X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
cdk8 (148) 148
index medicus (134) 134
humans (97) 97
transcription (60) 60
animals (56) 56
cell biology (55) 55
mediator complex (55) 55
rna-polymerase-ii (53) 53
biochemistry & molecular biology (49) 49
mediator (49) 49
cyclin-dependent kinase 8 - metabolism (43) 43
cancer (41) 41
beta-catenin (40) 40
expression (37) 37
activation (35) 35
mediator complex - genetics (34) 34
human cdk8 subcomplex (33) 33
oncology (33) 33
cyclin-dependent kinase 8 - genetics (32) 32
cyclin c (30) 30
article (28) 28
gene expression (28) 28
gene-expression (28) 28
mediator complex - metabolism (28) 28
protein binding (28) 28
female (27) 27
genes (27) 27
mice (26) 26
mutation (26) 26
complex (25) 25
phosphorylation (25) 25
analysis (24) 24
genetic aspects (24) 24
colorectal-cancer (23) 23
research (23) 23
cell line, tumor (22) 22
cyclin-dependent kinases (22) 22
kinases (22) 22
transcription, genetic (22) 22
cell cycle (21) 21
med12 (21) 21
cdk19 (20) 20
genetic transcription (20) 20
transcriptional activation (20) 20
cyclin-dependent kinase 8 (18) 18
genetics & heredity (18) 18
proteins (18) 18
signal transduction (18) 18
cyclin-dependent kinases - metabolism (17) 17
proliferation (17) 17
transcription factors - metabolism (17) 17
apoptosis (16) 16
gene expression regulation, neoplastic (16) 16
rna (16) 16
transcription factors - genetics (15) 15
cell proliferation (14) 14
cell-cycle (14) 14
developmental biology (14) 14
kinase (14) 14
male (14) 14
rna polymerase ii - metabolism (14) 14
yeast (14) 14
chemistry, medicinal (13) 13
cyclin c - metabolism (13) 13
progression (13) 13
biology (12) 12
cyclin-dependent kinase 8 - antagonists & inhibitors (12) 12
dependent kinase 8 (12) 12
gene (12) 12
growth (12) 12
promoter regions, genetic (12) 12
rna polymerase ii (12) 12
transcription factors (12) 12
transcriptional regulation (12) 12
tumors (12) 12
colon cancer (11) 11
colorectal cancer (11) 11
gene expression profiling (11) 11
gene expression regulation (11) 11
health aspects (11) 11
med13 (11) 11
medicine, research & experimental (11) 11
phosphotransferases (11) 11
physiological aspects (11) 11
binding (10) 10
cyclin c - genetics (10) 10
cyclin-dependent kinase 8 - chemistry (10) 10
molecular sequence data (10) 10
multidisciplinary sciences (10) 10
protein (10) 10
protein kinase inhibitors - pharmacology (10) 10
wnt (10) 10
amino acid sequence (9) 9
beta catenin - metabolism (9) 9
breast cancer (9) 9
cells (9) 9
cyclin-dependent kinases - antagonists & inhibitors (9) 9
elongation (9) 9
genomics (9) 9
hela cells (9) 9
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Oncotarget, ISSN 1949-2553, 01/2019, Volume 10, Issue 6, pp. 622 - 623
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 36, pp. 13778 - 13785
Journal Article
British Journal of Cancer, ISSN 0007-0920, 04/2014, Volume 110, Issue 9, pp. 2246 - 2249
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2018, Volume 9, Issue 6, pp. 540 - 545
Cortistatin A is a natural product isolated from the marine sponge Corticium simplex and was found to be a potent and selective inhibitor of CDK8. Many... 
Cortistatin A | CDK8 | kinase inhibitor | CDK19 | E3 ligase | Cereblon | PROTAC | mediator complex | degradation | ACTIVATION | CHEMISTRY, MEDICINAL | SRB10/CDK8 | TURNOVER | KINASE | TRANSCRIPTION | CORTISTATIN | ELONGATION | GENES
Journal Article
Cell Cycle, ISSN 1538-4101, 06/2016, Volume 15, Issue 11, pp. 1479 - 1493
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 356, Issue 2, pp. 613 - 627
Journal Article
by Guo, ZL and Wang, G and Lv, YF and Wan, YY and Zheng, JN
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 08/2019, Volume 10
Foxp3 expressing regulatory T (Treg) cells, as the central negative regulator of adaptive immune system, are essential to suppress immune response and maintain... 
TGF-BETA | SMALL-MOLECULE | IMMUNOLOGY | CANCER | Cdk8/Cdk19 | TRANSITION | CDK8 | TGF-beta signaling | POTENT | experimental autoimmune encephalomyelitis (EAE) | REGULATORY T-CELLS | Treg cells | Foxp3 | KINASES | TGF-β signaling
Journal Article
mBio, ISSN 2161-2129, 01/2019, Volume 10, Issue 1, p. e02320-18
Candida albicans is the most common cause of invasive fungal infections in humans. Its ability to sense and adapt to changing carbon dioxide levels is crucial... 
Candida albicans | Ume6 | Carbon dioxide signaling | Ssn3/Cdk8 | Hyphal development | ENCODES | KINASE | carbon dioxide signaling | MICROBIOLOGY | VIRULENCE | hyphal development | REGULATOR | GENE | ADENYLYL-CYCLASE | 2C PROTEIN PHOSPHATASES | GROWTH | ABSCISIC-ACID | TRANSCRIPTION FACTOR
Journal Article
Oncotarget, ISSN 1949-2553, 03/2018, Volume 9, Issue 17, p. 13474
The CDK8/19 kinase module comprises a subcomplex that interacts with the Mediator complex and regulates gene expression through phosphorylation of... 
Journal Article
G3 (Bethesda, Md.), ISSN 2160-1836, 04/2019, Volume 9, Issue 6, pp. g3.400077.2019 - 1908
The transcriptional changes that occur in response to oxidative stress help direct the decision to maintain cell viability or enter a cell death pathway.... 
Cdk8 | Mediator | Cyclin C | Oxidative Stress | RNA-seq
Journal Article
Pharmaceuticals (Basel, Switzerland), ISSN 1424-8247, 06/2019, Volume 12, Issue 2, p. 92
Improvements in cancer therapy frequently stem from the development of new small-molecule inhibitors, paralleled by the identification of biomarkers that can... 
mediator complex | CDK8 | cancer
Journal Article
The Journal of Pathology, ISSN 0022-3417, 12/2015, Volume 237, Issue 4, pp. 508 - 519
CDK8 is a dissociable kinase module of the Mediator complex and has been shown to play an important role in transcriptional regulation in organisms as diverse... 
Cdk8 | Min | Apc | colon cancer | cyclin C | Colon cancer | RNA | Analysis | Melanoma | Tumors
Journal Article