitor | mBC | metastatic BC | PALBOCICLIB | DEPENDENT KINASE 4/6 | CDK6 | THERAPY | hormone receptor-positive BC | RESISTANCE | PHARMACOLOGY & PHARMACY | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Receptors, Estrogen - metabolism | Humans | Aminopyridines - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Treatment Outcome | Cyclin-Dependent Kinase 6 - metabolism | Protein Kinase Inhibitors - adverse effects | Cyclin-Dependent Kinase 4 - metabolism | Breast Neoplasms - drug therapy | Receptors, Progesterone - metabolism | Breast Neoplasms - enzymology | Animals | Aminopyridines - therapeutic use | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Female | Hormone Antagonists - therapeutic use | Benzimidazoles - adverse effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Receptor, ErbB-2 - deficiency | Benzimidazoles - therapeutic use | Care and treatment | Enzyme inhibitors | Development and progression | Breast cancer | Genetic aspects | Health aspects | Phosphotransferases | Medical research | Regulatory agencies | Estrogens | Medical services | Clinical trials | FDA approval | Disease control | Machinery | ErbB-2 protein | Cyclin-dependent kinase 4 | Metastases | Anticancer properties | Cyclin-dependent kinase | Signal transduction | Signaling | Inhibitors | Antitumor agents | Antitumor activity | Cyclin D | Retinoblastoma | Viability | Cancer | Phosphorylation | Lung cancer | Metastasis | Kinases | Cancer therapies | Proteins | Cell cycle | Drug dosages | Cyclin-dependent kinases | Stem cells | Tumors | Abemaciblib | Hormone-Receptor Positive BC | Breast Cancer
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2019, Volume 25, Issue 3, pp. 921 - 927
The uncontrolled proliferation of cancer cells has led to the development of small-molecule inhibitors to target cell-cycle progression. Palbociclib,... 
BREAST-CANCER | ACTIVATION | DEPENDENT KINASE 4/6 | DINACICLIB SCH 727965 | CDK6 | EFFICACY | ONCOLOGY | PHOSPHORYLATION | CYCLIN D3 | ACQUIRED-RESISTANCE | SENESCENCE
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 07/2018, Volume 153, pp. 230 - 241
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2019, Volume 25, Issue 1, pp. 21 - 28
Dysregulation of cell division resulting in aberrant cell proliferation is a key hallmark of cancer, making it a rational and important target for innovative... 
BREAST-CANCER | CDK6 INHIBITOR | DEPENDENT KINASE 4/6 | RB/E2F PATHWAY | ONCOLOGY | CDK4/6 INHIBITOR | GENE-EXPRESSION | HIGH-FREQUENCY | PHASE-II | CELLULAR SENESCENCE | ESTROGEN-RECEPTOR
Journal Article
Neuro-Oncology, ISSN 1522-8517, 07/2012, Volume 14, Issue 7, pp. 870 - 881
Journal Article
Oncogene, ISSN 0950-9232, 09/2018, Volume 37, Issue 37, pp. 5066 - 5078
CDK4/6 inhibitors are being used to treat a variety of human malignancies. In well-differentiated and dedifferentiated liposarcoma their clinical promise is... 
SURVIVAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | SUPPRESSION | CELL BIOLOGY | BREAST-CANCER | PALBOCICLIB | DEDIFFERENTIATED LIPOSARCOMA | CDK6 | ONCOLOGY | SARCOMA | GENETICS & HEREDITY | TUMOR-GROWTH | PROGRESSION | Aging | Cadherins | Research | Gene expression | Cyclins | Proteins | MDM2 protein | Senescence | Liposarcoma | Clinical trials | Tumor cell lines | Cyclin-dependent kinase 4
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 04/2019, Volume 18, Issue 4, pp. 771 - 779
The interaction of a drug with its target is critical to achieve drug efficacy. In cases where cellular environment influences target engagement, differences... 
DEPENDENT KINASE CDK6 | 1ST-LINE TREATMENT | PALBOCICLIB | P16(INK4A) EXPRESSION | ONCOLOGY | CRYSTAL-STRUCTURE | SENSITIVITY | COMBINATION | ABERRATIONS | CANCER
Journal Article
Cell Reports, ISSN 2211-1247, 03/2019, Volume 26, Issue 10, pp. 2667 - 2680.e7
CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptor-positive (ER ) breast cancer, so that defining mechanisms of... 
targeted therapy | SMAD4 | CDK6 | exosomes | breast cancer | microRNA | TGF-β | drug resistance | palbociclib | ribociclib | BREAST-CANCER | CELLS | DEPENDENT KINASE 4/6 | MOLECULAR PORTRAITS | THERAPY | AMPLIFICATION | CYCLIN D1 | ABEMACICLIB | EXPRESSION | CELL BIOLOGY
Journal Article
Cell Reports, ISSN 2211-1247, 03/2018, Volume 22, Issue 11, pp. 2978 - 2994
Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), has recently been approved for the treatment of hormone receptor-positive breast... 
PD-L1 | combination immunotherapy | cancer | CDK4/6 | PD-1 | abemaciclib | BREAST-CANCER | IMMUNITY | PALBOCICLIB | THERAPY | CDK6 | SENESCENCE | ANTITUMOR-ACTIVITY | CELL BIOLOGY
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 11/2019, Volume 18, Issue 11, pp. 2158 - 2170
CDK4/6 inhibitors are FDA-approved drugs for estrogen receptor-positive (ER+) breast cancer and are being evaluated to treat other tumor types, including... 
BREAST-CANCER | COMPLEX | CDK6 | METABOLISM | NEXUS | ONCOLOGY | TRANSLATION | COMBINATION | EXPRESSION | ESTROGEN-RECEPTOR
Journal Article
Journal Article